돼지 신장세포(PK15)의 이종이식 거부반응에 대한 재조합 IL-18의 영향

최연실,김은미,김영관,박상연,심정현,윤도영,강형식,명평근 충남대학교 형질전환복제돼지연구센터 2004 논문집 Vol. No.8

Various cytokines including IL-1β, IL-2, IL-4, IL-10, IL-12p40, IFN-r, and TNF-α have been recently reported to play important roles in both host and donor cell activations during xenotransplantation. Interleukin (IL)-18, a proinflammatory cytokine, can induce IL-4 and IL-13 production in T cells, NK cells, B cells, mast cells, and basophils. IL-18 has the capacity to stimulate innate immunity and both Th1-and Th2- mediated responses, but little is known to involve in the xenograft rejection. In order to investigate the role of IL-18 in xenograft rejection, we transplanted the pig kidney (PK15) cells to C57BL/6 mouse with or without intraperitoneal injection of mouse recombinatant IL-18, It was analyzed the population of T cell, B cell and NK cell in the mice transplanted with PK 15 cells and recombinant IL-18 by flow cytometry. We found that splenic CD3+ T cells were increased in mice injected PKl5 cells with recombinant IL-18. These results suggest that recombinant IL-18 is critical in the xenograft rejection by increasing T cell population of the recipients.

신고리 지역 기상관측을 통한 계절별 대기안정도 특성분석

송상근,김유근,오인보,정주희,조윤미,우경은,강태훈 부산대학교 환경문제연구소 2003 環境硏究報 Vol.21 No.-

In this study, we analyzed the characteristics of atmospheric stability to investigate local environment change at an atomic power plant in Gori region. The used data was obtained from field observation of major meteorological variables such as wind direction and speed, air temperature, relative humidity, and solar radiation using AWS (Automatic Weather System) in Gori region from February to September in 2003. As a result, when strong northerly winds (more than 4~6 m/s) and weak northwesterly winds (2~3m/s) blow, atmospheric stability was neutral and stable from winter to spring, respectively. Atmospheric stability (neutral) in summer was similar to that in two other seasons (winter and spring), but it was stable for weak southwesterly winds (2~3 m/s). Finally, atmospheric stability was neutral for strong winds (over 4~6 m/s) in fall without respect to wind direction, while that was stable for very weak winds (less than 2 m/s).

돼지 신장세포(PK15)의 이종이식 거부반응에 대한 재조합 IL-18의 영향

최연실,김은미,김영관,박상연,심정현,윤도영,강형식,명평근 충남대학교 생물공학연구소 2004 생물공학연구지 Vol.10 No.1

Various cytokines including IL-1β, IL-2, IL-4, IL-10, IL-12p40, IFN-γ, and TNF-α have been recently reported to play important roles in both host and donor cell activations during xenotransplantation. Interleukin (IL)-18, a proinflammatory cytokine, can induce IL-4 and IL-13 production in T cells, NK cells, B cells, mast cells, and basophils. IL-18 has the capacity to stimulate innate immunity and both Th1-and Th2- mediated responses, but little is known to involve in the xenograft rejection. In order to investigate the role of IL-18 in xenograft rejection, we transplanted the pig kidney (PK15) cells to C57BL/6 mouse with or without intraperitoneal injection of mouse recombinatant IL-18. It was analyzed the population of T cell, B cell and NK cell in the mice transplanted with PK 15 cells and recombinant IL-18 by flow cytometry. We found that splenic CD3+ T cells were increased in mice injected PK15 cells with recombinant IL-18. These results suggest that recombinant IL-18 is critical in the xenograft rejection by increasing T cell population of the recipients.

기질성 정신장애환자에서 불안과 우울

신석철,왕성근,강민희,신윤오 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.2

Atuhors applied the self-rating anxiety scale(SAS) and the self-rating depression scale(SDS) devised by Zung to 95 psychiatric outpatients with organic mental disorder in order to investigate about anxiety and depression manifest in organic mental disorder and tried factor ananlysis using both test scores. 1. In SAS, 4 factors were extracted as paresthesia & facial flushing, fear & dizziness, palpitation & urinary frequency, and nervousness & fatigability. 2. In SDS, 4 factors were extracted as depressed affect & suicidal rumination, dissatisfaction & indecisiveness, fatigability & sleep distrubance, and emptiness & hopelessness.

존속범죄의 실태에 관한 연구

권규일,강덕지,함근수,표주연,박종각 內務部 國立科學搜査硏究所 1996 國立 科學 搜査 硏究所 年報 Vol.28 No.-

두부손상 환자의 정신과적 합병증에 관한 장애 감정례의 일반 사항에 관한 분석

신석철,왕성근,신윤오,김덕호,김상국,강동숙 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.2

Authorst ried retrospective analysis to find out general characteristics of the patients undergoing disability evaluation at the department of psychiatry Chungnam National University Hospital from 1986 to 1990. The subjects, who were suffered from psychiatric complications due to head trauma by traffic accident, were 66 patients and they were classified depending on the demographic status, situations of traffic accident, evalaution periods, whether or not perform operation, and rates of evaluated disability and diagnosis. The results were summarized as follows. 1. General background of the subjects were as follows. 1) The frequency order of request were court(59 %) and insurance company(19.7%). 2) The place of accident was more common in large city, common accident vehicle were bus, truck, and cabs. 3) The season of accident were more common in Spring and Autumn. 2. Male(71.2%) was more common than in female and more common in the age group of 5-19 years old(37.9%). The most frequent job of the patients was labour, and the education level was more common in the graduates of elementary school(47.9% ). 3. The interval between accident and evaluation was most frequent in 12-23 months(47.5%), and duration of evaluation was mostly 14 to 21 days. Performed brain operation was 31.8% and non-operated patients was 50.0%. The rates of disability according to the McBride's disability evaluation were mostly belonged to the group of beow 40%(74.1%). 4. The final diagnosis after evaluation were organic personality disorder(45.5%) and dementia(31.8%).

원자력발전소 PSI/ISI 데이터 관리를 위한 지능형 데이터 베이스 프로그램 개발

박은수,박익근,엄병국,박윤원,강석철 韓國非破壞檢査學會 1998 한국비파괴검사학회지 Vol.18 No.5

Windows 95 환경하에서 PSI/ISI 데이터의 효율적 관리를 위한 종합지원시스템의 구축과 다원적평가와 분석이 가능하고, 비파괴검사에 의한 원전기기의 건전성 평가시 규제측면에서 기술적인 지원을 할 수 있는 고리 원전 PSI/ISI 데이터 베이스 구축과 프로그램을 개발하였다. 이 프로그램을 활용하면 현재까지 수행된 고리 원전 PSI/ISI의 수행현황과 지금까지 발견된 결함에 대한 조사분석이 가능하며, 향후 국내 PSI/ISI결과의 자료분석이 가능한 전문가 시스템(expert system)개발에 한단계 접근하게 되었다. 그리고, PSI/ISI에서 발견된 결함에 대한 조사분석 결과를 근거로 결함의 종류, 형태, 처리방법 등에 대한 자세한 분석을 통하여 국내 원전 PSI/ISI 결과의 확률론적 신뢰도 평가, 또는 확률론적 안전성평가를 위한 결함검출확률곡선의 작성과 위험도에 근거한 가동중검사제도의 도입에 필요한 기초 자료를 제공하였다. 더 나아가 지금까지의 자료분석을 바탕으로 보다 경제적이며 신뢰성이 높은 PSI/ISI의 수행으로 원전 압력경계기기의 건전성과 신뢰성 확보 및 수명예측을 위한 기초자료를 제공하였다. For an effective and efficient management of large amounts of preservice/inservice inspection(PSI/ISI) data in nuclear power plants, an intellegent Windows 95-based data management program was developed. This program enables the prompt extraction of previously conducted PSI/ISI conditions and results so that the time-consuming data management, painstaking data processing and analysis in the past are avoided. The program extracts, and the associated remedies. Furthermore, additional inspection data and comments can be easily added or deleted for subsequent PSI/ISI operation. Although the initial version of the program was applied to Kori nuclear power plant, this program can be equally applied to other nuclear power plant. And also this program can be used to offer the fundamental data for application of evaluation data related to fracture mechanics analysis(FMA), probabilistic reliability assessment(PRA) of PSI/ISI results, performance demonstration initiative (PDI) and risk-informed ISI based on probability of detection(POD) information of ultrasonic examination. Besides, the program can be further developed as a unique PSI/ISI data management expert system that can be apart of PSI/ISI data management expert system that can be a part of PSI/ISI Total Support System(TSS) for Korean nuclear power plants.

회맹장 및 대장을 침범한 장 결핵에 있어서 바륨을 이용한 방사선 이중조영촬영 소견에 대한 연구

진용현,전혜정,이용근,강철호,조성범,김윤환,박철민,차상훈,김일영,이혜경 건국대학교 의과학연구소 2002 건국의과학학술지 Vol.12 No.-

To determine the characteristic double contrast barium enema findings of ileo-cecal and colonic tuberculosis and to make differential diagnosis from other bowel inflammatory disease. Sixty-seven patients confirmed as ileo-cecal and/or colonic-tuberculosis in six hospitals were evaluated retrospectively. The diagnosis was proven by endoscopic biopsy, surgery, and clinical follow up. Nine of 67 patients were excluded because radiologic findings were normal though endocopic biopsy examinations resulted in tuberculosis. Histopathological diagnosis were madein 58 cases as follows: endoscopic biopsy(n=29), operation(n=12), follow up examination(n=14), tissue culture(n=1), laparoscopic biopsy(n=2). There were 30 men and 28 females. The mean age were 36 yrs(range:16-67), 34 patients were in the second and third decade. The distribution of lesions, morphological characteristics, mucosal changes, ulcer shape and depth, associated with other tuberculous lesion, multiplicity were retrospectively analyzed in the findngs of double contrast barim enema. The commonest clinical symptoms were abdominal pain(n=35, 60%) and diarrhea(n=18, 31%). The chest radiography revealed association of pulmonary tuberculosis in 39 cases. Tuberculous lesions of other organs except chest were present in five cases. Double contrast barium enema findings showed a thickening and irregularity of intestinal mucosal fold(n=29, 50%), bowel contraction and/or shortening(n=26, 45%). There were small, nodular, superficial ulcers in the case of ulcer depth less than 2 mm in the depth. As many as 39 cases(67%) in this series had two or more lesions in the intestinal tuberculosis. The involved segment revealed symmetrical feature(n=21, 36%). Inflammatory pseudopolypoid lesions were noted in 30 cases(52%). The ileo-cecal region was involved in 38 cases(66%). The ascending colon(n=25, 43%) was the second commonest site with or without contiguous cecal involvement. Lesions in terminal ileum, ileo-cecal valve, transverse colon, descending colon and appendix were seen in 19, 18, 18, 12 and seven cases, respectively. Among 18 cases of ileo-cecal valve lesions, there were incompetency in nine cases(16%) and wide gapping in four cases(7%). In 14 cases, tuberculous enterocolitis was diagnosed by clinical follow-up and double contrast barium enema study. 12 out of 14 cases, the findings of double contrast barium enema of tuberculous enterocolitis were normalized after anti-tuberculous medication. However, two cases showed more aggravated state than before due to inappropriate treatment. Double contrast barium enema plays an important role in the diagnosis of tuberculous enterocolitis, determines the type, site and extent of the involvement and helps in treatment guide by using sequential studies.

Evaluation of the Biochars pH on NH₃ Volatilization

Yun-Gu Kang(강윤구),Jin-Hyuk Chun(천진혁),Jae-Han Lee(이재한),Yeo-Uk Yun(윤여욱),Gi-Bum Yi(이기범),Taek-Keun Oh(오택근) 한국토양비료학회 2021 한국토양비료학회 학술발표회 초록집 Vol.2021 No.11

Nitrogen (N) is one of the most vital nutrient elements in plant growth. The plant quality and quantity varies depending on the amount of N. However, owing to the moderately low N use efficiencies by the growing crops, a considerably large percentage of it about 10 - 20% is volatilized to the atmosphere as form of NH₃ and N₂O. The volatilized NH₃ reacts with various oxides (NO<SUB>x</SUB>, SO<SUB>x</SUB>) to generate secondary particulate matter (PM2.5). Therefore, this study aimed to assess if biochars pH can impact its capacity of lessening NH3 emitted from the fertilized agricultural fields. Biochar was applied with 1% (w w<SUP>-1</SUP>) while N in form of urea was applied at three different rates of 160, 320, and 640 kg ha<SUP>-1</SUP>. NH₃ was collected using a dynamic chamber method and analyzed following the indophenol blue method after extraction with 2 M KCl solution. Based on the results indicate that the daily NH₃ emissions peaked within 4 - 7 days after fertilizations and decreased sharply afterwards. biochar amendments greatly reduced NH₃ emissions in all the treatments. The greatest reduction of 25% in relation to the control came from the neutral biochar (pH 6.7) applied to the soil fertilized with the 320 kg N ha<SUP>-1</SUP> and is thus, the most effective way of reducing NH3 volatilizations.

Adsorption characteristics of NH₄-N by biochar derived from pine needles

Yun-Gu Kang,Jun-Young Lee,Jin-Hyuk Chun,Jae-Han Lee,Yeo-Uk Yun,Taek-Keun Oh 충남대학교 농업과학연구소 2021 Korean Journal of Agricultural Science Vol.48 No.3