비장 침범을 동반한 전신적 림프관종증 1예

이정환,김성태,김윤배,김창덕,진윤태,엄순호,류호상,전훈재,현진해,허병원,강창돈,박철희,강민승,송치욱 대한내과학회 2000 대한내과학회지 Vol.58 No.2

Lymphangiomatosis is a very rare and slow-growing benign tumor generally accepted to be the result of a congenital malformation of the lymphatic system. It is most commonly found in the neck, axilla and less commonly retroperitoneum, mediastinum, mesentery, omentum, pelvis, bone, skin, scrotum, and spleen. We present a patient who had systemic lymphangiomatosis with splenic involvement. She was presented with the cystic neck mass suspected to be a cystic hygroma during the first decade. She complained of the mass on left upper quadrant of abdomen at the age of 28. Under full investigations, we had diagnosed the lymphangiomatosis involving spleen and right adrenal gland, and splenectomy was done. We present a case of systemic lymphangiomatosis with emphasis on diagnosis, management, and prognosis.(Korean J Med 58:234-239, 2000)

Slide Session : OS-HEM-04 ; Hematology : Investigation of Crosstalk Between Germline and Tumor Dna in Patients with Germline Cancer-Hotspot Alterations

( Youngil Koh ),( Hyun Jung Lee ),( Kwang Sung Ahn ),( Young Wook Kim ),( Jong Sun Jung ),( Hyung Lae Kim ),( Jung Whan Yook ),( Hyun Kyung Park ),( Keunchil Park ),( Sung Soo Yoon ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Current cancer research using massive parallel sequencing technologies primarily focuses on somatic changes in the cancer genome. However, it is anticipated that individual germline variations might contribute to tumorigenesis, as exemplified by several well-known examples, such as BRCA2 variations in breast cancer. Thus, it is also important to explore crosstalk between germline variation and somatic mutation in cancer. Methods: We performed whole-exome sequencing (WES) of 80 acute myeloid leukemia (AML) samples and 180 non-small cell lung cancer (NSCLC) samples. First, we searched for cancer hotspots in germline DNA of these samples. Also, we called somatic variants using in-house pipeline Adiscan. Germline hotspot alteration was validated in a separate AML cohort. Results: Non-synonymous changes including MLH1 (Chr3;37067240, T>A), KIT (Chr4;55593464, A>T), and MET (Chr 7;116340262, A>C) were observed in germline of both AML and NSCLC patients. MLH1 germline change was not found in 18 healthy control samples. Frequency of MLH1, KIT, and MET germline changes were similar in AML and NSCLC patients. In contrast to AML, some of NSCLC patients had PTEN, TP53 and STK11 germline changes. When we focused on the crosstalk between germline change and somatic mutation, MET germline alteration seemed to have coupling with IDH2 somatic mutation, while MLH1 germline mutation seemd to have coupling with TTN somatic mutation. When validated in a separate cohort, AML patients with MET germline mutation had good prognosis compred to MET wild-types suggesting prognostic impact of MET germline alteration. Conclusions: Cancer hotspot variations are present in germline of cancer patients, and their frequency might be different across various cancer subtypes. Germline alteration per se may have prognostic impact, and coupling between certain germline alteration and somatic mutation would exist.

무결정결함영역을 유지하면서 에너지를 절감하는 초크랄스키 실리콘 단결정 성장로 수냉관 최적 설계

채강호(Kang Ho Chae),조나영(Na Yeong Cho),조민제(Min Je Cho),정현준(Hyeon Jun Jung),정재학(Jae Hak Jung),성수환(Su Whan Sung),육영진(Young Jin Yook) 한국태양광발전학회 2018 Current Photovoltaic Research Vol.6 No.2

Recently solar cell industry needs the optimal design of Czochralski process for low cost high quality silicon mono crystalline ingot. Because market needs both high efficient solar cell and similar cost with multi-crystalline Si ingot. For cost reduction in Czochralski process, first of all energy reduction should be completed because Czochralski process is high energy consumption process. For this purpose we studied optimal water-cooling tube design and simultaneously we also check the quality of ingot with Von mises stress and V(pull speed of ingot)/G(temperature gradient to the crystallization) values. At this research we used CG-Sim<SUP>Ⓡ</SUP> S/W package and finally we got improved water-cooling tube design than normally used process in present industry. The optimal water-cooling tube length should be 200mm. The result will be adopted at real industry.

제2기 위암에서 3 Subgroup간의 비교 분석

서병선,김병식,김용호,육정환,오성태,김완수,박건춘,Suh Byung Sun,Kim Byung Sik,Kim Yong Ho,Yook Jung-Whan,Oh Sung-Tae,Kim Wan-Soo,Park Kun-Choon 대한위암학회 2001 대한위암학회지 Vol.1 No.1

Purpose: Three subgroups of stage II stomach cancer (T1N2M0, T2N1M0, T3N0M0) by UICC-TNM staging system show obvious survival difference to each other, which becomes the pitfall of the current staging system. We analyzed the survival and relapse pattern of stage II stomach cancer patients in three subgroups retrospectively to prove the need for change in staging system. Materials and Methods: From July 1989 to December 1995, curative gastric resection was performed in 1,037 patients with gastric adenocarcinoma, and among them 268 patients ($26\%$) were in stage II. The number in each of subgroups (T1N2M0, T2N1M0, and T3N0M0) were 17, 139 and 112 respectively. Survival and relapse pattern were analyzed and median follow up period was 46 months. Results: The 3-year cumulative survival rates of T1N2M0, T2N1M0, and T3N0M0 were $50\%,\;80\%,\;and\;76\%$ respectively (p=0.001). And the 3-year cumulative survival rates of T1N2M0 was comparable to those of 2 subgroups of stage IIIa (T2N2M0, T3N1M0), $47\%\;and\;45\%$ (p>0.05). Peritoneal recurrence was the most frequent in T3N0M0. And hematogenous spread was more frequent in T2N1M0 while nodal spread was more frequent in T1N2M0. Ten out of 17 cases of T1N2M0 died of recurrence. Most of them showed submucosal tumor with depressed lesion and mean tumor size was 3.3 cm. Conclusions: Up-staging of T1N2M0 should be considered because it has the lowest survival rate and the worst prognosis among the three subgroups of Stage II stomach cancer patients. In early gastric cancer patients with high-risk factors (large tumor size, invasion into the submucosal layer, and lymphatic vessel involvement), lymph node dissection and postoperative adjuvant therapy is recommended in an attempt to prevent recurrence in the form of lymph node metastasis.

장막 침윤이 없는 위암 환자에서 수술 후 보조적 화학 요법에 대한 전향적 연구 -중간 보고-

김용호,김병식,이창환,김완수,육정환,오성태,박건춘,Kim Yong-Ho,Kim Byung-Sik,Lee Chang-Hwan,Kim Wan Su,Yook Jung-Whan,Oh Sung-Tae,Park Kun-Choon 대한위암학회 2001 대한위암학회지 Vol.1 No.4

Purpose: We have carried out prospective randomized clinical trial to compare survival benefit and side effect among three postoperative adjuvant chemotherapeutic regimens in serosa-negative gastric cancer patients. Materials and Methods: Total 317 cases were recognized as serosa negative and randomized into three groups at operating room. Out of them, 172 cases were excluded because of various reasons and 135 cases were analyzed finally; Group A 36 cases, Group B 49 cases, Group C 50 cases. Group A were treated with intravenous FP combination therapy, group B with MF combination therapy and group C with oral $UFT^{(R)}$ (mixture of Tegafur and Uracil) for one year. The median follow-up period was 30 months. Results: $88.9\%$ of Group A, $83.7\%$ of Group B and $90.4\%$ of Group C received adequate chemotherapy. The complication rates of Group A ($44.4\%$) was significantly higher than group B ($20.4\%$) and group C ($24.0\%$)(P<0.05). Most frequent complications were nausea and vomiting. The 3-year survival rates and disease-free survival rates were $92.2\%$ and $89.9\%$ respectively (Group A: $96.6\%,\;87.8\%$, B: $90.3\%,\;87.7\%$, C: $95.7\%,\;93.8\%$). There were no significant differences in survival rate and disease-free survival rate among the three groups (P>0.05). Conclusion: This study might suggest that the survival benefit of postoperative adjuvant chemotherapy for gastric Pseudomonas aeruginosa, and therefore it may be a useful adjunct tool for detection of Pseudomonas aeruginosa infection in combination with other conventional techniques.

2개 대학병원 응급센터에 내원한 급성 불화수소산 노출 환자에 대한 임상적 경험

한규홍,양중일,조성욱,조용철,유승,이진웅,김승환,유인술,유연호,박정수,Han, Kyu-Hong,Yang, Jung-Il,Jo, Seung-Yook,Cho, Yong-Chul,Ryu, Seung,Lee, Jin-Woong,Kim, Seung-Whan,Yoo, In-Sool,You, Yeon-Ho,Park, Jung-Soo 대한임상독성학회 2009 대한임상독성학회지 Vol.7 No.2

Purpose: We investigated the clinical characteristics and demographics of patients who suffered from hydrofluoric acid chemical injury and the mechanism of damage. Methods: We retrospectively reviewed the medical records of patients who were exposed to hydrofluoric acid from March 2004 to March 2009 and who were seen at the emergency centers in two university teaching hospitals. Results: Forty four patients out of 47 patients suffered from chemical burn, while the injuries of the remaining 3 could not be identified by the medical records. A total of 17 hydrofluoric acid chemical injury patients were enrolled during the study period, and their mean age was $29.6{\pm}7.0$. All the patients were accidentally injured by contact with the material and none of them inhaled or ingested the material. Only 6 patients wore appropriate protective equipments and 5 underwent the water irrigation for more than 10 minutes. The most common exposure area was the hand and forearm (70.5%). Less than 1% of all of the patients had their total body surface (TBS) exposed to hydrofluoric acid (mean=0.35%). The mean time interval from calcium gluconate administration to pain relief was $33.6{\pm}8.8$ hours. Conclusion: When exposed to hydrofluoric acid, it is important to wear protective equipment and undergo water irrigation for more than 10 minutes. Pain and skin damage were observed in all the patients. After treatment, we concluded that administration of calcium gluconate and pain killers was successful in relieving pain, and the prognosis was also positive for the admitted and followed up patients when less than 1% of the TBS was exposed.