음성 인식 헬스케어 시스템

신진우,조우승,조성빈,김재훈,정지은,사예지,백경동,박동규 순천향대학교 부설 산업기술연구소 2021 순천향 산업기술연구소논문집 Vol.27 No.2

As modern people's interest in health grows, wearable healthcare-related technologies that can collect biometric information and receive health-related services regardless of time and place are developing. This paper proposes the healthcare system based on voice recognition function. Unlike conventional wearable healthcare systems, the proposed system provides real-time telemedicine and diagnosis and the direct connection with doctors is possible through it. And almost all functions of the application in it are operated with voice commands to lower user access barriers. Because it deals with personal information including medical information, encryption algorithms have been applied between all data movements. Finally, the healthcare system proposed in this paper is expected to increase convenience in health care and reduce the medical gap.

경기도와 강원도 야생들쥐의 리켓치아 감염에 대한 혈청학적 조사

백락주,송진원,송기준,고은영,정기모,이용주 대한감염학회 1998 감염 Vol.30 No.5

목적: 1997년과 1998년 경기도의 농경지에서 채집한 4종의 야생들쥐 211수와 강원도 산악지대에서 채집한 3종 302수의 야생들쥐를 대상으로 O. tsutsugamushi의 Gilliam주와 Karp주에 대한 항체검사를 실시하여 농경지와 산악지대에서 서식하는 야생들쥐의 항체양성율을 비교하고자 하였다. 방법: 경기도 6개 지역과 강원도의 7개 산악지대에서 야생들쥐 총 513수를 채집하여 O.tsutsugamushi의 Gilliam주와 Karp주에 대한 항체검사를 간접형광항체법으로 실시하였다. 결과: 경기도에서는 등줄쥐, 갈밭쥐 및 멧밭쥐에서 항체양성을 확인할 수 있었고 항체양성율은 지역에 따라 차이가 있었지만 전체적으로 17.5%의 항체양성율을 나타내었다. 강원도의 7개 산의 해발 500미터 이상의 지점에서 채집한 야생들쥐중 등줄쥐와 흰넓적다리붉은쥐서는 항체양성을 확인할 수 있었고 대륙밭쥐는 모두 항체음성으로 나타났다. 전체적으로는 3.3%의 항체양성율을 나타내었다. 결론: 국내에서 발생하는 열성질환인 쯔쯔가무시병은 농경지에서 서식하고 있는 야생들쥐를 숙주로 하는 털진드기의 매개로 사람에 감염된다. 야생들쥐의 리켓치아 감염은 최우점종인 등줄쥐를 대상으로 연구가 이루어져 왔으며 항체양성율은 15∼20%로 보고되었다. 본 연구에서도 경기도의 농경지에서 채집한 야생들쥐의 리켓치아 감염율은 17.5%로 나타났다. 그러나 강원도 산악지대에서 채집한 야생들쥐의 감염율은 3.3%로 나타나 큰 차이를 보이고 있다. 이와 같은 결과는 두지역에서 서식하는 야생들쥐의 종별 차이에 관계가 있는 것이 아니고 O. tsutsugamushi의 매개곤충으로 알려진 L. palpale, L. pallidum, L.scutellae, L.orientale, L. zetum의 시식밀도나 서식분포에 관련이 있을 것으로 사료되며 향후 이에 대한 추가적 연구가 요구된다. Background: This study was designed to determine the serpositivity for rickettsial infection among wild rodents captured in farms of Kyunggi province and in mountains of Kangwon province in Korea. Methods: A total of 513 wild rodents of 5 species were captured in 1997∼1998. Serological evidence for rickettsial infection was obtained using Orientia tsutsugamushi antigens by indirect immunofluorescent antibody technique(IFA). Results: 168 Apodemus agrarius, 35 Microtus fortis 3 Micromis minuets and 2 Eothenomys regulus were captured in Kyunggi province, of which 32 Apodemus agrarius, 4 Microtus fortis, 1 Micromis minutus were IF antibody positive against O. tsutsugamushi. 196 Apodemus agrarius, 77 Apodemus peninsulae and 29 Eothenomys regulus were captured in Kangwon province, of which 4 Apodemus agrarius and 5 Apodemus peninsulae were positive. Conclusion: Seropositivity rate against O. tsutsugamushi of wild rodents captured in Kyunggi and Kangwon provinces were 19.6% and 3.0% by IFA tests, respectively.

대구지역의 대기오염도 특성평가(I) : 지역별 및 계절별 농도변동을 중심으로 Locational and Seasonal variations

백성옥,최진수,황승만,김광은 嶺南大學校 環境問題硏究所 1996 環境硏究 Vol.15 No.2

본 연구는 대구지방환경관리청과 유관기관 등에서 과거 7년간(1988~1994년) 측정한 대기질 관련자료중 아황산가스, 분진, 일산화탄소, 질소산화물 및 오존을 대상으로 통계분석하여 각기 배출강도가 다른 지역별 농도분포 특성을 평가하였고 대구지역의 전반적인 대기질 변화추이를 파악하였다. 그 결과 각 지점별 아황산가스의 농도는 전형적인 동고하저형을 나타내었으며, 도시가스공급과 황함량규제등 연료변환 정책의 효과로 인해 점차적으로 감소하고 있는 추세를 보이고 있다. 부유분진은 결측치가 많아 장기적인 농도변화추이를 판단하기는 어려웠으나 아황산가스와 같이 큰 계절적인 변동은 보이지 않았다. 질소산화물의 전반적인 농도분포는 장기 환경기준치 50ppb를 초과하지 않는 수준이었으나 최근엔 이동배출원의 영향이 가중되어 그 농도가 꾸준히 증가하는 추세인 반면 동고하저형의 계절적인 변동을 나타내는 일산화탄소는 가정용 무연탄 사용량의 감소로 대기중 일산화탄소의 농도는 점점 감소하고 있는 추세이다. 오존은 전반적으로 일사량이 많은 하절기에 농도가 높았고 동절기에는 농도가 낮은 경향을 보였다. 한편 주요 대기오염물질의 장·단기 기준달성도를 비교분석한 결과 대구지역의 대기오염물질중 아황산가스의 고농도 발생빈도는 공업지역에 집중되어 있었으며 질소산화물과 일산화탄소는 아직은 장·단기 환경기준을 초과하지 않는 수준으로 나타났고, 분진과 오존의 경우는 공업지역 뿐만 아니라 전지역에서 그 발생빈도가 유사하게 나타났다. In this study, characteristics and distributional patterns of the concentrations of air pollutants in Taegu area were evaluated using a data-base established from the ambient air quality monitoring stations for the period of 1989 to 1994. The result of this study demonstrated that in each sampling site, the SO_2 concentrations were much higher in winter than those in summer. However, a decreasing tendency was clearly shown in the annual variation of SO_2 concentrations, largely due to the use of LPG instead of anthracite coal for local heating systems and to the fuel policy of using lower sulfur content fuel in industrial sectors. Unlike SO_2, there was no distinct seasonal variation in the concentrations of suspended particulate matter. Concentrations of NO_x were found to be generally lower than the long term ambient air quality standard (50 ppb). The NO_x concentration has been gradually increased, reflecting the rapidly increased number of vehicles In this area, while the CO levels In ambient air were declind because of the reduced use of coal for domestic purposes. The Ozone concentrations in Taegu area exhibited that there has been already photochemical smog phenomena during the summer season when the insolation is strong.

심전도에서 조기재분극을 보인 특발성 심실세동

이정은,함효주,이관용,노지웅,유진석,정우백 이화여자대학교 의과학연구소 2014 EMJ (Ewha medical journal) Vol.37 No.2

Early repolarization is a common electrocardiographic (ECG) feature found in young adults, men and athletes, and has been considered to be a benign feature for the last several decades. But recent studies suggest that early repolarization may be related to idiopathic ventricular fibrillation and sudden cardiac death. We report a young man, 35 years old, who had life threatening ventricular fibrillation and sudden cardiac arrest. He was evaluated for cardiac causes of ventricular fibrillation. There was no explanation other than that his ECG showed an early repolarization pattern so we treated him with implantable cardioverter defibrillator. Thus, we suggest that early repolarization may be related with life threatening ventricular arrhythmia.

근적외분광분석법을 이용한 참기름 정량 분석 및 진위 판별

서은정,백주현,우영아,김효진 동덕여자대학교 종합약학연구소 2002 동덕약학연구지 Vol.6 No.-

In this study, sesame oil have been analyzed by near infrared spectroscopy (NIRS). Sesame oil was mixed with the other edible oil. NIR transmittance spectra of sesame oil mixtures were acquired by using a dip probe. Partial least squares regression (PLSR) was applied to develop a calibration model over the spectral range 1100-1750nm. The calibration model predicted the content of sesame oil for validation set with a standard errors of prediction (SEP) of 0.3871%. Soft Independent Modeling of Class Analogy (SIMCA) was used to identify sesame oil and adulteration. This model identified the sesame oil and adulteration for validation set with 100% accuracy. This study showed that the rapid and non-destructive the determination of the quantitative analysis of sesame oil, the identification of sesame oil and adulteration was successfully performed by portable NIR system.

2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석

이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.

흉요추 이행부 골절환자의 임상분석

김준수,김은상,이종서,박용규,백선하,박인성,정진명,한종우 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.10

To clarify the prognostic factors influencing clinical outcome. the authors retrospectively analyzed 50 cases of thoracolumbar vertebral junctuon fracture treated at our hospital between September 1989 and October 1992. The age of the patients ranged from 23 to 75years(median 49years) and the male-to-female ratio was 33:17. Falling was the major mode of injury(n=27). The kyphotic angle between fractured vertebrae and the ratio of neural canal encroachment was measured in a simple X-ray and a computed tomography(CT) of the thoracic spine. An ANOVA test was performed to evaulate the predicting factors to determine the final outcome. The kyphotic angle and loss of height of vertebral body were not significantly correalted with the neurological status of the patients. However. the ratio of the compromised area of the neural canal was closely correlated with the neurological outcome(p value<0.05). The worst prognosis was found in patients with fracture-dislocation. In conclusion. it is suggested that early surgical intervention must be considered in the neurologically compromised patients whose CT demonstrates neural canal encroachment by bony fragments.

Efavirenz, indinavir, lopinavir, ritonavir의 LC-MS/MS를 이용한 동시 정량법

채정우,배경진,백인환,서정원,이병요,이은주,남진경,강원구,권광일 충남대학교 약학대학 의약품개발연구소 2009 藥學論文集 Vol.24 No.-

Efavirenz indinavir and kaleta (co-formulation of lopinavir and ritonavir) are important antiretroviral drugs which have been proved to be human immunodeficiency virus (HIV) protease inhibitors and reduced the morbidity and mortality associated with HIV-1 infection. A brief and fast high performance liquid chromatography coupled with electrospray mass spectrometry (LC-MS/MS, API 4000) method for the determination of 4 anti-retroviral agents (efavirenz, lopinavir, indinavir, ritonavir) in human plasma was developed and validated. A simple protein precipitation method was used on 100μl of human plasma. And internal standard solution (10 ng/ml methaqualone) 1ml and reconstitution solution (MeOH) 1ml were added. After vortexing for 30 s and centrifuging at 13,200rpm for 10min, 2μl of supernatant was injected into the column (XTerra MS C_(18) column, 2.1mm × 50mm 3.5㎛ particle size). The mobile phase consisted of MeOH and 0.1% formic acid in water (80:20 , v/v). The chromatogram was run for 1.5 min at a flow rate of 300μl/min. A triple quadrupole mass spectrometer was operated in a positive ion mode (lopinavir, indinavir, ritonavir) and negative mode (efavirenz), simultaneously and multiple reaction monitoring (MRM) was used for drug quantification. The precursor-to-product ion transitions of m/z 316→69 (efavirenz) and 629→447 (lopinavir) and 614→421 (indinavir) and 721→296 (ritonavir)were used to measure and quantify the analyte. The limit of quantitation (LOQ) was 50 ng/ml (efavirenz, indinavir, ritonavir) and 100 ng/ml (lopinavir). The weighted (l/y²) calibration curve was linear over human plasma range 50∼5000ng/ml (efavirenz), 100∼20000ng/ml (lopinavir), 50∼10000ng/ml (indinavir), 50∼2000ng/ml (ritonavir), correlation coefficient(r²) of 4 antiretroviral agents were higher than 0.998. Accuracies and intra-run precisions ranged within 86.60 and 113.29%, 1.06 and 11.16% for all 4 drugs analysed. This analytical method used to determine these drugs was fast and easy to perform, with minimal sample preparation, and without compromising precision and accuracy. The developed method was successful to determine antiretroviral agents in human plasma, and proved suitable for clinical pharmacokinetic study.

후천성 면역 결핍증에서의 폐렴구균 감염 부검 1예 : An Autopsy Report

이미숙,우준희,진소영,김종원,최창현,김양수,김은옥,김백남,이동화,류지소 대한감염학회 1996 감염 Vol.28 No.3

28세 남자의 후천성 면역 결핍증 환자에서 S. pneumoniae 폐렴이 합병되어 사망한 1예를 경험하여 부검소견과 함께 보고하는 바이다. Pulmonary infections such as Pneumocystis carinii, cytomegalovirus, and tuberculosis are a major cause of morbidity and mortality in patients with human immunodeficiency virus(HIV) infection. Patients with HIV infection are at increased risk for bacterial pneumonia in addition to opportunistic infection. Although in a primary defect, HIV infection is associated with substantial dysfunction of humoral immunity, which predisposes patients to bacterial infections, particularly with encapsulated organisms, such as Streptococcus pneumoniae. We report a case of 28 year-old Korean male with HIV infection who died of respiratory failure due to pneumococcal pneumonia with autopsy findings.

뇌동맥류 파열에 의한 급성 경막하 혈종이나 뇌내혈종을 동반한 혼수상태 환자에 대한 뇌혈관 조영술을 시행하지 않은 응급수술

황수현,박용규,백선하,박인성,김은상,정진명,한종우 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.10

Neurologically based clinical grading scales offer excellent prognostic information for the patient suuffering diffuse subarachnoid hemorrhaging. These grading scales are less applicable to patients with life-threatening intraparenchymal or subdural hematomas after aneurysmal rupture. During 2 and half years. 9 patients(ICH;5.SDH:1. ICH+SDH:3) in a comatose state with brain stem compression syndromes documented by computerized tomographic scans have undergone emergent operation without angiography in our neurosurgical departement. Each patient was so critically ill that we believed it unwise to delay craniotomy for diagnostic angiography. The average delay from the detection to operation was 2 hours. The origin of the hematoma was identified as a berry aneurysm of the middle cerebral artery bifurcation in seven patients and a posterior communicating artery aneurysm in two patients. One patient had a good recovery. two patients recovered with hemipardsis and mild cognitive dysfunction. two patients were vegetative and died due to pneumonia. and four patients died due to brain swelling within two weeks postoperatively. Emergent craniotomy with empiric exploration of appropriate subarachnoid cisterns after hematoma decompression may be life-saving management in some cases. The delay imposed for diagnostic angiography may be avoided in attempts to save vital minutes of severe brain stem compression.