특수 언어발달 장애 환아의 임상 및음향음성학적 특성연구

김연희,박세훈,신용일,김찬양,김현기,김정수 大韓再活醫學會 2000 Annals of Rehabilitation Medicine Vol.24 No.1

흰쥐 Kupffer 세포에 대한 Propofol의 작용

박세훈,지대림,성언기,김희선,송인환,박희영,김준수,이덕희,박대팔 대한마취과학회 2002 Korean Journal of Anesthesiology Vol.43 No.4

Background: Propofol has an antioxidant capacity and can be used for ischemia-reperfusion injury of the liver. However, the effects of propofol on the Kupffer cells have not been establisked. Methods: Kupffer cells were isolated and cultured from male Sprague-Dawley rats. The effects of propofol on the Kupffer cells were evaluated by a phagocytosis assay, TNF-α gene expression, and superoxide anion release after administering propofol in different concentrations on the cultured Kuprrer cells. Results: The latex bead phagocytosis by the Kupffer cells was suppressed when the Kupffer cells were exposed to propofol irrespective of concentrations. Higher propofol concentrations decreased the loss of Kupffer cells after latex bead phagocytosis. Propofol induced TNF-α mRNA expression in the Kupffer cells, but the mRNA expression level after 50㎍/ml of propofol decreased. The pattern of TNF-α mRNA expression induced by propofol was different to that induced by LPS: TNF-α mRNA was expressed continuously in the propofol-treated cells until 16 hours after exposure to propofol, whereas the level of TNF-α mRNA expression induced by LPS was evident after 2 hours and was not found thereafter. TNF-α production after propofol treatment was not higher than that of the control. Formazan presipitation did not show any qualitative differences between cells untreated or treated with propofol concentrations of 0.5, 5.0, and 50 ㎍/ml. Conclusions: These results showed that propofol might inhibit Kupffer cells. This suggests that propofol and be used for patients with ischemia-reperfusion injury of the liver. (Korean J Anesthesiol 2002; 43: 475~484)

동진강 유역 비점오염원 정밀조사

원찬희,정팔진,김민정,조선영,김세훈,김종천 전북대학교 공학연구원 ( 구 전북대학교 공업기술연구소 ) 2002 工學硏究 Vol.33 No.-

Nonpoint source pollution(NSP) arises due to agriculture activity and it is quite an extensive and complicated problem in order to control and has received a great deal of concern during the recent years, whereas point source are known to originate from an estimated volume of contaminant discharged from a distinguishable source. Extensive research work have been conducted and presented in the past with regard to the various characteristics of watershed on Dong Jin River(DJR), however there are certain drawbacks of existing survey for determining important polluting sources, distribution features of pollutants and estimated load of the organic and nutrients from the creeks. Unfortunately, investigation for loadings originating due to agricultural drainage was not satisfactory, although the regional consideration for DJR across Kim Je Field(KJF) as an agricultural area receives a reasonable source point in the agri-pollution management. Therefore it was necessary to carry out a thorough investigation into the diffuse sources resulting, to form the pollution-developing estimation and to evaluate the output roperties and determining various factors in the generation of non-point pollution. Eventually, this research work would serve as an useful tool for the development of predictive pollution management for DJR. Non-point sources in the present work were classified as municipal non-treated sewage water discharged into the river, loadings through agricultural drainages in the dry/wet field and inadequate treatment of wastewater generated from livestocks. The entire duration of the research work was from December-2001 to July-2002. Site measurement were conducted during various season, in a dry season(December), in rainfall, in seed-sowing time and also collecting data from the rural public organizations related to water management was done and examined and examined during the mid of research work. Similarly, domestic wastewater loadings due to population was based on area unit, as City, Country, Up, Myon, Dong, Ri. The Dong Jin River watershed contains small three Creeks, KoBu(KB), DongJin(DJ, including JeongEup(JE) and ChilBo(CB), WonPyong(WP). It was further divided into 32 sub-watersheds which comprises of further 5,18,9 watersheds in the creeks respectively. The results obtained from research work are presented as follows. Animal productions have marked differences in the rate of pollutant loadings reported in the following sequence: DJ(only CE)>WP>CB>KB, in a case of Korean cow and milk cow. However, it was revealed that WP creek became significantly higher than any other livestocks. According to statistical data for land use, rice field(369.0㎢) and forest(378㎢) have much occupation prior to dry paddies(125.0㎢), residential land(32.0㎢) and others(5.0㎢). Especially, rice fields receives 2.5∼3 times than dry paddies in size.

Thiamine결핍 유도후 쥐 전뇌의 성상교세포 Glial Fibrillary Acidic Protein(GFAP) 면역화학 활성도에 대한 변화

김승현,김희태,김주한,김명호,황세진,김명권,백태경 대한신경과학회 1999 대한신경과학회지 Vol.17 No.1

직무특성과 직무스트레스가 아동병원 간호사의 이직의도에 미치는 영향

김세영(Se-Young Kim),백성희(Seong-Hee Back) 한국콘텐츠학회 2016 한국콘텐츠학회논문지 Vol.16 No.4

목적: 본 연구는 아동병원 간호사를 대상으로 직무특성, 직무스트레스, 이직의도 정도 및 이들 변수간의 관계를 파악하고, 이직의도에 미치는 영향 요인들을 규명하기 위한 서술적 조사연구이다. 연구의 대상은 G시에 위치한 60병상이상의 아동병원에서 근무하는 간호사 129명이며, 본 연구에 사용된 연구도구는 대상자의 일반적 특성을 묻는 12개의 문항과 직무특성 관련 16문항, 직무스트레스 36문항, 이직의도 6문항으로 총 70개 문항으로 구성된 설문지를 이용하였다. 연구자료는 SPSS 21.0 프로그램을 이용하여 분석하였으며 빈도분석 및 기술통계, t-test, ANOVA, Pearson 상관관계 분석, stepwise 방법에 의한 다중회귀분석을 이용하여 검정하였다. 본 연구의 결과는 직무특성의 하위요인은 직무도전성과 직무적합성, 직무스트레스, 급여는 이직의도에 영향을 미치는 것으로 확인되었다. Purpose: This study was performed to investigate the influence of childrens hospital nurses job characteristics and job stress on turnover intention. Method: The subjects were 148 nurses who have been working in 6 childrens hospitals located in G city. Measurement tools used for this study included job characteristics were created by Lee, and modified by Hong, and job stress tool developed Kim & Ku and modified by Choi. And the tools used for assessing turnover intention were created by Mobley and Becker and modified by Kim. The collected data was analyzed using descriptive statistics, the independent t-test, one-way ANOVA, Pearson Correlation and regression on SPSS 21.0 program. Result: Job challenge and job fitness among the sub-areas of job characteristics, job stress and salary were identified as factors influencing turnover intention. These factors explained 36.5% of variance of turnover intention. Conclusion: In conclusion, this results can be used to help the childrens hospitals creates an environment where nurses can enhance Job challenge and job fitness also, reduce job stress which lead to turnover rate and turnover intention.

주의력결핍/과다활동장애(ADHD) 아동에 대한 약물-부모훈련 병합치료의 효과

김세실,이양희,안동현 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.4

목 적 : 주의력결핍/과다활동장애 아동의 문제 행동, 어머니의 양육태도 및 양육스트레스에 대한 약물 및 부모 훈련 병합치료의 효과를 검증하고자 한다. 대상 및 방법 : 한양대학교병원에서 주의력결핍/과다활동장애로 진단받은 24명의 아동(만 5∼11세)과 어머니를 대상으로 하였다. 세 군으로 나누었는데, 약물단독치료군(N=6), 약물 및 부모훈련 병합치료군(N=6), 병합치료 대기군(N=6)으로 구분하였다. 약물치료는 메칠페니데이트를 0.5∼0.7㎎/㎏/day를 투여하였다. 부모훈련은 주 1회, 9주간 실시하였고, 4주후 추후모임을 가졌다. 평가는 약물치료군(N=12)과 병합치료군(N=12)에서 각각 치료 전후에 비교하였으며, 병합치료군에서는 장기 효과를 보기 위하여 6개월후에 재평가하였다. 평가는 아동변인(아동행동조사표, 코너스부모용평정척도, 가정상황질문지), 어머니변인(어머니양육태도검사도구, 부모양육스트레스목록표, 결혼적응척도), 프로그램변인(부모사용자만족도 질문지)을 각각 조사하였다. 결 과 : 어머니의 양육태도 및 양육스트레스, 아동의 문제 행동에서 약물 단독치료군에 비해 약물-부모훈련 병합치료군에서 월등히 좋은 결과를 얻었다. 또한 이 효과는 6개월후의 추적조사에서도 대부분 유지되었고, 어머니들의 프로그램에 대한 만족도도 매우 높았다. 결 론 : 주의력결핍/과다활동장애 아동의 치료에 있어서 약물단독보다는 약물-부모훈련병합치료가 매우 우수한 치료 효과를 갖는다. Objective : We attempted to confirm the effects of the combined treatment of medication and parent training on the behavioral problems of referred ADHD chidren, the maternal behavior and the parenting stress of their mothers. Methods : Twenty-four children between the ages of 5 to 11 and their mothers were selected as subjected from Child Psychiatric Clinics of Hanyang University Hospital. Three groups were organized : combined treatment group of medication and parent training(N=6) ; wating list group(N=6) ; and medication only group(N=6). Methylphenidate(0.5-0.7㎎/㎏/day) was prescribed for children. Mothers of the combined treatment group of medication and parent training and the wating list group attended the parent training once a week for nine weeks and a booster session 4 weeks later. Treatment outcomes were evaluated by comparing both treatment groups at pre- and post-treatment using the various rating scales. Especially the combined treatment group was followed up after 6 months to evaluate the stability of treatment effects. Results : This study showed greater effectiveness of the combined treatment of medication and parent training relative to the medication only in decreasing the overall behavioral problems of ADHD children and the parenting stress of mothers as well as in increasing the desirable maternal behavior. In addition, these improvements were maintained at 6 month follow-up. Conclusion : The combined treatment of medication and parent training facilitated the behavioral improvement of referred ADHD children in several aspects.

광중합기의 광도와 시간에 따른 글래스 아이오노머의 치수내 온도변화

김희량,이형일,이광원,이세준 대한치과보존학회 2001 Restorative Dentistry & Endodontics Vol.26 No.5

When cavity floor is near the pulp, polymerization of light-activated restorations results in temperature increase. this temperature increase cause by both the exothermic reaction process and the energy absorbed during irradiation. Therefore instating base is reqired. Most frequently used insulating base is glass ionmer. The purpose of this study was to evaluate intrapulpal temperature changes of glass ionomer according to various curing intensity and curing time. Caries and restoration-free mandibular molars extracted within three months were prepared Class I cavity of 3×6mm with high speed handpiece. 1mm depth of dentin was evaluated with micrometer in mesial and distal pulp horns. Pulp chambers were filled with 37.0±0.1℃ water to CEJ. Chromium-alumina thermocouple was placed in pulp horn for evaluating of temperature changes. Glass ionomer material was placed in 2mm. total curing time was 40s ; continuous 40s, intermittent 20s, intermittent 10s. Glass ionomer material was cured with 300mW/㎠, 550mW/㎠ light curing unit. The results were as follows : 1.Temperature in pulp increased as curing unit power is increased. 2.Temperature in pulp more increased continuous emission than intermittent emission. Key words : Sealing ability, Retrograde filling material

다양한 치근단공 크기와 근관단면의 형태를 가지는 치아에서 taper의 정도가 미세누출에 미치는 영향

김정희,이경하,이세준,유미경,이광원 大韓齒科保存學會 2005 Restorative Dentistry & Endodontics Vol.30 No.2

The aim of this study was to evaluate the microleakage of teeth according to root canal preparation with & without apical enlargement in various size of apical foramen. 60 extracted one canal roots were cross-cutted at 5 mm from root apex and divided into two groups according to their apical foramen size of large (L) and small (S). Each group was subdivided into two groups accordance with their cross-sectional configuration at 5 mm from apex, round (R) and ovoid (O); SR Group, SO Group LR Group, LO Group. Each group was shaped in .02 taper by Quantec series Nickel-Titanium (NiTi) rotary file, obturated by lateral condensation method. Leakage was measured using a fluid transport model under 40cmH₂O pressure. After the leakage test, blocks which had showed the leakage retreated with .04 taper and ,06 taper and evaluated the degree of fluid filtration in each group. The data was analysed statistically using chi-square test and fisher's exact test. The results obtained were as follows : 1. Significant difference in leakage was found in groups which had different apical foramen size in .02 taper instrumentation (p < 0.05), but not in .04 taper instrumentation (p > 0.05) 2. The difference in microleakage according to the shape of canal was not evident at 5 mm from apex (p > 0.05). 3. There was correlation between .02 taper instrumentation and .04 taper instrumentation in LR group, LO group (p < 0.05). 이 연구의 목적은 근단공의 크기가 다양한 치아에서 근단공 확대의 유무에 따른 근관성형시 치아의 미세누출을 평가하기 위함이다. 1근관 치아 60개를 치근첨 상방 5mm에서 절단후 각 치아의 근단공 크기에 따라 큰 근단공 (L) 작은 근단공 (S)으로 나누었다 이 두 군을 치근첨 상방 5mm의 횡단면상 근관의 형태로 원형 (R)과 난형 (O)으로 나누었다(SR, SO, LR, LO). 각 군은 Quantec series Nickel-Titanium (Ni-Ti) rotary file을 이용하여 .02 taper로 성형 후 측방가압법으로 충전하였다. 누출은 40cmH₂O 압력하에 fluid transport method로 측정하였다. 측정 후 누출이 있는 시편은 .04 taper와 .06 taper로 재근관치료 하여 다세 미세누출을 평가하였다. 통계학적으로 chi-square test와 fisher's exact test를 이용하였다. 결과는 다음과 같다. 1. .02 taper로 성형한 군에서는 근단공의 크기에 따른 미세누출은 통계적으로 유의성이 있었고 (p < 0.05) .04 taper로 성형한 군에서는 통계적으로 유의한 차이를 보이지 않았다 (p > 0.05). 2.근첨 상방 5 mm에서 근관단면의 형태에 따른 미세누출은 통계적으로 유의하지 않았다 (p > 0.05). 3. LR group과 LO group에서는 .02 taper로 성형한 군과 .04 taper로 성형한 군사이에 유의한 차이를 보였다 (p < 0.05).

조리방법에 따른 식품 중 영양소 잔존률(retention factor)에 관한 연구(Ⅰ) : 채소류 및 감자류 Vegetablesn ane potatoes

김대병,장영미,김인복,이혜영,장재희,박정현,엄세정 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-

조리조건에 따른 식품의 영양소 잔존를을 측정하여 보다 정확한 조리식풍에 의한 영양소 섭취량을 평가할 수 있도록 하기 위하여 합리적인 영양소섭취량 조사, 영양 평가를 위한 개선책을 제시하고자 끓였다. 대상 시료와 조리법은 시금치(데치기, 끓이기), 배추(끓이기), 콩나물(데치기, 끓이기), 호박(끓이기, 볶기). 당근(끓이기, 볶기), 우엉(조림), 감자(끓이기, 볶기)이었으며, 조리 전 후의 비타민 A(β -carotene), Bl, B2, C, E, 나이아신, 칼슘, 철, 아연, 칼륨, 인, 나트륨의 함량을 분석하여 조리법에 따른 잔즌률을 국하였다. 조리조건별 잔존률을 구한 결과 무기질은 데치기의 경우 조리수를 제거하므로 손실이 있었으나 끓이기, 볶기 등의 조리법에서는 손실이 거의 없었다. 비타민 A와 I는 대부분 80%이상으로 많이 손실되지 않았으며 비타민 Bi은 데치기가 가장 낮았고, 조림, 괄이기, 볶기의 순으로 잔존률이 높았다. 비타민 B2와 나이아신은 비타민 Bi보다는 잔존를이 높은 경향이었다. 비타민 C는 대부 분의 조리법에서 크페 손실되었다. 본 연구의 결과는 합리적이고 정확한 영양소 섭취량 평가를 위한 기초자료로서 기존의 평가방법을 개선 보완하여 영양소섭취량 평가으 과학화에 기여할 것으로 기대된다. In various mutrition activities, the necessary values of nutrient intake were usually calculated from food composition tables which have nutrient contents of raw ingredients and dishes, but Korean food composition tables of dishes were lacking, So we studied todetermine the nutnent retention factors(RF) of vegetables and potatoes by cooking methods. Atfirst, we surveyed cooking methods of vegetables and potatoes, and selected major vegetablesand cooking methods. Selected items and cooking methods were sp.mach(blanching and boiling),cRnese cabbage(boiling), soybean sprout(bBanchlng and boiling), pumpkin(boiling andstir-frying), carlot(boiling and stir-frying), burdock(braising), and potato(boiling and stir-frying)We analyzed 6 vitamins luhich were vitamin A(β-carotene), Bl, B2, C, E, and niacin, and 6minerals which were calciurrl, iron, zinc, potassium, phosphorus, and sodium. The results wereas follows : Minerals almost retained in boiling, stir-frying, except in blanching method, RF ofvitamin A and I were 80% or more. RF of vitandn Bl were decreased in order of sfir-frying,boiling, braising, blanching and the RF of vitamin B2 and niacin were higher than vitandn Bl,RF of the vitamin C were varird in So~90% in all cooking methods

감염성 심내막염 환자에서 증상 없이 발견된 뇌동맥류 1예

김희만,임세중,이주용,이꽃실,김준명,홍유선,이규창 대한내과학회 2003 대한내과학회지 Vol.64 No.4

30세 남자 환자로 심내막염 진단 후 발견된 무증상의 감염성 뇌동맥류로 항생제 치료 후 단계적인 수술로 심장판막 대치술과 뇌동맥류 결찰술을 시행하여 심각한 뇌신경학적 후유증이나 합병증이 발생하기 전에 성공적으로 치료한 경험을 하였기에 문헌 고찰과 함께 보고하는 바이다. Cerebral mycotic aneurysm is an uncommon complication of infective endocarditis. In spite of low incidence, mycotic aneurysm is a serious complication because of the high risk of its rupture. Therefore, early diagnosis and management of cerebral mycotic aneurysm are imperative before the rupture. We experienced a case of asymptomatic cerebral mycotic aneurysm in a 30-year old man with infective endocarditis. He was admitted for splenic and renal infarction due to systemic embolization. The echocardiography showed severe mitral regurgitation, mitral valve prolapse and vegetation on the mitral valve. Streptococcus mitis was identified from blood cultures. In the course of antibiotics therapy, brain magnetic resonance image and 4-vessel cerebral angiography were performed, which revealed multiple unruptured cerebral mycotic aneurysms. Considering the high risk of rupture we performed mitral valve replacement with bioprosthesis. On follow-up cerebral angiography after the valve replacement surgery, one of aneurysms was enlarged, and successfully treated by surgical intervention without complication. We report one case of mycotic aneurysm without neurologic symptom in an infective endocarditis patient, who was treated without serious sequelae of the aneurysm. (Korean J Med 64:477-481, 2003)