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RISS 인기검색어
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- 저자 : Zhentao Zhang (검색결과 4 건)
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Hydroxychloroquine and chloroquine: a potential and controversial treatment for COVID-19
Li Zou,Lijun Dai,Xingyu Zhang,Zhaohui Zhang,Zhentao Zhang 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.8
A novel coronavirus, later named SARS-CoV-2,was fi rst reported in China in December 2019 and subsequentlywidely identifi ed in the United States, Japan, SouthKorea, France, India, and other countries. The diseasecaused by SARS-CoV-2 infection was called COVID-19. The high fatality and morbidity rates of COVID-19 makeit the third largest global epidemic in this century. However,there are currently no approved antiviral drugs for theCOVID-19 treatment. Recently, two old antimalarial drugs,hydroxychloroquine and chloroquine, have been found toexert anti-SARS-CoV-2 eff ects both in vitro and in vivo. Preliminaryclinical evidence suggests these drugs may havean eff ect on the treatment of COVID-19. Herein, we reviewthe pharmacokinetics characteristics and antiviral eff ects ofthese drugs, in addition to their side eff ects and clinical evidenceof their use for the COVID-19 treatment.
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Zhentao Li,Jie Dong,Jian Huang,Tao Guo,Shihua Wang,Xin Zhao,Qinghua Zhang 한국고분자학회 2020 Macromolecular Research Vol.28 No.1
In this work, two sets of high performance polyimide (PI) fibers fabricated by a more environmentally-friendly and highly efficient “reaction-spinning” method were firstly reported. The relationship between the spinning rate, chemical structure and the imidization degree of the PI precursor fibers were investigated, and the results indicated a moderate low spinning speed and relatively flexible molecular chains are both favorable for the partial imidization reaction in the spinning process. 2D WAXD results demonstrate that the rigid PDA-based PI fibers possess a higher alignment of polymer chains along the fiber axis during the spinning compared to the flexible ODA-based PIs, resulting in enhanced mechanical properties, with the tensile strength of 1.2-2.8 GPa and modulus of 53.6-111.2 GPa, respectively. Meanwhile, ODA sets of PI fibers exhibit a higher loop strength and knot strength than the commercial Aramid and PBO fibers. The process used in this study has a significant potential for realizing industrial level production of high strength and high modulus PI fibers.
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Zhentao Guo,Qianxue Chen,Baohui Liu,Daofeng Tian,Shenqi Zhang,Mingchang Li 연세대학교의과대학 2014 Yonsei medical journal Vol.55 No.5
Purpose: Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) are an inhibitor of receptor tyrosine kinases (RTKs) that was discovered in recent years, and many studies showed that LRIG1 is a tumor suppressor gene and may be related to tumor drug resistance. In this study, we explored whether LRIG1 protein expression can improve the chemosensitivity of glioma cells and what was its mechanism. Materials and Methods: We collected 93 cases of glioma tissues and detected the expression of LRIG1 and BCL-2. We constructed a multidrugresistance cell line U251/multidrug resistance (MDR) and examined the change of LRIG1 and BCL-2 at mRNA and protein expression levels. LRIG1 expressionwas upregulated in U251/MDR cells and we detected the change of multidrug resistance. Meanwhile, we changed the expression of LRIG1 and BCL-2 and explored the relationship between LRIG1 and BCL-2. Finally, we also explored the relationship between LRIG1 and RTKs. Results: LRIG1 was negatively correlated with BCL-2 expression in glioma tissue and U251/MDR cells, and upregulation of LRIG1 can enhance chemosensitivity and inhibit BCL-2 expression. Furthermore, LRIG1 was negatively correlated with RTKs in U251/MDR cells. Conclusion: These results demonstrated that LRIG1 can improvechemosensitivity by modulating BCL-2 expression and RTK signaling in glioma cells.
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Effect of pre-slaughter fasting time on carcass yield, blood parameters and meat quality in broilers
Wu Xuezhuang,Zhou Yahao,Lu Zhentao,Zhang Yunting,Zhang Tietao 아세아·태평양축산학회 2024 Animal Bioscience Vol.37 No.2
Objective: The aim of this study was to evaluate the effect of pre-slaughter fasting time on carcass yield, meat quality, blood parameters and glucose metabolism in broilers. Methods: Four hundred and fifty Arbor Acres (AA) broilers at 42 days of age were divided into 5 groups with 6 replicates in each group and 15 chickens as one replicate. Following this period, broilers from each group were distributed among five groups according to preslaughter fasting period as 4, 8, 12, 16, or 20 h. Results: With increasing fasting time, the carcass yield (p<0.01), the breast muscles yield (p<0.01) and the thigh yield (p<0.01) of the broilers were all linearly increased. With increasing fasting time, the L* values (p<0.01), cooking loss (p = 0.020), moisture content (p<0.01) in the leg muscles linearly downregulated, while the drip loss (p = 0.043), pH45 min (p<0.01) and pH24 h (p<0.01) were linearly upregulated. A trend for a lower (p = 0.071) shear force in the leg muscles was also observed in broilers fasted for longer time. Similar results were also found in breast muscles. The different fasting treatments did not influence the breast muscles glycogen content (p>0.10), while the increase of fasting time resulted in a linear decrease of the blood glucose (p = 0.021) and, more specifically, the glycogen content of the liver and leg muscles (p<0.001). With increasing fasting time, the aspartate transaminase (p<0.01), uric acid (p<0.01), and triglycerides (p<0.01) in serum linearly downregulated, while the alanine aminotransferase was linearly upregulated. Conclusion: The results of this study show a significant influence of fasting time on carcass yield and meat quality in broilers. Moderate fasting (8 to 12 h) before slaughter can reduce the weight loss of broilers. Prolonged fasting (≥16 h) increased body weight loss, decreased slaughtering performance and fluctuating blood indexes of broilers.
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