개 비장 질환의 미세세침흡입술을 통한 세포병리학 검사 4례

김현아,윤기영,최호정,정성목,이영원,조성환,박성준 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2011 動物醫科學硏究誌 Vol.18 No.1

To evaluate the accuracy and diagnostic significance of cytopathological diagnosis of canine splenic disorders, cytopathological examination throgh fine-needle aspiration(FNA) referred to Veterinary Medical Teaching Hospital of Chungnam National University were retrospectived. Splenic neoplasm, hemolymphatic neoplasm, hyperplasia, extramedullary hematopoiesis and splenitis were diagnosed canine splenic disorders through cytopathological examination. The patient should be identified what coagulation profile are normal before aspiration, because complication such as hemorrhage could happen. The 4 cases were identified symmetric, asymmetric splenomegaly on abdominal ultrasonography and then were performed ultrasound-guided FNA. The 4 cases were diagnosed hemangiosarcoma(2), hyperplasia(1) and extramedullary hematopoiesis(1) by clinical signs, hematological examination, and cytopathological examination. Cytopathological examination through FNA was cost-effective, no gneral anesthesia, no complication, and non-invasive method of diagnosis for canine splenic disorders.

건축디자인과정에서 스케치와 창조적 디자인 행위의 인지적 상호작용분석을 위한 기초연구

최현아,전한종 대한건축학회 2004 대한건축학회논문집 Vol.20 No.7

One of characteristics of the design process in the area of architectural design is the use of a number of different types of sketches. Designers place great emphasis on the sketch often because it is thought to be associated with innovation and creativity. Because of this emphasis researchers have also begun to focus on the sketch and its role of design. Especially emergent shapes through the sketches plays a significant role in the creative design. The first aim of this paper is to collect together and review the results closely related researches that have looked at the role of sketches in design process. The second aim of this paper is to review analogy and emergence that can be effective in facilitating creative design. At last the mutational emergent shapes are introduced.

인천 인현동 호프집 화재 피해자 분석

최정태,안무업,안희철,최영미,정재봉,서정열,유기철,이삼우,박석현,조준휘,김성환,김아진,송근정 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4

Purpose : This study was conducted to develop field triage, transportation, distribution, and prehospital care at a fire disaster by analyzing the victims of the fore that broke out at a bar in Incheon. Method : We analyzed the cases of the victims of a fire in Incheon in Oct. 1999. We determined the primary care hospital, the arrival time, the burn size, the outcome, and the injury type from the medical records, the concerned organ records, and interviews with concerned persons. Result : The total number of victims was 137: 56 prehospital deaths, 1 hospital death, and 80 survivals. The Pearson correlation coefficient between the burn size and the severity was -0.175. There were 121(89.6%) cases of inhalation injury, 59 (43.7%) cases of flame burns, 66 (48.9%) cases of hypoxic brain damage, and 16 (11.9%) cases involving other types of injury. Conclusion : The causes of death of the fire victims were inhalation injury and hypoxic brain damage due to CO poisoning and other toxic inhalants. We propose the use of a simple triage and rapid treatment(START) system and a reassessment the delayed category in fire disasters.

Meckel 게실의 합병증으로 수술 받은 환아의 임상양상

김현아,최금자,한후재 이화여자대학교 2003 EMJ (Ewha medical journal) Vol.26 No.2

Objectives : The purpose of study is to assess the clinical characteristics of complicated Meckel's diverticulum in children. Methods : A retrospective review of pediatric cases of complicated Meckel's diverticulae that were surgically treated at Ewha Womans University Hospital from 1985 was performed. The charts were reviewed for the age and sex of the patients, operation finding, treatment, and outcome. Results : A total 13 patients with a complicated Meckel's diverticulum were identified. There were 8 boys(61.5%) and 5 girls (38.5%) with a mean age of 5.3 years (range, 1month to 14years). Presenting signs and symptoms included digestive hemorrhage (6), intestinal obstruction(4), perfora-tion (1), intussusception due to inverted Meckel's diverticulum (1) and diverticulitis (1). A ^(99m) technetium pertechnetate scintiscan was positive in 3 of 4 patients. Barium contrast studies and colonoscopys were not diagnostic. The mean distance from the ileocecal valve to the diverticulum was 47.0±15.7cm. Average length of the diverticulum was approximately 4.7±3.0cm. Segmen-tal small bowel resection including Meckel's diverticulum (84.6%) or wedge excision(15.4%) was done for treatment. In the bleeding group, ectopic gastric mucosa was present in 5 of 6 patients. Postoperative morbidity and mortality was each 0%. Conclusion : The results of this study draw attention to the fact that the complicated Meckel's diverticulum must be suspected in children with acute abdomen or gastrointestinal bleeding. 목적: Meckel 게실의 합병증의 원인이 되어 수술적 치료를 받은 소아 환자들의 임상적 증상과 수술소견, 병리학적 소견을 분석하여 이들의 특징을 알아보고자 하였다. 방법 : 1985년 이후 이화대학교의료원에서 Meckel 게실의 합병증으로 수술을 받은 15세 이하의 소아들 대상으로 하여 의무기록과 조직병리 검사 결과를 조사하였다. 결과: 총 13명의 환아가 Meckel 게실의 합병증으로 수술을 받았으며 남녀의 비는 1.6:1로 남아에서 호발하는 경향을 보였으며, 수술 시 평균 연령은 5.3세였다. 수술의 원인이 된 Meckel 게실의 진단은 장출혈 6예, 장폐색 4예,Meckel 게실의 천공 1예, 장중첩 1예, 게실염 1예였다. 회맹판에서 게실까지의 평균길이는 47.0±15.7cm이었으며, 소장부분절제술과 쐐기절제술이 각각 84.6%와 15.4%에서 시행되었다. 장출혈을 나타내었던 환아 6명 중 5예에서 병리조직에서 이소성 위 점막이 관찰되었다. 술 후 합병증과 사망예는 없었다. 결론 : 소아에서 외과적 급성 복증이나 장출혈의 증상이 나타날 경우, Meckel 게실의 합병증의 가능성에 대한 외과의의 인식이 필요하다.

유방 병변의 초음파 유도 하 8 Gauge 맘모톰 생검과 11 Gauge 맘모톰 생검의 비교

김현아,문병인,최금자,최혜영 이화여자대학교 의과대학 2005 EMJ (Ewha medical journal) Vol.28 No.2

Purpose The goal of this study was to compare the diagnostic accuracy, complication rate between 11 and 8 gauge Mammotome probe during ultrasound-guided Mammotome biopsy. Methods Sixty eight patients who showed breast mass in sonography were included in this study. Statistical comparisons between the 11 and 8 gauge group were done. Results 75 biopsies were performed using the Mammotome biopsy system guided by sonography. 63 LESIONS(84.0%) had benign pathology and 12 lesions(16.0%) were malignant. 49(65.3%) of these biopsies were performend with the 11-gauge Mammotome probe, and 26(34.7%) with the 8-gauge probe. Complications such as pain, bleeding , hematoma and skin discoloration were compared between 11 and 8 gauge group. There were nostatistically significant differences in complications such as pain, bleeding, hematoma and skin discoloration. All complications had no significant difference between 11 gauge group and 8 gauge group. Conclusion The ultrasound-guided 8 gauge Mammotome biopsy system is as safe as ultrasound-guided 11 gauge Mammotome biopsy system.

한국비서자격시험의 개선점과 비교연구

남자현,이미정,이미영,이아영,정해금,최유정,이미숙,전인선,정혜림 이화여자대학교 법정대학 비서학과 1997 비서학연구 Vol.- No.17

BALB/c 생쥐에서 천식 발생에 대한 dehydroepiandrosterone의 억제효과

최용,최인선,고영일,고영아,이현철 대한천식 및 알레르기학회 2004 천식 및 알레르기 Vol.24 No.1

Background : Dehydroepiandrosterone(DHEA). and adrenal androgen, may regulate Th1/Th2 cytokines. Objective : To determine whether DHEA have a preventive effect against the development of asthma, a Th2-associated disease. Materials and methods : Female BALB/c mice were fed with a standard diet incorporated with 0.1% (w/w) of DHEA for 1 week before sensitization with ovalbumin(OVA. 20㎍ i.p. twice with 2-week intervals). Enhanced pause (Penh) was monitored after 1% OVA inhalations for 3 successive days, and then the methacholine bronchoprovocation tests were performed using a whole-body plethysmography system. Analyses of inflammatory cells, cytokines, and OVA-specific IgE were carried out. Results : Both the excessive airway narrowing (maximum Penh) and the airway hypersensitivity (PC200, ㎎/mL) to methacholine were significantly suppressed with the DHEA pretreatment (F<.05 and F<.01, respectively). However, the numbers of the inflammatory cells and the levels of interleukin(IL)-4, IL-5, and IFN-γ in the bronchoalveolar lavage fluid, the production of IL-4, IL-5, and IFN-γ by Con A-stimulated splenocytes, and the serum IgE level in DHEA group were not significantly different from those in asthma group. Conclusion : DHEA pretreatment could suppress the development of asthmatic airway hyperresponsiveness without suppression of Th2 cytokines and airway inflammation. (J. Asthma Allergy Clin Immunol 24 : 116-26, 2004)

Inoue Balloon을 이용한 PMV의 장·단기 결과 분석

진은선,이연아,전숙,김현숙,정승묵,박상선,최락경,임달수,홍석근,황흥곤 대한순환기학회 2003 Korean Circulation Journal Vol.33 No.11

국내산 중하(Metapenaeus joyneri) 내 주알레르겐 규명 : 가열 및 소화액에 의한 변화

윤성호,김현아,김현미,최정희,서창희,남동호,김윤근,민경업,박해심 대한알레르기학회 2004 천식 및 알레르기 Vol.24 No.2

스프렌딜 지속정(펠로디핀 5㎎)에 대한 스타핀 지속정의 생물학적동등성

조혜영,강현아,이석,백승희,박은자,최후균,문재동,이용복 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.4

Felodipine is a calcium antagonist that lowers blood pressure by reducing peripheral resistance by means of a direct, selective action on smooth muscle in arterial resistance vessels. Furthermore, it have been approved for the effective in angina pectoris and cardiac failure. The purpose of the present study was to evaluate the bioequivalence of two felodipine extended release (ER) tablets, Splendil (YuHan Corporation) and Stapin (Hana Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). THe felodipine release from the two felodipine formulations in vitro was tested using KP Ⅷ Apparatus Ⅱ method at pH 6.5 buffer solution. Twenty six healthy male subjects, 22.73±1.78 years in age and 66.66±7.28 ㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After two tablets containing 5 ㎎ as felodipine were orally administered, blood sample was taken at predetermined time intervals and the concentrations of felodipine in serum were determined using column-switching HPLC method with UV detector. The dissolution profiles of two formulations were similar at pH 6.5 buffer solution. Besides, the pharmacokinetic parameters such as AUG_(t), C_(max) and T_(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC_(t) and C_(max) and untransformed T_(max). The results showed that the differences between two formulations based on the Splendil were 2.53%, 1.32% and 18.32% for AUC_(t), C_(max) and T_(mzx), respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25) (e.g., log(0.86)∼log(1.20) and long(0.89)∼long(1.23) for AUC_(t) and C_(max), respectively). Thus, the criteria of the KFDA guidelines for the bioequivalence was satisfied, indicating Stapin ER tablet and Splendil ER tablet are bioequivalent.