http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Kuang Biao (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
Numerical investigation of heat transfer characteristics for Subsea Xmas tree assembly
Biao Hu,Hongwu Zhu,Kuang Ding,Fangling Xu,Youjiang Zhang 대한기계학회 2015 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.29 No.11
This study focuses on the heat transfer characteristic of a horizontal subsea Xmas tree assembly at a high spatial resolution. Computationalfluid dynamics (steady Reynolds-averaged Navier-Stokes) in combination with Low Reynolds number modelling (LRNM) isadopted for heat transfer analysis, which has been validated against a full scale underwater gate valve heat transfer experiment with goodagreements. The characteristics of cold sea water flowing through the subsea tree, and of convection heat transfer between the subsea treeand ambient cold water are obtained. The typical “hot spots,” which have high Convection heat transfer coefficient (CHTC) and creategreat large amounts of heat loss, are numerically determined. Under the designed water depth, the effects of installation orientation, seawater velocity, and inner oil temperature on convection heat transfer are investigated as well. Such work is significant for thermal designof the subsea tree to increase structural reliability and flow assurance level.
-
Liang Li,Zhang Fengmei,Feng Naibo,Kuang Biao,Fan Mengtian,Chen Cheng,Pan Yiming,Zhou Pengfei,Geng Nana,Li Xingyue,Xian Menglin,Deng Lin,Li Xiaoli,Kuang Liang,Luo Fengtao,Tan Qiaoyan,Xie Yangli,Guo Fen 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Osteoarthritis (OA) is a full-joint, multifactorial, degenerative and inflammatory disease that seriously affects the quality of life of patients due to its disabling and pain-causing properties. ER stress has been reported to be closely related to the progression of OA. The inositol-requiring enzyme 1α/X-box-binding protein-1 spliced (IRE1α/XBP1s) pathway, which is highly expressed in the chondrocytes of OA patients, promotes the degradation and refolding of abnormal proteins during ER stress and maintains the stability of the ER environment of chondrocytes, but its function and the underlying mechanisms of how it contributes to the progression of OA remain unclear. This study investigates the role of IRE1α/ERN1 in OA. Specific deficiency of ERN1 in chondrocytes spontaneously resulted in OA-like cartilage destruction and accelerated OA progression in a surgically induced arthritis model. Local delivery of AdERN1 relieved degradation of the cartilage matrix and prevented OA development in an ACLT-mediated model. Mechanistically, progranulin (PGRN), an intracellular chaperone, binds to IRE1α, promoting its phosphorylation and splicing of XBP1u to generate XBP1s. XBP1s protects articular cartilage through TNF-α/ERK1/2 signaling and further maintains collagen homeostasis by regulating type II collagen expression. The chondroprotective effect of IRE1α/ERN1 is dependent on PGRN and XBP1s splicing. ERN1 deficiency accelerated cartilage degeneration in OA by reducing PGRN expression and XBP1s splicing, subsequently decreasing collagen II expression and triggering collagen structural abnormalities and an imbalance in collagen homeostasis. This study provides new insights into OA pathogenesis and the UPR and suggests that IRE1α/ERN1 may serve as a potential target for the treatment of joint degenerative diseases, including OA.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
