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치료 불응성 Still's병에서 자가 조혈모세포 채집시 사용된 G-CSF에 의한 급성 악화 1예
이재웅,박성현,왕준광,오호석,최정혜,배상철,이영열,김인순,최일영,안명주 대한조혈모세포이식학회 2003 대한조혈모세포이식학회지 Vol.8 No.2
치료 불응성 자가면역질환에서 고용량 항암화학요법 및 자가 조혈모세포이식술이 시행되고 있으나 조혈모세포 가동화 및 이식술 시 사용되는 G-CSF에 의해 오히려 기존의 자가면역질환의 증세가 악화되었다는 보고가 있다. 저자들은 만성적으로 재발되는 Still's병 환자에서 조혈모세포 가동화를 위해 사용한 G-CSF에 의해 자가면역질환이 급성 악화된 1예를 경험하였기에 보고하는 바이다. High-dose immunosuppressive therapy with autologous stem cell transplantation is an increasingly used treatment for severe refractory autoimmune disorder including multiple sclerosis, rheumatoid arthritis, juvenile chronic arthritis, systemic lupus erythematosus. Although the optimal method of collecting stem cell is not determined, G-CSF-based mobilization is generally considered safe. However, worsening of disease status was reported in autoimmune disease undergoing mobilization with G-CSF. We report a 24-year-old male with refractory Still's disease who developed acute disease flare after administration of G-CSF for stem cell mobilization.
서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)
김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2
Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.
Myung-Ju Ahn,Ho-Suck Oh,최정혜,Young-Yeul Lee,In-Soon Kim,Il-Young Choi,Oh Young Lee,Heung-Woo Lee 대한암학회 2003 Cancer Research and Treatment Vol.35 No.5
Purpose: To evaluate the efficacy and toxicity ofoxaliplatin and capecitabine in patients with metastaticcolorectal cancer.Materials and Methods: Between December 2001 andApril 2003, fourteen patients were enrolled in this study.Oxaliplatin, 80 mg/m2, was administered intravenously onday 1, and capecitabine, 1,250 mg/m2 bid po (total dailydose 2,500 mg/m2), was given on days 1∼14 of 3 weekcycles.Results: The median age of the patients was 57 years(range: 41∼74), and the most common sites of metastasiswere liver, lung or lymph node. Of the 12 evaluablepatients, the overall response rate was 41.7%, but withno complete response. The median response durationand median progression free survival of 12 patients were42 and 24.4 weeks, respectively. The median overallsurvival was not reached. A median 6 (range: 1∼9), anda total 80, cycles were administered to 14 patients. 80cycles were evaluable for toxicity. The most commonhematological toxicities were NCI grades I/II anemia (45%),leucopenia (33.75%) and thrombocytopenia (17.5%). Themost common non-hematological toxicities were nausea/vomiting (28.75/5%) and neurotoxicity (8.75%). Hand andfoot syndrome was noted in only 3.75%. There was nolife-threatening toxicity.Conclusion: Oxaliplatin and oral capecitabine combinationchemotherapy showed significant activity andfavorable toxicity in patients with metastatic colorectalcancer. Further studies, with larger numbers of patientsand long-tern follow-up will be needed. (Cancer Res Treat. 2003;35:407-410)
Myung-Ju Ahn,Ho-Suck Oh,최정혜,Young-Yeul Lee,In-Soon Kim,Il-Young Choi,Oh Young Lee,Ho-Soon Choi,Sung-Joon Kwon 대한암학회 2004 Cancer Research and Treatment Vol.36 No.3
PURPOSE: To evaluate the efficacy and toxicity of heptaplatin, paclitaxel, and 5-fluorouracil combination chemotherapy in patients with advanced gastric cancer. MATERIALS AND METHODS: Between July 2002 and September 2003, nineteen patients were enrolled in this study. Paclitaxel 135 mg/m2 iv on day 1, heptaplatin 400 mg/m2 iv on day 2 and 5-fluorouracil 800 mg/m2 on day 2~4 were administered and the regimen was repeated every 3 weeks. RESULTS: The median age of the patients was 60 years (range: 32~74) and the most common sites of metastasis were liver and lymph nodes. In the 16 evaluated patients, the overall response rate was 43.8%, but this was without any complete response. The median time to disease progression was 3.93 months (range: 0.26~8.1) and the median response duration for the 7 responding patients was 3.83 months (range: 1.48~6.07). The median overall survival for 19 patients was 7.01 months (range: 0.26~17.44). A median of 3 cycles (range: 1~7) and a total of 65 cycles were administered and evaluated for toxicity. The most common hematologic toxicities were NCI grade I/II anemia (47.7%), neutropenia (9.2%) and thrombocytopenia (6.2%). The most common non-hematologic toxicities more than grade II were nausea/vomiting (30.8%/9.2%). One elderly patient with ECOG 2 had a life- threatening complication of pneumonia. CONCLUSION: The combination of heptaplatin, paclitaxel, and 5-fluorouracil showed significant activity and favorable toxicity profiles in patients with advanced gastric cancer. However, one elderly patient who had poor performance experienced a life-threatening toxicity/complication. Our results suggest that the efficacy of this combination chemotherapy can be maximized when administered to the patients with good performance status. Further studies with large numbers of patients and long-term follow-up study will be needed. (Cancer Res Treat. 2004;36:182-186)
요추부 척추 협착증에 대한 수술 술식 개선에 관한 임상적 연구
오석전,정환영,김광명,김남규,이상봉 한양대학교 의과대학 1990 한양의대 학술지 Vol.10 No.1
The problem of lumbar spinal stenosis has attracted little attention until very recently. Surgeons focused primarily on soft tissue lesion abandoning the causative treatment on the bony change in degenerative lumbar stenosis. Rapid development of CT scan, microsurgical technique and air drill encouraged this surgical study challenging radical removal of causative bony change of the narrow lumbar canal. Several creative surgical refinements were achieved and a total of 723 cases of humbar spinal stenosis underwent surgery. Results and conclusion were as follows. 1. Lumbar CT scan or CT-myelography was most useful for the preoperative narrow bony canal study. These studies were also essential for the postoperative confirmation. 2. Microsurgical technique is superb in comparison with conventional standard procedure. Medial and inferior facetectomy and internal foraminotomy could only be performed by microsurgery. A new internal foraminotomy consists of medial and inferior facetectomy and foraminal osteophytectomy of the posterolateral vertebral body preserving the facet joint function. 3. Round bone dowel graft assured good fusion and easy performance in comparison with conventional peg graft in posterior lumbar interbody fusion. 4. A newly devised bone impactor with wide tip and slender handle was very convenient for the exact and uneventful insertion of the round grafts into the intervertebral space.