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가미윤조탕(加味潤燥湯)이 LPS로 유도된 RAW 264.7 대식세포에서의 항염 효과 연구
최종민,김용민,김희택,Choi, Jong-Min,Kim, Yong-Min,Kim, Hee-Taek 대한한방안이비인후피부과학회 2015 한방안이비인후피부과학회지 Vol.28 No.1
Objectives : Allergic disease has been well known as an IgE-dependent immunologic response. Recently, interest about the late inflammatory reaction has grown up as well as early allergic reaction characterized by IgE and mast cell. The purpose of this study was to find the anti-inflammatory effect of Gamiyunjo-tang(GMYJT) in allergic reaction. Methods : The experiment was performed using Raw 264.7 cells pretreated with GMYJT extracts. In this study, we observed the toxicity of cells by MTT analysis and measured the production of LPS-induced NO, $PGE_2$, IL-$1{\beta}$, IL-6 and TNF-${\alpha}$ at a concentration of 50, 100, 200 and $400{\mu}g/ml$. Results : No toxicity of GMYJT (50, 100, 200, $400{\mu}g/ml$) on RAW 264.7 cells was found after 24 hours incubation. LPS-induced NO production was reduced after treatment with GMYJT (100, 200, $400{\mu}g/ml$)(P<0.05). $PGE_2$ was reduced after treatment with GMYJT (100, 200, $400{\mu}g/ml$)(P<0.05). IL-$1{\beta}$ did not decrease at any dose. IL-6 decreased at 200, $400{\mu}g/ml$(P<0.05). TNF-${\alpha}$ production decreased only at $400{\mu}g/ml$(P<0.05). Conclusions : These data suggest that GMYJT has anti-inflammatory effects in late allergic reaction.
음성신호와 전기성문파를 이용하는 새로운 매개변수 ; 성대 폐쇄 지연비율(Glottal Closure Delay Ratio)
최종민,권택균,정은정,이명철,김광현,성명훈,박광석,Choi, Jong-Min,Kwon, Tack-Kyun,Jung, Eun-Jung,Lee, Myung-Chul,Kim, Kwang-Hyun,Sung, Myung-Whun,Park, Kwang-Suk 대한후두음성언어의학회 2007 대한후두음성언어의학회지 Vol.18 No.1
Background and Objectives: Biomedical signals have been usually used for the diagnosis of the laryngeal function such as speech, electroglottograph(EGG), airflow and other signals. But, in most cases these signals were analysed separately. Here, we propose a new interchannel parameter Glottal Closure Delay Ratio(GCDR) which is estimated from speech and EGG measured simultaneously. Materials and Method: Speech and EGG signal were recorded simultaneously from 13 normal subjects, 39 patients. The patients' data included 16 polyps and 23 vocal folds palsy. Time difference between glottal closing instance on EGG and the first maximum peak on speech in a pitch period was calculated. Glottal closing instance was defined as the maximum peak on the first derivative of EGG signal(dEGG). Results: The standard deviation and jitter were calculated using 20-30 GCDRs extracted from each data, and they are significant different between normal and vocal fold paralysis group. Conclusion: The GCDR may be the first index reflecting speech and EGG characteristics and the perturbation of this parameter was significant different between normal and vocal fold paralysis group.
최종민,김희택,류주현,이인수,Choi, Jong-Min,Kim, Hee-Taek,Ryu, Ju-Hyun,Lee, In-Su 대한한방안이비인후피부과학회 2005 한방안이비인후피부과학회지 Vol.18 No.1
Objective : The purpose of this study was to know the clinical effect of Hydrotherapy based Ultasonic spa on Atopic Dermatitis and Allergic Rhinitis. Methods : Allery Test(MAST CLA Allergy system, inhalant panel), DITI, Bio Chemistry, Hematology were investigated in 20 patients(Atopic Dermatitis 10, Allergic Rhinitis 10) who visited Department of Ophthalmology & Otolaryngology & Dermatology, Semyung Oriental medicine hospital from November 2004 to January 2005. Results : 1. In atopic dermatitis patients, there was good in 7 cases(70%), excellent in 3 cases(30%). 2. In allergic rhinitis patients there was improved in 5 eases(50%), good in 2 cases(20%), unimproved in 3cases(30%). 3. In conclusion, there was good(doctor and patients ail) in 6(60%), unimproved in 3(30%) Conclusion : Hydrotherapy based Utasonic spa showed useful effect on Atopic Dermatitis and Allergic Rhinitis.
Human Liver Microsomes과 HepG2 세포를 이용한 약물유래 간독성 평가 방법의 최적화
최종민,전장수,김상겸,Choi, Jong Min,Jeon, Jang Su,Kim, Sang Kyum 대한약학회 2015 약학회지 Vol.59 No.5
The aim of the present study was to optimize in vitro method for the prediction of drug-induced liver injury using human liver microsomes (HLM). Cytotoxicity test of cyclophosphamide and acetaminophen in HepG2 cells cultured with HLM showed that the newly established condition using 0.375 mg/ml HLM for 24 hr incubation was comparable or more sensitive than the previously established condition using 0.75 mg/ml HLM for 12 hr incubation. Although the cytotoxic effect of troglitazone was completely attenuated by 0.75 mg/ml HLM, it was augmented by 0.375 mg/ml HLM in the presence of the NADPH-generating system. The cytotoxic effect of chlormezanone, a withdrawn drug due to hepatotoxicity in human, was increased by HLM in the presence of the NADPH-generating system. In contrast, the cytotoxic effect of methapyrilene, a withdrawn drug due to hepatotoxicity in rats, was decreased by HLM in the presence of the NADPH-generating system. The present study suggests that the optimized in vitro method using HLM can be useful for the prediction of drug-induced hepatotoxicity.
이코너마이저 적용 열펌프 시스템의 부하변화에 따른 성능 특성 연구
최종민(Jong Min Choi),박용정(Yong-Jung Park),강신형(Shin-Hyung Kang) 한국지열·수열에너지학회 2014 한국지열에너지학회논문집 Vol.10 No.3
Heat pumps have received a fair amount of attention all over the world for their high efficiency and low environmental impact. Employing heat pumps for residential heating and cooling produces only about 2038 kg-CO₂/year, an amount which is less than half that of conventional boiler systems. However, the use of single-stage heat pumps becomes uneconomical when they are operated at very low evaporating temperature or high condensing temperature. Two-stage heat pumps systems can be used successfully for low or high temperature applications. In this paper, the experimental study on the performance of two-stage heat pump with an economizer was executed in heating mode. When the secondary fluid inlet temperature to the indoor that exchanger increased, the COP enhancement rate of two-stage heat pump with an economizer was increased. For all outdoor inlet temperature conditions, the performance of the heat pump with an economizer was higher than it without an economizer.
지열원 물대공기 멀티 히트펌프의 일일 난방 운전 특성에 관한 실증 연구
최종민(Jong Min Choi),임효재(Hyo-Jae Lim),강신형(Shin-Hyung Kang),문제명(Jemyung Moon),김록희(RockHee Kim) 대한설비공학회 2009 설비공학 논문집 Vol.21 No.9
The aim of this study is to investigate the daily heating performance of ground source multi-heat pump system with vertical single U-tube type GLHXs, which were installed in a school building located in Cheonan. Daily average COP of heat pump unit on Jan. 12th, 2009 at heating mode was lower than it on Nov. 10th, 2008 and Dec. 15th, 2008, because of lower EWT of the outdoor heat exchanger and relatively smaller size of condenser and evaporator. But, the system COP on the former was higher than it on the latter because ground loop circulating pump was operated in rated speed. It is suggested that the new algorithms to control the flow rate of secondary fluid for GLHX according to load change have to be developed in order to enhance the performance of the system COP.