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Yun Gu Gwon,Seul Gi Lee,Jeong Un Choi,A-Yeong Jang,Weerawan Rod-In,Woo Jung Park 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Lysimachia capillipes, a traditional herbal medicine, has been used to treat cold and arthritis. The aim of this study was to investigate the anti-inflammatory activity of L. capillipes extract in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Treatments with L. capillipes extract at concentrations of 3.75,7.5,15, and 25 μg/mL had no cytotoxicity in LPS-stimulated RAW264.7 cells. L. capillipes extract dose-dependently suppressed the production of nitric oxide (NO) and the expression of pro-inflammatory cytokines including interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α in LPS-stimulated RAW264.7 cells. These were associated with the decrease of the mRNA expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) by L. capillipes extract (3.75-25 μg/mL). Moreover, L. capillipes extract also significantly inhibited the phosphorylation of MAPKs including p38, JNK and ERK1/2 as well as the expression of phosphorylated NF-κB-p65 in a dose-dependent manner. These results suggest that L. capillipes extract has anti-inflammatory properties, which activates through the inhibition of the NF-κB and MAPKs signaling pathway.
Dietary glucosinolates inhibit splenic inflammation in high fat/cholesterol diet-fed C57BL/6 mice
HyunJi Gu,Min-Hee Gwon,Sang-Min Kim,Jung-Mi Yun 한국영양학회 2021 Nutrition Research and Practice Vol.15 No.6
BACKGROUND/OBJECTIVES: Obesity is associated with chronic inflammation. The spleen is the largest organ of the lymphatic system and has an important role in immunity. Obesity-induced inflammatory responses are triggered by Toll-like receptor (TLR)-myeloid differentiation primary response 88 (MyD88) pathway signaling. Phenethyl isothiocyanate (PEITC) and 3,3′-diindolylmethane (DIM), major dietary glucosinolates present in cruciferous vegetables, have been reported to produce anti-inflammatory effects on various diseases. However, the effects of PEITC and DIM on the obesity-induced inflammatory response in the spleen are unclear. The purpose of this study was to examine the antiinflammatory effects of PEITC and DIM on the spleen and their mechanism in high fat/cholesterol diet (HFCD)-fed C57BL/6 mice. MATERIALS/METHODS: We established an animal model of HFCD-induced obesity using C57BL/6 mice. The mice were divided into six groups: normal diet with AIN-93G diet (CON), high fat diet (60% calories from fat) with 1% cholesterol (HFCD), HFCD with PEITC 30 mg/kg/day or 75 mg/kg/day (HFCD+P30, HFCD+P75), and HFCD with DIM 1.5 mg/kg/day or 7.5 mg/kg/day (HFCD+D1.5, HFCD+D7.5). Enzyme-linked immunosorbent assay was used to evaluate proinflammatory cytokine secretion. Western blot and quantitative polymerase chain reaction were used to analyze protein and mRNA levels of nuclear factor kappa B (NF-κB) p65, interleukin 6 (IL-6), cyclooxygenase 2 (COX-2), TLR2, TLR4, and MyD88 in spleen tissue. RESULTS: Serum IL-6 levels were significantly higher in the HFCD group than in groups fed a HFCD with PEITC or DIM. Levels of NF-κB p65 protein and TLR2/4, MyD88, NF-κB p65, IL-6, and COX-2 mRNA were significantly higher in the HFCD group than in the CON group and were reduced by the PEITC and DIM supplements. CONCLUSIONS: PEITC- and DIM-supplemented diets improved splenic inflammation by modulating the TLR2/4-MyD88 pathway in HFCD-fed mice. We suggest that dietary glucosinolates may at least partially improve obesity-induced inflammation of the spleen.
콘벌루션 부호를 적용한 900㎒ 대역 RFID 시스템 구현 및 성능분석에 관한 연구
김선구(Sun-Gu Kim),윤성기(Sung-Ki Yun),강병권(Byeong-Gwon Kang) 한국정보기술학회 2005 Proceedings of KIIT Conference Vol.2005 No.-
RFID는 각종 서비스 산업은 물론 물류, 산업 현장, 제조 공장과 물품의 흐름이 있는 곳이면 어디에서나 적용이 가능하여 사회 여러 분야로부터 큰 관심을 받고 있다. 하지만 현재 900Mhz 대역의 RFID에서 사용하는 ISO/IEC 18000-6의 프로토콜에서는 에러검출을 위한 CRC16만을 사용하여, 에러정정능력을 갖추지 못해 그 신뢰성이 떨어질 것으로 여겨진다. 본 논문에서는 이러한 RFID 시스템의 신뢰성 향상을 위해 Reader에서 Tag로의 명령어 및 데이터 전송시에 콘벌루션부호를 적용하여 시스템의 신뢰성 향상을 목적으로 하며, 이러한 방식을 적용했을 때와 적용하지 않았을 때의 에러율을 측정 비교하였다. In recent years, RFID is widely used in industrial applications including factory, material flow, logistics and defense areas. In this paper, The convolutional encoding and viterbi decoding is also implemented to improve the system performance. in an FPGA chip. The used convolution code is constraint length K=3 and rate R=1/2. The length of command frame and response frame is total of 48bits consisting of SOF 8 bits, command 16 bits, CRC 16 bit, and EOF 8 bits. And also the frame error rates are measured under the channel of line-of-sight and non line-of-sight, respectively. The performances are analyzed with FSK modulation only and FSK modulation added with convolutional encoding. These two measured results are compared with that of a RFID system with ASK modulation.
김윤숙 ( Kim Yun Sug ),이해혁 ( Lee Hae Hyeog ),김형문 ( Kim Hyeong Mun ),조인숙 ( Jo In Sug ),김태희 ( Kim Tae Hui ),심일구 ( Sim Il Gu ),남계현 ( Nam Gye Hyeon ),이권해 ( Lee Gwon Hae ),박성진 ( Park Seong Jin ),고은석 ( Go Eun 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.12
Hydatidiform moles are generally separated into two classifications. Complete hydatidiform moles are characterized by cystic swelling of all villi, often pronounced diffuse trophoblastic hyperplasia, lack of fetal parts, all 46 chromosomes of paternal ori
볼트결합부를 포함한 구조물의 정적 및 동적 해석을 위한 유한요소 모델링
권영두,구남서,김성윤,조민호,Gwon, Yeong-Du,Gu, Nam-Seo,Kim, Seong-Yun,Jo, Min-Ho 대한기계학회 2002 大韓機械學會論文集A Vol.26 No.4
Many studies on the finite element modeling for bolted joints have proceeded, but the structures with bolted joints are complicated in shape and it is difficult to find out the characteristics according to joint condition. Usually, experimental methods have been used for bolted joint analysis. A reliable and practical finite element modeling technique for structure with bolted joints is very important for engineers in industry. In this study, three kinds of model are presented; a detailed model, a practical model and a simple model. The detailed model is modeled by using 3-D solid element and gap element, and the practical model is modeled by using shell element (a portion of bolt head) and beam element (a portion of bolt body), the simple model is modeled by simplifying practical model without using gap elements. Among these models, the simple model has the least degree of freedom and show the effect of memory reduction of 59%, when compared with the detailed model.
Genetic parameters of calving ease using sire-maternal grandsire model in Korean Holsteins
Alam, Mahboob,Dang, Chang Gwon,Choi, Tae Jeong,Choy, Yun Ho,Lee, Jae Gu,Cho, Kwang Hyeon Asian Australasian Association of Animal Productio 2017 Animal Bioscience Vol.30 No.9
Objective: Calving ease (CE) is a complex reproductive trait of economic importance in dairy cattle. This study was aimed to investigate the genetic merits of CE for Holsteins in Korea. Methods: A total of 297,614 field records of CE, from 2000 to 2015, from first parity Holstein heifers were recorded initially. After necessary data pruning such as age at first calving (18 to 42 mo), gestation length, and presence of sire information, final datasets for CE consisted of 147,526 and 132,080 records for service sire calving ease (SCE) and daughter calving ease (DCE) evaluations, respectively. The CE categories were ordered and scores ranged from CE1 to CE5 (CE1, easy; CE2, slight assistance; CE3, moderate assistance; CE4, difficult calving; CE5, extreme difficulty calving). A linear transformation of CE score was obtained on each category using Snell procedure, and a scaling factor was applied to attain the spread between 0 (CE5) and 100% (CE1). A sire-maternal grandsire model analysis was performed using ASREML 3.0 software package. Results: The estimated direct heritability ($h^2$) from SCE and DCE evaluations were $0.11{\pm}0.01$ and $0.08{\pm}0.01$, respectively. Maternal $h^2$ estimates were $0.05{\pm}0.02$ and $0.04{\pm}0.01$ from SCE and DCE approaches, respectively. Estimates of genetic correlations between direct and maternal genetic components were $-0.68{\pm}0.09$ (SCE) and $-0.71{\pm}0.09$ (DCE). The average direct genetic effect increased over time, whereas average maternal effect was low and consistent. The estimated direct predicted transmitting ability (PTA) was desirable and increasing over time, but the maternal PTA was undesirable and decreasing. Conclusion: The evidence on sufficient genetic variances in this study could reflect a possible selection improvement over time regarding ease of calving. It is expected that the estimated genetic parameters could be a valuable resource to formulate sire selection and breeding plans which would be directed towards the reduction of calving difficulty in Korean Holsteins.