유리섬유 제조업체 근로자의 건강장해

이세휘,김규상,최정근,김양호,강성규,최경숙,문영한,Lee, Se-Wi,Kim, Kyoo-Sang,Choi, Jung-Keun,Kim, Yang-Ho,Kang, Seong-Kyu,Choi, Kyuong-Suk,Moon, Young-Hahn 대한예방의학회 1996 예방의학회지 Vol.29 No.2

The industrial use of MMMF(man-made mineral fibers), has been increasing, particularly since the banning of most asbestos products. Fibrous minerals can cause health abnormalities currently associated with occupational exposure to glass fiber. This study was conducted to evaluate health risks of glass fiber manufactory workers within the country. We examined questionaries, physical examination including auscultation, chest x-ray, pulmonary function test for 488 male workers, to go through their dermal itching symptoms and respiratory evaluation. we had the results as follows. 1. In 45% of the workers itching had been expressed at their entrance. At that time we was investigating, 18.5% had itching, and most of them complained it when they fall asleep and night. The Sequent itching site is waist and groin, upper and lower extremity in order, and it had been expressed mainly during summer and winter. 2. As the results of ventilatory functions test, 6.0% were obstructive type, 1.0% were restrictive type. So, glass fiber exposures should be controlled or elimination by protective devices in the workplace. 3. The means of FVC, $FEV_1,\;FEV_1%$ were in normal range. As the comparison of ventilatory functions by age groups, MMF was decreased significantly for the group, 50 years old and more than other groups. And the comparison by the serving periods at glass fiber producing factory, MMF was decreased for the workers had worked for $11\sim15$ years. Therefore, MMF be more sensitive index in the evaluation of ventilatory impairments caused by glass fiber workers.

경견완 장애를 보이는 영상 단말기근로자들의 심리적 특성에 따른 분류와 업무지각특성

조선미,이세휘,임기영,이명숙 용인정신의학연구소 1999 용인정신의학보 Vol.6 No.2

곡물사료 취급 근로자의 곡물유발 천식 위험요인에 관한 연구

김은아,김규상,이세휘,박해심 大韓産業醫學會 1997 대한직업환경의학회지 Vol.9 No.4

This study was carried out to manifest risk factors related grain dust induced asthma, especially allergic and immunologic factors. Six grain workers first diagnosed as grain dust induced asthma by specific antigen bronchial asthma challenge test(cases) and 37 grain workers showed negative finding(controls) in the same firm were selected. Questionnaire survey for respiratory symptoms, interview, physical examination, PFT, methacholine bronchial hyperresponsiveness, specific challenge test, and skin prick test for four grains(grain, corn, rye and seed dust) were conducted. To evaluate the role of specific antibodies to grain dust, we detected serum specific IgE and IgG antibodies by ELISA in 43 employees. The results were summarized as follows: 1. Compared with the group having no respiratory symptoms, odds ratio of grain dust induced asthma with respiratory symptoms was 3.04(95% CI 0.32-28.80). 2. Compared with the group having no ventilatory impairment, odds ratio of grain dust induced asthma with ventilatory impairment was 0.54 (95% CI 0.06-5.21). 3. Compared with the group showed negative skin test for general respirable antigen, odds ratio of grain dust induced asthma with atopy was 8.02(95% CI 0.42-153.25). 4. Compared with the group showed negative finding on specific allergic skin test, odds ratio of grain dust induced asthma with positive finding was 5.88 (95% CI 0.63-55.38). 5. In immunologic test, compared with the group not increased total IgE(<160 IU/ml), odds ratio of grain dust induced asthma with increased group (≥160 IU/ml) was 4.78(95%CI 0.50-44.57). 6. Compared with the group showed negative finding on specific IgE antibody, odds ratio of grain dust induced asthma with positive finding was 2.63(95% CI 0.43-16.16). 7. Compared with the group showed normal finding on nonspecific(methacholine) bronchial hyperresponsiveness, odds ratio of grain dust induced asthma with positive finding was 76.82(95% CI 3.37-1566.34). Statistically significant odds ratio were found for specific skin test with grain, total IgE and nonspecific(methacholine) bronchial hyperreponsiveness.

상지 단순반복 작업자의 수근관증후군에 대한 연구

진미령,최용휴,이세휘,김규상 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.4

The objectives of this study were to investigate the prevalence and risk factors of occupationally related carpal tunnel syndrome(CTS) among workers employed in services and manufacturing industries analysing the sensitivity and specificity of clinical symptoms and signs. Three surveys were made for this study. The first survey was done for 1,447 workers employed by 25 companies. The jobs of the employees were repetitive works at VDT and assembly lines. Therefore, employees could be divided to two groups, doing repetitive works and non repetitive works. The second survey was made for 189 workers who were randomly selected from 517 workers complained some symptoms at their hands and wrists. We examined their symptoms and carried out neurological examinations for CTS(Tinel's sign, Phalen's sign, pin prick test, carpal compressive test, toniquet compression test). The third survey was made for nerve conduction study(NGS) for 57 workers who had shown positive signs for CTS. The main results of this study were as follow: 1. From the first survey, we have found that there were significant statistical differences in getting uncomfortable neuromuscular symptoms by sex, job type, total working hours during a week, duration of current work, and kinds of work. Odds ratio in male vs female, repetitive vs non repetitive, service vs manufacturing companies, total working hours during a week, and duration of current work were 1.867(95% CI=1.467-2.377), 1,680(95% CI=1.121-2.279), 1.663(95% CI=1.123-2.279), 1.016(95% CI=1.006-1.027) and 1.283(95% CI=1.097-1.501) respectively. 2. From the second survey, we have found that 46 peoples (25.0%) were positive for one or more than one signs in neurological examination of NIOSH criteria. Positive findings from neurological examinations were high among workers of low level of education(p-value=0.008), manufacturing jobs(p-value=0.00), long hours a week(p-value=0.028), and long duration of current work(p-value=0.00). 3. From the third survey, we diagnosed 35 peoples (61.4%) had CTS by NCS. They had abnormally delayed latent period or velocity in median nerve conduction velocity.

황화수소 중독증 2례

김종구,이경종,이세휘,박재범 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.1

평택시에 위치한 펄프 회사에서 탱크 내부를 청소하고자 근로자가 탱크 속으로 들어가는 도중 의식을 잃었다. 펄프제지 과정에서 유기물질의 발효로 인하여 유해한 가스가 발생한다. 발생할 수 있는 가스의 종류에는 이산화탄소(CO₂), 일산화탄소(CO), 암모니아(NH₃), 황화수소(H₂S) 그리고 메틸 머캅탄(methyl mercaptans, CH₃SH) 등이 있다. 작업환경 측정전 이러한 가스들이 존재할 것으로 추정하였으나 실제적으로 황화수소와 일산화탄소만 검출되었을 뿐 암모니아와 메틸 머캅탄은 측정되지 않았다. 그런데 상기 환자들에 있어서 HbCO이 정상 범주이므로 일산화탄소의 중독은 배제할 수 있었다. 따라서 황화수소 중독에 의한 의식소실임을 알 수 있었다. Hydrogen sulfide poisoning is frequently encountered in the workplace. Two workers lost their consciousness In an underground tank at a factory producing paper. The tank contained liquid mixture of used paper, sodium oxygenate chloride (NaOCl), and sodium thiosulfate pentahydrate(Na₂S₂O₃.□H₂O). A worker(worker A; 36-year-old man) entered tank to remove sludge. When worker A lost his consciousness, worker B entered the tank to rescue worker A, however he lost consciousness inside the tank. We discuss in detail the clinical features of this condition. Hydrogen sulfide poisonings have occurred in industries involving petroleum refining, the manufacture of heavy water, tanning of hides, vulcanization of rubber, and the manufacture of rayon. And it is necessary to stress the health education for workers and managers in these industries.

항공기 소음이 지역 주민들에게 미치는 건강영향

이경종,장재연,박재범,조선미,이세휘,김종구,이순영,곽정자,정호근 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.4

Objectives : This study was conducted to reveal the health effects of aircraft noise on the residents live near the military airport. Methods : We sampled systematically 87 residents as the high exposed group, 58 residents as the low exposed group according to the geographical distance from the airport. We also sampled 67 residents as the control group lived far from the airport. Noise levels were measured for conform the exposures. Self-administered questionnaires for symptoms, air conduction hearing threshold level, blood pressure blood cholesterol with health examinations, and SCL-90-R were introduced to get the data from the residents. Results : The Ld/n at the area near the airport was 72.4 dB, however that of control area was 67.7 dB. The value of pure tone average, high pure tone average, and threshold of 4,000 Hz were decreased with exposure level significantly. Linear regression analysis showed that the noise exposure level of the airport was related to the hearing threshold at pure tone average, threshold of 4,000 Hz, and high pure tone average. The systemic and diastolic blood pressure showed dose-response relationship with noise exposure. The prevalence of hypertension was higher in exposed group, but not statistically significant. In linear regression, noise level was related to systolic and diastolic blood pressure with other variables such as age, sex, BMI(Body Mass Index), and family history of hypertension. SCL-90-R showed that exposed group had higher score significantly in neurotic and psychologic variable and felt the various somatic symptoms. Conclusions : These results suggest that aircraft noise would influence hearing loss at low frequencies as well as 4,000 Hz and higher frequencies, systolic and diastolic blood pressure, and psychological response.

Isocyanates 폭로 근로자들의 기관지 과민성

최경숙,김규상,최병순,최정근,이세휘,문영한,Choi, Kyeong-Sook,Kim, Kyoo-Sang,Choi, Byung-Soon,Choi, Jung-Keun,Lee, Se-Hui,Moon, Young-Hahn 대한예방의학회 1996 Journal of Preventive Medicine and Public Health Vol.29 No.1

We studied the association of nonspecific bronchial hyperresponsiveness with general characteristics, exposure concentration, respiratory symptoms, chest x-ray findings, past histories and pulmonary function. We determined bronchial hyperresponsiveness by methacholine challenge test. And we conducted a respiratory symptom questionnaire and performed spirometry on 111 workers occupationally exposed to isocyanates in various industries. About 21.6% of subjects had bronchial hyperresponsiveness. No significant differences were observed between the hyperresponsive and non-responsive group with respect to age, sex, employment period, height, and smoking histories. Cough and breathlessness were significantly associated with the bronchial hyperresponsiveness. The hyperresponsive group had more experience of bronchitis and asthma in the past than the non-responsive group. The lower $FEV_1\;and\;FEV_1%$ were closely related with bronchial hyperresponsiveness. Bronchial hyperresponsiveness seems to be associated with some of respiratory symptoms, past histories and pulmonary function parameters in workers exposed to isocyanates.

Ethanol이 Trichloroethylene 대사효소의 활성도와 유도성에 미치는 영향

김기웅,강성규,조영숙,이세휘,문영한,최병순,박상신,Kim, Ki-Woong,Kang, Seung-Kyu,Cho, Young-Sook,Lee, Sei-Hui,Moon, Young-Hahn,Choi, Byung-Soon,Park, Sang-Shin 대한예방의학회 1995 Journal of Preventive Medicine and Public Health Vol.28 No.1

This study was performed to find out the influences of ethanol on the metabolism of trichloroethylene(TRI) in rats. TRI in corn oil at the dosage of 150, 300, 600 mg/kg was injected peritoneally once a day for two days to two groups. In one group ethanol(4 g/kg) was taken orally 30 minutes before TRI injection, and the other group ethanol was not. The results of experiments are as follows: 1. The contents of cytochrome P-450 and $b_5$ had inverse relationship with in-jected TRI amounts in both groups. 2. The activity of NADPH P-450 reductase was decreased slowly in TRI injected group related with TRI amount, but decreased drastically in the group pretreated with ethanol. 3. The activity of NADH $b_5$ reductase had relationship with injected nt amount , but the statistical significance was found only in the groups of 300 and 600 mg/kg of TRI injected without relevance to ethanol when compared with the group that was not injected. 4. The activity of ADH was more decreased and ALDH activity was more increased in groups that TRI injected and ethanol was pretreated with ethanol groups than in group without any treatment. These results suggest that ethanol may inhibit epoxide formulation, the first step of TRI metabolism, and change from TCE-OH to TCA also.

근골격계 위험요인이 농부증에 미치는 영향

박재범(Jae-Beom Park),이경종(Kyung-Jong Lee),이세휘(Se-Wi Lee),김종구(Jong-Goo Kim),정호근(Ho-Keun Chung) 한국농촌의학 지역보건학회 2000 농촌의학·지역보건 Vol.25 No.1