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- 저자 : Kwon Young-Yon (검색결과 149 건)
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박원봉,문유선,권영주,주혜진 서울여자대학교 자연과학연구소 2003 자연과학연구논문집 Vol.15 No.-
베타카로틴의 물에 대한 용해도는 담즙산염의 임계미셀농도에서 급속히 증가하였으며, 혼합미셀을 형성시 용해도가 더욱 우수하였다. 또한, 베타카로틴을 수용화 하는데 필요한 계면활성제의 최적비율은 1:5이며, 글리세롤, 레시틴, STPP, 젤라틴, 카라기난 등 각종 안정화제를 적절한 비율로 첨가하여 업자크기를 측정한 결과, 0.48 μm 의 안정된 혼합미셀 조성불을 얻을 수 있었으며, 이 조성불은 항산화활성이 거의 그대로 유지됨을 알수 있었다. β-Carotene is a member of hydrophobic pigments known as carotenoids, which are responsible for the bright warm colors in some fruits and vegetables, β-Carotene is an important antioxidant which protects the body from free radicals. The body converts β-carotene, a nontoxic vitamin A precursor, to vitamin A as needed. Dissolution in surfactant solutions above the critical micelle concentration offers one approach to the formation of poorly soluble materials in solution form. In the present study, the β-Carotene was dissolved in mixed micelles of bile salts (sodium cholate and sodium deoxycholate). Water-solubility of β-Carotene was estimated by measuring absorbance and phase diagram of water/β-Carotene/bile salts system was plotted. Effects of stabilizer on the stability of soluble β-Carotene was estimated by measuring the size of mixed micelles containing β -carotene. Antioxidative activity of hydrophobic and aqueous β-Carotene was estimated by measuring TBA value of linoleic acid emulsion incubated with anti oxidative components.
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수술적으로 치료한 통증을 동반한 흉추부의 후외상성 Schmorl씨 결절 : 2례 보고 Report of Two Cases
신병준,이재철,송화용,정석봉,권계원,조영일,김연일 순천향의학연구소;Soonchunhyang Medical Research Institute 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2
Study Design : Two patients who had painful Schmorl's node at thoracic level from acute trauma were adopted and taken operation for its treatment Objectives : To document the effect of operation for the treatment of painful Schmorl's node at thoracic level summary of background data : Schrmorl's nodes are common spinal lesion generally believed to be asymptomatic, but in some cases there were painful symptom by Schmorl's node. This case report is to explain the effect of operative treatment for the painful Schmorl's node. Methods : Two patients were adopted who had traumatic painful Schmorl's node at thoracic level for our case report. They were treated conservative methods at first but it's effect were poor, so they were taken anterior decompression and fusion, and checked back pain symptom. Result : In all two patients, the symptom of back pain by Schmorl's nodes at thoracic level was almost subsided. conclusion : For the treatment of traumatic painful Schmorl's node, most of surgeon says that conservative treatments were treatment of choice, but operative treatments are also benefit to subsidence of back pain by Schmorl's node.
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Kwon, Young-Yon,Choi, Kyung-Mi,Cho, ChangYeon,Lee, Cheol-Koo Korean Society for Molecular and Cellular Biology 2015 Molecules and cells Vol.38 No.12
Mitochondria play a crucial role in eukaryotic cells; the mitochondrial electron transport chain (ETC) generates adenosine triphosphate (ATP), which serves as an energy source for numerous critical cellular activities. However, the ETC also generates deleterious reactive oxygen species (ROS) as a natural byproduct of oxidative phosphorylation. ROS are considered the major cause of aging because they damage proteins, lipids, and DNA by oxidation. We analyzed the chronological life span, growth phenotype, mitochondrial membrane potential (MMP), and intracellular ATP and mitochondrial superoxide levels of 33 single ETC component-deleted strains during the chronological aging process. Among the ETC mutant strains, 14 ($sdh1{\Delta}$, $sdh2{\Delta}$, $sdh4{\Delta}$, $cor1{\Delta}$, $cyt1{\Delta}$, $qcr7{\Delta}$, $qcr8{\Delta}$, $rip1{\Delta}$, $cox6{\Delta}$, $cox7{\Delta}$, $cox9{\Delta}$, $atp4{\Delta}$, $atp7{\Delta}$, and $atp17{\Delta}$) showed a significantly shorter life span. The deleted genes encode important elements of the ETC components succinate dehydrogenase (complex II) and cytochrome c oxidase (complex IV), and some of the deletions lead to structural instability of the membrane-$F_1F_0$-ATP synthase due to mutations in the stator stalk (complex V). These short-lived strains generated higher superoxide levels and produced lower ATP levels without alteration of MMP. In summary, ETC mutations decreased the life span of yeast due to impaired mitochondrial efficiency.
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Kwon, Young-Yon,Lee, Sung-Keun,Lee, Cheol-Koo Korean Society for Molecular and Cellular Biology 2017 Molecules and cells Vol.40 No.4
Caloric restriction (CR) has been shown to extend lifespan and prevent cellular senescence in various species ranging from yeast to humans. Many effects of CR may contribute to extend lifespan. Specifically, CR prevents oxidative damage from reactive oxygen species (ROS) by enhancing mitochondrial function. In this study, we characterized 33 single electron transport chain (ETC) gene-deletion strains to identify CR-induced chronological lifespan (CLS) extension mechanisms. Interestingly, defects in 17 of these 33 ETC gene-deleted strains showed loss of both respiratory function and CR-induced CLS extension. On the contrary, the other 16 respiration-capable mutants showed increased CLS upon CR along with increased mitochondrial membrane potential (MMP) and intracellular adenosine triphosphate (ATP) levels, with decreased mitochondrial superoxide generation. We measured the same parameters in the 17 non-respiratory mutants upon CR. CR simultaneously increased MMP and mitochondrial superoxide generation without altering intracellular ATP levels. In conclusion, respiration is essential for CLS extension by CR and is important for balancing MMP, ROS, and ATP levels.
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( Ji Young Kang ),( Hye Seon Kang ),( Hye Yon Lee ),( Chin Kook Rhee ),( Seong Joon Kim ),( Seok Chan Kim ),( Soon Seog Kwon ),( Young Kyoon Kim ),( Sook Young Lee ) 대한결핵 및 호흡기학회 2013 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.116 No.0
Background and Objectives: Recent research demonstrate that administration with low dose macrolide has an effect on chronic inflammatory airway diseases such as chronic obstructive pulmonary disease through anti-inflammatory action. However, the influence of the drug on asthma is not clearly verified. The aim of this study was to investigate whether low dose azithromycin, a kind of macrolide, affects on allergic airway inflammation in a murine model of acute asthma. Methods: 6 weeks old-female BALB/c mice were sensitized and challenged with ovalbumin. Low dose azithromycin (75 mg/kg) was administered subcutaneously daily 30 min before the challenge for 1 week. Six mice were used in each group (control vs OVA vs Azithromycin). Total and differential cell counts in bronchoalveolar lavage fluid (BALF) were measured and Th2 cytokine profiles in BALF were analyzed by ELISA. Interleukin (IL)-17, neutrophils elastase, IL-8 were assessed. Results: The BALF counts in total cell and eosinophils decreased significantly after the azithromycin administration. Th2 cytokines such as IL-4, IL-5, and IL-13 showed lower concentrations in azithromycin group than in OVA group. The levels of IL-17, netrophil elastase, and IL-8, which are known as parameters are related with the action of azithromycin, lessened by the treatment with azithromycin. Conclusion: This study suggests that low dose azithromycin has some effects on airway inflammatory responses in acute asthma of murine model.Background and Objectives: Recent research demonstrate that administration with low dose macrolide has an effect on chronic inflammatory airway diseases such as chronic obstructive pulmonary disease through anti-inflammatory action. However, the influence of the drug on asthma is not clearly verified. The aim of this study was to investigate whether low dose azithromycin, a kind of macrolide, affects on allergic airway inflammation in a murine model of acute asthma. Methods: 6 weeks old-female BALB/c mice were sensitized and challenged with ovalbumin. Low dose azithromycin (75 mg/kg) was administered subcutaneously daily 30 min before the challenge for 1 week. Six mice were used in each group (control vs OVA vs Azithromycin). Total and differential cell counts in bronchoalveolar lavage fluid (BALF) were measured and Th2 cytokine profiles in BALF were analyzed by ELISA. Interleukin (IL)-17, neutrophils elastase, IL-8 were assessed. Results: The BALF counts in total cell and eosinophils decreased significantly after the azithromycin administration. Th2 cytokines such as IL-4, IL-5, and IL-13 showed lower concentrations in azithromycin group than in OVA group. The levels of IL-17, netrophil elastase, and IL-8, which are known as parameters are related with the action of azithromycin, lessened by the treatment with azithromycin. Conclusion: This study suggests that low dose azithromycin has some effects on airway inflammatory responses in acute asthma of murine model.
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Yoo, Mi Young,Oh, Kwang-Seok,Lee, Jung Won,Seo, Ho Won,Yon, Gyu Hwan,Kwon, Dae Young,Kim, Young Sup,Ryu, Shi Yong,Lee, Byung Ho Heyden & Son 2007 Phytotherapy research Vol.21 No.2
<P>The vascular relaxant effect of the rhizome extract of Rheum undulatum was evaluated with isolated rat thoracic aorta preparations. The methanol extract of the rhizome induced a concentration-dependent relaxation of aortic preparations precontracted with 0.3 µm phenylephrine (EC<SUB>50</SUB> value: 5.8 µg/mL). The activity-guided fractionation of the extract led to the isolation of seven hydroxystilbene components as active principles, i.e. piceatannol, resveratrol, desoxyrhapontigenin, rhapontigenin, piceid, rhaponticin and ϵ-viniferin. Of these, piceatannol, a tetrahydroxystilbene, exhibited the most potent vascular relaxant effect in rat aortic preparations (EC<SUB>50</SUB> value 2.4 µm). The vasorelaxant effect of piceatannol on endothelium-intact aorta rings was diminished completely by the removal of functional endothelium or by pretreatment of the aortic tissues with N<SUP>G</SUP>-nitro-l-arginine methyl ester. These results suggest that piceatannol may be the major mediator responsible for the vasorelaxing properties of the rhizome extract of Rheum undulatum and the vasorelaxant effects of the piceatannol may be mediated via endothelium-dependent nitric oxide signaling pathway. Copyright © 2006 John Wiley & Sons, Ltd.</P>
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( Sei Won Kim ),( Chin Kook Rhee ),( Hea Yon Lee ),( Hwa Young Lee ),( Ji Young Kang ),( Sook Young Lee ),( Young Kyoon Kim ),( Soon Suk Kwon ),( Hyoung Kyu Yoon ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-
Background: Asthma is characterized by airway inflammation and remodeling. Roflumilast is a selective phosphodiesterase-4 (PDE4) inhibitor that has anti-inflammatory effect in chronic obstructive pulmonary disease (COPD). However, little is known regarding the effect of roflumilast in chronic asthma. This study is aimed to evaluate the effects of roflumilast on airway inflammation and remodelling in a murine model of chronic asthma. Methods: Female BALB/c mice, 6 weeks of age, were used. We developed a mouse model of airway remodeling in which ovalbumin (OVA)-sensitized mice were repeatedly exposed to intranasal OVA administration twice a week for 3 months. Roflumilast was administered orally starting on the 38th and 5 days a week thereafter for 3 months during the intranasal OVA challenge. A lung fibroblast cell line was used in the proliferation assay. Results: Compared with control mice, mice chronically exposed to OVA developed sustained eosinophilic airway inflammation, airway hyperresponsiveness (AHR), and exhibited features of airway remodeling. Administration of roflumilast significantly inhibited eosinophilic inflammation and AHR. The levels of interleukin (IL)-4, IL-5, and IL-13 in the bronchoalveolar lavage (BAL) fluids were significantly lower in the roflumilast group. The level of hydroxyproline was also significantly lower in the roflumilast group. In vitro, roflumilast significantly inhibited stem cell factor (SCF) induced cell proliferation of fibroblasts. Conclusions: These results suggest that roflumilast administration modulates the airway inflammation, AHR, and airway remodeling associated with chronic allergen challenge.
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