급성 납중독된 흰쥐의 이물질 대사효소의 활성도에 관한 연구

김기웅,송용범,장성근 ( Ki Woong Kim,Young Beam Song,Sung Keun Chang ) 생화학분자생물학회 1994 BMB Reports Vol.27 No.2

In rats treated with lead nitrate and/or red ginseng extract mixture we observed a change in the level of hepatic cytochrome P-450 and electron transport system for P-450 dependent reaction, and a content of zinc protoporphyrin (ZPP) and hemoglobin (Hb) in whole blood. The contents of cytochrome P-450 and b_5, and the activity of ECDEase, AHHase and NADPH-cytochrome C (P-450) reductase were slowly decreased according to the dosage of lead nitrate. On the other hand, the activity of NADH-bs reductase was increased according to the dosage of lead nitrate, but in case of treatment with red ginseng mixture, this enzyme activity was slightly decreased. In whole blood, the contents of hemoglobin and ZPP were not shown any critical change but lead content increased according to dosage of lead nitrate. These results suggest that content and activity of cytochrome P-450-dependent monooxygenase may be dependent on specificity of substrates and exposure duration.

Ethanol이 Trichloroethylene 대사효소의 활성도와 유도성에 미치는 영향

김기웅,강성규,조영숙,이세휘,문영한,최병순,박상신,Kim, Ki-Woong,Kang, Seung-Kyu,Cho, Young-Sook,Lee, Sei-Hui,Moon, Young-Hahn,Choi, Byung-Soon,Park, Sang-Shin 대한예방의학회 1995 Journal of Preventive Medicine and Public Health Vol.28 No.1

This study was performed to find out the influences of ethanol on the metabolism of trichloroethylene(TRI) in rats. TRI in corn oil at the dosage of 150, 300, 600 mg/kg was injected peritoneally once a day for two days to two groups. In one group ethanol(4 g/kg) was taken orally 30 minutes before TRI injection, and the other group ethanol was not. The results of experiments are as follows: 1. The contents of cytochrome P-450 and $b_5$ had inverse relationship with in-jected TRI amounts in both groups. 2. The activity of NADPH P-450 reductase was decreased slowly in TRI injected group related with TRI amount, but decreased drastically in the group pretreated with ethanol. 3. The activity of NADH $b_5$ reductase had relationship with injected nt amount , but the statistical significance was found only in the groups of 300 and 600 mg/kg of TRI injected without relevance to ethanol when compared with the group that was not injected. 4. The activity of ADH was more decreased and ALDH activity was more increased in groups that TRI injected and ethanol was pretreated with ethanol groups than in group without any treatment. These results suggest that ethanol may inhibit epoxide formulation, the first step of TRI metabolism, and change from TCE-OH to TCA also.

혈장(血漿) MHPG와 HVA 농도(濃度)의 24시간(時間) 주기성(週期性) 변화(變化)에 관한 연구(硏究)

김기웅,이정희,우종인,Kim, Ki-Woong,Lee, Jung Hie,Woo, Jong Inn 대한생물정신의학회 1995 생물정신의학 Vol.2 No.2

We invesigated whether the circadian rhythms of plasma MHPG and HVA concentrations exist in 11 healthy young adults, and analyzed the patterns of their circadian rhythms. The results were as follows : 1) The change in the mean plasma MHPG concentrations analyzed by repeated measures ANOVA was not statistically significant. Five subjects showed significant circadian rhythms of plasma MHPG concentrations of each individual, and 4 of those had the acrophases between 17PM and 24PM. 2) The change in the mean plasma HVA concentrations analyzed by repeated measures ANOVA was not statistically significant. Six subjects showed significant circadian rhythms of plasma HVA concentrations of each individual, and 4 of those had the acrophases between 21PM and 6AM. In conclusion, the circadian rhythm pattern of plasma HVA concentrations in our result is consistent with the previous study. It was suggested that plasma MHPG and HVA concentrations should be measured more frequently, and the physical activities of subjects be controlled more strictly for the following study.

중소기업의 성장 관점에서 사내 기업가정신이 경영성과에 미치는 영향 실증분석

김기웅,김문선,Kim, Ki Woong,Kim, Moon Sun 한국벤처창업학회 2017 벤처창업연구 Vol.12 No.5

Entrepreneurship is an important factor not only for start-ups, but also for scale-up of businesses. In other words, the two aspects of establishment and growth of businesses must be balanced through entrepreneurship. However, it is true that entrepreneurship has been biased toward the former in previous researches and government policies. Here in this research, the causal relationships between the entrepreneurial characteristics of Korean firms and the performance of the company, which is measured by proposal, activity, and business performance are examined as a growth perspective. Based on these relationships, a model describing the operating mechanism of corporate entrepreneurship is derived and policy implications are provided. In conducting research, the hypotheses on the interrelationship of variables are builded using '2016 Entrepreneurship Situation Survey(Corporate)' data from Korea Entrepreneurship Foundation and analyzed by structural equation modeling. In addition, the moderating effect according to the firm size and the mediating effect between entrepreneurship and business performance are analyzed. As a result of this research, the fact that entrepreneurship affects business performance is identified and it is necessary to prioritize corporate vision and strategy for enhancement of entrepreneurship. In particular, necessity of operating system for SMEs is confirmed considering SMEs' entrepreneurship level. The implications of this research are expected to be applied by the government in establishing policy direction to enhance corporate entrepreneurship of SMEs in the future.

정신건강 어려움이 있는 국내 초등학생의 학교-기반 중재

김기웅(Ki-Woong Kim),조선영(Sun-Young Cho) 한국콘텐츠학회 2018 한국콘텐츠학회논문지 Vol.18 No.10

본 연구는 정신 건강에 어려움을 가진 국내 초등학생의 학교기반 중재를 체계적으로 고찰하여 추후 더욱 효과적인 정신건강 관련 학교 기반 중재를 모색하고자 하였다. PRISMA 체크리스트와 흐름도를 통해 체계적 고찰을 시행하였고, 데이터베이스는 한국교육학술정보원, 국가과학기술센터, 국회도서관을 이용하였다. 대상 연구의 중재 특성, 대상자 특징, 평가도구로 분석하였다. 최종적으로 25개의 연구를 선정하였으며, 학교 기반 중재 특징에 따라 심리교육 중재(자기관리기술, 사회기술, 사회정서학습), 행동 중재(긍정적 행동지원, 모델링), 심리치료 중재(미술치료, 상담치료 및 부모교육), 레크리에이션 중재(로봇 중재, 원예치료)로 분류하였다. 연구의 대상자로는 지적장애가 가장 많았고, 주의력 결핍 과잉행동장애가 그 다음으로 많았다. 평가 영역은 주로 정서의 변화, 주의력의 변화를 알아보는 도구가 사용 되었다. 본 연구를 통해 학교기반중재의 연구 분야, 대상자, 평가도구의 근거를 마련하였다. 이는 추후 더욱 효과적인 정신건강 관련 학교 기반 중재를 마련하는데 있어 중요한 기본 자료로 활용 할 수 있을 것이다. The purpose of this study was to find more effective mental health intervention for school based intervention with mental health problem in an elementary school. A systematic review was conducted according to the PRISMA checklist. We accessed databases including RISS, KISS, and the National Assembly Library of Korea. Subject studies were classified according to type of intervention, subject characteristic, and evaluation. Finally, twenty-five studies matched the inclusion criteria. According to types of intervention, it was classified into four types which are psychoeducation(self-management skills, social skills, social emotional learn ing), behavior intervention(positive behavior support, modeling), psychotherapy(art therapy, counseling and parent coaching), and recreation intervention(robot intervention, horticultural therapy). The most of subjects were intellectual disability, the following subjects were ADHD. The most areas of evaluation were emotional change and attention. The findings of this review support school based intervention and provide evidence. And it can be used as an important basic data for preparing more effective mental health-related school-based interventions.

비용에 근거한 공항 사용료 결정에 관한 연구 : 항공기 착륙료 중심

김기웅 ( Ki Woong Kim ),유광의 ( Kwang Eui Yoo ),노요섭 ( Yo Sup Noh ) 한국항공경영학회 2004 한국항공경영학회지 Vol.2 No.2

드론을 활용한 포트홀 보수물량 산출 측정에 관한 연구

김기웅(Kim, Ki-Woong),유무영(Yoo, Moo-Young) 대한건축학회 2022 대한건축학회 학술발표대회 논문집 Vol.42 No.2

n-Hexane 노출에 의한 신경행동학적 증상에 monoamine oxidase(B)와 serotonin transporter receptor 유전자다양성의 영향

김기웅 ( Ki Woong Kim ) 한국산업위생학회 2011 한국산업보건학회지 Vol.21 No.2

Human occupational exposure to n-hexane has been associated with neurobehavioral symptoms such as depression, irritablity, acute irritation symptom, concentration disturbance and fatigue. Effects of monoamine oxidase (MAO) B and serotonin transporter receptor (5-HTTR) polymorphisms on the neurobehavioral symptoms were investigated in 70 male workers from TV and computer monitor manufacturing plants exposed to n-hexane. Neurobehavioral symptoms were assessed through a self-reported questionnaire and ambient level of n-hexane was measured by NIOSH method. Blood and urine were collected from each workers to determine the MAO(B), 5-HTTR and urinary 2,5-hexanedione(2,5-HD). The mean concentration of volatile n-hexane was 18.8±28.8ppm and that of urinary 2,5-HD was 1.07±1.47 ㎎/g creatinine. Statistically significant associations with sexual disturbance were age and smoking. The frequencies of MAO(B) AA, AG and GG were 18.6%, 45.7% and 35.7%, respectively, and the frequencies of 5-HTTR ll, ls and ss genotype were 82.9%, 15.7% and 1.4%, respectively. MAO (B) gene polymorphisms had susceptibility to the neurobehavioral symptoms such as fatigue, concentration disturbance, irritability and acute irritation symptom and 5-HTTR gene polymorphism had susceptibility to the sleep disturbance and acute irritation symptom. On multiple logistic regression analysis for the neurobehavioral symptoms, memory disturbance was significantly associated with smoking(OR=6.752, 95% CI=37.46) and drinking(OR=4.033, 95% CI=1.252-12.98), emotional lability was MAO(B) genotype(OR=0.412, 95% CI=0.170-0.996), fatigue (OR=1.011, 95% CI=1.000-1.021) and acute irritation(OR=0.990, 95% CI=0.981-1.000) were working duration and sexual disturbance were significantly associated with age(OR=1.208, 95% CI=1.042-1.399), ambient n-hexane(OR=1.077, 95% CI=1.005-1.154) and 2,5-HD(OR=0.186, 95% CI=0.041- 0.841). This finding implies that the MAO (B) and 5-HTTR polymorphisms may affect susceptibility for specific neurobehavioral symptoms associated with n-hexane exposure in workers

건설현장의 작업성 향상을 위한 기초적 연구 - 이동식 비계의 연구개발 동향 분석을 중심으로 -

김기웅(Ki-Woong Kim),유무영(Moo?Young Yoo) 한국콘텐츠학회 2022 한국콘텐츠학회논문지 Vol.22 No.11

건설업에서 비계는 다른 공사와 더불어 공사장 안팎의 고소작업에 널리 사용된다. 이동식 비계는 조립과 해체가 쉽고 이동이 간편하지만, ‘전도’, ‘추락’ 등의 안전사고가 발생한다는 결점이 있다. 본 연구는 작업성을 향상시킨 이동식 비계의 개발을 위한 기초적 연구로써, 현재까지 보고된 비계 관련 연구 동향을 정리하고 작업성 관점에서 비계발판에 대한 분석을 실시하였다. 비계를 사용함에 있어 반복적인 작업을 줄이고 세부적인 설치를 간편화하게 된다면, 작업성을 증대시킬 수 있다. 숙련도와 관계없이 안전사고가 발생할 가능성이 있기 때문에 안전성을 중심으로 분석하였다. 그러나 작업성과 안전성을 향상시키기 위한 기술개발을 위해서는 높은 비용이 측정되며, 이를 보완하기 위한 비계 자재의 재사용 또는 재활용을 통한 비용감소가 필요할 것으로 판단된다. In the construction industry, scaffolding, along with other construction works, is widely used for high-rise work inside and outside the construction site. Mobile scaffolding is easy to assemble and dismantle and move, but it has the disadvantage of safety accidents such as “conducting” and “falling.” This study is a basic study for the development of mobile scaffolding that improved workability, and the research trends related to scaffolding reported so far were summarized and the analysis of scaffolding was conducted from the perspective of workability. If repetitive tasks are reduced and detailed installation is simplified in using scaffolding, workability can be increased. Safety was analyzed mainly because there is a possibility of safety accidents regardless of proficiency. However, high costs are measured to develop technologies to improve workability and safety, and it is judged that costs should be reduced through reuse or recycling of scaffolding materials to supplement them.

소상공인의 디지털 전환 촉진에 대한 연구: 소상공인의 디지털 전환 영향 요인 실태를 중심으로

김기웅(Ki Woong Kim),박재성(Jaesung James Park),김준엽(Joon Yeop Kim) 한국경영학회 2020 Korea Business Review Vol.24 No.신년 특별호

본 논문은 도매 및 소매업, 숙박 및 음식점업, 제조업 소상공인 300개 사업체를 대상으로 디지털 전환에 관한 설문조사를 실시하고, 구조방정식 모형을 통해 디지털 전환과 관련된 주요 요인 간의 관계를 검토하였다. 주요 결과는 다음과 같다. 첫째, 소상공인의 디지털 전환에 대한 인식, 디지털 전환을 위한 기술수용성, 디지털 전환을 위한 준비 정도는 대체로 미흡한 것으로 나타났다. 둘째, 디지털 전환을 위한 기술수용성이 디지털전환의사에 미치는 영향과 디지털 전환을 위한 준비 정도가 디지털전환실행에 미치는 영향은 각각 통계적으로 유의하였다. 셋째, 디지털 전환에 대한 인식도 디지털전환의사에 유의하게 영향을 미쳤으나, 디지털 전환을 위한 기술수용성과 디지털 전환을 위한 준비정도에 비해서는 영향력이 작은 것으로 평가되었다. 넷째, 사업주 연령, 사업체 종사기간, 사업체 매출액을 대상으로 디지털전환의사 및 디지털전환실행을 위한 조절효과(Moderation Effect)를 평가한 결과, 사업주 연령이나 사업체 종사기간의 영향은 통계적으로 유의하지 않은 반면, 사업체 매출액의 효과는 유의하였다. 이 같은 결과는 소상공인의 디지털 전환을 위해서는 인프라, 인력, 지식 등과 같은 준비정도 개선과 기술 이해도 및 학습 용이성과 같은 기술수용성 제고가 중요하며, 소상공인의 매출액 수준에 주목해야 함을 의미한다. 또한, 디지털 전환에 대한 인식 개선만으로는 디지털 전환을 촉진하기 어려우며, 기업 성장과 함께 디지털 전환의 필요성이 제고된다는 점에서, 매출액 규모가 큰 소상공인의 디지털 전환에 특히 주목해야 함을 시사한다. In this paper, we surveyed 300 micro enterprises in each main sector and examined the relationship between major factors related to digital transformation using the structural equation model. The main results are as follows: First, the recognition level, technology acceptability, and readiness for digital transformation of micro enterprises were generally insufficient. Second, the effects of technology acceptance for digital transformation on digital transformation willingness and digital transformation readiness on the digital transformation implementation were statistically significant, while the effect of digital transformation recognition on digital transformation willingness was relatively small. Third, the larger the sales volume of micro enterprises, the higher the degree of digital transformation readiness and digital transformation technology acceptance. These results imply that for the digital transformation of micro enterprises, it is important to improve the readiness level such as infrastructure, human resources, knowledge, etc., and increase the acceptability level of technology understanding and technology learning, and pay attention to the sales level of micro enterprises. Increasing awareness of digital transformation alone cannot promote digital transformation, and as the company scales up, the need for digital transformation increases, suggesting that special attention should be paid to digital transformation of micro enterprises with large sales volume.