고혈압 단계별 변증특성 분석

양창섭(Chang Sop Yang),김영은(Youn Geun Kim),김창석(Chang Seok Kim),김철(Chul Kim),송미영(Mi Young Song) 한의병리학회 2012 동의생리병리학회지 Vol.26 No.6

Increased in vivo immunological potency of HB-110, a novel therapeutic HBV DNA vaccine, by electroporation

Chae Young Kim,Eun Sung Kang,Seon Beom Kim,Han Eol Kim,Jae Hoon Choi,Dong Sop Lee,Se Jin Im,Se Hwan Yang,성영철,Byong Moon Kim,김병기 생화학분자생물학회 2008 Experimental and molecular medicine Vol.40 No.6

Pulse-induced permeabilization of cellular membranes, generally referred to as electroporation (EP), has been used for years as a tool to increase macromolecule uptake in tissues, including nucleic acids, for gene therapeutic applications, and this technique has been shown to result in improved immunogenicity. In this study, we assessed the utility of EP as a tool to improve the efficacy of HB-110, a novel therapeutic DNA vaccine against chronic hepatitis B, now in phase 1 of clinical study in South Korea. The potency of HB-110 in mice was shown to be improved by EP. The rapid onset of antigen expression and higher magnitude of humoral and cellular responses in electric pulse-treated mice revealed that EP may enable a substantial reduction in the dosage of DNA vaccine required to elicit a response similar in magnitude to that achievable via conventional administration. This study also showed that EP-based vaccination at 4-week-intervals elicited a cellular immune response which was about two-fold higher than the response elicited by conventional vaccination at 2-week intervals. These results may provide a rationale to reduce the clinical dose and increase the interval between the doses in the multidose vaccination schedule. Electric pulsing also elicited a more balanced immune response against four antigens expressed by HB-110: S, preS, Core, and Pol.

기능성 소화불량증에 사용된 침구치료방법에 대한 체계적 문헌고찰

김보영 ( Bo-young Kim ),서복남 ( Bok-nam Seo ),박지은 ( Ji-eun Park ),양창섭 ( Chang-sop Yang ),김익태 ( Ick-tae Kim ),임지원 ( Ji-won Im ),김영은 ( Young-eun Kim ) 대한경락경혈학회 2017 Korean Journal of Acupuncture Vol.34 No.1

The aim of this study is to review the methodology of clinical trials conducted with the acupuncture and moxibustion treatment on functional dyspepsia. Methods : We searched four international databases and three Korean databases including English, Korean and Chinese, through March 2016 for randomized controlled trials(RCT) and non-randomized case-control trials(CCT) that evaluated the effects of the acupuncture and moxibustion on functional dyspepsia. We abstracted the designs of the trials and the method of acupuncture and moxibustion treatment according to the Standards for Reporting Interventions in Clinical Trials of Acupuncture. Results : A total 117 papers were reviewed. The 106 studies were conducted in China. There were 111 RCTs(95%), and 6 CCTs(5%). Sixty eight studies(59%) were conducted with the manual acupuncture, 29 studies of electro- acupuncture(25%), 11 studies of moxibustion(9%), 5 studies of acupoints embedding therapy(4%), 4 studies of acupoint injection therapy(3%) were conducted. ST36, CV12, ST25 were most frequently used for acupoints to treat functional dyspepsia. In 59 studies(50%), western medication was used in the control group, and the effects of acupuncture and moxibustion were evaluated with the symptoms in most studies. Conclusions : These results suggest that it is necessary to develop more detailed reporting standards about acupuncture and moxibustion treatment method as the method of acupuncture and moxibustion is getting more diverse, and more objective tools are needed in evaluating functional dyspepsia.

현대 중의학 관점의 고혈압 연구동향 분석

김창석(Chang-Seok Kim),송미영(Mi-Young Song),양창섭(Chang-Sop Yang),김영은(Young-Eun Kim),예상준(Sang-Jun Yea),김철(Chul Kim) 한국의사학회 2013 한국의사학회지 Vol.26 No.1

Objectives : This study was performed to investigate the research trends of hypertension in Traditional Chinese Medicine(TCM), and it aims to promote hypertension research in Korean Medicine. Methods : We first collected more than 1,900 papers about hypertension research, and finally selected 108 papers related to this study. They were analyzed by the annul situation, the subject of the study, the perspective of TCM, the study stream, the research fields, the diagnostic patterns, and the distinguishing treatments of TCM. Results : The first review about hypertension in TCM was performed in 1963, and the number of studies has increased since 2000s. Doctors and researchers in China tried various diagnostic patterns to treat the patient because the diagnostic patterns were not unified. For this reason, most researches were reported to the diagnostic patterns and the treatments. Also we have discovered the diversity in treatments methods such as not only the typical herbal medicine, acupuncture, and Qigong but also specific treatments like Chuna, herbal acupoints stimulation, footbath, and pillow. Conclusions : Based on the results of this study, it can be proposed as follows : First, the various approach about hypertension in Korean Medicine is required. Second, the domestic research is needed to be extended to the external treatments as the distinguishing treatments of TCM.

한국산 광대버섯속에 대한 분류학적 연구

김양섭 한국균학회 1976 韓國菌學會誌 Vol.4 No.1

For the purpose of investigating the distribution and flora of wild mushrooms in Korea, this study was conducted primarily on the genus Amanita. Through survey of Suweon, Kwangneung, Mt. Chiri, Taegwanryung, Yeongdong district, and Mt. Hanla, 25 species of Amanita including 3 unrecorded species were discovered and are described in this paper. The author proposes to group 25 Korean species of Amanita into 3 smbgenera according to morphological characteristics by the modern taxonomic system, and also designated the 3 unrccorded species of Amanita including one variety in Korean common name.

임상검체에서의 Haemophilus aphrophilus 분리 5예

김태숙,정윤섭,이삼열,설준희,양성익,이의웅 대한미생물학회 1985 大韓微生物學會誌 Vol.20 No.1

Haemophilus aphrophilus is a fastidious gram-negative bacillus found in mouth of normal individuals. Though H. aphrophilus infection is quite rate, it includes such serious ones as endocarditis and brain abscess. The authom isolated H. aphrophilus from five patients with the diagnosis of lung abscess, conjunctivitis, brain abscess and facial masticator space abscaa Two of the patients died. Three of the patients also yielded other species of bacteria from the same specimens. One of the isolate was intermediately susceptible to amikacin and resistant to tobramycin, indicating the necessity of a routine susceptibility test in order to select the proper antimicrobial agents. Since FS. Aphrophilus can be diffetentiated from other similar organisms by morphological and biochemical chamcteristics, one should determie the possibility of this organisrn when faptidious gram-negative bacilli are isolated from blood or from sites adjacent to upper respiratory tract.

Serum Haptoglobin Level in Epidemic Hemorrhagic Fever

Kim, Ki Ho,Yang, Kyung Ho,Hong, Kyong Ja,Oh, Myung Won,Shim, bong Sop 최신의학사 1970 最新醫學 Vol.13 No.7

유행성출혈열은 그 원인이 아직 밝혀저 있지 않으며 특이한 검사실 소견이 발견보고 되어 있지 않으므로 그 진단은 순전히 일상적 소견에 의존하고 있는 실정이다. 저자들은 8명의 유행성 출혈열 환자의 혈청중 haptoglobin 농도를 측정한바 비교적 초기부터 (저혈압기) 혈청 haptoglobin농도가 저명히 증가함을 보았다. 혈청담백질의 전기영동 상이 정상인 신염에서는 혈청 haptoglobin농도가 정상이고 nephrosis시에는 증가하며 그밖에 용혈성 질환에서는 혈청 haptoglobin 농도가 감소하므로 위의 소견은 유행성 출혈열 환자의 감별진단에 응용될 수 있을 것으로 생각된다.

사용자 맞춤형 e-Ring(Enterprise Ring Back Tone) 시스템 설계 및 구현

김정숙(Kim Jung-Sook),양명연(Yang Myeong-Yeon),김홍섭(Kim Hong-Sop) 한국컴퓨터정보학회 2007 韓國컴퓨터情報學會論文誌 Vol.12 No.2

본 논문에서는 각 조직과 사용자의 특성에 맞는 맞춤형 e-Ring(Enterprise Portal Back Tone) 시스템을 설계하고 개발하였다. e-Ring 시스템은 고객들이 조직에 전화를 걸 때, 전화 통화를 시작하기 전까지 기다리게 되는 귀중한 시간을 최대한 낭비하지 않도록 하기 위해 고객에게 통화연결음 서비스를 비롯하여 부가 서비스를 제공하는 시스템이다. 이는 일반적인 전화 통화에서 듣게 되는 의미없는 링연결음을 대신하여 조직의 이미지에 적합한 홍보를 할 수 있으며, 또한 서비스 사용자 자동 응대 및 서비스 사용자에게 필요한 서비스를 제공하여 서비스 가용성과 업무의 효율성을 극대화 할 수 있다. In this paper, we proposed a new customized e-Ring(Enterprise Ring Back Tone) system which could be represented each user and organization feature. The e-Ring system provided the ring back tone and additional services to reduce the waiting time when the client called an organization. This system was for an appropriate organization public relations instead of the meaningless ring back tone which was used usual call, also was maximized the service availability and work efficiency which was obtained from the automatic response and service suppling to users who had needs and questions.

녹용 및 녹용약침이 동물의 성장과 지능발달에 미치는 영향

한상원,김영태,손양선,진수희,심인섭,임사비나,이학인 대한침구학회 2001 대한침구의학회지 Vol.18 No.5

The effects of Cervus elaphus and Cervus elaphus aquapuncuture on body weight, protein efficiency ratio, body length, serum growth hormone and intellectual development were studied for thirty-four days. The results were summarized as follows. 1. Body weight significantly increased in Cervus elaphus aquapuncture oral administration group compared to GH groups. 2. Protein efficiency ratio had no significant difference within all groups. 3. Body length significantly increased in Cervus elaphus aquapuncture group compared to GH in - jection group on 3rd day, tail length significantly increased in Cervus elaphus aquapuncture group and Cervus elaphus aquapuncture - oral administration group compared to GH injection group but, body length has no significant difference within all groups. 4. Serum GH significantly increased in Cervus elaphus aquapuncture·oral administration group compared to that of GH injection group. 5. As results of observing memory acquisition using Morris water maze system, there was no significant difference within all groups. 6. As results of observing retention using Morris water maze system, staying times significantly increased in Cervus elaphus aquapuncture - oral administration group compared to that of GH injection group at Ist trial and 3rd trial. 7. As results of observing staining intensity of NADPH-d-positive neurons in tissue of hippocampal part, significant increasing of staining intensity were observed in septum and VDB of hippocampus in Cervus elaphus aquapuncture . oral administration group compared to that of GH injection group. According to the above results, it is concluded that Cervus elaphus oral administration and Cervus elaphus aquapuncture on acupoint G39 showed effects on growth and intellectual development of animals.

동북아지역 수산물 교역에 있어서 한국의 무역 진흥 전략

김기수(Ki Soo Kim),장영수(Young Soo Jang),어윤양(Youn Yang Eh),정형찬(Hyung Chan Jung),김병호(Beong Ho Kim),박명섭(Myong Sop Park) 한국수산경영학회 2001 수산경영론집 Vol.32 No.1

The study tries to suggest policy proposals for enhancing competitiveness of our country as the base of fisheries logistics in East-North Asia. The study strongly recommends the adoption of the system of fisheries free trade area(FTA) to achieve the object under the analysis of structure of international fisheries trade in East-North Asian countries.