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대장 선종과 암의 동시성 병변에서 K-ras 유전자의 돌연변이 및 k-Ras, p16, Cyclin D1과 p53 단백질의 발현
오용열 ( Y. L. Oh ),전훈재 ( H. J. Chun ),박동규 ( D. K. Park ),박재홍 ( J. H. Park ),박철희 ( C. H. Park ),진윤태 ( Y. T. Jeen ),이홍식 ( H. S. Lee ),이상우 ( S. W. Lee ),엄순호 ( S. H. Um ),최재현 ( J. H. Choi ),김창덕 ( C. D. Kim 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
<Background> The colorectal adenoma-carcinoma sequence represents a well-known paradigm for the sequential development of cancer driven by the accumulation of genomic defects, Although the colorectal adenoma-carcinoma sequence is well established, the stu
Control of Thermoelectric Properties through the addition of Ag in the Bi0.5 Sb1.5 Te3Alloy
( J. K. Lee ),( S. D. Kim ),( M. W. Oh ),( S. H. Cho ),( B. K. Min ),( H. W. Lee ),( M. H. Kim ) 대한금속재료학회 ( 구 대한금속학회 ) 2010 ELECTRONIC MATERIALS LETTERS Vol.6 No.4
In this study, the thermoelectric properties of the Ag-doped Bi0.5Sb1.5Te3 compounds were investigated in the temperature range from 323 K to 573 K. Ingots were fabricated by a conventional melting process and the powder crushed from ingots was then sintered using a hot-pressing method. The temperature dependence of the Seebeck coefficient and the electrical conductivity of the Ag-doped Bi0.5Sb1.5Te3compound are characteristic of degenerate semiconductors, which is fairly different from the conventional Bi0.5Sb1.5Te3 compound. The power factor (α 2 σ) of the quaternary compound was larger than that of the ternary, which is mainly due to the increase in the electrical conductivity with doping content of Ag. The thermal conductivity was greater than that of the Ag-freeBi0.5Sb1.5Te3compound in the temperature range from 323 K to 523 K. The lattice thermal conductivity showed low values throughout the temperature range. The maximum value of the dimensionless figure of merit (ZT) of the 0.05 wt. % Ag-doped compound and the ternary alloy were 1.2 at 373 K and 0.88 at 323 K, respectively. Each of the maximum peak ZT shifts to a higher temperature region with increases in the doping content of Ag. This is likely due to the control of the lattice thermal conductivity by the twin structure, which had a nano-ordered layer.
Yu, K‐,H.,Hong, K‐,S.,Lee, B‐,C.,Oh, M‐,S.,Cho, Y‐,J.,Koo, J‐,S.,Park, J‐,M.,Bae, H‐,J.,Han, M‐,K.,Ju, Y‐,S.,Kang, D‐,W.,Appelros, P. Blackwell Publishing Ltd 2011 Acta neurologica Scandinavica Vol.123 No.5
<P>Yu K‐H, Hong K‐S, Lee B‐C, Oh M‐S, Cho Y‐J, Koo J‐S, Park J‐M, Bae H‐J, Han M‐K, Ju Y‐S, Kang D‐W, Appelros P, Norrving B, Terent A. Comparison of 90‐day case‐fatality after ischemic stroke between two different stroke outcome registries using propensity score matching analysis. Acta Neurol Scand: 2011: 123: 325–331. © 2010 John Wiley & Sons A/S.</P><P><B>Background – </B> It has not been clarified whether the disparity in ischemic stroke outcome between populations is caused by ethnic and geographic differences or by variations in case mix. Propensity score matching (PSM) analysis can overcome some analytical problems but is rarely used in stroke outcome research. This study was to compare the ischemic stroke case‐fatality between two PSM cohorts of Sweden and Korea.</P><P><B>Methods – </B> Prognostic variables related to baseline characteristics and stroke care were included in our PSM model. Then, we selected 7675 Swedish and 1220 Korean patients with ischemic stroke from each stroke registers and performed one‐to‐one matching based on propensity scores of each patient.</P><P><B>Results – </B> After PSM, all measured variables were well balanced in 1163 matched subjects, and the 90‐day case‐fatality was identical 6.2% (HR 0.997, 95%CI 0.905–1.099) in Sweden and Korea.</P><P><B>Conclusions – </B> No difference is found in the 90‐day case‐fatality in propensity score‐matched Swedish and Korean patients with ischemic stroke.</P>
Eugenol Inhibits K<sup>+</sup> Currents in Trigeminal Ganglion Neurons
Li, H. Y.,Park, C.-K.,Jung, S. J.,Choi, S.-Y.,Lee, S. J.,Park, K.,Kim, J. S.,Oh, S. B. SAGE Publications 2007 Journal of dental research Vol.86 No.9
<P>Eugenol, a natural capsaicin congener, is widely used in dentistry. Eugenol inhibits voltage-activated Na<SUP>+</SUP> and Ca<SUP>2+</SUP> channels in a transient receptor potential vanilloid 1 (TRPV1)-independent manner. We hypothesized that eugenol also inhibits voltage-gated K<SUP>+</SUP> currents, and investigated this in rat trigeminal ganglion neurons and in a heterologous system using whole-cell patch clamping. Eugenol inhibited voltage-gated K<SUP>+</SUP> currents, and the inhibitory effects of eugenol were observed in both capsaicin-sensitive and capsaicin-insensitive neurons. Pre-treatment with capsazepine, a well-known antagonist of TRPV1, failed to block the inhibitory effects of eugenol on K<SUP>+</SUP> currents, suggesting no involvement of TRPV1. Eugenol inhibited human Kv1.5 currents stably expressed in <I>Ltk</I><SUP>−</SUP> cells, where TRPV1 is not endogenously expressed. We conclude that eugenol inhibits voltage-gated K<SUP>+</SUP> currents in a TRPV1-independent manner. The inhibition of voltage-gated K<SUP>+</SUP> currents is likely to contribute to the irritable action of eugenol. Abbreviations: human Kv1.5 channel, hKv1.5; transient receptor potential vanilloid 1, TRPV1.</P>
Association of Sequence Variations in DGAT 1 Gene with Economic Traits in Hanwoo (Korea Cattle)
Kong, H.S.,Oh, J.D.,Lee, J.H.,Yoon, D.H.,Choi, Y.H.,Cho, B.W.,Lee, H.K.,Jeon, G.J. Asian Australasian Association of Animal Productio 2007 Animal Bioscience Vol.20 No.6
The effects of diacylglycerol O-acyltransferase (DGAT1) candidate gene polymorphism on the economic traits of Hanwoo were studied. Through sequencing analysis, two polymorphism sites at K232A and T11993C were established and were analyzed by PCR-RFLP. The PCR-RFLP analysis for K232A showed that the frequencies of alleles K and A were 0.75 and 0.25, respectively, and the frequencies of genotypes for K/K, K/A and A/A were estimated as 0.509, 0.491 and 0, respectively. In the PCR-RFLP analysis for T11993C, we found allele frequencies of 0.773 and 0.227 for T and A, respectively, and 0.546, 0.454 and 0 for the T/T, T/C and C/C genotype frequencies, respectively. No significant effects on economic traits in Hanwoo were found in the separate analysis of K232A and T11993C polymorphisms, but the interaction between K232A and T11993C showed a significant effect (p<0.005) on marbling score. The DGAT1 candidate gene was found to have a significant effect not only on milk yield and component traits but also on the metabolism of intramuscular fat.
Hong, S.H.,Nam, H.K.,Kim, K.R.,Kim, S.W.,Oh, D.K. Elsevier Science Publishers 2014 Journal of biotechnology Vol.169 No.-
A recombinant aldo-keto reductase (AKR) from Marivirga tractuosa was purified with a specific activity of 0.32unitml<SUP>-1</SUP> for all-trans-retinal with a 72kDa dimer. The enzyme had substrate specificity for aldehydes but not for alcohols, carbonyls, or monosaccharides. The enzyme turnover was the highest for benzaldehyde (k<SUB>cat</SUB>=446min<SUP>-1</SUP>), whereas the affinity and catalytic efficiency were the highest for all-trans-retinal (K<SUB>m</SUB>=48μM, k<SUB>cat</SUB>/K<SUB>m</SUB>=427mM<SUP>-1</SUP>min<SUP>-1</SUP>) among the tested substrates. The optimal reaction conditions for the production of all-trans-retinol from all-trans-retinal by M. tractuosa AKR were pH 7.5, 30<SUP>o</SUP>C, 5% (v/v) methanol, 1% (w/v) hydroquinone, 10mM NADPH, 1710mgl<SUP>-1</SUP> all-trans-retinal, and 3unitml<SUP>-1</SUP> enzyme. Under these optimized conditions, the enzyme produced 1090mgml<SUP>-1</SUP> all-trans-retinol, with a conversion yield of 64% (w/w) and a volumetric productivity of 818mgl<SUP>-1</SUP>h<SUP>-1</SUP>. AKR from M. tractuosa showed no activity for all-trans-retinol using NADP<SUP>+</SUP> as a cofactor, whereas human AKR exhibited activity. When the cofactor-binding residues (Ala158, Lys212, and Gln270) of M. tractuosa AKR were changed to the corresponding residues of human AKR (Ser160, Pro212, and Glu272), the A158S and Q270E variants exhibited activity for all-trans-retinol. Thus, amino acids at positions 158 and 270 of M. tractuosa AKR are determinant residues of the activity for all-trans-retinol.