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Lee, Yong-Sub,Lee, Mun-Woo,Kam, Sang-Ho,Jeong, Yoon-Ha Wiley Subscription Services, Inc., A Wiley Company 2010 MICROWAVE AND OPTICAL TECHNOLOGY LETTERS Vol.52 No.6
<P>This article represents analog predistortion linearization of Doherty power amplifier (DPA) using bandwidth reduction of error signal. To verify our methods, two DPAs are implemented using a push-pull GaN HEMT and a push-pull Si LDMOS at 2.14 GHz and tested using the memory-compensated analog predistorter with transistor-based error generators and three-branch nonlinear paths. From the measured four-carrier WCDMA results, the proposed analog predistortion DPAs show the significant linearity improvement. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1313–1316, 2010; Published online in Wiley InterScience (www.interscience. wiley.com). DOI 10.1002/mop.25190</P>
Shen, Jian Guo,Cheong, Jae Ho,Hyung, Woo Jin,Kim, Junuk,Choi, Seung Ho,Noh, Sung Hoon Wiley Subscription Services, Inc., A Wiley Company 2005 Journal of surgical oncology Vol.91 No.2
<B>Background and Objectives</B><P>A negative correlation between anemia and outcome has been demonstrated in various cancers treated with radiotherapy. However, it is rarely studied whether this correlation may exist in surgical setting. Our aim was to investigate the relationship between pretreatment anemia and survival in surgically treated patients with gastric cancer.</P><B>Methods</B><P>A total of 1,688 patients who had undergone curative resection for gastric cancer between 1991 and 1995 were reviewed. Anemia was defined as a hemoglobin level <12.0 g/dl. The influence of anemia on patient overall survival was evaluated by univariate and multivariate analysis.</P><B>Results</B><P>Pretreatment anemia was present in 39.9% of the patients. The 10-year overall survival rate in anemic patients was 48.2% as compared with 62.6% in nonanemic patients (P < 0.001). In subgroup analysis according to the stage, the significant difference in 10-year overall survival rate between anemic and nonanemic patients was found in stage I and II gastric cancer (76.1% vs. 83.5% in stage I, P = 0.030; 55.1% vs. 67.2% in stage II, P = 0.043). On multivariate analysis, anemia was an independent prognostic predictor in patients with stage I and II disease (P = 0.007; RR, 1.466; 95% CI, 1.109–1.937).</P><B>Conclusions</B><P>Pretreatment anemia was found to have an independent relationship to the long-term survival of patients with stage I and II gastric cancer. J. Surg. Oncol. 2005;91:126–130. © 2005 Wiley-Liss, Inc. J. Surg. Oncol. 2005;91:?–?. © 2005 Wiley-Liss, Inc.</P>
Kim, Dongkyun,Kim, Jungsoo,Kang, Shin-Sung,Jin, Eun-Jung Wiley Subscription Services, Inc., A Wiley Company 2009 Journal of cellular biochemistry Vol.107 No.4
<P>Endochondral ossification is characterized by a significant interdependence between cell shape and cytoskeletal organization that accompanies the onset of chondrogenic signaling. However, the mechanisms mediating these interactions have not been well studied. Here, treatment with transforming growth factor (TGF)-β3 at a later stage of chondrogenesis led to activation of Smad-2 signaling and the formation of intense stress fibers, which resulted in suppressing chondrogenic differentiation of leg bud mesenchymal cells. Moreover, specific siRNA knockdown of Smad-2 reduced TGF-β3-induced stress fibers via physical interactions with β-catenin. In conclusion, our results indicate that TGF-β3-induced Smad signaling, in conjunction with β-catenin, is involved in the reorganization of the actin cytoskeleton into a cortical pattern with a concomitant rounding of cells. J. Cell. Biochem. © 2009 Wiley-Liss, Inc.</P><P>This article was published online on 28 May 2009. An error was subsequently identified. This notice is included in the online and print versions to indicate that both have been corrected 8 June 2009. J. Cell. Biochem. 107: 622–629, 2009. © 2009 Wiley-Liss, Inc.</P>
An enhanced bandwidth planar inverted‐F antenna with a modified shorting strip
Park, Hoon,Jung, Heekyung,Hong, Sukjin,Choi, Jaehoon Wiley Subscription Services, Inc., A Wiley Company 2007 MICROWAVE AND OPTICAL TECHNOLOGY LETTERS Vol.49 No.3
<P><B>Abstract</B></P><P>This article presents a novel design method for a wideband planar inverted F‐antenna that simultaneously covers GSM900, GPS, DCS1800, IMT2000, WLAN, and DMB services. The proposed antenna consisted of a main patch with stubs, an I‐shaped patch, and a modified shorting strip. It had dimensions of 16 × 36 × 6 mm<SUP>3</SUP>. The dual band characteristic could be achieved by changing the length of a main patch. A very wide impedance bandwidth characteristic was obtained by optimizing the length of stubs, an I‐shaped patch, and a modified shorting strip. Commercial electromagnetic software, CST Microwave Studio, was used to design the structure. The maximum gains at the frequencies of 915, 1576, 1785, 2170, 2400, and 2630 MHz were 1.0, 2.7, 5.4, 4.56, 1.52, and 2.95 dBi, respectively. The overall radiation pattern was suitable for mobile applications. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 49: 513–515, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.22179</P>
DVB-H antenna structure using Z-type hexagonal ferrite for folder-type mobile phones
Rhyu, Hanphil,Jung, Chang Won,Lee, Byungje Wiley Subscription Services, Inc., A Wiley Company 2009 MICROWAVE AND OPTICAL TECHNOLOGY LETTERS Vol.51 No.9
<P>A new internal antenna structure using a Z-type hexagonal ferrite is introduced for the DVB-H reception in folder-type mobile phones. The antenna element operates as a coupling element to excite the chassis as a radiator. Using a Z-type hexagonal ferrite, the proposed antenna can be designed with a considerably low volume of 0.75 cm<SUP>3</SUP> and meets the requirements of antenna for the DVB-H service. The high isolation over 15 dB between the DVB-H band and the communication bands (GSM, DCS, and PCS) is obtained. © 2009 Wiley Periodicals, Inc. Microwave Opt Technol Lett 51: 2196–2199, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24551</P>
Moon, Yon-Tae,Choi, Woon-Kyung,Choi, Young-Wan Wiley Subscription Services, Inc., A Wiley Company 2010 MICROWAVE AND OPTICAL TECHNOLOGY LETTERS Vol.52 No.7
<P>A broadband linearization method with a novel opto-electrical predistorter was experimentally demonstrated. With the proposed method, the third-order intermodulation distortion was simultaneously enhanced by more than 10 dB for 510 MHz ranges and by 24 dB at 2.2 GHz without any change in electrical circuitry. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1638–1640, 2010; Published online in Wiley InterScience (www.interscience. wiley.com). DOI 10.1002/mop.25240</P>
A new K-band push-push VCO using a miniaturized hairpin resonator
Lee, Hyun-Wook,Yoon, Ki-Cheol,Nam, Hee,Eo, Yun-Seong,Lee, Jong-Chul Wiley Subscription Services, Inc., A Wiley Company 2010 MICROWAVE AND OPTICAL TECHNOLOGY LETTERS Vol.52 No.3
<P>In this article, a K-band push-push Voltage Controlled Oscillator (VCO) is presented using a miniaturized hairpin resonator (MHR) with a higher loaded quality factor and the reduced circuit area within 50% compared to the conventional one at 9.2 GHz.The MHR combined with the GaAs MESFET varactor shows a tuning range of 140 MHz, and this voltage tunable MHR is used to compose a push-push VCO. It provides the frequency tuning range of 71 MHz with flatness of +0.13 dB, which is increased by 31 MHz compared to the conventional VCO. The voltage controlled push-push oscillator based on the series feedback topology is implemented on 0.54 mm-thick Teflon substrate with a dielectric constant of 2.54. The measurement shows the output power of 1.18 dBm, the fundamental signal power suppression of −33 dBc, and phase noise performance of −86.78 dBc/Hz at 100 kHz offset. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 699–701, 2010; Published online in Wiley InterScience (www.interscience. wiley.com). DOI 10.1002/mop.25007</P>
Song, Su Jin,Lee, Jeong Min,Kim, Young Jun,Kim, Se Hyung,Lee, Jae Young,Han, Joon Koo,Choi, Byung Ihn Wiley Subscription Services, Inc., A Wiley Company 2007 JOURNAL OF MAGNETIC RESONANCE IMAGING Vol.26 No.1
<B>Purpose</B><P>To compare the diagnostic performance of multirow-detector computed tomography (MDCT) and magnetic resonance imaging (MRI) in the differentiation of intraductal papillary mucinous neoplasms (IPMNs) from other pancreatic cystic masses.</P><B>Materials and Methods</B><P>A total of 53 patients with pathologically proven pancreatic cystic lesions who had undergone MDCT and MRI were included in this study. Two radiologists analyzed the morphologic features of the lesions and graded the lesion conspicuity on each examination. The readers assigned their confidence level regarding the differentiation of IPMN from other lesions and predicting ductal communication of the lesion. The radiologists' diagnostic confidence was compared using receiver operating characteristic (ROC) analysis.</P><B>Results</B><P>The Az values for each observer for predicting ductal communication of the lesion and differentiating IPMN from other lesions were as follows: For MRI they were respectively 0.949 and 0.995 for reader 1, and 0.916 and 0.932 for reader 2. For MDCT they were respectively 0.790 and 0.875 for reader 1, and 0.774 and 0.850 for reader 2. In addition, for differentiating IPMNs from other lesions, MRI was significantly more accurate than MDCT (P < 0.05) for one observer, but for the other observer there was no significant difference between the two examinations (P = 0.059). For predicting ductal communication of the cystic lesions for both observers, MRI was significantly more accurate than MDCT (P < 0.05). The weighted κ values indicate good agreement (κ = 0.61) between observers for MDCT, and excellent agreement (κ = 0.82) for MRI.</P><B>Conclusion</B><P>Pancreatic MRI shows better diagnostic performance than MDCT for differentiating IPMNs from other cystic lesions of the pancreas. J. Magn. Reson. Imaging 2007;26:86–93. © 2007 Wiley-Liss, Inc.</P>
High accuracy template based modeling by global optimization
Joo, Keehyoung,Lee, Jinwoo,Lee, Sunjoong,Seo, Joo-Hyun,Lee, Sung Jong,Lee, Jooyoung Wiley Subscription Services, Inc., A Wiley Company 2007 Proteins Vol. No.
<P>For high-accuracy template-based-modeling of CASP7 targets, we have applied a procedure based on the rigorous optimization of score functions at three stages: multiple alignment, chain building, and side-chain modeling. We applied the conformational space annealing method to a newly developed consistency based score function for multiple alignment. For chain building, we optimized the MODELLER energy function. For side-chain modeling, we optimized a SCWRL-like energy function using a rotamer library constructed specifically for a given target sequence. By rigorous optimization, we have achieved significant improvement in backbone as well as side-chain modeling for TBM and TBM/HA targets. For most TBM/HA targets (17/26), the predicted model was more accurate than the model one can construct from the best template in a posteriori fashion. It appears that the current method can extract relevant information out of multiple templates. Proteins 2007. © 2007 Wiley-Liss, Inc.</P>
Kim, Min Hee,Lee, Yu Jin,Kim, Mi Ok,Kim, Jin Sang,Han, Ho Jae Wiley Subscription Services, Inc., A Wiley Company 2010 Journal of cellular biochemistry Vol.111 No.3
<P>The actual leukotriene D<SUB>4</SUB> (LTD<SUB>4</SUB>) signaling pathways that regulate cell proliferation have not been elucidated thoroughly although fatty acid and its metabolites play a key role in regulations of embryonic functions. Thus, this study investigated the response of mouse embryonic stem (ES) cells exposed to LTD<SUB>4</SUB> and elucidated the signaling pathways as well. LTD<SUB>4</SUB> increased DNA synthesis in concentration-dependent (≥10<SUP>−7</SUP> M) and time-dependent (≥12 h) manners, as determined by [<SUP>3</SUP>H] thymidine incorporation and increased cell number. LTD<SUB>4</SUB> induced the phosphorylation of signal transducer and activator of transcription-3 (STAT3) and the increase of intracellular Ca<SUP>2+</SUP> levels via cysteinyl leukotriene (CysLT) 1 and 2 receptors. LTD<SUB>4</SUB> increased Akt activation and calcineurin expression, which were blocked by STAT3 inhibitor and calcium chelators. LTD<SUB>4</SUB>-induced glycogen synthase kinase (GSK)-3β phosphorylation was decreased by LY294002, Akt inhibitor, and cyclosporine A. LTD<SUB>4</SUB> inhibited the phosphorylation of β-catenin. In addition, LTD<SUB>4</SUB>-stimulated migration through increased activation of focal adhesion kinase (FAK) and paxillin which were blocked by Akt inhibitor and cyclosporine A. LTD<SUB>4</SUB>-induced increases in protooncogene and cell cycle regulatory proteins were blocked by cyclosporine A, FAK siRNA, and β-catenin siRNA. In conclusion, LTD<SUB>4</SUB>-stimulated mouse ES cell proliferation and migration via STAT3, phosphoinositide 3-kinases (PI3K)/Akt, Ca<SUP>2+</SUP>-calcineurin, and GSK-3β/β-catenin pathway. J. Cell. Biochem. 111: 686–698, 2010. © 2010 Wiley-Liss, Inc.</P>