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국내 유방암 환자의 삶의 질 측정 도구 개발에 관한 연구
채영란,최명애 성인간호학회 2001 성인간호학회지 Vol.13 No.3
The purpose of this study was to develop a Quality of Life(QOL) scale for breast cancer patients in Korea and to test the validity and reliability of the instrument. To achieve the purpose of the study, a questionnaire was developed to interview 10 breast cancer patients and distributed to 155 patients with breast cancer in Korea. For data analysis. SPSS WIN 8.0/PC were used. Item analysis and factor analysis were carried out to test validity of the QOL scale. Cronbach's α and Guttman split half coefficient were used to test reliability of the scale The results were as follows ; As a result of the item analysis, 27 items were selected from the total of 34 items. 6 factors were selected by factor analysis. Six factors were labeled as 'response to cancer diagnosis and treatment', 'family well-being', 'physical concerns', 'psychological well-being', 'spiritual well-being', and 'economic concerns'. Six factors were explained by 72.236% out of the total variance. The first factor explained 20.738% and the second factor explained 16.593%. which were major factors for Korean breast cancer patients. Chronbach's α coefficient of the tool was .9120. and Guttman split-half coefficient was .8148. The scale was identified to be a tool with a high degree of reliability and validity. Therefore, this scale can be effectively utilized for assessment of Quality of Life of patients with breast cancer in Korea.
소규모사업장 용접근로자들의 소음·용접흄·망간 노출에 관한 연구
김동구,문덕환,이채관,박명희,함성애,손병철,김대환,이창희,김휘동,이채언 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.5
Objective : This study was conducted for the purpose of investigating the level exposure of welders to noise, welding fume and Manganese(Mn) related to this process. Methods and Material : All subjects in this study were welders engaged in CO2 arc and coated arc welding process especially in small-scale enterprises classified by type of manufacture of ship building, repairing and of other fabricated metal products, which is located in Gimhae and Milyang of Kyeongsang province in south Korea. Air sampling of welding fume was measured, shipped and analyzed on the basis of national institute for occupational safety and health(NIOSH) method in U.S. and work environment measurement method established in south Korea. To measure Noise in the work environment, Noise dosimeter was used on the basis of work environment measurement method established in south Korea. Result : This study was performed during a period from January, 2000 to December, 2001 and Results were as follows: 1. Noise level measured in this work environment was higher than national criteria for permissible exposure limit on health examinations related to hearing loss. 2. The concentration of welding fume and Mn in manufacture of ship building and repairing was higher than those in manufacture of other fabricated metal products. 3. In conditions of existing in ventilation system installed and operated, the concentration of welding fume and Mn was slightly lower than those of not existing. 4. In conditions of existing in sufficient air supply from out door into the work place relied on natural exhaust system, the concentration of welding fume and Mn was slightly lower than those of in not sufficient. 5. In all subjects, a rate of wearing ear plug and respiratory mask for dust and fume was lower than that of not wearing. Conclusion : According to above results, this study suggests that more positive work environment managements such as the use of portable local ventilation system, the supply of highly qualified personal protective equipment, and consecutive education and training related to health protection should be need to acquire suitable health protection program for welders engaged in small-scale enterprises in Korea.
윤복연,문덕환,박명희,황용식,함성애,손병철,김대환,이창희,김휘동,이채언 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.5
Objective : This study was conducted to prepare the fundamental data on heavy metal concentration in hair permanents agents and to prevent the health impairment due to heavy metal. Methods and Material : The author determined of 5 heavy metals(Pb, Cr, Mn, Ni, and Cu) concentration hair permanent agents in the market with flameless atomic absorption spectrophotometer. Results : The results were as follows: 1. The geometic mean concentrations of total subjects were 0.04㎍/g for Pb, 0.09㎍/g for Cr, 0.06㎍/g for Mn, 0.03㎍/g for Ni, and 0.04㎍/g for Cu. 2. The most highest mean concentrations of heavy metals in hair permanent agents by using type were Cr for wave agent and straight cream agent, Cu for setting iron agent, Cr and Cu for coating perm agent. 3. Metal most hlghest mean concentrations of heavy in hair permanent agents by type of color was green for Cu. 4. The mean concentration of Cu among 5 heavy metals in hair permanent agents by marker was most highest. 5. There was most statistically significant difference on mean concentration in hair permanent agents between domestic and foreign products. 6. The exposure amount of heavy metal concentration by one time using the permanent agent were 4.O㎍ for Pb, 9.O㎍ for Cr, 6.0㎍ for Mn, 3.O㎍ for Ni and 4.0㎍ for Cu. Conclusion : As above results author suggest to prepare the preventive program of health impairment due to heavy metal by long term chronic exposure to who were using the hair permanent agents hair designer and customers.
Monitoring of Preservatives in Cosmetics for Children
Myung-sook Lee,Su-un Kim,Chae-man Choi,Ae-sook Park,Yun-hee Kim,In-sook Hwang 한국분석과학회 2021 학술대회논문집 Vol.2021 No.11
We monitored the content of 7 preservatives (phenoxyethanol (PE), benzoic acid (BA), benzyl alcohol (BAl), methyl paraben (MP), Isopropyl paraben (IPP), methylisothiazolinone (MIT), chloromethylisothiazoline (CMIT)) in 31 cosmetics (n=31) for children by the simultaneous analysis of HPLC in 2020. The detection ranges were as follows; 0.58~0.61% (n=3) for PE, 0.09~0.48% (n=9) for BA, 0.60~0.62% (n=2) for BAl, 0.01~0.06% (n=3) for MP. The order of detection rates was cleanser (71%) 〉shampoo, rinse (50%) 〉 lotion, cream (40%) 〉 bath (33%). At least one of target preservatives was contained in 45% (14/31) of samples and the content of the detected preservatives was within maximam allowed amount established by KFDA. Benzoic acid was used the most frequently in 31 cosmetics for children.
( Myung Sin Lim ),( Myeong Ae Kim ),( Chae Mi Lim ),( Byung Hoon Cho ),( Jeong Woo Kang ),( Seong Wan Son ) 한국수의공중보건학회 2012 예방수의학회지 Vol.36 No.3
A liquid chromatographic-tandem mass spectrometric (LC-MS/MS) multi-residue method for simultaneous quantification and identification of 37 anthelmintic veterinary drug residues (including benzimidazoles, macrocyclic lactones, and flukicides, levamisole, pyrantel and niclosamide) in milk has been developed and validated. For sample preparation, we used a simple modification of the QuEChERS (quick, easy, cheap, effective, rugged and safe) method, which was initially developed for analysis of pesticide residues. Anthelmintic residues were extracted into acetonitrile:methanol (9:1, v/v) using sodium chloride to induce liquid-liquid partitioning followed by dispersive solid phase extraction for cleanup. The extract was concentrated into dimethyl sulphoxide, which was used as a keeper to ensure that analytes remain in solution. Using rapid polarity switching in electrospray ionization, a single injection was capable of detecting both positively and negatively charged ions within a 15 min run time. The Limit of detection (LOD) and the Limit of quantification (LOQ) method ranged from 0.1 ng/g to 4.4 ng/g and from 0.3 ng/g to 14.6 ng/g, respectively. Validation of the developed method was based on international guidelines. Average recoveries ranged from 70% to 120%, except for 54.7% at 0.5× MRL (rafoxanide) and 69.0% at 0.5× MRL (closantel). The coefficient of variation for the described method was less than 15% over the range of concentrations studied. The result of the method was verified successfully by participation in a proficiency study for analysis of anthelmintic drugs.
( Young Ae Yang ),( Gyu Yeun Kim ),( Jae Hee Kim ),( Sun Hee Park ),( Se Yong Jang ),( Myung Hwan Bae ),( Jang Hoon Lee ),( Dong Heon Yang ),( Hun Sik Park ),( Yong Keun Cho ),( Shung Chull Chae ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Despite prognostic value of anemia, there have been few effective risk models incorporating anemia to predict major adverse cardiac events (MACEs). We aimed to assess whether modifi ed clinical SYNTAX score (mCSS) would improve the ability of the SYNTAX score (SS) and the Clinical SYNTAX score (CSS) to predict MACEs of patients undergoing primary percutaneous coronary intervention (PCI) after ST-elevation myocardial infarction (STEMI). Methods: The CSS was calculated in 642 patients by multiplying the SS to an ACEF score (age/left ventricular ejection fraction + 1 if estimated glomerular fi ltration rate >60ml/min). The mCSS was calculated by adding anemia to ACEF score (ACEF score + 1 if hemoglobin levels < 12. 0g/dL in women and Results: During the follow-up, rate of MACE was signifi cantly higher in the highest tertile group compared with patients in the lower 2 tertiles (1. 4% versus 4. 2% versus 14. 7%; log-rank p Conclusions: Novel mCSS incorporating anemia improves the discrimination accuracy of SS and CSS to predict MACEs of patients underwent primary PCI after STEMI.
Nam, Myung H.,Jang, Jin W.,Kim, Hanna,Han, Eun T.,Lee, Won J.,An, Seong S. A.,Park, Ae S. D.,Lim, Chae S. Blackwell Publishing Ltd 2011 Tropical medicine & international health Vol.16 No.8
<P><B>Summary</B></P><P>Thrombospondin‐related adhesive protein (TRAP) from <I>Plasmodium vivax</I> (<I>P.?vivax</I>) became one of the important vaccine candidates for malaria, because <I>P.?vivax</I> TRAP (PvTRAP) is responsible for the sporozoite–host interactions. PvTRAP polymorphisms in the isolates from Republic of Korea (ROK) were analysed, setting the valuable baseline data for the future vaccine developments and clinical trials with PvTRAP, as a strong vaccine candidate. A total of 54 isolates were collected in 2010. PvTRAP genes from above isolates were amplified and sequenced, and the results were analysed and compared against Sal‐1 strain. Sequencing analysis of 1424‐bp‐size PvTRAP PCR products revealed one major allelic type with six non‐synonymous substitutions, where S81T, E95D, I121V and T127R substitutions were found in region II, and K371N and A425E substitutions from region IV. The ROK isolates revealed the limited sequence polymorphisms in PvTRAP in comparison with the reported isolates from other nations.</P>
Genomic Surveillance of SARS-CoV-2: Distribution of Clades in the Republic of Korea in 2020
Park Ae Kyung,Kim Il-Hwan,Kim Jun-Young,Kim Jeong-Min,Kim Heui Man,Lee Chae young,Han Myung-Guk,이기은,Kwon Donghyok,Nam Jeong-Gu,Park Young Joon,Gwack Jin,Lee Nam-Joo,Woo SangHee,No Jin Sun,Lee Jaehee,H 질병관리본부 2021 Osong Public Health and Research Persptectives Vol.12 No.1
Since a novel beta-coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in December 2019, there has been a rapid global spread of the virus. Genomic surveillance was conducted on samples isolated from infected individuals to monitor the spread of genetic variants of SARS-CoV-2 in Korea. The Korea Disease Control and Prevention Agency performed whole genome sequencing of SARS-CoV-2 in Korea for 1 year (January 2020 to January 2021). A total of 2,488 SARS-CoV-2 cases were sequenced (including 648 cases from abroad). Initially, the prevalent clades of SARS-CoV-2 were the S and V clades, however, by March 2020, GH clade was the most dominant. Only international travelers were identified as having G or GR clades, and since the first variant 501Y.V1 was identified (from a traveler from the United Kingdom on December 22nd, 2020), a total of 27 variants of 501Y.V1, 501Y.V2, and 484K.V2 have been classified (as of January 25th, 2021). The results in this study indicated that quarantining of travelers entering Korea successfully prevented dissemination of the SARS-CoV-2 variants in Korea.