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- 저자 : LIM Sung Mook (검색결과 270 건)
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임성묵,김기태,박순달 한국경영과학회 2000 經營 科學 Vol.17 No.2
In this research, we compare and anlyze the two initial basis construction procedures : LPAKO's procedure proposed by Seo et. al. and symbolic crash procedure proposed by Maros et. al.. Based on the analysis, we present a new procedure which complements the previous procedures. The new procedure shows superiority to the previous procedures with respect to the optimality of initial basis. Also, the initial basis constructed by the new procedure reduces the number of simplex iterations.
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Lim,Sung-Mook,Jung,Ki-Chang,Kim,Eung-Sik,Kim,Hong 한국화재소방학회 1997 한국화재소방학회 학술대회 논문집 Vol.1997 No.-
In this work, a new type of UV flame detection system was developed. In order to measure the performance of UV flame detector, various kinds of experiments was performed. The results show that the maximum response time of the UV flame detector is 0.2 seconds when the detection distance is one meter The advantages of this system include wide area, high speed response and high sensitivity. After testing the W flame detector in engine compartment it detected fire within 0.09 seconds and extinguished within 5 seconds. Hence, the UV flame detector can be applied in automatic fire suppression system for automobiles.
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임성묵,박순달 한국경영과학회 2000 經營 科學 Vol.17 No.2
In this study, we deals with the implementation of an optimal basis identification procedure for interior point methods, Our implementation is based on Meglddo's strongly polynomial algorithm applied to Andersen and Ye's approximate LP construction. Several techniques are explained such as the used of effective indicator for obtaining optimal partition when constructing the approximate LP, the efficient implementation of the problem reduction technique proposed by Andersen, the crashing procedure needed for fast dual phase of Megiddo's algorithm, and the construction of the stable initial basis. By experimental comparison, we show that our implementation is superior to the crossover scheme implementation.
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김현영,임철홍,정용현,이권섭,이성배,이준연,한정희,전윤석,이용묵 한국환경독성학회 2001 환경독성보건학회지 Vol.16 No.4
The purpose of this study was to investigate the acute (4 hours) and repeated-dose (6 hours a day, 5 days a week, 4 weeks) toxic effects of I -hexene on Sprague- Dawley (SD) rats which were treated by inhalation. The results were as follows; I. The median lethal concentration (LC_(50)) was estimated 52,694 ppm (confidence limit 95%; 49,494~55,447 ppm) in acute inhalation. Abnormal clinical signs related to the l-Hexene were not observed with the acute inhalation dose. Gross findings of necropsy revealed on evidence of specific toxicity related to the 1-hexene, II. By repeated inhalation exposure the body weight of male were more or less reduced by the dose of 2,500 ppm and 5,000 ppm compared with control group. However there were no significant variation hematology and blood biochemistry for the exposed rats compared with the control rats. Abnormal clinical signs and gross findings of necropsy related to the 1-hexene were not shown. In conclusion when we exposed I-hexene to SD rats for 4 weeks, 5 days per week, 6 hours per day, the Lowest observed effect level (LOEL) was over 2,500 ppm and Non observed effect level (NOEL) was below 500 ppm.
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S.D. Rats를 이용 1, 1-Dichloro-1-fluoroethane의 아민성 흡입독성 연구
김현영,이성배,임철홍,김철우,점용현,한정희,전윤석,최수영,강대봉,이용묵 한국환경독성학회 2002 환경독성보건학회지 Vol.17 No.1
There were no specific effects for test materials on Sprague-Dawley (S.D.) rats in clinical symptoms, amounts of food intakes, weight changes, laboratory findings, and pathology after whole body l, l-Dichloro-1 -fluoroethane (used as coolant, metal cleaner and solvents) exposure(0, 1,500, 3,000, and 6,000 ppm) for 13 weeks (6 hour/day, 5 days/week). However, the loss of capillary vessels in eyeball (pupil) was observed in a female rat among 6,000 ppm group. Though there was a tendency for MCHC (Mean Corpuscular Hemoglobin Concentration) in rat to be decreased (p<0.05), it was not regarded as abnormal because the values were within normal limits. In asthma-stimulation related evaluations, there was also a tendency for inflammatory cell counts in bronchoalveolar lavages to be increased. But it had no statistical significance, and also no dependency on sex and the exposed concentration. Based on this result, the non observed effect level (NOEL) induced by 1, 1-Dichloro-l -fluoroethene inhalation was evaluated in groups with 3,000 ppm below (S .D. Rats, 13 weeks). Finally, it was concluded that the short term exposal of 1, 1-Dichloro-l-fluoroethane is not considered as a asthma stimulant by inhalation despite of some study limitations such as test animals use and short-term exposure .
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김현영,이성배,임철홍,이권섭,정용현,이종성,한정희,전윤석,황호순,이용묵 한국산업위생학회 2003 한국산업보건학회지 Vol.13 No.1
The CrO3 mostly used in plating. metal surface disposal, leather, cosmetic manufacturing, as an experiment material by repeatedly inhaling and exposure the male S.D. rats at a 0.00, 0.2., 0.50, 1.25 mg/㎡ concentration(particle size: 0.5-0.5 aerosol)6hours a day, 5day a week in 13weeks comparing with 2weeks, 8weeks of recovery group about the noxiousness of the experiment animal and the reduce scale of the CrO3 in the internal organ especially in blook and respiratory organ with the period of convalescent and clearance. The experiment results which we received are as follows. 1. In blood the RBC, HGB and HCT experiment, rats with 0.20, 0.50 mg/㎡ concentration showed that there were some decreases but not dependent. The kidneys absolute weight compared with control group was reduced intentionally(p〈0.05) and the lungs absolute weight compared with control group showed intentional increase(p〉0.05). 2. After the exposure of the experiment material, the whole blook, l\blood plasma and red blood cell in blood by (x): the period of convalescent, per (y); the decreasing of Cr concentration, was y=66.51 e -0.057x, y=67.2 e-0.101x, y=70.01 e-0.030 in 0.50 mg/㎡ exposure concentration by calculating the clearance coefficient of correlation, and the half life (day)was estimated 12.0, 6086, 23.0 each. 3, After the exposure of the experiment material, the experiment animals lung, liver and kidneys by(x); the period of convalescent, per (y); the decreasing of Cr conentration, was y=1808 e-0.00493x, y=12.02e-0.0297x, y=67.61 e-0.0292x in 0.50mg/㎡ exposure concentration by calculating the clearance coefficient of correlation, and the half life(day)was estimated 140.6, 23.3, 23.7, each, and including lung, liver with all of the experiment internal organs, the Cr clearance decreased as the exposure concentration increased.
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Lim, Sung Mook,Jang, Sung Hwan,Oh, Se Heang,Yuk, Soon Hong,Im, Gun Il,Lee, Jin Ho WILEY-VCH Verlag 2010 Advanced Engineering Materials Vol. No.
<P>Polycaprolactone/Pluronic F127 porous scaffolds are prepared using a modified melt-molding particulate-leaching method. The scaffolds are highly porous (about 90% porosity) and have open-cellular pore structures. Growth factors (TGF-β<SUB>2</SUB>, BMP-7 or dual TGF-β<SUB>2</SUB>/BMP-7) can be easily immobilized on the pore surfaces of the PCL/F127 scaffolds via binding with heparin. The growth-factor-immobilized scaffolds can induce the chondrogenesis of ATMSCs seeded onto them. Using TGF-β<SUB>2</SUB> and BMP-7 growth factors together leads to a better chondrogenic differentiation behavior than using single-growth-factor immobilized scaffolds.</P> <B>Graphic Abstract</B> <P>Dual-growth-factor (TGF-β<SUB>2</SUB>/BMP-7)-immobilized PCL/Pluronic F127 porous scaffolds were fabricated using a modified melt-molding particulate-leaching method followed with the binding of heparin and growth factors onto the pore surfaces of the scaffolds. From the in vitro chondrogenesis study, it was observed that the dual TGF-β<SUB>2</SUB>/BMP-7-immobilized scaffold induced better chondrogenic differentiation than the single-growth-factor-immobilized scaffolds or control scaffold (without growth factor), probably owing to the synergistic effect of both growth factors. <img src='wiley_img/14381656-2010-12-1-2-ADEM200980153-content.gif' alt='wiley_img/14381656-2010-12-1-2-ADEM200980153-content'> </P>
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Novel fabrication of PCL porous beads for use as an injectable cell carrier system
Lim, Sung Mook,Lee, Hyo Jung,Oh, Se Heang,Kim, Jin Man,Lee, Jin Ho Wiley Subscription Services, Inc., A Wiley Company 2009 Journal of Biomedical Materials Research Part B Vol. No.
<P>Injectable polycaprolactone (PCL) porous beads were fabricated for use as cell carriers by a novel isolated particle-melting method (for nonporous beads) and the following melt-molding particulate-leaching method (for porous beads). The prepared beads showed highly porous and uniform pore structures with almost the same surface and interior porosities (porosity, over 90%). The PCL porous beads (bead size, 400–550 μm) with different pore sizes (25–50 and 50–100 μm) were compared for their in vitro cell (human chondrocyte) growth behavior with the nonporous beads. The porous beads showed higher cell seeding density and growth than the nonporous beads. The pore size effect between the porous beads was not significant up to 7 days, but after that time the beads with pore sizes of 50–100 μm showed significantly higher cell growth than those of 25–50 μm. To evaluate the tissue compatibility of the PCL porous beads, the beads were dispersed, uniformly, in cold Pluronic F127 solution and injected into hairless mice, subcutaneously, in the gel state of Pluronic F127 at room temperature, leading to the homogeneous bead delivery. The histological findings confirmed that the PCL porous beads in Pluronic F127 gel are biocompatible: surrounding tissues gradually infiltrated into the porous beads for up to 4 weeks with little inflammatory response. The PCL porous beads with highly porous and uniform pore structures fabricated in this study can be widely applicable as cell carriers. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009</P>
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