Paraquat lung에서 Fibronectin 분포에 관한 연구

강상균,양승하,김대중,김의한,김성용 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.1

To investigate the process of the Paraquat induced pulmonary fibrosis, 10 mg/Kg and 20mg/kg of paraquat was administered intraperitoneally each of 10 rats respectively. Three, five, seven, ten and fifteen days after this injection, the rats were sacrificed. Immunohistochemical studies for fibronectin and histologic studies were carried out. Results were as follows. 1. Toxic effect of the paraquat seems to be depend on the dose of administered paraquat since the groups of the rate treated with 10 mg/kg revaled no significant tissue damage after 7 days. 2. The pulmonary changes seen in 20 mg/Kg treated group could be classified into two stages: the early changes such as hemorrhage, edema and hyaline membrane formation which are similar to the findings observed in adult respiratory distress syndrome and the late change characterized by fibrosis which observed in mild degree even after 2 weeks, so the fibrosis seen to need more time for full blown. 3. The positivity of fibronectin were observed in macrophage and exudate in the early stage of tissue destruction that the fibronectin productin is preceded fibrosis and plays an important role for the collection of inflammatory cells such as macrophaques and fiboblasts. The more tissue desturction is severe, the more strong positivity of fibronectin was observed in the early stage of tissue destruciton.

Paraquat lung에서 TNF alpha 분포에 관한 연구

강상균,양승하,김대중,김의한,정용민 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.1

To investigate the process of the Paraquat induced lung damage, the white rats were administered 20 mg/Kg of Paraquat intraperitoneally. Three, seven, ten, 24 hours, three, five, seven, ten and fifteen days after this injection, the rats were sacrificed. The removed lung were evaluated by tumor necrosis factor and histologic study, so following results were obtained. 1. The significant inflammatory changes appeared after 3 days and most severity was seen in 7 days. The fibrosis appeared after 7 days and the degree was mild through observation period which indicate that the developement of fibrosis need more time. 2. TNF-∝ positivity precedes morphologic changes of the lung induced by Paraquat administratin, then positiviey of TNF-∝ decreases if the tissue destrucion is severe. 3. Early histologic change such as edema and ARDS like finding may be due to vascular leakage, caused by retraction of endothelium influenced by TNF-∝.

풍력 발전 시스템의 피치제어

강상수,강승균,임종환,허종철 濟州大學校工科大學産業技術硏究所 1999 尖端技術硏究所論文集 Vol.10 No.1

Wind turbine system converts wind energy into electric energy. Since the velocity of wind is random in nature, control of the angular velocity of the blade is necessary in order to generate high quality electric power. The control of the blade can be divided into the stall regulation type and the pitch control type. The stall regulation type which utilizes an aerodynamic stall is simple and cheap, but it suffers from fluctuation of the resulting power. On the contrary, pitch control type is based on the fact that the torque of the blade can be changed by varying the pitch angle of the blade. It is mechanically and mathematically complicated, but the control performance is better than that of the stall regulation type. This paper derives a mathematical modeling of the wind turbine system, and suggests a pitch control algorithm. The validity of the algorithm is demonstrated with the results produced through sets of experiments.

위선암에서 p53과 EGFR 및 PCNA 발현에 관한 연구

강현욱,양승하,강상균 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.1

Expression of oncogene in the gastric adenocarcinoma was considered as a determinant factor of cancer progression or prognosis by some authors, however, the results were so fluctuated according to the authors that there was no uniform agreement in their clinicopathological correlation as well as in its practical application. To evaluate correlation between the pathologic finding and the expression of p53, EGFR and PCNA, immunohistochemical studies were performed on paraffin-embedded sections of 84 gastric adenocarcinomas. Pathologic findings were classified as 4 subgroups by their histologic types, differentiation, invasion and lymph node metastasis. The correlation of PCNA labelling index with various clinicopathologic factors and oncogene expression was studied. The results were as follows; 1. p53 expression was seen in 47cases(55.56%) of gastric carcinoma, and correlation between p53 expression with tumor type, differentiation, invasion and lymph node metastasis was not proved. EGFR positive expression was found in 37(44.05%) cases and was increased in advanced gastric carcinoma, and cases of lymph node metastasis. 2. Co-expression of p53 and EGFR was observed in 18 cases(33.33%), suggesting existence of both oncogene in the same case, while both negative cases were 18 cases(33.33%) that suggest the possibility of presence of the other factors. 3. PCNA labelling index was higher in advanced gastric carcinoma and in cases of lymph node metastasis, but there was no statistical significance. 4. There was no statistical significance between PCNALI and p53 expression. 5. PCNALI and EGFR expression was parallel with pathologic finding such as differentiation, progression and metastasis of the carcinoma, these results suggest that there was significant correlation between PCNALI and EGFR. 6. PCNALI was statistically significant between two groups of both p53 and EGFR positive and both negative. 7. PCNALI showed statistical significance between EGFR positive and negative groups in cases of lymph node metastasis. In summary, the value of p53 expression as a prognostic factor was still doubtful but EGFR and PCNA expression tended to be associated with tumor progression and seemed to be objective and reliable prognostic factors, respectively. Combined method of EGFR and PCNA thought to be more helpful in preoperative decision or prediction of prognosis in gastric carcinoma.

Sol-Gel 코팅법에 의한 TiN/Al_2O_3/Tialon 복합체의 제조 및 분석에 관한 연구

姜益均,車銀姬,韓相鉉,金勇權 慶熙大學校 1990 論文集 Vol.19 No.-

TiN/Al_2O_3/Tialon comlposite was prepared by sol-gel processing of alumina sol, TiN, AIN, and Y_2O_3. The resultant composite was calcined at 900℃ and a number of test bars were cut from the composite to press uniaxially and isostatically at 20,000 psi and to sinter at 1650℃ and 1,700℃ for one hour in nitrogen atmosphere. Examination of the bar showed the structure of the composite to be a mixure of closest packed microcrytalline materials, and its mechanical property to be available for metal cutting, abrasive, protective, and decorative object ;

‘債權執行’에 있어서 消滅時效中斷事由에 관한 小考

김성균,강병훈 梨花女子大學校 法學硏究所 2017 法學論集 Vol.21 No.3

소멸시효가 완성되면 그 효과로 권리가 소멸하나 진행하던 소멸시효는 일정한 사유가 존재하면 더 이상 진행되지 않고 중단되어 시효의 대상이 된 권리는 존속하게 된다. 이처럼 소멸시효 완성 여부는 권리의 존부와 관련되어 있어 소송의 승패를 좌우하게 되는 매우 중요한 법률적 문제이다. 본고에서는 소멸시효 중단에 관한 사유 그 중에서도 ‘채권집행’이 소멸시효중단에 어떠한 영향을 미치는지에 대하여 분석하고자한다. 먼저 집행채무자의 제3채무자에 대한 채권이 압류된 경우에 이에 의한 집행채권의 소멸시효에 관하여 살펴보았다. 여기서는 집행채권이 압류에 의해 시효중단이 되는 경우 그 시효중단의 시기와 종기가 언제인지 여부가 쟁점이므로 이를 중심으로 검토하였다. 나아가 압류가 취소되는 경우에 그것이 시효중단의 효력에 미치는 영향에 대하여 민법 제175조를 중심으로 분석하였다. 또한 집행채권의 소멸시효가 중단되는 사유 가운데 ‘청구’ 그 중에서도 ‘최고’에 의해 시효가 중단되는지 여부는 특히 압류가 취소되는 경우에 있어서 중요한 문제로 부각되고 있어 이에 대하여도 논의하고자 하였다. 그리고 단순 최고가 아닌‘재판상 최고’로서의 효력을 인정할 수 있는지에 대하여도 논의하였다. 다음으로 채권집행 절차에서 배당요구의 방법으로 참여한 채권자의 배당요구 채권이 압류 또는 최고에 의해 시효가 중단되는지 여부를 검토하였으며, 부동산 강제 집행에서 문제되는 채권신고가 소멸시효의 중단에 미치는 영향에 대하여도 간단히 살펴보았다. 마지막으로 채권집행이 이루어지는 경우에 피압류채권의 소멸시효 중단의 문제에 대해서 살펴보았다. A right is extinguished due to the effect if completion of extinctive prescription is made but the ongoing extinctive prescription does no more proceed and the right still exists if there is a certain reason. Like this, completion of extinctive prescription is a very important legal issue determining the outcome of a lawsuit because it is related to existence of a right. Among reasons for suspension of extinctive prescription, this study reviewed influence of ‘claim execution’ on suspension of extinctive prescription. First, it investigated the extinctive prescription of claim execution by attachment. Here, in the case of suspension of extinctive prescription, its time and expiration are the main issue and therefore, this study reviewed the issue. Further, it conducted a review mainly on the article 175 of the Civil Law with respect to influence of attachment cancellation on suspension of the extinctive prescription. Next, whether claim execution is suspended by a ‘notification’ out of ‘claims’, one of the reasons for suspension of extinctive prescription, becomes an important matter in the case of attachment cancellation and therefore, it also discussed the matter. Among reasons for suspension of extinctive prescription, it also analyzed issue of the suspension by a judicial notification out of ‘notifications’, one of the reasons for suspension of the extinctive prescription, and reviewed whether credit of request for dividend by a creditor participating in claim execution procedures in a manner of request for dividend is suspended by an attachment or a notification, and it finally intended to analyze suspension of the extinctive prescription of attached claim if credit execution is made.

정상인의 입각기에서 발바닥압력측정시 압력중심점의 위치

허재균,박시복,이상건,이강목,김영호,양길태,장윤희 大韓再活醫學會 1998 Annals of Rehabilitation Medicine Vol.22 No.2

제2형 당뇨병 환자에서 알부민뇨와 심혈관계 질환의 유병율에 대한 연구

강태수,최소래,김영아,박흥수,서정건,황학진,윤세정,신석균,강신욱,최규헌,이호영,한대석,허애정,하성규 대한신장학회 2000 대한신장학회잡지 Vol.19 No.5

바터 팽대부에 생긴 유암종 1예

강명주,지삼룡,박석주,이재익,조영완,김준영,박성재,박은택,이연재,이상혁,설상영,배상균 인제대학교 2006 仁濟醫學 Vol.27 No.-

Carcinoid tumors have been reported in a wide range of organs but most commonly involve the lungs, bronchi and gastrointestinal tract. Within the gastrointestinal tract, appendix is the most common location for carcinoid, followed by the distal small intestine, the rectum, and the stomach. Among these, primary involvement of the ampulla of Vater is extremely rare. We report a case of carcinoid tumor of ampulla of Vater. A 62-year-old man presented with epigastric soreness. Gastroduodenal endoscopy showed hyperemic bulging mass on ampulla of Vater and diagnosed as carcinoid tumor by histologic finding, with immunohistochemical study. In ^(111)In-octreoscan, tumor had regional lymph node metastasis, but no evidence of distant metastasis. Pancreatoduodenectomy with lymph node dissection was performed.

대장선암에서 p53 과 P-glycoprotein의 분포에 관한 연구

강상균,김의한,장인성,김대중,양승하 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.1

Adenocarcinoma of colon and rectum express many oncogenes. The p53 acts as tumor suppressor in normal tissue but mutant forms are known as doing important role in carcinogenesis of many malignant tumors, such as colorectal cancer, gastric cancer, and breast cancer. P-glycoprotein shows distribution in many normal tissues and malignant tumor. This protein occurs multidrug resistance to therapeutic anticancer drug, resulting in poor prognosis of patients. The expression of p53 and P-glycoprotein has been studied by many authors according to clinicopthologic findings of colorectal adenocarcinoma, but these results are controversial yet. To observe the relationship between both antigen and pathologic findings, including prognostic factos, of colorectal adenocarcinoma, we analysed 13 cases adenoma and 62 cases adenocarcinoma then processed for immunohistochemical stain by SLAB method using mouse monoclonal anti-p53 and JSB-1. The results were as followings; 1) The expression rate of p53 in adenoma and adenocarcinoma are 38.5% and 71.0%, respectively, and P-glycoprotein are 46.6% and 58.1%, respectively. 2) The p53 revealed higher expression rate in case of well differnetiated form, invasion to serosa and surrounding adipose tissue, lymphatic metastasis compared to that of moderately and poorly differentiated form, invasion to muscle, no lymphatic metastasis, but no difference accoding to site. 3) P-glycoprotein revealed higher positive rate in case of right side, invasion to surrounding adipose tissue, lymphatic metastasis compared to that of left side, invasion to muscle and serosa, no lymphatic metastasis, but no difference according to differentiation. 4) Both of p53 and P-glycoprotein revealed higher ex pression in case of right side, well and moderately differentiated form, invation to serosa and surrounding adipose tissue, lymphatic metastasis compared to that of left side, poorly differentiated form, invasion to muscle, no lymphatic metastasis. Above results revealed that the expression of p53 begins in adenoma and shows close relation with development of colorectal carcinoma. p53 and P-glycoprotein may reveal the relation with poor prognosis. Adenocarcinoma showing both positive reaction of p53 and P-glycoprotein is also similar prognostic relation.