정신분열병 환자에서 얼굴 영상의 작동기억 장애 : 기능자기공명영상연구

이창욱,김태석,주라형,박주미,박여진,김종진,전신수,배치운,김정진,이수정,이철,백인호 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.2

Objectives : Impaired processing of facial information is one of the broad ranges of cognitive deficits seen in patients with Schi-zophrenia. We aimed to elucidate the differences in brain activities involved in the process of facial working memory between schizophrenic patients and healthy comparison subjects. Methods : Twelve patients with schizophrenia were recruited along with twelve demographically matched healthy volunteers as a comparison group. Functional magnetic resonance imaging (fMRI) was used to assess cortical activities during the Perfor-mance of a 2-back working memory paradigm using images of neutral faces as mnemonic content. Rcsults : The patient group performed the tasks with reduced accuracy. Group analysis revealed that the left fusiform gyrus, the right superior frontal gyrus, the bilateral middle frontal gyri/insula, the left middle temporal gyrus, the precuneus, the quadrangular lobules and the vermis of cerebellum showed decreased cortical activities in the patient group. On the other hand, an increased level of activation in the lateral prefrontal cortex and the pahetal lobule was observed from the patient group, all in the right hemisphere. Conulusion : A decreased level of activity in the left fusiform gyrus among the patient group implicates inefficient processing of facial information. An increased level of activation in prefrontal and parietal neural networks from the patient group confirms earlier findings on the impaired working memory of patients with schizophrenia.

정신분열병의 인지적 표지자와 Catechol-O-Methyltransferase Val158Met 유전자 다형성의 연합연구

박해정,박동연,조은영,김나라,전현옥,이유상,이동수,홍경수 대한신경정신의학회 2008 신경정신의학 Vol.47 No.2

Objectives : Catechol-O-methyltransferase (COMT) gene has been identified as a positional and functional candidate gene of schizophrenia. Although specific mechanism of increasing schizophrenia susceptibility by this gene has not been well described yet, recent studies suggest that the valine allele of COMT Val158Met polymorphism may contribute to cognitive decline in schizophrenia. The present study investigated the association between this polymorphism of COMT gene and cognitive markers related to schizophrenia in both schizophrenia patients and normal controls. Methods : The subjects were 78 patients with schizophrenia diagnosed by DSM-IV and 97 normal controls. Comprehensive neurocognitive tests for which performance deficits have been reported in schizophrenia were administered. Genotyping for COMT Val158Met polymorphism was done with SNapShot method. Association analyses between genotype and cognitive functions were performed using ANCOVA and MANCOVA. Results : In the comparison of allele frequencies between patient and control groups, no significant association between the polymorphism and schizophrenia was observed. Significant differences of cognitive performance among genotype groups were not identified in control group. This trend was also observed in the patient group. In the combined analysis of both patient and control groups, there was no significant genotype or genotype-by group effect on any cognitive function measure. Conclusion : These findings do not support a major role of COMT gene in the regulation of the cognitive processes of schizophrenia.

명암(鳴巖) 이해조(李海朝) 한시(漢詩) 연구(硏究) : 기행시(紀行詩)를 중심으로

이유라 ( Lee Yu-ra ) 우리한문학회 2016 漢文學報 Vol.35 No.-

鳴巖 李海朝(1660∼1711)는 환국을 거듭한 숙종 조에 활동한 문인으로 月沙 李廷龜(1564∼1635) 이래 3대에 걸쳐 문형을 배출한 집안의 후손이다. 선조만큼의 文名을 드날린 것은 아니지만 현전하는 그의 문집에는 시인적 재능과 작가적 개성이 드러나는 여러 작품이 남아 있다. 이해조의 문집인 『鳴巖集』에는 430여 수의 시가 전하는데 대부분 그가 일생동안 山水探勝을 즐기면서 그 경험을 문학적으로 형상화한 것들이다. 이해조 본연의 시인적 자질뿐만 아니라 農巖 金昌協·三淵 金昌翕을 비롯한 당대 시문단의 주요 인사들과의 교유를 통한 문학적 영향 또한 남아있어 17·18세기 시단의 한 면모를 확인할 수 있는 자료가 된다. 이해조의 시를 살펴보는데 있어 가장 아쉬운 지점이라고 한다면 시편 외에는 다른 기록이 남아있지 않다는 것이다. 작가의식을 파악할 만한 이해조 본인의 기록이 남아있지 않기 때문에 이해조가 평생 從遊하며 隨時聞學하였던 김창흡의 기록을 통해 이해조의 시가 어떤 점을 지향하였는지 유추하였다. 그 결과 이해조는 언어의 조탁에 전념하여 미사여구에만 골몰하는 당시 시풍을 배척하려는 의식을 가지고 시를 지었던 시인이었음을 알수 있었다. 唐詩의 격조나 宋詩의 풍격에 얽매여 조탁하거나 답습하는 것이 아닌 자연스러운 풍격이 묻어나도록 하는 것이 그가 시에서 고수한 기준이자 원칙이었다. 이해조의 作詩는 `逼眞`과 `摸奇`를 중점으로 하였다. 이해조는 전대 문인들이 노정한 폐단을 비판하면서 당시 유입된 명말 문예이론의 영향을 받았다. 그러나 의고파의 복고가 난삽한 고어로 변개되는 것과 공안파의 眞情의 결핍을 경계했던 삼연의 시론을 적극 수용하여 `逼眞`과 `摸奇`를 추구하는 作詩 경향을 보였다. 결과적으로 이해조의 作詩 경향은 명대 의고 파와 공안파의 문예이론을 비판적으로 수용하였던 백악시단의 시론에서 크게 벗어나지 않으며, 일면 그 詩脈을 유지하였다고 볼 수 있다. 17,18세기 조선은 사회적, 정치적으로 격동의 시기였고 문단에 있어서도 일대 변혁이 일어났던 시기이다. 이해조는 그 시기를 살아가면서 변화의 중심에 있던 이들과 교유하였다. 거기서 받은 문학적 영향은 그의 시편에서 그 영향관계의 실제를 확인할 수 있다. 그의 시편은 문학적 비평 교유의 과정을 확인할 수 있는 자료로서 가치가 있을 뿐만 아니라, 作詩 의식에서 보이는 진실한 성정의 발현과 기이함의 참신한 모사의 특징은 17,18세기 농암·삼연을 주축으로 시작된 새로운 문학 풍조의 일면을 보여준다. 더불어 시와 국문문학의 교섭을 시도한 점이나 지역 정보를 결합하여 다시 새로운 독립적 작품을 탄생시킨 점 등은 18세기 한시의 多岐한 면을 보여주는 또 하나의 예라고 할 수 있다. Myeongam Lee Haejo (1660 ~ 1711) is a writer who worked in the Joseon Sookjong period and was a descendant of a family of three generations since Wolsa Lee Jeong-gu (1564 ~ 1635). Although he did not have the high literary honors of his ancestors, his works still contain poetic talent and artistic personality. Lee Haejo `s collection contains more than 430 poems, most of which are literary representations of the experience of enjoying nature trips throughout his lifetime. In addition to the poetic qualities of Lee Haojo, Nongam Kim Chang-hyup, Samyeon Kim Chang-heup and other literary influences of the poetical arena have also remained in common with the poetical arena of the 17th and 18th centuries. It is the data which can confirm the aspect. One of the most unfortunate things when considering Lee Haejo`s poem is that there are no other records left outside of poetry. Since Lee Haejo `s own record is not enough to grasp the artist` s consciousness, Kim Changheup `s record, which he has learned and learned all along, has inferred what Lee Haejo` s poetry aimed at. As a result, Lee Haejo showed that he was a poet who made poetry as a consciousness for rejecting the contemporary style when he devoted himself only to flowery rhetoric. It was a standard and principle that he adhered to in the poem, not to be tangled or followed by Tang poetry or Song poetry. Lee Haejo `s poetry creation focused on `Pipjin[逼眞]` and `Mogi[摸奇]`. He was influenced by the Late Ming period literary theory that came into being at that time criticizing the discontent of the expatriates. However, he positively accepted Samyeon `s poetry, which was a turning point of Uigopa` s retrofit into a slippery gore, and the lack of Gonganpa `s Jinjeong[眞情], and he pursued` Pipjin `and` Mogi ` . As a result, Lee Haejo`s poetry tendency did not deviate much from the poetics of the Backak poetical arena, which critically accepted the literary theory of Ming period Uigopa and Gonganpa. In the 17th and 18th centuries, Chosun was a period of social and political upheaval and a period of revolution in the paragraph. Lee Haejo has been living with those who were at the center of change during that time. The literary influence that comes from it confirms the reality of its influence in his poem. Not only is his poems worthy of being able to confirm the process of literary criticism, but also the novel features of the manifestation of true emotions and the mysterious manifestations of creativity in the creation consciousness are the new literary trends that began with the 17th and 18th centuries Nong Yeon . In addition, the attempt to negotiate poetry with Korean literature and the creation of a new independent work by combining local information is another example of the multifaceted aspect of the 18th century.

Digital ulceration due to the change of hand microvasculature induced by rheumatoid arthritis

( Yu Ra Sim ),( Yea Jin Lee ),( Sung Jae Choi ),( Young Ho Seo ),( Gwan Gyu Song ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1

Background: Severe Raynaud’s phenomenon enough to make digital necrosis is a rare manifestation of rheumatoid arthritis(RA) without other evidences of overlapped systemic sclerosis. Here we report a case of a severe Raynaud’s phenomenon with finger tip ulceration and gangrene in uncontrolled RA patient. Case Report: A 54-year-old male with 8-year history of taking weekly methotrexate 7.5 mg for RA visitedour cardiovascular surgery department complaining of 2-week history of ulceration of left third fingertip with Raynaud’s phenomenon. Physical examination revealed tenderness, swelling, and limitation of movement in bilateral wrist, 2nd & 3rd MCP and PIP joints. The ulcerative lesion in left 3rd fingertip was combined with bluish color change. He had normal bilateral radial and ulnar pulses. Left forearm arteriography revealed localized hypervascularity of RA affected joints and multiple occlusions at interosseous arteries and digital arteries, especially most severe in third finger. We increased the dosage of methotrexate to 12.5 mg/week, additionaly preiscribed methylprednisolone 4 mg/day and tadalafil. We strongly recommended quitting of smoking. After 2 months, the ulcerated lesion in fingertip was improved and arthritic joint pain was resolved. Conclusions: In uncontrolled RA activity, deprivation of distal blood flow induced by the shunt like filling of the veins through hypervascularized region in severely affected arthiritic joints, can result in Raynaud’s phenomenon and digital gangrene.

Utilization of End-of-Life Care Rooms by Patients Who Died in a Single Hospice Unit at a National University Hospital in South Korea

Gyu Lee Kim,Seung Hun Lee,Yun Jin Kim,Jeong Gyu Lee,Yu Hyeon Yi,Young Jin Tak,Young Jin Ra,Sang Yeoup Lee,Young Hye Cho,Eun Ju Park,Young In Lee,Jung In Choi,Sae Rom Lee,Ryuk Jun Kwon,Soo Min Son Korean Society for Hospice and Palliative Care 2023 한국호스피스.완화의료학회지 Vol.26 No.2

Purpose: For the dignity of patients nearing the end of their lives, it is essential to provide end-of-life (EoL) care in a separate, dedicated space. This study investigated the utilization of specialized rooms for dying patients within a hospice unit. Methods: This retrospective study examined patients who died in a single hospice unit between January 1, 2017, and December 31, 2021. Utilizing medical records, we analyzed the circumstances surrounding death, the employment of specialized rooms for terminally ill patients, and the characteristics of those who received EoL care in a shared room. Results: During the 1,825-day survey period, deaths occurred on 632 days, and 799 patients died. Of these patients, 496 (62.1%) received EoL care in a dedicated room. The average duration of using this dedicated space was 1.08 days. Meanwhile, 188 patients (23.5%) died in a shared room. Logistic regression analysis revealed that a longer stay in the hospice unit was associated with a lower risk of receiving EoL care in a shared room (odds ratio [OR]=0.98, 95% confidence interval [CI] 0.97~0.99; P=0.002). Furthermore, a higher number of deaths on the day a patient died was associated with a greater risk of receiving EoL care in a shared room (OR=1.66, 95% CI 1.33~2.08; P<0.001). Conclusion: To ensure that more patients receive EoL care for an adequate duration in a private setting, additional research is necessary to increase the number of dedicated rooms and incorporate them into the hospice unit at an early stage.

Effects of Barley Leaf Powder on Antidiabetic Activities on db/db Mice

Yu Mi Lee,Jae Joon Lee,Ah Ra Kim,Yun Gyeong Hwang,Myung Yul Lee 한국식품저장유통학회 ( 구 한국농산물저장유통학회 ) 2009 한국식품저장유통학회 학술대회 Vol.2009 No.-

Pelvic organ prolapse is correlated with osteoporosis: HIRA NPS Data analysis

( Yu Ra Ko ),( Hyun Jin Kim ),( Do Young Kim ),( Sa Ra Lee ),( Sung Hoon Kim ),( Hee Dong Chae ),( Byung Moon Kang ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-

Objective: Deficiencies in pelvic collagen are believed to exist in pelvic organ prolapse (POP). Conversely, a predisposition to POP is identified in women with generalized connective tissue disorders. However few data were reported on the relationship between the POP and osteoporosis (OP). Therefore To examine the association between OP and POP in Korean women. Methods: We used the Health Insurance Review and Assessment Service-National Patient Samples (HIRA-NPS) between 2015 and 2017. The HIRA-NPS, including approximately 1.4 million individuals, is a stratified random sample of 3% of the entire Korean population using 16 age groups and 2 sex groups. Total 4,368,141 individuals were included in HIRA-NPS between 2015 and 2017 and a total of 842,228 individuals aged 50 years and above were included in the final analysis. POP patients were defined by KOICD (KCD-7, N81 or N99.3) and patients who proceeded pelvic reconstructive operation. The OP patients were defined by KOICD (KCD-7, R4113, R3620, R0402) & Patients who prescribed medication(BP, SERM, PTH, Denosumab). 1:10 Age-stratified Matching and Chi-squared test was used for statistical analysis and P<0.05 was considered as significant. Results: A total of 7,359 women were included in this analysis. The advanced pelvic organ prolapse is correlated with osteoporosis in Korean women aged 50 years and above in 2015-2017(P<.0001). After adjusting the age, advanced pelvic organ prolapse is correlated with osteoporosis in 2015, 2016, 2017 dataset (P = 0.013, 0.0009, 0.0119, respectively). Conclusion: The advanced pelvic organ prolapse is correlated with osteoporosis in Korean women aged 50 years and above. Evaluation of the osteoporosis and education about the bone health can be especially important even in relatively young, aged 50-59 years, POP patients.

Activation of NLRP3 Inflammasome by Palmitic Acid in Human Sebocytes

( Yu-ra Jung ),( Jung-min Shin ),( Chang-hyeon Kim ),( Sooil Kim ),( Chang-deok Kim ),( Young-joon Seo ),( Jeung-hoon Lee ),( Myung Im ),( Young Lee ),( Young Ho Lee ) 대한피부과학회 2021 Annals of Dermatology Vol.33 No.6

Background: Sebocytes are the main cells involved in the pathogenesis of acne by producing lipids and inflammatory cytokines. Although palmitic acid (PA) has been suggested to induce an inflammatory reaction, its effect on sebocytes remains to be elucidated. Objective: In the present study, we investigated whether PA promotes inflammasome-mediated inflammation of sebocytes both in vivo and in vitro. Methods: We intradermally injected PA into the mice ears. And, we treated cultured human sebocytes with PA. Inflammasome-mediated inflammation was verified by immunohistochemistry, Western blot and ELISA. Results: PA-treated mice developed an inflammatory response associated with increased interleukin (IL)-1β expression in the sebaceous glands. When PA was added to cultured human sebocytes, caspase-1 activation and IL-1β secretion were significantly enhanced. In addition, NLRP3 knockdown attenuated IL-1β production by sebocytes stimulated with PA. PA-mediated inflammasome activation required reactive oxygen species. Conclusion: These findings indicate that PA activates the NLRP3 inflammasome before induction of an inflammatory response in sebocytes. Thus, PA may play a role in the inflammation of acne.

Highly Conductive, Stretchable, and Transparent PEDOT:PSS Electrodes Fabricated with Triblock Copolymer Additives and Acid Treatment

Lee, Jin Ho,Jeong, Yu Ra,Lee, Geumbee,Jin, Sang Woo,Lee, Yong Hui,Hong, Soo Yeong,Park, Heun,Kim, Jung Wook,Lee, Sang-Soo,Ha, Jeong Sook American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.33

<P>Here, we report on a highly conductive, stretchable, and transparent electrode of poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) fabricated via modification with triblock copolymer, poly(ethylene glycol)-<I>block</I>-poly(propylene glycol)-<I>block</I>-poly(ethylene glycol) (PEO<SUB>20</SUB>-PPO<SUB>70</SUB>-PEO<SUB>20</SUB>, Pluronic P123), and post-treatment with sulfuric acid. The fabricated electrode exhibits high transparency (89%), high electrical conductivity (∼1700 S/cm), and minimal change in resistance (∼4%) under repetitive stretch-release cycles at 40% tensile strain after stabilization. P123 acts as a secondary dopant and plasticizer, resulting in enhanced electrical conductivity and stretchability of PEDOT:PSS. Furthermore, after sulfuric acid post-treatment, P123 helps the electrode to maintain its stretchability. A successful demonstration of the stretchable interconnection was shown by stretching the P123-modified PEDOT:PSS electrodes, which were connected with light-emitting diodes (LEDs) in series. Finally, a stretchable and transparent touch sensor consisting of our fabricated electrodes and an LED array and stretchable semitransparent supercapacitor were presented, suggesting a great potential of our electrodes in the application to various deformable devices.</P> [FIG OMISSION]</BR>

Determination of Bambermycin in Egg using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Yu Ra Kim,Sang-Mok Lee,Hyunjin Park,Sujeong Han,Byeong-Hoon Cho,Kangbong Lee 한국식품영양과학회 2018 한국식품영양과학회 학술대회발표집 Vol.2018 No.10