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Gardner's syndrome is a rare hereditary disorder transmitted by autosomal dominant inheritance and charactrized by multiple adenomatous polyps throughout large intestine associated with multiple osteomas, epidermal cysts, fibromas, etc. Extracolic tumors such as periampullary carcinoma, papillary carcinoma of the thyroid gland, adrenal adenoma/carcinoma and tumors of the CNS have been reported to be associated with Gardner's syndrome. The authors report a case of Gardner's syndrome in a 53-year-old male who presented colorectol polyposis with osteoma of the frontal bone, schwannoma of neck and multiple adenomas of the gallbladder. A review of literature with empha.'is on the association of adenomata of the gallbladder was made. The colorectum was carpeted by multiple sessile and pedunculated polyps with microscopic foci of adenocarcinoma confined to the submucosa. The gallbladder was stuffed with multiple polyps, which were histologically adenomas with varying degrees of atypical change from mild dysplasia to carcinoma in situ.
The first aim of this study was to observe the early changes of exocrine function and morphology after single large dose of irradiation on rat pancreas. In addition, the relationships among irradiated pancreas, hypertrophied pancreas and acute pancreatitis were investigated. Male Sprague Dawley rats were used. Single irradiation was given using linear accelerator with 6 MeV elecrron beam, dose of 2000 cGy. Acute interstit,ial pancreatitis was induced by four subcutaneous injections of caerulein 20ug/kg at every hour. Camostat 200 mg. Kg(I. G.) was administered for four days to induce pancreatic hypertrophy. The pancreas weight(g/ 100g B. W.) was increased after irradiation but tissue protein and amylase content.s were decreased. The pancreatic juice volume were increased at 3 days and 1 week, and t.hen normalized at 3 weeks after irradiation. The pancreatic juice voume, protein and amylase output were decreased in rats with caerulein induced acute pancreatitis. A decrement of the pancre- atic juice volume in acute pancreatit,is was larger in rats with irradiation than in rats without irradiation. Irradiation worsend the morphologic changes associated with caerulein induced pancreatitis, which were markedly noted at I week after irradiation. Camostat induced hypertrophied pancreas exhibited rnore severe morpologic changes in response tho irradiation combined with caerulein.