천담중국전통희곡지곤요(淺談中國傳統戱曲之困擾)

사백양 한국중국희곡학회 1994 중국희곡 Vol.2 No.1

Coronary Atherosclerosis T₁-Weighed Characterization With Integrated Anatomical Reference

Xie, Y.,Kim, Y.J.,Pang, J.,Kim, J.S.,Yang, Q.,Wei, J.,Nguyen, C.T.,Deng, Z.,Choi, B.W.,Fan, Z.,Bairey Merz, C.N.,Shah, P.K.,Berman, D.S.,Chang, H.J.,Li, D. Elsevier Science B.V. Amsterdam 2017 JACC CARDIOVASCULAR IMAGING Vol.10 No.6

Objectives: The aim of this work is the development of coronary atherosclerosis T<SUB>1</SUB>-weighted characterization with integrated anatomical reference (CATCH) technique and the validation by comparison with high-risk plaque features (HRPF) observed on intracoronary optical coherence tomography (OCT) and invasive coronary angiography. Background: T<SUB>1</SUB>-weighted cardiac magnetic resonance with or without contrast media has been used for characterizing coronary atherosclerosis showing promising prognostic value. Several limitations include: 1) coverage is limited to proximal coronary segments; 2) spatial resolution is low and often anisotropic; and 3) a separate magnetic resonance angiography acquisition is needed to localize lesions. Methods: CATCH acquired dark-blood T<SUB>1</SUB>-weighted images and bright-blood anatomical reference images in an interleaved fashion. Retrospective motion correction with 100% respiratory gating efficiency was achieved. Reference control subjects (n = 13) completed both pre- and post-contrast scans. Stable angina patients (n = 30) completed pre-contrast scans, among whom 26 eligible patients also completed post-contrast scans. After cardiac magnetic resonance, eligible patients (n = 22) underwent invasive coronary angiography and OCT for the interrogation of coronary atherosclerosis. OCT images were assessed and scored for HRPF (lipid-richness, macrophages, cholesterol crystals, and microvessels) by 2 experienced analysts blinded to magnetic resonance results. Results: Per-subject analysis showed none of the 13 reference control subjects had coronary hyperintensive plaques (CHIP) in either pre-contrast or post-contrast CATCH. Five patients had CHIP on pre-contrast CATCH and 5 patients had CHIP on post-contrast CATCH. Patients with CHIP had greater lipid abnormality than those without. Per-segment analysis showed elevated pre- and post-contrast plaque to myocardium signal ratio in the lesions with HRPF versus those without. Positive correlation was observed between plaque to myocardium signal ratio and OCT HRPF scoring. CHIP on pre-contrast CATCH were associated with significantly higher stenosis level than non-CHIP on invasive coronary angiography. Conclusions: CATCH provided accelerated whole heart coronary plaque characterization with simultaneously acquired anatomical reference. CHIP detected by CATCH showed positive association with high-risk plaque features on invasive imaging studies.

Consistent inflow boundary conditions for modelling the neutral equilibrium atmospheric boundary layer for the SST k-ω model

Yang, Yi,Xie, Zhuangning,Gu, Ming Techno-Press 2017 Wind and Structures, An International Journal (WAS Vol.24 No.5

Modelling an equilibrium atmospheric boundary layer (ABL) in computational wind engineering (CWE) and relevant areas requires the boundary conditions, the turbulence model and associated constants to be consistent with each other. Among them, the inflow boundary conditions play an important role and determine whether the equations of the turbulence model are satisfied in the whole domain. In this paper, the idea of modeling an equilibrium ABL through specifying proper inflow boundary conditions is extended to the SST $k-{\omega}$ model, which is regarded as a better RANS model for simulating the blunt body flow than the standard $k-{\varepsilon}$ model. Two new sets of inflow boundary conditions corresponding to different descriptions of the inflow velocity profiles, the logarithmic law and the power law respectively, are then theoretically proposed and numerically verified. A method of determining the undetermined constants and a set of parameter system are then given, which are suitable for the standard wind terrains defined in the wind load code. Finally, the full inflow boundary condition equations considering the scale effect are presented for the purpose of general use.

Signaling Pathways Controlling Microglia Chemotaxis

Yang Fan,Lirui Xie,Chang Y. Chung 한국분자세포생물학회 2017 Molecules and cells Vol.40 No.3

Microglia are the primary resident immune cells of the central nervous system (CNS). They are the first line of defense of the brain’s innate immune response against infection, injury, and diseases. Microglia respond to extracellular signals and engulf unwanted neuronal debris by phagocytosis, thereby maintaining normal cellular homeostasis in the CNS. Pathological stimuli such as neuronal injury induce transformation and activation of resting microglia with ramified morphology into a motile amoeboid form and activated microglia chemotax toward lesion site. This review outlines the current research on microglial activation and chemotaxis.

Joint FrFT‐FFT basis compressed sensing and adaptive iterative optimization for countering suppressive jamming

Yang Zhao,Chaoxuan Shang,Zhuangzhi Han,Yuanwei Yin,Ning Han,Hui Xie 한국전자통신연구원 2019 ETRI Journal Vol.41 No.3

Accurate suppressive jamming is a prominent problem faced by radar equipment. It is difficult to solve signal detection problems for extremely low signal to noise ratios using traditional signal processing methods. In this study, a joint sensing dictionary based compressed sensing and adaptive iterative optimization algorithm is proposed to counter suppressive jamming in information domain. Prior information of the linear frequency modulation (LFM) and suppressive jamming signals are fully used by constructing a joint sensing dictionary. The jamming sensing dictionary is further adaptively optimized to perfectly match actual jamming signals. Finally, through the precise reconstruction of the jamming signal, high detection precision of the original LFM signal is realized. The construction of sensing dictionary adopts the Pei type fast fractional Fourier decomposition method, which serves as an efficient basis for the LFM signal. The proposed adaptive iterative optimization algorithm can solve grid mismatch problems brought on by undetermined signals and quickly achieve higher detection precision. The simulation results clearly show the effectiveness of the method.

SNPs of Excision Repair Cross Complementing Group 5 and Gastric Cancer Risk in Chinese Populations

Yang, Wan-Guang,Zhang, Shan-Feng,Chen, Ju-Wu,Li, Li,Wang, Wan-Peng,Zhang, Xie-Fu Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12

We conducted a case-control study to determine the association between several potential SNPs of excision repair cross complementing group 5 (XPG) and gastric cancer susceptibility, and roles of XPG polymorphisms in combination with H.pylori infection in determining risk of gastric cancer. In our study, we collected 337 newly diagnosed gastric cancer cases and 347 health controls. Three SNPs of XPG, rs2296147T>C, rs2094258C>T and rs873601G>A, were genotyped using the Taqman real-time PCR method with a 7900 HT sequence detector system. H. pylori infection was diagnosed by ELISA. By multivariate logistic regression analysis, the rs2296147 CC genotype was associated with a decreased risk of gastric cancer (OR=0.52, 95% CI=0.27-0.97), and rs2094258 TT was associated with elevated risk (OR=2.13, 95% CI=1.22-3.35). Positive H.pylori individuals with rs2094258 TT genotypes demonstrated increased risk of gastric cancer (OR=2.13, 95% CI=1.22-3.35), while rs2296147 CC was associated with lower risk among patients with negative H.pylori (OR=0.45, 95%CI=0.22-0.89). Our findings suggested that XPG polymorphisms might contribute to risk of gastric cancer among Chinese populations, but the effect needs to be further validated by larger sample size studies.

A novel method for the discrimination of Hawthorn and its processed products using an intelligent sensory system and artificial neural networks

Xie, Da-Shuai,Peng, Wei,Chen, Jun-Cheng,Li, Liang,Zhao, Chong-Bo,Yang, Shi-Long,Xu, Min,Wu, Chun-Jie,Ai, Li 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.6

Hawthorn (CFS) has commonly been applied as an important traditional Chinese medicine and food for thousands of years. The raw material of CFS is commonly processed by stir-frying to obtain yellow (CFY), dark brown (CFD), and carbon dark (CFC) colored products, which are used for different clinical uses. In this study, an intelligent sensory system (ISS) was used to obtain the color, gas, and flavor samples data, which were further employed to develop a novel and accurate method for the identification of CFS and its processed products using principal component analysis. Moreover, this research developed a model of an artificial neural network, which could be used to predict the total organic acid, total flavonoids, citric acid, hyperin, and 5-hydroxymethyl furfural via determination of the color, odor, and taste of a sample. In conclusion, the ISS and the artificial neural network are useful tools for rapid, accurate, and effective discrimination of CFS and its processed products.

eDNA-based bioassessment of coastal sediments impacted by an oil spill

Xie, Yuwei,Zhang, Xiaowei,Yang, Jianghua,Kim, Seonjin,Hong, Seongjin,Giesy, John P.,Yim, Un Hyuk,Shim, Won Joon,Yu, Hongxia,Khim, Jong Seong Elsevier 2018 Environmental pollution Vol.238 No.-

<P><B>Abstract</B></P> <P>Oil spills offshore can cause long-term ecological effects on coastal marine ecosystems. Despite their important ecological roles in the cycling of energy and nutrients in food webs, effects on bacteria, protists or arthropods are often neglected. Environmental DNA (eDNA) metabarcoding was applied to characterize changes in the structure of micro- and macro-biota communities of surface sediments over a 7-year period since the occurrence of <I>Hebei Spirit</I> oil <I>spil</I>l on December 7, 2007. Alterations in diversities and structures of micro- and macro-biota were observed in the contaminated area where concentrations of polycyclic aromatic hydrocarbons were greater. Successions of bacterial, protists and metazoan communities revealed long-term ecological effects of residual oil. Residual oil dominated the largest cluster of the community-environment association network. Presence of bacterial families (<I>Aerococcaceae</I> and <I>Carnobacteriaceae</I>) and the protozoan family (<I>Platyophryidae</I>) might have conferred sensitivity of communities to oil pollution. Hydrocarbon-degrading bacterial families (<I>Anaerolinaceae</I>, <I>Desulfobacteraceae</I>, <I>Helicobacteraceae</I> and <I>Piscirickettsiaceae</I>) and algal family (<I>Araphid pennate</I>) were resistant to adverse effects of spilt oil. The protistan family (<I>Subulatomonas</I>) and arthropod families (<I>Folsomia</I>, <I>Sarcophagidae Opomyzoidea,</I> and <I>Anomura</I>) appeared to be positively associated with residual oil pollution. eDNA metabarcoding can provide a powerful tool for assessing effects of anthropogenic pollution, such as oil spills on sediment communities and its long-term trends in coastal marine environments.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Long-term ecological impact on coastal sediment community by an oil spill were accessed by eDNA metabarcoding. </LI> <LI> Residual oils altered the alpha-diversity, beta-diversity and compositions of multiple sedimentary communities. </LI> <LI> The largest cluster of the sedimentary community-environment association network was dominated by residual oils. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Sodium aescinate alleviates bone cancer pain in rats by suppressing microglial activation via p38 MAPK/c-Fos signaling

Yang Guang,Li Jiajing,Xu Qian,Xie Huilan,Wang Lijun,Zhang Minhao 대한독성 유전단백체 학회 2022 Molecular & cellular toxicology Vol.18 No.4

Background Bone cancer pain (BCP) severely compromises the life quality of patients with advanced cancer or bone metastases . Objective This study investigates the analgesic effect of sodium aescinate (SA) on BCP, and the underlying mechanisms within the spinal cord (SC) and dorsal root ganglion (DRG). Walker 256 cells were intratibially inoculated into rats to establish a BCP model. 10, 20, and 40 g/L of SA was intrathecally injected, respectively, and then, hyperalgesia and allodynia were evaluated by measuring the paw withdrawal threshold (PWT) and paw withdrawal latency (PWL). The effect of SA on neuroinflammation was observed by detecting the production of the pro-inflammatory cytokines based on RT-qPCR and ELISA. The NF-κB and p38 MAPK/c-Fos signaling was detected by WB analysis. Furthermore, RT-qPCR and WB analyses of Iba-1and CD206 were performed to assess microglial activation. Result The development of hyperalgesia and allodynia, and an increase of pro-inflammatory cytokines production, as well as microglial activation, were observed in the BCP rats. SA (40 g/L) not only relieved the pain-related behaviors induced by BCP but also suppressed the release of pro-inflammatory cytokines and the activation of microglia in the SC and DRG. SA could also inhibit p38 MAPK/c-Fos signaling in both the SC and DRG, which might contribute to the suppression of microglial activation. Conclusion Our findings suggest that SA plays a promising analgesic role in the BCP rats by suppressing infl ammation and microglial activation, and these effects may be associated with the suppression of p38 MAPK/c-Fos signaling.

A new small molecule acceptor based on indaceno[2,1-b:6,5-b’]dithiophene and thiophene-fused ending group for fullerene-free organic solar cells

Xie, Dongjun,Liu, Tao,Lee, Tack Ho,Gao, Wei,Zhong, Cheng,Huo, Lijun,Luo, Zhenghui,Wu, Kailong,Xiong, Wentao,Kim, Jin Young,Choi, Hyosung,Sun, Yanming,Yang, Chuluo Elsevier 2018 Dyes and pigments Vol.148 No.-

<P><B>Abstract</B></P> <P>A new small molecule acceptor of IDTCN with indaceno[2,1-b:6,5-b’]dithiophene as electron-donating core and CPTCN (2-(6-oxo-5,6-dihydro-4H-cyclopenta[<I>c</I>]thiophen-4-lidene)malononitrile) as electron-withdrawing end-capping group was synthesized and investigated in organic solar cells. The IDTCN shows strong and broad absorption with a high extinction coefficient and appropriate energy levels matching with wide bandgap donor polymer. The best device based on PBT1-EH:IDTCN exhibits an open circuit voltage (<I>V</I> <SUB>oc</SUB>) of 0.93 V, a short circuit current (<I>J</I> <SUB>sc</SUB>) of 13.31 mA/cm<SUP>2</SUP>, a FF of 0.702, achieving a PCE of 8.69%.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A thiophene-fused electron-withdrawing group is used as end group for small molecule acceptors. </LI> <LI> The OPV devices achieve high power conversion efficiencies of up to 8.69% with a high fill factor of 0.702. </LI> <LI> IDTCN in neat film tend to form unusual isotropic orientation instead of face-on orientation. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>