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Song, Yingze,Zhao, Wen,Kong, Long,Zhang, Li,Zhu, Xingyu,Shao, Yuanlong,Ding, Feng,Zhang, Qiang,Sun, Jingyu,Liu, Zhongfan The Royal Society of Chemistry 2018 ENERGY AND ENVIRONMENTAL SCIENCE Vol.11 No.9
<P>Lithium-sulfur (Li-S) batteries are deemed as one of the most promising next-generation energy storage systems. However, their practical application is hindered by existing drawbacks such as poor cycling life and low Coulombic efficiency due to the shuttle effect of lithium polysulfides (LiPSs). We herein present an <I>in situ</I> constructed VO2-VN binary host which combines the merits of ultrafast anchoring (VO2) with electronic conducting (VN) to accomplish smooth immobilization-diffusion-conversion of LiPSs. Such synchronous advantages have effectively alleviated the polysulfide shuttling, promoted the redox kinetics, and hence improved the electrochemical performance of Li-S batteries. As a result, the sulfur cathode based on the VO2-VN/graphene host exhibited an impressive rate capability with ∼1105 and 935 mA h g<SUP>−1</SUP> at 1C and 2C, respectively, and maintained long-term cyclability with a low capacity decay of 0.06% per cycle within 800 cycles at 2C. More remarkably, favorable cyclic stability can be attained with a high sulfur loading (13.2 mg cm<SUP>−2</SUP>). Even at an elevated temperature (50 °C), the cathodes still delivered superior rate capacity. Our work emphasizes the importance of immobilization-diffusion-conversion of LiPSs toward the rational design of high-load and long-life Li-S batteries.</P>
Song, Yingze,Zhao, Wen,Zhu, Xingyu,Zhang, Li,Li, Qiucheng,Ding, Feng,Liu, Zhongfan,Sun, Jingyu American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.18
<P>The lithium-sulfur (Li-S) battery has been deemed as one of the most promising energy-storage systems owing to its high energy density, low cost, and environmental benignancy. However, the capacity decay and kinetic sluggishness stemming from polysulfide shuttle effects have by far posed a great challenge to practical performance. We herein demonstrate the employment of low-cost, wet-chemistry-derived VO<SUB>2</SUB> nanobelts as the effective host additives for the graphene-based sulfur cathode. The VO<SUB>2</SUB> nanobelts displayed an ultrafast anchoring behavior of polysulfides, managing to completely decolor the polysulfide solution in 50 s. Such a fast and strong anchoring ability of VO<SUB>2</SUB> was further investigated and verified by experimental and theoretical investigations. Benefitting from the synergistic effect exerted by VO<SUB>2</SUB> in terms of chemical confinement and catalytic conversion of polysulfides, the Li-S batteries incorporating VO<SUB>2</SUB> and graphene manifested excellent cycling and rate performances. Notably, the batteries delivered an initial discharge capacity of 1405 mAh g<SUP>-1</SUP> when cycling at 0.2 C, showed an advanced rate performance of ∼830 mAh g<SUP>-1</SUP> at 2 C, and maintained a stable cycling performance at high current densities of 1, 2, and 5 C over 200 cycles, paving a practical route toward cost-effective and environmentally benign cathode design for high-energy Li-S batteries.</P> [FIG OMISSION]</BR>
Liang Li,Zhang Fengmei,Feng Naibo,Kuang Biao,Fan Mengtian,Chen Cheng,Pan Yiming,Zhou Pengfei,Geng Nana,Li Xingyue,Xian Menglin,Deng Lin,Li Xiaoli,Kuang Liang,Luo Fengtao,Tan Qiaoyan,Xie Yangli,Guo Fen 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Osteoarthritis (OA) is a full-joint, multifactorial, degenerative and inflammatory disease that seriously affects the quality of life of patients due to its disabling and pain-causing properties. ER stress has been reported to be closely related to the progression of OA. The inositol-requiring enzyme 1α/X-box-binding protein-1 spliced (IRE1α/XBP1s) pathway, which is highly expressed in the chondrocytes of OA patients, promotes the degradation and refolding of abnormal proteins during ER stress and maintains the stability of the ER environment of chondrocytes, but its function and the underlying mechanisms of how it contributes to the progression of OA remain unclear. This study investigates the role of IRE1α/ERN1 in OA. Specific deficiency of ERN1 in chondrocytes spontaneously resulted in OA-like cartilage destruction and accelerated OA progression in a surgically induced arthritis model. Local delivery of AdERN1 relieved degradation of the cartilage matrix and prevented OA development in an ACLT-mediated model. Mechanistically, progranulin (PGRN), an intracellular chaperone, binds to IRE1α, promoting its phosphorylation and splicing of XBP1u to generate XBP1s. XBP1s protects articular cartilage through TNF-α/ERK1/2 signaling and further maintains collagen homeostasis by regulating type II collagen expression. The chondroprotective effect of IRE1α/ERN1 is dependent on PGRN and XBP1s splicing. ERN1 deficiency accelerated cartilage degeneration in OA by reducing PGRN expression and XBP1s splicing, subsequently decreasing collagen II expression and triggering collagen structural abnormalities and an imbalance in collagen homeostasis. This study provides new insights into OA pathogenesis and the UPR and suggests that IRE1α/ERN1 may serve as a potential target for the treatment of joint degenerative diseases, including OA.
Non-uniform wind environment in mountainous terrain and aerostatic stability of a bridge
Xingyu Chen,Junjie Guo,Haojun Tang,Yongle Li,Lei Wang 한국풍공학회 2020 Wind and Structures, An International Journal (WAS Vol.30 No.6
The existence of a dam has potential effects on the surrounding wind environment especially when it is located in mountainous areas. In this situation, the long-span bridge over the reservoir can easily be exposed to non-uniform incoming flows, affecting its wind-resistance performance. This paper presents a study on the aerostatic stability of such a bridge. Wind tunnel tests were first carried out to investigate the wind environment above a mountainous reservoir. The results show that the angle of attack and the wind speed along the bridge axis show obvious non-uniform characteristics, which is related to the inflow direction. When winds come from the south where the river is winding, the angle of attack varies along the span direction significantly. The finite element model for the bridge was established using ANSYS software, and effects of non-uniform wind loads on the aerostatic stability were computed. Non-uniform angle of attack and wind speed are unfavorable to the aerostatic stability of the bridge, especially the former. When the combined action of non-uniform angle of attack and wind speed is considered, the critical wind speed of aerostatic instability is further reduced. Moreover, the aerostatic stability of the bridge is closely related to the dam height.
Effects of Secondary Elements on Vortex-Induced Vibration of a Streamlined Box Girder
Xingyu Chen,Fang Qiu,Haojun Tang,Yongle Li,Xinyu Xu 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.1
Box girders are aerodynamically favorable, and the paper presents a study on the vortex-induced vibration (VIV) of this girder type at large angles of attack. Taking a box girder as an example, the form of the guardrails and the position of the maintenance tracks were improved to increase the VIV performance. The aerodynamic mechanism was further investigated according to the change in flow field around the girder. Results showed that the VIV performance of the box girder at positive angles of attack is worse. Improving secondary elements is an effective way to increase the VIV performance. Adding four rectangle bars above the original guardrails could achieve the target by preventing the generation of the vortex and blocking its movement. Moving the maintenance tracks inwards with a reasonable distance could also achieve the target as the flow passes through the girder more smoothly. With the combination of the optimal form of the guardrails and the optimal position of the maintenance tracks, the VIV performance of the bridge is higher. The countermeasures provide reference for the inhibition of the VIV of box girders.
Hydroxychloroquine and chloroquine: a potential and controversial treatment for COVID-19
Li Zou,Lijun Dai,Xingyu Zhang,Zhaohui Zhang,Zhentao Zhang 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.8
A novel coronavirus, later named SARS-CoV-2,was fi rst reported in China in December 2019 and subsequentlywidely identifi ed in the United States, Japan, SouthKorea, France, India, and other countries. The diseasecaused by SARS-CoV-2 infection was called COVID-19. The high fatality and morbidity rates of COVID-19 makeit the third largest global epidemic in this century. However,there are currently no approved antiviral drugs for theCOVID-19 treatment. Recently, two old antimalarial drugs,hydroxychloroquine and chloroquine, have been found toexert anti-SARS-CoV-2 eff ects both in vitro and in vivo. Preliminaryclinical evidence suggests these drugs may havean eff ect on the treatment of COVID-19. Herein, we reviewthe pharmacokinetics characteristics and antiviral eff ects ofthese drugs, in addition to their side eff ects and clinical evidenceof their use for the COVID-19 treatment.
Li Di,Liu Xingyue 한국응용곤충학회 2020 Journal of Asia-Pacific Entomology Vol.23 No.4
The genus Dilar Rambur, 1838 (Neuroptera, Dilaridae) is the most species-rich genus of the family Dilaridae and is diverse in China, previously with 32 described species. Here we report two new species of Dilar from the southern part of the Hengduan Mountains, Sichuan, southwestern China, namely Dilar muliensis sp. nov. and Dilar punctulosus sp. nov. A revised key to species of Dilar from China is provided.
Simulation Research on Control System of Main Converter Unit
Li Xingyu,Zheng Zhongxiang,Wu Dali 제어로봇시스템학회 2019 제어로봇시스템학회 국제학술대회 논문집 Vol.2019 No.10
The main converter unit needs to provide high-quality AC and DC power for the ship AC/DC hybrid power system. The reliability of its control system is very important. In order to study and optimize the control system of the converter unit, it is very meaningful to model and simulate it. The working characteristics and operation requirements of the converter unit in the ship hybrid power system are introduced. According to the control system structure, the corresponding simulation model is built. The simulation results meet the unit operation requirements and provide technical support for optimizing the converter unit control system.