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- 저자 : Rui Ling Yao (검색결과 4 건)
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Optimum Ca(NO3)2 Supply Develops Salt Tolerance in NaCl-stressed Cyclocarya paliurus Seedlings
Rui Ling Yao,Yin Wang 한국원예학회 2012 Horticulture, Environment, and Biotechnology Vol.53 No.1
The effect of varying Ca(NO3)2 supply (0, 6, 12, and 18 mM) on growth, ion uptake, leaf chlorophyll concentration and photosynthesis of NaCl-stressed (85 mM NaCl) Cyclocarya paliurus seedlings was investigated. Addition of Ca(NO3)2 stimulated the shoot growth more than root growth. Ca(NO3)2 supply increased K+ and Ca2+ concentration,whereas the Na+ transport to the leaves was inhibited. There was a strong increase in the K+/Na+ ratio in the leaves of Ca(NO3)2-treated seedlings. Leaf chlorophyll concentration and photosynthesis rate were low, but both factors were enhanced by 12 mM Ca(NO3)2. Therefore, moderate Ca(NO3)2 supply (12 mM) had optimal effects on growth and metabolism of NaCl-stressed C. paliurus seedlings.
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Ling Chen,Cheng-Zhi Zhan,Tao Wang,Hua You,Rui Yao 연세대학교의과대학 2020 Yonsei medical journal Vol.61 No.1
Purpose: Curcumin exerts its anti-cancer effects, partly by targeting special microRNAs, in human cancers. MiR-21 is a key oncomirin carcinogenesis of multiple human cancers. Here, we aimed to further explore the mechanistic insight into the link betweencurcumin and miR-21 on diffuse large B-cell lymphoma (DLBCL). Materials and Methods: Quantitative real-time PCR assays were performed to assess the levels of miR-21 and Von Hippel-Lindau(VHL) mRNA. In situ hybridization assay was used for miR-21 expression visualization in lymphoma tissues. Western blot was usedfor determination of VHL protein, Ki-67, caspase-3, and cleaved caspase-3 levels. Dual-luciferase reporter assay and RNA immunoprecipitationassay were employed to confirm the direct target of miR-21. MTT assay, flow cytometric analysis, and transwell assaywere used to evaluate cell proliferation, apoptosis, and migration and invasion capacities, respectively. Results: Curcumin repressed the proliferation, migration, and invasion abilities and promoted apoptosis in SU-DHL-8 cells. Curcumininhibited miR-21 expression and curcumin exerted its anti-proliferation, anti-migration, anti-invasion, and pro-apoptosiseffects by miR-21 in SU-DHL-8 cells. VHL was a direct target of miR-21. Moreover, curcumin exerted its regulatory effects on SUDHL-8 cells by VHL. Conclusion: Curcumin exerted its anti-proliferation, anti-migration, anti-invasion, and pro-apoptosis functions, at least partly, byrepressing miR-21 and regulating VHL expression in DLBCL cell line. Our findings provided a possible molecular mechanism ofcurcumin-mediated anti-cancer effect.
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Yang, Zhi-Ping,Xie, Yong-Hong,Ling, Dan-Yan,Li, Jin-Rui,Jiang, Jin,Fan, Yao-Hua,Zheng, Jia-Lian,Wu, Wan-Xin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.17
SCY1-like 1-binding protein 1 (SCYL1BP1) is a newly identified transcriptional activator domain containing protein with many unknown biological functions. Recently emerging evidence has revealed that it is a novel regulator of the p53 pathway, which is very important for the development of human cancer. However, the effects of SCYL1BP1 on human lung squamous carcinoma cell biological behavior remain poorly understood. In this study, we present evidence that SCYL1BP1 can promote the degradation of MDM2 protein and further inhibit the G1/S transition of lung squamous carcinoma cell lines. Functional assays found that reintroduction of SCYL1BP1 into lung squamous carcinoma cell lines significantly inhibited cell proliferation, migration, invasion and tumor formation in nude mice, suggesting strong tumor suppressive function of SCYL1BP1 in lung squamous carcinoma. Taken together, our data suggest that the interaction of SCYL1BP1/MDM2 could accelerate MDM2 degradation, and may function as an important tumor suppressor in lung squamous carcinomas.
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Lin Fang,Fei-Hu Yan,Chao Liu,Jing Chen,Dan Wang,Chun-Hui Zhang,Chang-Jie Lou,Jie Lian,Yang Yao,Bo-Jun Wang,Rui-Yang Li,Shu-Ling Han,Yi-Bing Bai,Jia-Ni Yang,Zhi-Wei Li,Yan-Qiao Zhang 대한암학회 2021 Cancer Research and Treatment Vol.53 No.1
Purpose Systemic inflammatory response is a critical factor that promotes the initiation and metastasis of malignancies including pancreatic cancer (PC). This study was designed to determine and compare the prognostic value of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and fibrinogen-to-albumin ratio (FAR) in resectable PC and locally advanced or metastatic PC. Materials and Methods Three hundred fifty-three patients with resectable PC and 807 patients with locally advan-ced or metastatic PC were recruited in this study. These patients were classified into a training set (n=758) and a validation set (n=402). Kaplan-Meier survival plots and Cox proportional hazards regression models were used to analyze prognosis. Results Overall survival (OS) was significantly better for patients with resectable PC with low preoperative PLR (p=0.048) and MLR (p=0.027). Low FAR, MLR, NLR (p < 0.001), and PLR (p=0.003) were significantly associated with decreased risk of death for locally advanced or metastatic PC patients. FAR (hazard ratio [HR], 1.522; 95% confidential interval [CI], 1.261 to 1.837; p < 0.001) and MLR (HR, 1.248; 95% CI, 1.017 to 1.532; p=0.034) were independent prognostic factors for locally advanced or metastatic PC. Conclusion The prognostic roles of FAR, MLR, NLR, and PLR in resectable PC and locally advanced or metastatic PC were different. FAR showed the most prognostic power in locally advanced or metastatic PC. Low FAR was positively correlated with OS in locally advanced or metastatic PC, which could be used to predict the prognosis.
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