그람양성구균에 대한 Teicoplanin과 Vancomycin의 시험관내 항균력

최태열,김경숙,전용관,서일혜,김정욱,이웅수,안정열,김홍석,정재용,최효선,김덕언,유진우 대한감염학회 1994 감염 Vol.26 No.1

An increasing frequency of methicillin resistant S. aureus(MRSA), methicillin resistant coagulase negative staphylococci(MRCNS) and Enterococcal infection have been observed in recent years. Teicoplanin is a new glycopeptide antibiotic obstained from the Actinoplanes teicomycetius. The molecular structure and spectrum of antimicrobial activity of teicoplanin is simillar to those of vancomycin, and has been reported to have an excellent in vitro and in vivo effect against various gram-positive infections. Therefore, we evaluated the in vitor susceptibility of gram positive cocci, such as, S. aureus, coagulase negative Staphylococci(CNS), and Enterococci to teicoplanin and vancomycin. The total 253 strains consisted of MSSA(40), MRSA(53), MSCNS(47), MRCNS(48), and Enterococci(65). They were assayed by disc diffusion and agar dilution. During the study, 57% of S. aureus and 49% of CNS showed resistance to methicillin. The inhibitory diameter of teicoplanin was 15-20mm in MSSA, 12-19mm in MRSA, 13-24mm in MSCNS, 11-23mm in MRCNS, and 15-22mm in Enterococci respectively, and showed sensitivity in all but 8 strains(3.2%). The range of the minimum inhibitory concentration (MIC) of teicoplanin to MSSA, MRSA, MSCNS, MRCNS and Enterococci were 9.12-2.0㎍/ml, 0.25-2.0㎍/ml, & 0.25-32㎍/ml, 0.12-1.0㎍/ml respectively. One case of S. haemolyticus was resistant to teicoplanin (32㎍/ml) by the agar dilution method. Eight minor (3.2%) and one major(0.4%) error was observed when the MIC and disk diffusion data were correlated with teicoplanin. As for vancomycin the inhibitory diameter was 17-21mm in MSSA, 15-21mm in MRSA, 18-26mm in MSCNS, 18-25mm in MRCNS, and 16-22mm in Enterococci respectively. The range of the MIC of vancomycin to MSSA, MRSA, MSCNS, MRCNS, and Enterococci were 0.25-1.0㎍/ml, 0.25-4.0㎍/ml, 0.5-2.0㎍/ml and 0.5-2.0㎍/ml respectively. One minor error (0.4%) was seen with the vancomycin disk. The MIC90 of MSSA and MRSA exhibited the same results in teicoplanin (1.0㎍/ml, 1.0㎍/ml), and vancomycin(2.0㎍/ml, 2.0㎍/ml). MSCNS and MRCNS exhibited greater MIC90 with teicoplanin(4.0㎍/ml, 8.0㎍/ml) than vancomycin(2.0㎍/ml, 2.0㎍/ml). Incontrase Enterococci were more susceptible to teicoplanin(0.5㎍/ml) than to vancomucin (2.0㎍/ml). Results from this analysis indicated that both teicoplanin and vancomycin were very excellent for gram positive infections, especially those resistant to methicillin.

Risperidone 조기 중단군 및 장기 유지군의 임상적 특성 비교

김광수,박원명,전태연,배치운,김대진,백인호,이철,김정수,한상익,최보문,장계호,고효진 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.3

연구목적 : Risperidone 투여후 조기 중단한 환자들과 장기적으로 계속 risperidone을 복용하고 있는 환자의 임상적 특성을 평가하고 나아가 risperidone장기 유지와 조기 중단의 요인을 분석하고 정신병리가 약물 투여에 미치는 영향을 조사하고자 하였다. 방 법 : 연구 대상자는 1996년 1월부터 1996년 12월까지 가톨릭대학교 의과대학 부속 8개 병원 정신과에서 risperidone을 투여 시작한 환자 580명중 DSM-IV기준에 의해 정신분열병으로 진단받고 투여 기간이 6개월 미만(조기 중단군)이거나 2년 이상(장기 유지군)을 경과하였으며 의무기록의 누락이 없는 210명을 선정하였다. 두 군간 임상적 특성을 조사하기 위하여 인구학적 변인, 정신병리학적 변인, 약물 투여기록 및 부작용 등을 과거 의무기록을 근거로 평가하였다. 결 과 : 대상환자 210명 중 조기 중단군이 67명(31.9%)이었고 장기 유지군은 143명(68.1%)이었으며 두 군간 인구학적 변인과 정신병리학적 변인에 따른 특징에는 두 군간 차이가 없었다. 두 군간 risperidone의 시작 용량과 변인과 정신병리학적 변인에 따른 특징에는 두 군간 차이가 없었다. 두 군간 risperidone의 시작 용량과 최대 용량은 유의한 차이가 없었으나 유지용량은 조기 중단군에서 4.49(±1.44)mg,장기 유지군에서 3.67(±1.50)mg으로 유의한 차이가 있었다(t=3.698, p<0.05). 또한, 이전 항정신병약물의 사용 기왕력 변인에서 조기 중단군은 기왕력이 없는 환자가 39명(58.2%), 고역가 항정신병약물을 사용한 기왕력이 있는 환자는 27명(40.3%), 저역가 항정신병약물을 사용한 기왕력이 있는 환자는 1명(1.5%)이었고, 장기 유지군은 기왕력이 없는 환자가 58명(40.6%), 고역가 항정신병약물을 사용한 기왕력이 있는 환자는 77명(53.8%), 저역가 항정신병약물을 사용한 기왕력이 있는 환자는 8명(5.6%)으로 유의한 차이가 있었다.(x²=6.559, df-=2, p<0.05). 결 론 : 본 연구결과에 의하면 가급적 환자 상태에 따라 낮은 최적 치료 용량을 투여하는 것이 장기잔의 투여를 바람직한 것으로 생각된다. 본 연구와 같은 대규모의 후향적 자연적 연구는 일반 실제 진료에서 risperidone의 효과 및 기타 다른 측면에서의 유용한 정보를 얻을 것으로 기대된다. Objective : This retrospective naturalistic study was designed to compare the clinical characteristics including psychopathology of two groups of patients, long-term maintenance group and short-term drop-out group, who were taking risperidone. Method : Datas were collected for 210 schizophrenic patients with complete medical records among 580 patients who were enrolled with risperidone administration from January 1996 to December 1996 in 8 affiliated hospital of the Catholic University. The short-term drop-out patients group were assigned to whom treatment period was less than 6 month, and the long-term maintained patients group, treatment period was more than 2 years. We assessed demographics, psychopathology, and other variables related with medication based on past medical records. Results : Among subjects of 210, short-term drop-out patients group were 67(31.9%) and long-term maintained patients group were 143(68.1%). Demographics and psychopathology were not significantly different between two groups. The stating and maximal dosage of risperidone was not significantly different between two groups but the maintenance dosage of risperidone was lower in long-term medicated patients group than short-term drop-out patients group(t=3.698, p<0.05). Additionally, the result of this study showed differences in experiences of past antipsychotic use as following. The number of no previous use of antipsychotic was 39(58.2%), the number of high potency amtipsychotic use was 27(40.3%), and the number of no previous use of antipsychotic was 58(40.6%), the number of high potency ntipsychotic use was 77(53.8%), the number of low potency antipsychotic use was8(5.6%) in long-term maintained group.(x²=6.559, df-=2, p<0.05). Conclusions : According to these results, administration of low therapeutic dosage should be recommended for long-term maintenance as if possible. Multi-center based retrospective naturalistic study like this would be useful for getting informations about efficacy and some other aspects of antipsychotic administration in practial field.

Fabrication of Fluid Wing Structure for Microfluidic Blood Plasma Seperation

Jeong Un Choi,Jihye Lee,Young-Shik Yun,Jiyun Park,Jong-Souk Yeo 한국진공학회 2014 한국진공학회 학술발표회초록집 Vol.2014 No.8

Anti-inflammatory and Anti-oxidant Effects of Ledebouriella seseloides produced by Different Cultivation Method

Un Yul Jeong,Ji-Hye Choi,Eun Byeol Lee,Si Hyun Kim,Ji Su Kim,Ju-Hui Kim,Hwal Choi,Sung Hyen Lee 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10

Ledebouriella seseloides (LS) is a medicinal plant with high functional activity in anti-inflammatory and anti-stroke effects. Recently, LS has been cultivated widely in plant factory with artificial light (LS-A). We evaluated the effects of LS-A and LS cultivated in the open field (LS-F) on anti-oxidative and anti-inflammatory activities. In DPPH and ABTS radical scavenging tests and total polyphenol analysis, LS-A and LS-F extracts showed similar antioxidant activity. They significantly reduced lipopolysaccaride (LPS, 1 μg/mL)-induced nitric oxide (NO) concentration in a dose-dependent manner without cytotoxicity in RAW264.7 cells cultured with the extracts. In the western blot analysis, they decreased the expression of iNOS, COX-2, and NF-κB proteins in the RAW.264.7 cells. The results suggests that LS-A has anti-oxidative activity and anti-inflammatory effects like as LS-F extracts. LS-A may be used as a potential therapeutic candidate for the prevention and treatment of macrophage-derived chronic immune diseases.

Lipid extracted from Arctoscopus japonicus eggs enhance immunosuppression in cyclophosphamide-treated mice

Jeong Un Choi,Yun Gu Gwon,Seul Gi Lee,One Jun Kim,Zhang Yutung,Kou Fang,A-Yeong Jang,Weerawan Ron-In,Woo Jung Park 한국식품영양과학회 2022 한국식품영양과학회 학술대회발표집 Vol.2022 No.10

Lysophosphatidic acid‐induced expression of periostin in stromal cells: Prognoistic relevance of periostin expression in epithelial ovarian cancer

Choi, Kyung Un,Yun, Jeong Sup,Lee, Il Hwan,Heo, Soon Chul,Shin, Sang Hun,Jeon, Eun Su,Choi, Yoon Ji,Suh, Dong‐,Soo,Yoon, Man‐,Soo,Kim, Jae Ho Wiley Subscription Services, Inc., A Wiley Company 2011 International journal of cancer: Journal internati Vol.128 No.2

<P><B>Abstract</B></P><P>Lysophosphatidic acid (LPA) is a bioactive lipid crucial for the initiation and progression of ovarian cancer. Identification of LPA‐induced biomarkers is necessary for predicting prognosis of ovarian cancer patients. Here we report periostin, an extracellular matrix protein, as an LPA‐induced protein in stromal cells and as a prognostic marker in patients with epithelial ovarian cancer (EOC). In human EOC tissues, periostin was mainly expressed in cancer‐associated stromal fibroblasts, but not in cancer cells. The expression levels of periostin highly correlated with poor survival and tumor recurrence of ovarian cancer patients. Treatment of human adipose tissue‐derived stromal cells with LPA or conditioned media from human ovarian adenocarcinoma cell lines, such as SK‐OV‐3 and OVCAR‐3, induced expression of periostin. The periostin expression induced by cancer‐conditioned media was abrogated by silencing of the LPA receptor 1 expression using small hairpin RNA lentivirus. Recombinant periostin stimulated adhesion and invasion of SK‐OV‐3 human ovarian adenocarcinoma cells and induced expression of matrix metalloprotease‐2 in the cancer cells. These results suggest that LPA is associated with the expression of periostin in cancer‐associated fibroblasts of EOC.</P>

Immunomodulation activities of crude polysaccharide extracted from ginseng berry on peritoneal macrophage of immune-suppression mice

Jeong Un Choi,Ju Hyun Nam,Jun Hyeok Lim,Gyoung Su Choi,Yun Gu Gwon,Seul Gi Lee,Weerawan Rod-in,Chaiwat Monmai,Woo Jung Park 한국식품영양과학회 2020 한국식품영양과학회 학술대회발표집 Vol.2020 No.10

사업보고서에 대한 투자자 관심 집중도와 가치관련성

최정운 ( Jeong Un Choi ) 한국회계학회 2021 회계저널 Vol.30 No.3

본 연구는 사업보고서 공시일의 사업보고서에 대한 투자자 관심 집중도와 기업의 가치관련성을 조사한다. 구체적으로 검색량지수(Search Voulme Index)를 이용하여 투자자의 사업보고서 관심 집중도를 측정하며, 표본기간 대비 사업보고서 공시일에 검색량지수가 집중되는 수준과 이익의 가치관련성을 조사한다. 기업의 정보공시와 관련된 선행연구는 투자자에게 제공되는 정보의 양과 질 뿐만 아니라 이사회 또는 외부감사인과 같이 정보가 작성되는 환경과 과정 등, 다양한 측면에서 깊이 있게 다루어져 왔다. 이러한 관점은 투자자의 합리성을 가정하여, 정보의 유용성을 주로 정보를 제공하는 기업 측면에서 접근하였다. 그러나 투자자의 제한된 합리성을 고려한다면, 제공된 수많은 정보에 대한 투자자의 선택과 반응 등을 고려할 필요가 있다. 따라서 본 연구는 네이버 데이터랩의 검색어 트렌드 지표를 이용하여, 사업보고서에 대한 투자자의 관심 집중도와 가치관련성의 관계를 조사하였다. 실증결과, 사업보고서 공시일의 투자자 관심 집중도는 이익의 가치관련성과 유의한 음의 관계로 나타났다. 이러한 실증결과는 기업이 제공하는 다양한 정보에도 불구하고, 투자자가 주로 사업보고서에 집중하고 의존할수록 기업의 가치관련성이 낮게 나타난다고 이해할 수 있다. 본 연구는 기업이 제공하는 정보의 유용성을 정보 수요자 관점에서 분석하였다는 점에서 의미가 있으며, 정보에 대한 투자자의 관심과 반응을 확인하였다는 점에서 의의가 있다. This study investigates the relationship between the concentration of investors’ attention in the business report on the business report disclosure date and value relevance. Specifically, the search volume index (SVI) is used to measure the concentration of investors’ attention in the business report, and this study investigates the relationship between the level of SVI concentration on the business report disclosure date, compared to sample period, and value relevance of EPS. Prior research related to information disclosure has been studied in depth in various aspects, such as the quantity and quality of information provided to investors, as well as the environment and process in which information is prepared, such as the board of directors or external auditors. This perspective assumes the rationality of investors, and approaches the usefulness of information mainly from the side of firms (providing information). However, considering the limited rationality of investors, it is necessary to consider investors' choices and reactions to the numerous information provided. Therefore, this study investigated the relationship between the concentration of investors’ attention in the business report on the business report disclosure date and value relevance by using the searching volume index (SVI) of the keyword of Naver Data Lab. As a result, the concentration of investors’ attention showed a significant negative relationship with value relevance of EPS. This empirical result can be understood that despite the various information provided by the firm, the more investors focus and rely on business reports, lower the value relevance. This study is meaningful in that it analyzes the usefulness of information provided by firms from the perspective of information consumers, and is meaningful in that it confirms investors' attention and reaction to information.

레이더 펄스 탐지를 위한 통신 전자파잡음 동적제거 기법

정운섭 ( Un-seob Jeong ),이치헌 ( Chi-hun Lee ),최채택 ( Chae-taek Choi ),최승호 ( Seung-ho Choi ) 한국정보처리학회 2012 한국정보처리학회 학술대회논문집 Vol.19 No.2

본 논문은 지상에서 발생하는 전자파 잡음 신호의 유입에 의해 많은 영향을 받을 수 있는 헬기 등 항공기의 레이더경보수신기(Radar Warning Receiver)에서도 레이더 펄스 신호를 탐지할 수 있는 통신전 자파잡음 동적제거 기법을 제안하였다. 본 논문은 지상의 노이즈 신호를 분류하는 방법을 제시하였고, 노이즈 신호 레벨을 판단하여 효과적으로 잡음을 제거하는 알고리즘을 제안하였다.

증례 : 전신성 홍반성 루푸스에서 고용량 스테로이드 치료 후 발생한 저체온증

최운정 ( Un Jung Choi ),신유섭 ( Yu Seob Shin ),김정은 ( Jeong Eun Kim ),최정희 ( Jeong Hee Choi ),남동호 ( Dong Ho Nahm ),박해심 ( Hae Sim Park ),서창희 ( Chang Hee Suh ) 대한내과학회 2004 대한내과학회지 Vol.67 No.-