韓牛 肥育促進을 위한 Cobalt(Co) 給與效果에 關한 硏究

尹熙燮,吳世正,姜昌鎭,金時明 건국대학교 1978 學術誌 Vol.22 No.1

For an increase of body weight, feed efficiency, and profitability of Korean cattle fattening through the effective fattening of the Korean cattle concentrates with an addition of 0.05 mg of cobalt for test plot I, 0.05 mg of cobalt for test plot II 0.10 mg, and 0.15 mg for test plot III, per kg of concentrate were given to sampled cattle. Experiments were designed to repeat control plot and three test plots (I, II, III) five times far 140 days on the 20 cattle sampled by completely randomized design. The results of the experiments are presented in the following. I. Amount of Body Weight Gain The average weight gain per head, and weight gain per day are commonly highest in the test plot II (132.6 kg ㆍ 0.92 kg), second in the test plot I (128.5 kg ㆍ 0.91 kg), third in the test plot III (121.1 kg ㆍ 0.87 kg), and lowest in the control plot (120.4 kg ㆍ 0.87 kg). The rull hypothesis was accepted while there was no statistical significance between the test plots and the control plot, and also among the test plots. But the test plots with an addition of cobalt resulted in higher gain of body weigh comparing to that of the control plot. II. Amount of Feed Intake and Feed Effeciency The efficiency of concentrate required to increase on Kilogram of beef was highest in the test plot II 6.42 kg, second in the test plot I 6.53kg, third in the test plot III 7.00 kg, and lowest in the control plot 7.18 kg respectively. In case of flay and pellets the test plot I showed the highest weight gain, the test plot II, and III resulted in the same performance, and the control plot was the lowest one in the gain of body weight. There was no statistical significance between the test plots and control plot, and among the test plots. Thus, the test plots with ail addition of cobalt comparing to the control plot resulted in a higher feed efficiency. III. Profitability Feed costs required to increase one Kilogram of fresh meat was 636 casts won in the test plot II, 641 won in the test plot I, 685 fresh meat won in the test plot III, and 703 won in the control plot respectively. While there was no statistical significance with profitability, the test plot with an addition of cobalt required lower feed cost increase one kilogram if fresh meat comparing to the control plot. IV. Fattening outcome Of the sampled 20 cattle 18 cattle were slaughtered after 6 days from the last day of the tests. The carcass rate of the sloughtered cattle was 56.4 percent in the test plot II, 55.0 percent in the test I, 54.8 percent in the test plot III, and 54.6 percent in the control plot. There was no statistical significance with the rate of carcass, but the test plats with an addition to cobalt presented a little higher carcass rate comparing to the control plot. It was rather difficult to distinguish meat color with eyes, but comparing to the control plot the meat color of the test plots was heavily red.

基礎單位 敎育自治制度 模型 開發과 關聯된 變數

오세윤,이강 호남대학교 1998 호남대학교 학술논문집 Vol.19 No.1

The purpose of this study is to extract major variables which are necessary when we try to design a model of local educational autonomy system. Considering the political and social condition in Korea since 1990, the system should be operated, but the impact of so called IMP system is delaying it. For this purpose, I reviewed major concerning theories and practices in the developed countries such as US, France, Germany, Japan. The major variables, that should be considered in the model, are geographical or land unit, the relationship between administrative and educational organizations within the same or neighboring district, the functions of educational committees, the methods of selecting educational committee members, the status and selecting method of educational district head, relationship with current administrative district, personnel and management system, school committee and so on. The content of this model made here using these variables will be discussed and tested in the future study.

자가 면역성 간염에서 자가항체의 발현 양상과 스테로이드 치료의 효과

박기오,채경훈,허원석,강윤세,정재훈,김연수,문희석,이엄석,김선문,이병석,김남재,이헌영 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

목적 : 최근 8년간 본원에서 경험한 자기면역성 간염의 혈액학적 특징과 스테로이드의 치료효과를 알아보고자 본 연구를 시행하였다. 방법 : 1996년 이후부터 2002년까지 충남대학교 병원에서 1999년 International Autoimmune Hepatitis Group(LAHG)에서 제시한 수정 진단 기준안에 의거하여 총 진단점수가 probable 이상에 해당하는 환자들을 대상으로 임상적 특징, 검사실 및 조직 소견과 스테로이드와 azathioprine의 치료 효과를 후향적으로 조사하였다. 결과 : 9예의 환자들은 여성이 78%, 40대가 많았고, 급성 발병이 33.3%, 피로감, 식욕부진 및 황달 등이 나타났으며, 항핵항체가 55.6%에서 그리고 항평활근 항체가 77.8%에서 양성이었고, 동반 질환은 류마치스 관절염이 2예, 특발성 혈소판 감소증 1예, Henoch-Sch nlein 자반증 및 그레브스병이 각각 1예 씩이었다. 7예에 대해서 스테로이드와 azathioprine으로 치료하여 생화학적 임상적 완해가 이루어져서 유효한 치료 결과를 얻었다. 결론 : 자가면역성 간염은 우리 나라에서 원인을 찾을 수 없는 만성 간질환의 경우, 특히 중년여성에서 다른 자가면역성 질환이 동반되었을 때 자가면역성 간염을 의심하여 자가항체 선별검사를 시행해 보아야 할 것으로 생각된다. 향후 다기관 연구를 통하여 좀 더 많은 증례를 모으고 전향적인 연구를 시행하여야 할 필요가 있다. Although autoimmune hepatitis(AIH) is common in western contries, some studties have been reported in Korea. The aim of the study was to analyze the clinical and histological features and expression pattern of the autoantibody and to examine clinical course of AIH in Korea. For 9 patients diagnosed as having AIH in our hospital since 1996, we reviewed medical records and analyzed clinical and laboratory findings retrospectively. They had a probable or definite AIH according to the revised criteria of International AIH group. The mean age was 42.7(21∼68)years and 7(77.8%) were female. Three of them(33.3%) showed acute hepatitis and five of them showed cirrhosis. Fatigue and anorexia were the most frequently complained symptoms(55.6%). Four patients(44.4%) were accompanied with other autoimmune diseases. Antinuclear antibody was detected in 5(55.6%) and anti-smooth muscle antibody was detected in 7(77.8%). Three patients showed focal picemeal necrosis and four showed periportal fibrosis. Among 7 patients who received immunosuppressive therapy, six patients(85.7%) showed initial response. and biochemical and serologic remission were achived in 5(71.4%) and 3(42.8%) patients, AIH seems to be partly responsible for chronic liver disease of unknown etiology in Korea. AIH should be suspected in female patients with unknown chronic liver disease of unknown etiolgy, especially accompanied with other autoimmune disease. The clinical characteristics of AIH may not be quite different from those of Western countries.

간세포암과 감별이 어려웠던 악성중피종 치험 1예

김선문,허원석,채경훈,강윤세,정재훈,김연수,박기오,문희석,이엄석,김석현,성재규,이병석,이헌영,신경숙,조준식,송인상,강대영 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

Malignant peritoneal mesothelioma is a rare neoplasm that arises from the mesothelium of a serosal cavity and is a rapidly fatal disease with a median survival of 4 to 12 months for untreated cases. Recently, we experienced a case with malignant peritoneal mesothelioma who was suspected hepatocelluar carcioma by abdominal CT scan and was confirmed by biopsy including immunohistochemical stain(calretinin) after surgery. We performed tumor excisions and wedge resection of the liver(segment Ⅷ)and inserted Tencoff catheter in abdominal cavity at 25th day of post-operation. We treated with intraperitoneal paclitaxel(25mg/m^(2)/day for 5 days) six courses monthly. She was well tolerable and is still living without any evidence of recurrence for 14th month of post-operation.

Gilbert 증후군에서 열량 제한 시험과 Phenobarbital 자극 시험의 의의(14예)

이헌영,채경훈,정재훈,강윤세,김연수,문희석,박기오,이엄석,김선문,김석현,성재규,이병석,이강욱 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

Gilbert 증후군은 인구의 7%에서까지 나타날 수 있는 매우 흔한 증후군으로서 비진행성인 양성의 만성적 경과를 치하며, 간질환의 증상과 징후가 없는 경한 비포합형 고빌리루빈혈증이 특징인 일종의 체질적인 증상으로서 혈장 빌리루빈 농도에 대한 사춘기의 영향 때문에 10대와 20대에 자주 진단이 된다. 따라서 임상적인 중요성은 미약하지만 높은 빈도가 예상되는 점에 그 중요성이 부여되어야 할 것이다. 따라서 적정한 임상적 진단법으로 기왕에 소개된 열량제한 시험과 phenobarbital 유도 시험을 시행하고 이들의 진단적 가치를 알아보기 위하여 본 연구를 시행하였다. 1990년 7월부터 1999년 4월까지 충남대학교병원에 내원하여 HBsAg, IgG anti-HBc 및 anti-HCV가 음성이고, 간 초음파 스캔에서 이상이 없으며, 혈청 AST, ALT 및 AP가 정상인 비음주자에서 경한 비포합형 고빌리루빈혈증이 있는 14예의 환자들을 대상으로 ^(99m)Tc-DISID 스캔을 시행하였으며, 기저 치 총빌리루빈 및 포합형 빌리루빈 치를 측정한 다음에 하루에 400Kcal로 48시간동안 제한한 열량 제한 시험을 시행하였고, phenobarbital을 하루 60mg씩 5일간 투여한 후에도 각각 총빌리루빈과 포합형 빌리루빈 치를 검사하여 비포합형을 구하였다. 대상 환자들은 모두 14예로서 남자가 11예(78.6%)였고 여자가 3예(21.4%)여서 3.7:1로 남자에서 많았으며, 20대가 6예(42.9%), 30대가 역시 6예(42.9%) 및 40대가 2예(14.2%)로서 2,30대가 대부분(85.8%)이었다. 열량 제한 시험 후의 총빌리루빈 치, 비포합형 및 포합형 빌리루빈 치들은 평균 각각 5.5±2.7, 4.2±2.3 및 1.3±10mg/dL 로서, 시험 전 치들인 3.0±0.8, 2.2±0.8 및 0.7±0.4mg/dL 보다 유의하게(p=0.001, p=0.001, p=0.023) 상승하였다. 포합형 빌리루빈 치도 유의하게 상승하였으나 비포합형의 상승보다는 훨씬 낮아서 주로 비포합형이 증가하였다. phenobarbital 투여 중 설사가 발생하여 중단한 1예를 제외한 13예에서 열량 제한 시험 후에 상승하였던 총, 비포합형 및 포합형 빌리루빈 치가 phenobarbital 유도 시험후에는 2.0±1.1, 1.5±0.8 및 0.5±0.4mg/dL로서 열량 제한 시험 결과보다 유의하게 낮아졌고(p=0.00, p=0.000, p=0.001), 열량 제한 시험 전의 기초치들인 3.0±0.8, 2.2±0.8 및 0.7±0.4mg.dL 보다도 더욱 낮아졌으며 유의한 차이(p=0.001, p=0.02, p=0.005)를 나타내었다. 14예에서 시행한 ^(99m)-Tc DISIDA 스캔에서 9예(64.3%)가 정상이었고, 5예(35.7%)에서는 심장 및 신장으로의 간외 섭취가 3예였고, 60분까지 소장 배출이 없는 배설 지연 예와 담낭 수축 불량 예가 각각 1예 씩 발견되었다. Phenobarbital 투여시험에서 민감도가 열량제한시험에 비해 더 높았다(92.3%와 50.0%). Gilbert 증후군에서 1일 400 Kcal로 48시간의 열량제한 시험과 1일 60mg의 phenobarbital을 5일간 투여하는 유도 시험은 편리하고 유용한 임상적인 진단법으로 이용할 수 있다고 생각된다. 그러나 열량 제한 시험에서는 증가 기준의 통일이 필요하다고 유추되며 phenobarbital 유도 시험이 민감도가 더 높은 것으로 생각된다. Gilbert's syndrome is very frequent and benign chronic process characterized by mild, intermittent, unconjugated hyperbilirubinemia without any symptom and sign of liver disease. Previously intoduced caloric restriction test and phenobarbital stimulation test as two appropriate clinical tests had been examined and their diagnostic values were reevaluated. Fourteen patients with mild, persistent, unconjugated hyperbilirubinemia were included. Subsequently caloric restriction has been applicated by 400 Kcal/day for 48 hours and phenobarbital has been prescribed by 60 mg/day for 5 days. Therafter serum levels of total and direct bilirubin were measured. Most of the patients were third and fourth decade(85.8%) and male predominant. Each basal serum levels of total, indirect and direct bilirubin were 3.0±0.8, 2.2±0.8 and 0.7±0.4 mg/dL. After caloric restriction test, each levels were increased significantly to 5.5±2.7, 4.2±2.3 and 1.3±1.0 mg/dL(p=0.001, p=0.001, p=0.023). After phenobarbital stimulation test for 13 patients had been practiced, increased levels of each bilirubin after caloric restriction test were decreased significantly to 2.0±1.0, 1.5±0.8 and 0.5±0.4 mg/dL(p=0.000, p=0.000, p=0.001) and these levels were significantly lower than basal levels(p=0.001, p=0.02, p=0.005). The sensitivities of caloric restriction test were 85.7%, 50.0%, and 71.4%, 35.7%(1.0, 1.5 mg increase of total bilirubin and 1.0, 1.5 mg/dL increase of indirect bilirubin). The sensitivities of phenobarbital stimulation test were 93.2% and 92.3% at criteria of 1.5 mg/dL increase of total bilirubin and indirect bilirubin. On the diagnosis of Gilbert syndrome, caloric restriction test and phenobarbital stimulation test are convenient and useful diagnostic tools in clinical face. And also phenobarbital stimulation test has higher sensitivity than caloric restriction test. Furthermore, standardization of bilirubin increment would be necessary in caloric restriction test.

Insectisidal activity and feeding behavior of green peach aphid, Myzus persicae against bio-nano type of Pyrifluqinazon

Kang, Min Ah,Kyu Sik Yoon,Hye Ri Kwon,Min Woo Park,Shin Hyuk Jo,Shin Hyo Seob,Sae Hee Kim,Eun Jin Kang,Mi Ja Seo,Yong Man Yu,Young Nam Youn 한국응용곤충학회 2010 한국응용곤충학회 학술대회논문집 Vol.2010 No.10

Pyrifluquinazon, as a quinazinalone chemical group, based on a new mode of biological activity. It is reported that mode of action is modifies insect behavior, rapidly stopping feeding such that insects starve to death. Time-release feature and mortality effect on M. persicae using different pyrifluquinazon nano type and non-nano type were compared. Pyrifluquinazon nano type was formulated with different molecular weight and density of used chitosan (CS 30000 0.1% and CS 3000 0.3%). In the CS 30,000 0.1%, the mortality was weakly occurred at early time, but steadily increased after 4days. Finally, we confirmed more than 70% mortality as a peak at 16days. In CS 3000 0.3%, the mortality showed about 70% until 18days as a effective controlled release. Also, We examine time-release feature and mortality effect on M. persicae according to the different pyrifluquinazon nano type(CS 30000 0.1% and CS 3000 0.3%) of concentrations. The CS 30000 0.1% bioassay results of different concentration were showed that the highest concentration(100ppm) was measured better mortality than other concentration at 0 day, but cannot confirm different effect about dissimilar concentration. However, increasing rates of M. persicae were low as treatment concentrate was high. In CS 3000 0.3% 100ppm concentration bioassay result, aphid mortality reached peak at 24 days and increasing rate also low. Additionally, for the comparing of bioassay and feeding behavior of M. persicae against pyrifluquinazon nano types and non-nano type, EPG technique was carried out. In case of non nano type, feeding inhibition efficacy was showed during 4 days after treatment, but appeared similar level with control after 10days. In CS 3000 0.3% 50ppm, residual efficacy was specially showed until 28days after treatment whereas treatments with CS 30000 0.1% were similar to the control after 22days. These result show that the change of feedinng behavior and motrality of M. persicae is correlated with the change of nano type or non nano type of pyrifluquinazon.

Dietary assessment and the development of asthma in Korean adolescents and adults

Kang, Sung-Yoon,Song, Woo-Jung,Kim, Min-Hye,Kim, Sae-Hoon,Cho, Sang-Heon,Chang, Yoon-Seok,Yang, Min-Suk Wiley (Blackwell Publishing) 2018 Allergy Vol.73 No.11

A Study on Irrigating Solution in Neurosurgery

Yoon, Kang Joon,Oh, Sae Moon,Choi, Sun Kil,Kang, Seoung Koo 대한신경외과학회 1988 Journal of Korean neurosurgical society Vol.17 No.4

신경외과영역에서 수술시 사용되는 관류액이 뇌척수액의 전해질 성분에 가까운 것이 좋은 것은 자명하다. 관습적으로 사용되어오던 식염수는 등장액이지만 pH는 5-7, 그리고 비완충 용액이어서 이에 노출된 환부는 약산성 상태가 되어 결국은 뇌표피층에 불리한 조직변화를 초래한다. 본 연구에서 제안된 Glutathione-Bicarbonate-Ringer's Plus(GBR-Plus)용액은 안정된 pH(7.2±0.4)의 완충용액이다. 기관마취하의 쥐에서 개두술후 뇌표피에 생리식염수로 관류한 군과 GBR-Plus용액으로 관류한 군을 비교 관찰하였다. 광학현미경상에서는 별 차이가 없었으나, 전자현미경상에서는 GBR-Plus군에서 혈관주위조직이 정상에 가깝게 보존되었고 핵 주위 공포도 적었다. 또한, 비외상성 환자의 임상적 추시에서 수술후 경추 또는 요추천자로 4, 12, 24 그리고 48시간에 얻은 뇌척수액의 pH 및 전해질 비교에서 GBR-Plus로 관류한 군에서는 pH는 정상범위를 유지하였고, Na^(+), K^(+), HCO₃^(-) 그리고 Cl^(-)의 전해질은 생리식염수군보다 빠르게 정상범위로 돌아왔다. 비록 예비적인 연구보고이지만 GBR-Plus 용액은 비교적 쉽게 준비할 수 있고 관류액으로서 우수하다고 사료되어 보고하는 바이다.

「류마치스性」關節炎 193例에 對한 臨床的 考察

姜世潤(Sae Yoon Kang),韓文植(Moon Sik Hahn) 대한정형외과학회 1967 대한정형외과학회지 Vol.2 No.3

사지 관절운동 제한에 대한 임상적 고찰

강세윤(Kang Sae yoon),소병겸(So Byong Kyoum) 대한정형외과학회 1976 대한정형외과학회지 Vol.11 No.2