암 환자의 혈장 Transforming Growth Factor-β1 농도

박병규,하우송,이시은,이수진,박순태,박찬후,전지현,장정순 THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCINE 1999 Journal of biomedical laboratory sciences Vol.5 No.2

한국인의 대표적인 성인 고형 종양인 위암, 간암, 유방암과 소아 백혈병 및 2종의 소아 고형 종양 환자로부터 혈장 transforming growth factor-ß1 (TGF-ß1) 농도를 sandwich ELISA 분석법을 이용해 측정함으로써 TGF-ß1을 이 질환들에 대한 새로운 종양표지자 (tumor marker)로 사용할 수 있는지 검토하였다. 또한 연령 및 성별에 따른 혈장 TGF-ß1 농도의 정상치를 조사하였다. 신생아에서 70대까지 혈장 TGF-ß1 농도의 차이는 없었고 남녀간의 차이도 없었다. 위암 환자의 혈장TCF-ß1 농도는 16.0±6.8 ng/ml (평균 ±표준편차)로 정상 대조군의 TGF-ß1 농도 (8.3 ±5.0 ng/ml) 보다 유의하게 높았으나 간암, 유방암 환자의 혈장 TGF-ß1 농도는 대조군과 차이가 없었다. 그리고 위암 환자 16명, 간암 환자 8명, 유방암 환자 7명 중 각각 7명 (43.7%), 1명 (12.5%), 1명 (14.3%)에서만 혈장 TGF-ß1 농도가 증가되었다. 5명의 소아 백혈병 환자에서는 관해 (remission) 여부와 상관없이 혈장 TGF-ßl 농도가 모두 정상 범위에 있었으나 2명의 소아 고형암 환자에서는 종양 절제 전에는 혈장TGF-ß1 농도가 높았다가 절제 후 정상으로 떨어졌다. 결론적으로 1)정상인의 혈장 TGF-ßl 농도는 연령 및 성별에 따른 차이가 없다는 것을 알 수 있었고, 2)성인 고형암인 위암, 간암, 유방암에서는 낮은 민감도로 인해 TGF-ß1을 진단을 위한 선별 검사로 이용하기에는 부적절한 것으로 판단되었으며, 3) 정상 대조군보다 혈장 TGF-ß1 농도가 높았던 위암 환자와 종양 절제 전후로 혈장 TGF-ß1 농도가 민감하게 변했던 소아 고형 암 환자에 대해서는 향후 표본 수를 늘려 부가적인 연구를 해 야 할 것으로 사료된다. To evaluate the usefulness of transforming growth factor-ß1 (TGF-ß1)as a new tumor marker, we determined the plasma TGF-ß1 levels using sandwich ELISA assay in cancer patients. Patients with three most common adult cancers in Korea (stomach, liver and breast cancer) and children's cancers (leukemia and two kinds of solid tumor) were enrolled for the study. Furthermore, 39 individuals were subjected to age and sex-stratified plasma TGF-ß1 analysis. No statistical difference was demonstrated with respect to age or sex. The mean plasma TGF-ß1 level (16.0 ng/ml) of stomach cancer patients was significantly higher than that (8.3ng/ml) of controls. However, there was no difference among the mean plasma TGF-ß1 levels of liver, breast cancer patients and controls. Seven of 16 patients (43.7%) with stomach cancer, one of 8 (12.5%) with liver cancer, and one of 7 (14.3%) with breast cancer showed higher TGF-ß1 levels compared to controls. Plasma TGF-ß1 concentrations of five leukemic children remained in the normal range regardless of the remission state. In contrast, initial high TGF-ß1 levels from two children with solid tumors returned to normal range on surgical resection of tumors. From the above results, we could conclude that plasma TGF-ß1 levels of apparently healthy individuals seem to be rather constant irrespective of difference in age or sex, and the plasma TGF-ß1 has the limited value as a screening test for the diagnosis of aforementioned adult cancers because of its low sensitivity. Finally, additional studies need to be pursed for the large number of stomach cancer and pediatric solid tumor patients in order to reach a secure conclusion on the usefulness of plasma TGF-ß1 as a tumor marker in these patients.

私立大學生의 成長發育 및 營養狀態에 關한 硏究 : 中學校 入試有無過程을 通한 比較

朴淳永,具燾書,朴良元,金振浩,南炳執,朴昌植,朴喆斌 慶熙大學校 1980 論文集 Vol.10 No.-

In order to ascertain any possible changes in the physical and the nutritional status of Korean high school students before and after the abolishment of college entrance examination system, an intensive survey was conducted on the physical conditions of the incoming freshmen students (9532 males and 3428 females) of Kyung Hee University from 1972 to 1980. The finding are as below. 1. Physical growth conditions In each of the average physical dimensions of body height, body weight, chest girth and sitting height, a remarkable improvement was recorded for all age groups after the matriculation was abolished. 2. Physical and nutritional indices Relative body weight showed constant values of 35.0 in male and 32.0 in female. Relative chest girth showed the normal chest girth style in all age groups of both sexes. Relative sitting height showed a constant value of 54 for both sexes. The values of vervaeck index of th nutritional status were shown to be between 86-87 in male and 83-94 in female, Pelidisi index 91 and 92-93, Rohrer index of physical status 121-125 and 130-132, and Kaup index 206-211 and 202-210, respectively.

이면성 및 도플러 심초음파도를 이용하여 진단한 선천성 거대 좌회선지-좌심실 관동맥루

진승원,박준철,이영중,유병현,박현옥,김용주,윤호중,김재형,홍순조,최규보,권종범,원용순,박건 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

개에서 이중 결찰법을 통한 동맥관 개존증의 완치 예

윤헌영,정순욱,박희명,박철,정만복,김준영,한현정,황민,노병국,박상혁,장하영,박정윤 한국임상수의학회 2004 한국임상수의학회지 Vol.21 No.1

A ten months old, female Yorkshire terrier weighing 2.88 kg referred to veterinary teaching hospital of college of veterinary medicine, Konkuk University because of syncope, cough and dyspnea. First hematological and serum chemical test revealed thrombocytopenia, mild anemia, and increase of concentration of ALP (195 U/L). On 57 days later, second hematological and serum chemical test revealed polycythemia, increase of concentration of ALP (211 U/L), and Tchol (387 mg/dl). Right atrium enlargement, main pulmonary artery bulge and cardiomegaly (VHS = 11.5) were observed in radiographic findings. Ultrasonographic images showed both right and left ventricular dilation and turbulent flow between the descending aorta and the main pulmonary artery in color Doppler imaging. ECG showed left ventricular enlargement, SA block, and electrical alternant. Thoracotomy was performed through left fourth intercostal incision under isoflurane anesthesia. Patent ductus arteriosus was double ligated with 1-0 silk. Cough and dyspnea disappeared on 5 days after operation. Turbulent flow was not found in color doppler imaging of ultrasonography on 10 days after operation. Ten months later after the operation, syncope could not exist any more.

LED를 이용한 복합레진의 광조사시, 중합수축의 속도와 양, 미세경도에 관한 연구

박성호,김수선,조용식,이순영,김도현,장용주,문현승,서정원,노병덕 大韓齒科保存學會 2003 Restorative Dentistry & Endodontics Vol.28 No.4

This study evaluated the effectiveness of the light emitting diode(LED) units for composite curing. To compare its effectiveness with conventional quartz tungsten halogen (QTH) light curing unit, the microhardness of 2mm composite, Z250, which had been light cured by the LEDs (Ultralume LED2, FreeLight, Developing product D1) or QTH (XL 3000) were compared on the upper and lower surface. One way ANOVA with Tukey and Paired t-test was used at 95% levels of confidence. In addition, the amount of linear polymerization shrinkage was compared between composites which were light cured by QTH or LEDs using a custom-made linimeter in 10s and 60s of light curing, and the amount of linear polymerization shrinkage was compared by one way ANOVA with Tukey. The amount of polymerization shrinkage at 10s was XL3000 > Ultralume 2, 40, 60 > FreeLight, D1 (P<0.05) The amount of polymerization shrinkage at 60s was XL3000 > Ultralume 2, 60 > Ultralume 2, 40 > FreeLight, D1 (P<0.05) The microhardness on the upper and lower surface was as follows; <본문 참조> It was concluded that the LEDs produced lower polymerization shrinkage in 10s and 60s compared with QTH unit. In addition, the microhardness of samples which had been cured with LEDs was lower on the lower surfaces than the upper surfaces whereas there was no difference in QTH cured samples.

합성수지 반제품 생산 공장에서 발생한 반응성 기도과민 증후군

박소영,이종성,김부욱,이정오,박규철,최병순 大韓産業醫學會 2008 대한직업환경의학회지 Vol.20 No.4

배경 직업성 천식 감시체계의 활성으로 국내 직업성 천식의 보고가 증가하였음에도 불구하고 전체 직업성 천식의 약 5-18%를 차지한다고 알려진 반응성 기도과민증후군의 보고는 많지 않다 이에 저자들은 합성수지 반제품을 생산하는 사업장에서 발생한 반응성 기도과민 증후군 사례를 발견하였기에 이를 보고하는 바이다 증례 평소 건강하던 61세 남자 환자는 40세 때인 1987년부터 약 20년 간 합성수지 반제품을 생산하는 사업장에서 배합작업을 하였다 2007년 8월 PVC(polyvinyl chloride) DEHP (d₁-(2-ethylhexyl)phthalate) dibutyl tin maleate epoxidized soybean oil 등의 원료를 혼합하는 기계의 가열로 작업장내 연기가 자욱하게 된 사고가 발생한 직후 환자는 기침 콧물 호흡곤란 천명 등의 증상을 보였다 폐기능 검사에서는 FEV₁ 1.63 L(50%) FVC 3.81 L(82%) FEV₁/FVC 43% 소견을 보였으며 기관지 확장제 투여 후 FEV₁은 1.80 L로 투여 전에 비해 170 ml 10.4% 증가하였다 흡입용 스테로이드 및 기관지 확장제를 포함한 치료 시행 7개월 후에는 FEV₁ 3.21 L(99.3%) FVC 6.56 L(143.5%)로 회복되었으며 메타콜린 기관지 유발검사에서는 음성이었다 결론 혼합기 가열로 인해 발생한 원료물질 자체 또는 이들의 열분해산물에 고농도로 노출되면서 RADS가 발생한 것으로 판단된다. Background Reactive airways dysfunction syndrome (RADS). which represents between 5% and 18% of new-onset, work-related asthma remains underreported in spite of increasing reports of occupational asthma cases through occupational asthma surveillance in Korea We report a 61-year-old male who developed RADS after exposure to a high level of toxic gases from a workplace accident. Case The patient who had worked for 21 years at a PVC manufacture factory and had retained good health until Aug 22, 2007, when he was exposed to PVC (Polyvinyl chloride) DEHP (D₁ (2-Ethylhexyl) Phthalate) dibutyl tin maleate and epoxidized soybean oil gases from a heated mixer. Within several minutes of exposure, he developed coughing rhinorrhea dyspnea and wheezing. Pulmonary function tests (PFTs) showed an FVC of 3.81 L(82% of predicted) FEV₁ of 1.63 L/s (50% of predicted) FEV₁/FVC% of 43 % and FEV₁ of 1.80 L/s that increased by 170 ml and 10.4% in response to bronchodilator. After 7 months of treatment with inhaled steroids and bronchodilators, repeat PFTs showed an FVC of 6.56L(143.5% of predicted) FEV₁ of 3.21 L(99.3% of predicted) and FEV₁/FVC% of 48.9%. A methacholine challenge test was negative at a concentration of 25 ㎎/ml. Conclusion RADS occurred due to exposure to raw material vapors or their thermal decomposition products.

전통적 무도훈련 방법에 대한 고찰

박순진,류병관 龍仁大學校 武道硏究所 1998 武道硏究所誌 Vol.9 No.1

Various training methods had been contributioning in develop atheletic performance. But scientific development of training methods and theories were devided many subunit by it's own orgination of their scientific back-ground. Actually this severed develop of training methods are no more useful for the atheletic performance because atheletic performance basically include many different acpects of mental, physical, and technical. So if it persist in goes their own way then we must confronting the difficulties in put together to make one. Oriental training methods has more than thousand years of historical back ground. It always emphasis that unity of mind and body and this the main goal for the practicing matial art in oriental nations. The purpose of this research is try to find out that the possibilities of put together traditional oriental martial art training method to modern training method. So contents of this research consist of two parts. At first part it just tried look about the degrees of apply mordern training program. In second part is consist of research for the old traditional martial art program and it's scientific interpretation. Tradiational martial art training which usually called as a "Su-Ryen" is stress that unity of human movement and breathing and then finally go forward to get unity of movement and breathing and mind. So the main way of traditional martial art training program containing quite different three subjects in one time. This is in a different way compare to mordern method of training. The conclusion of this research is that mordern training theories must consider the old traditional way of training method and spirit.

큰느타리버섯 인공재배에 있어서 배지조성의 영향

박동철 ; 김순희 ; 강병태 김천대학교 2007 김천대학교 논문집 Vol.28 No.-

This study was performed to investigate on the combinations of optimal medium for the artificial cultivation of Pleurotus eryngii with the various kinds of substrate and nutrient. It was also tested to the mushroom yields and marketable quality of Pleurotus eryngii. Coconut ML. and bean-curd refuses were effective to the mycelial growth, which showed a similar effects compared to a standard medium. a Pine sawdust was more effective than the softened rice hulls and crude rice hulla on the mycelial growth. Elvan as additives was also showed promotive effects on the mycelial growth. In the test of medium weight, optimal weight in about 1400 ml polypropylene (PP) bottle was about 724 gram to 770 gram under 65% humidity. Most suitable periods of incubation were estimated about 40 days. It could be also considered to use TMR(Total mixed Ratio) in the medium combination as nutrients because the TMR addititon of 170 gram weight showed an excellent formation of fruiting body of Pleurotus eryngii. Finally, the optimum composition of nutrients for both yield and quality turned out to be combination of gluten feed( 21.7%), rice polishing (10.2%), wheat bran(52%), soy-hull uncrushed (13.5%) and shell lime (3.6%). Nutritional analysis of the combined nutrients was appeared to have 11.5% humidity, 15.4% crude protein, 4.5% crude fat, 12% crude fiber, 8.2% cash, 1.2% calcium, 0.94% phosphorus, and 55.4% NFE (nitrogen free extract). In the bulk test of artificial cultivation by mushroom farmer, both yield and quality were very excellent to the previous products by harvesting about 200 gram in a PP bottle without a significant deviation.

W-Thiocyanate Complex의 抽出에 있어서 Amberlite LA₁의 利用

朴茂淳,孫炳贊 순천향의과대학 1979 Journal of Soonchunhyang Medical Science Vol.2 No.1

Comparision studies onthe extraction of Tungsten thiocyanate complex have been carried out using several pure organic solvents and 0.1% Amberlite LA₁solvents diluted with each solvent. The latter solvents show more advantages not only on extractability but also on linearity for the spectrophotometric determination of the complex than the former cases.

마늘의 첨가가 두부의 품질과 저장성에 미치는 영향

박연주,남영란,전병록,오남순,인만진 한국응용생명화학회 2003 Applied Biological Chemistry (Appl Biol Chem) Vol.46 No.4

마늘이 함유되어 있는 기능성 두부를 제조함에 있어 마늘의 첨가량이 두부의 품질과 저장성에 미치는 영향을 조사하였다. 건조 대두를 기준으로 마늘을 5-20% 첨가하여 제조한 두부의 수율, 물성 및 저장성을 마늘을 첨가하지 않고 제조한 일반두부와 비교하였다. 두부의 수율은 마늘의 첨가량에 비례하여 다소 감소하였으나 그 영향은 미미하였다. 마늘의 첨가량이 5∼10%인 경우 두부의 물성 중 견고성이 통계적으로 유의하게 증가하였으며, 마늘을 20%사용한 두부는 견고성, 부착성, 응집성, 탄성, 씹힘성이 통계적으로 유의하게 감소하였다. 제조한 두부를 15℃로 보관하면서 pH와 총균수의 변화를 측정한 결과 마늘의 첨가량에 비례하여 두부와 두부 침지액에서 pH 하락과 미생물 생육이 효율적으로 지연되었다. 두부 제조시 마늘의 첨가량은 5∼10%가 적당하였다. The effect of garlic addition on quality and shelf-life of soybean curd was investigated. The yield of garlic soybean curd slightly decreased in proportion to amount of garlic added. In the case of texture, hardness of the garlic, soybean curd increased when 5~10% garlic wat added, whereas hardness, adhesiveness, cohesiveness, springiness and chewiness significantly decreased in the case of 20% garlic added. Microbial counts of soybean curd stored in sterilized distilled water as tofu-immersion solution increased, whereas pH decreased during storage at 15℃. During all storage periods, microbial counts of the soybean curds containing garlic were always lower than that of the ordinary soybean curd. These results imply that garlic is a useful additive in suppressing the proliferation of aerobic microorganism and has a potential use in extending the shelf-life of soybean curd. According to yield, textural properties and shelf-life data, the suitable concentration of garlic was around 5~10%.