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Lee, Moon Hee,Cha, Hee-Jae,Choi, Eun Ok,Han, Min Ho,Kim, Sung Ok,Kim, Gi-Young,Hong, Su Hyun,Park, Cheol,Moon, Sung-Kwon,Jeong, Soon-Jeong,Jeong, Moon-Jin,Kim, Wun-Jae,Choi, Yung Hyun Spandidos Publications 2017 International journal of molecular medicine Vol.39 No.3
<P>Natural phytochemicals of plant origin, including flavonoids, have been found to be potent antioxidants providing beneficial effects against oxidative stress-related diseases. The present study was carried out to investigate the antioxidant properties of morin, a flavonoid originally isolated from the flowering plants of the Moraceae family. Superoxide dismutase (SOD)-like activity and 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS(center dot+)) radical scavenging activity were determined. We also investigated the cytoprotective effects of morin against hydrogen peroxide (H2O2)-induced DNA damage and apoptosis in V79-4 Chinese hamster lung fibroblasts. Our results demonstrated that morin had strong scavenging effects against ABTS' radicals with enhanced SOD activity, which varied in a dose-dependent manner. Morin was found to reduce H2O2-induced intracellular reactive oxygen species generation and nuclear DNA damage, and it recovered cell viability damaged by H2O2 via inhibition of mitochondrial dysfunction-mediated apoptosis. Notably, the treatment of V79-4 cells with morin markedly enhanced the expression of heme oxygenase-1 (HO-1) but not quinone oxidoreductase-1, which was associated with the increased expression and phosphorylation of nuclear factor-erythroid 2-related factor 2 (Nrf2) and the downregulation of Kelch-like ECH-associated protein 1 expression. Based on our findings, we conclude that morin effectively ameliorated oxidative stress-induced DNA damage through intrinsic free radical scavenging activity and activation of the Nrf2/HO-1 pathway.</P>
Lee, Moon Hee,Han, Min Ho,Lee, Dae-Sung,Park, Cheol,Hong, Su-Hyun,Kim, Gi-Young,Hong, Sang Hoon,Song, Kyoung Seob,Choi, Il-Whan,Cha, Hee-Jae,Choi, Yung Hyun UNKNOWN 2017 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.39 No.2
<P>In the present study, we investigated the cytoprotective efficacy of morin, a natural flavonoid, against oxidative stress and elucidated the underlying mechanisms in C2C12 myoblasts. Our results indicated that morin treatment prior to hydrogen peroxide (H2O2) exposure significantly increased cell viability and prevented the generation of reactive oxygen species. H2O2-induced comet-like DNA formation and gamma H2AX phosphorylation were also markedly suppressed by morin with a parallel inhibition of apoptosis in C2C12 myoblasts, suggesting that morin prevented H2O2-induced cellular DNA damage. Furthermore, morin markedly enhanced the expression of heme oxygenase-1 (HO-1) associated with the induction and phosphorylation of nuclear factor-erythroid 2-related factor 2 (Nrf2) and the inhibition of Kelch-like ECH-associated protein 1 (Keapl) expression. Notably, these events were eliminated by transient transfection with Nrf2-specific small interfering RNA. Additional experiments demonstrated that the activation of the Nrf2/HO-1 pathway by morin was mediated by the extracellular signal-regulated kinase (ERK) signaling cascade. This phenomenon was confirmed with suppressed Nrf2 phosphorylation and consequently diminished HO-1 expression in cells treated with a pharmacological inhibitor of ERK. Collectively, these results demonstrated that morin augments the cellular antioxidant defense capacity through the activation of Nrf2/HO-1 signaling, which involves the activation of the ERK pathway, thereby protecting C2C12 myoblasts from H2O2,-induced oxidative cytotoxicity.</P>
차호성 민족음악학회 1996 음악과 민족 Vol.11 No.-
「화염에 싸인 천사」(English in Flammen) 소프라노, 여성합창 그리고 5대 악기를 위한 애필로그가 있는 오케스트라를 위한 교양시 (1994) 윤이상은 원래 이 교향시「화염에 싸인 천사」의 초연에 부쳐 자신의 생각을 일본어로 작성하여 발표할 계획을 가지고 있었다. 하지만 그는 오랫동안 시달리고 있는 심한 천식으로 인하여 건강을 잃게 되었기 때문에 이 계획은 베를린의 음악학자인 발터-볼프강 슈파러(Walter-Wolfgang Sparrer)와의 짧은 대담으로 끝날 수 밖에 없었다. 이 대담은 그가 운명하기 7개월 전인 1995년 4월 5일에 베를린의 클라도우(Berlin-Kladow)에 위치한 윤이상의 저택에서 이루어졌으며, 이 대담은 그가 남기는 마지막 글로서 그의 마지막 작품인 교향시「화염에 싸인 천사」(English in Flammen)에서의 그의 사상과 작품세계를 보여주고 있다. 이 대담의 말미에 슈파러는「화염에 싸인 천사」에 대한 짧막한 분석을 곁들이고 있어 갼략하게나마 작품의 대강을 엿볼 수 있게 하였다. 본 대담에서 슈파러가 윤이상에게 던졌던 질문들은 너무 간단하였기 때문에 역자가 질문자가 본 의도와 전체의 맥락에서 벗어나지 않는 한에서 각색하고 보충하였다. 윤이상의 대답은 원문 그대로 옮겨 놓았으며, 이름은 편의상 삭제하였다. 참고로 이 대담은 아직도 발표되지 않은 글임을 밝힌다. 1994년에 윤이상은 그의 마지막 작품이 된 교향시를 머나 먼 이국땅인 독일의 베를린에서 작곡하였다. 그는 이 교향시의 제목을 「화염에 싸인 천사」(English in Flammen)라고 정하며 거기에 다음과 같은 의미를 부여하고 있다.
차상민,배희은,최진호,최영휴 국립7개대학공동논문집간행위원회 2003 공업기술연구 Vol.3 No.-
During high-speed running of machine tools, serious vibrations often may occur in their feed-drive system. In this paper, a 4-D.O.F. planar motion model is proposed in order to analyze a ball screw feed-drive system. The equations of motion are derived for the proposed model and natural frequencies of the system are calculated. Also its transient response due to driving motor speed control input are calculated. The theoretical analysis results showed good agreement with experimental ones measured from a laboratory feed-drive test system. Consequently we concluded that the proposed 4-D.O.F model can be well applicable to the vibration analysis and dynamic design of machine tool feed-drive system.
만성두통 환자의 성격유형 A 행태, 스트레스, 우울 및 두통영향정도의 관계 연구
차남현,임사비나,정인태,김수영,안경애,김건식,이재동,이상훈,최도영,이윤호,이두익 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-
To examine an estimate factor and grasp the relation of difference for Ype A Behavior Pattern(TABP), Perceived Stress Questionnaire. Depression and HIT-6 in the Chronic headache client. Method: Data collected by self-reported questionnaires from 38 client in S city who were selected by criteria of IHS, from the 19^(th) of October to 10^(th) of December, 2004. Result: 1) Differences between biographical data by TABP was significant by SaSang constitutions, by Stress was significantly influenced by age, and by Depression were significantly influenced health status and SaSang constitutions. 2) Correlations Coefficients among Study Variables were Stress and Depression(r=.494, p=.002) and Depression and HIT-6(r=.432, p=.010). 3) In regression analysis, HIT-6 were significantly influenced by Depression and Type A Behavior Pattern(TABP). These variables explained 38% and 34% respectively. Conclusion: The result suggest that chronic headache management with psychological aspect, as well as physical aspect should be a focus to enhance the quality of life.