Pneumatosis intestinalis and portal venous gas secondary to gefitinib therapy for Lung adenocarcinoma

( Joo Young Lee1 ),( Hye-suk Han ),( Sung-nam Lim ),( Young Kwang Shim ),( Yong Hyeok Choi ),( Ok-jun Lee ),( Ki Hyeong Lee1 ),( Seung Taik Kim ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.-

의약정보담당자(MR)의 기능 및 역할에 관한 연구

이동일,제해관,윤석준,안형식,문영배 한국의료QA학회 2003 한국의료질향상학회지 Vol.10 No.1

Background : Aim of this study is focused on the analysis of the needed abilities of medical representatives resulting in building up the market and increasing sales. It is to propose methods to increase this ability ensuring continuous growth in market share and profit. Methods : A survey was conducted between January 6 and May 31, 2003. Using SPSS(Version 10.0), the collected data was analyzed by Hotelling T2, factor analysis. Some hypotheses were selected to include the conclusion. Some questionnaires for physicians working in hospitals or clinics and the medical representatives working in a pharmaceutical company were created and asked to them to either prove or reject those hypotheses. The results were analyzed to find the primary factors that effect the interactions between physician and the medical representatives. These factors were also studied along with the theoretical research based on published references. Results : The results were as follows. The main reasons for the physician to meet with a medical representatives were collection of product informations needed for patient treatment and collection of informations on current medical issue and as well as personal interests. The main parameters by which physicians evaluate the medical representatives are human relationship including sincerity and manners and supply of accurate and unbiased information on products. Overall, the medical representatives’ perception on the importance of medical knowledge and ability to deliver it are lower than that expected by physicians. Conclusion : Medical and pharmaceutical companies’ environment are changed rapidly. And those changes forced medical representatives to set new roles and competency. In order to drive away from the past ‘rule of thumb’ and ‘adaptation to circumstance’, optimal method and systemic development to train and support the medical representatives should be quipped. They will help ,medical representatives to be specialists in medical knowledge and to understand the exact need of health care professions. Product competitiveness will be increased and eventually successful business can be achieved through it.

광학활성 B-Alkoxy-9broabicyclo[3.3.1]nonane-Potassium Hydride 환원계에 의한 라세미 에폭시화물의 분할

李光雨,孔亨根,車震淳 嶺南大學校附設 基礎科學硏究所 1986 基礎科學硏究 Vol.6 No.-

In this study, chiral B-alkoxy-9-borabicyclo[3.3.1]nonane-potassium hydride systems were applied to the resolution of representative racemic epoxides, namely 1,2-epoxybutane, 1,2-epoxyoctane and styrene oxide. Chiral B-alkoxy-9-BBN systems were synthesized from the reaction of 9-BBN with (-)-isopinocampheol and (-)-cis-myrtanol, respectively. The resolution of 2 equiv of racemic epoxide was carried out with 1 equiv of the reducing system at 0℃. Thus, the 1 equiv of epoxide was reduced to the alcohol, remaining the other 1 equiv of epoxide intact. The resolving ability of these systems in terms of optical purity of the alcohol appeared to be 25-40% in the case of aliphatic epoxide and 9-12% in the case of styrene oxide. The absolute configuration of the alcohols is consistent with (R)-(-)-aliphatic alcohol and (S)-(-)-1-phenylethanol.

종합병원 전자건강카드 도입에 영향을 미치는 요인

안이수,윤석준,안형식,홍석원 한국의료QA학회 2005 한국의료질향상학회지 Vol.12 No.2

Objective : This research is focused on understanding the current status of the Health Smart Card already in use in other advanced countries. This research will analyze the current status of the medical institutions Health Smart Card system adoption process and its effects, and provide a basis for future policy decisions for the effective adoption and diffusion of a Health Smart Card system, in the medical field, through the completed research and analysis. Method : This research surveys the domestic, and foreign, status of Health Smart Card usage. The research also presents up-to-date methodology for the evaluation of the effects of medical and health care technology. The research also conducts a survey of the domestic medical institutions that have implemented a Health Smart Card system, and then analyzes the results of the survey. Additionally, the research carried out a survey and analysis of medical institutions with no Health Smart Card system implemented, and considered the factors affecting the diffusion of Health Smart Card systems in considering an effective policy for the introduction and diffusion of such a system. Research Results : Through the study of the methodology of medical and health care information technology in advanced countries, the methodology for assessing Health Smart Card technology has been established, and focuses on 6 aspects. The study on the status of foreign implementation has shown a model for the Health Smart Card system. A survey was conducted on the current status of medical institutions with an implemented Health Smart Card system, and the survey results have been analyzed. Also, factors influencing the adoption of Health Smart Card systems have been analyzed through the survey on those medical institutions that have not implemented a Health Smart Card system. Conclusion : The government must provide institutional measures for sharing medical records by constructing an IT infrastructure at the national level to enable the adoption and diffusion of a Health Smart Card system. Such a network will make connections between medical institutions possible, thus making the diffusion of the Health Smart Card system nationwide. For the successful adoption and diffusion of a Health Smart Card system, a model system development, under a medical record sharing system, should be conducted. Additionally, a regional unit based model should be developed for the model project, as is done in advanced countries, along with the application of such results.

P2P 기반 Mobile System 구현

황인선,이호현,전병균,김형균 광주보건대학 2004 論文集 Vol.29 No.-

P2P network environments provide mobile users with direct data transmission and sharingfacilities and those environments can be classified into hybrid P2P network environments and pure P2P network environments according to the arbitration mechanism among the peers in the network. In pure P2P network environments, however, each peer directly connects to another peer and gets services without server intervention, and so, network isolation can occur when the mediating peer fails to work. In this paper, we propose a scheme for each peer to keep connection to other peers continuously by maintaining IP addresses of its neighbor peers and connecting to the peers when the mediating peer fails to work. Although the P2P application that uses our proposed framework should obtain one or more IP addresses of the neighbor peers manually, after instantiation, the application can do its job while maintaining connection to the network continuously and automatically. In order to improve these weaknesses, we introduce LBS(Location Based Service) and mobile P2P(Peer to Peer)service into the existing systems, then design and implement the enhanced system for mobile SFA using them. Through this improvement, our system makes it possible for customers or sales agents to quickly share various information and increases the efficiency of sales activity by facilitating the competition and cooperation among sales agents and reducing time-cost.

키 프레임을 이용한 동영상 검색에 관한 연구

김희수,김형균,전병균,이호현 광주보건대학 2004 論文集 Vol.29 No.-

The primary goal of video parsing is to accurately detect fast/gradual scene changes to index the video data so that future retrieval may be performed efficiently. Due to the sheer volume of the video data, however, the goal of accurate detection must be met by some real-time (fast) automatic (or at least semi-automatic) video parsing mechanism. For this purpose, I have developed a fast algorithm to detect gradual scene change and also detect camera motions to reduce false positives (falsely declaring a scene-change). In this dissertation, we propose a new approach that detects the change of scene which contains fast motion, zooming, dissolve in AVI video sequence. The proposed scheme adopts the feature matching technique which ALH(Average of Luminance Histogram) in each frame with those in the previous frame. Experimental results show that the proposed method performs better in detection scene changes than other conventional methods.

사체간이식 환자와 생체간이식 환자들의 삶의 질 비교 연구

김금희,윤석준,안형식,이준영,박형근,서경석 한국의료QA학회 2004 한국의료질향상학회지 Vol.11 No.1

Objective : The aim of this study were to measure quality of life(QOL) in liver transplant recipicnts, to ocmpare QOL between living donor liver transplant recipicnts and cadavcric live transplant recipients and to investgatre whether SF-36 may be used as a disease-specific instrument in liver transplant recipients. Methods : We conducted a single-center cross-sectional study of 133 LT recipients ages 13 to 65 years, all of whom had had Liver Transplantion(LT) at least 1 months previously. QOL was assessed using a self-completion questionnaire consisting of the Bang Whal Ran(1991) instruments and the 36-Item Short-Firm Health Survey(SF-36) health status profile measure. We investigated whether the SF-36 instrument may be used as a disease-specific instrument in LT recipients. Individual scale scores range from 0 to 100 , with higher score reflecting better health. Data on demograpics, clinical status at pre transplantation 1 day, post transplantation clinical statns, and graft gunction were collected to identify predictors of post transplantation QOL. Results : Standard measures for test-rtest reliability, internal consistency, and discriminant and concurrent validity were examined. The reliability of the SF-36, as measured by test-retest correlation(Pearson coeffocoents: 0.729, p=0.002) and by internal consistency (Cronbach's alpha: 0.9431) exceeded conbentional acceptability criteria. The correlation between domain scores of SF-36 and the Bang Whal Ran(1991) was clear and logical in that the clinical characteristics of SF-36 strongly correlated with the clinical component summary score of the Bang Whal Ran(1991)(r = 0.8155, P<01). SF-36 scale scores were compared between Cadaveric Liver Transplant recipients and Living Donor Liver Transplant recipients. Donor types of post LT did not influence HRQOL(P >0.05). 87% of the liver transplant recipients were safisfied to get LT. Satisfaction of post LT showed significantly greater HRQOL(p<0.001). Conclusion : SF-36 is found reliable and valid. This study indicates thet Donor Type did not influence HRQOL after LT. The information gained from this study will help us to better define expectations and the colinical course after liver transplantation to patients and their families.

충수염의 임상적 고찰과 초음파의 유용성

박정배,양혁준,김형수,황성연,박철완,이근 대한응급의학회 1995 대한응급의학회지 Vol.6 No.2

Appendicitis is the most common acute abdomen in Emergency Medical Center & outpatient department. But sometimes, it is difficult for us to diagnose because of clinically variable symptoms. We reviewed the ultrasonographic findings and analyse 521 cases of appendectomy patients about its distribution of sex and age, seasonal prevalence, clinical symptom and signs, laboratory findings, duration from onset of symptom to arrival at hospital, duration from arrival at hospital to operation, vital signs, operative results, and associated diseases, which were treated at the department of General Surgery & Emergency Medical Center in Chung Ang Gil Hospital from July, 1994 to June, 1995. The results were as follows : 1. The most common age group was second decade. And male to female ratio was 1.43:1. Seasonal variation was not significant. 2. Of 521 cases, 141 cases(27.1%) visited the hospital within 24 hours from the onset of symptom, and 259 cases(49.7%) visited between 24 to 48 hours. 3. In duration from arrival to operation, the cases within 6 hours were 263 (50.5%), the cases between 6 and 12 hours were 131(25..1%). 4. In systolic blood pressure, cases below 90mmHg were 19(3.6%), cases above 160mmHg were 23(4.4%). Below 60mmHg diastolic pressure were 55 cases(10.6%), cases above 110mmHg were 9(1.7%). In pulse rate, above 90 rate/min were 171(32.8%). 5. On admission leukocytosis was found in 413 cases(79.3%) and 342 cases of them were pathologic appendicitis. 6. Ultrasoundgraphy was performed in the 87 cases, but 23 cases were suggested appendicitis. Among 23 cases, 22(95.7%) revealed pathologic appendicitis at ooperation and labortatory examination. Of the 64 cases which were normal on ultrasonography, only 2 cases(3.1%) were proved to be appendicitis. 7. The results of 496 operations without ultrasonography were appendicitis in 390 cases(78.6%), mesenteric lymphadenopathy 36(7.3%), pelvic inflammatory disease 28(5.6%), fecalith 15(3.0%), terminal ileitis 8(1.6%), diverticulitis 7(1.4%), urinary tract stones 5(1.0%), cecal cancer 2 cases, right ovarian tumor 2 cases, tubo-ovarian abscess 2 cases, grater omentum internal hernia 1 case. Our results showed that the sensitivity of ultrasonohraphy was 95.8% and the specificity 98.4% in the diagnosis of appendicitis, It suggests that the ultrasonography is very helpful in the diagnosis & differential diagnosis of acute appeendiditis.

고립성 폐결절의 조직학적 진단에 있어서 경기관지폐생검의 진단적 가치

김치훈,김정주,왕준호,연규민,김형수,리원연,용석중,신계철 건국대학교 의과학연구소 2002 건국의과학학술지 Vol.12 No.-

Transbronchial lung biopsy(TBLB) is a relatively simple and convenient diagnostic tool in solitary pulmonary nodule(SPN) on chest radiograph, which is cannot be diagnosed through routine tests. To investigate the diagnostic value and diagnostic rate of TBLB according to the variable factor, we analyzed 69 patients with radiologically SPN lesion on chest radiograph which was confirmed histologically. A histologic diagnosis of TBLB was made in 47 of 69 patients(68.1%), in which 26 of 37(70.3%) with malignancy and 21 of 32(65.6%) with benign lesion. There were no significant differences in diagnostic yield according to age, sex and location of the lesion. The diagnostic rate tended to increase with the more than 5 pieces to acquired by TBLB. When the size of SPN was less than 3 ㎝, it cannot be diagnosed. In conclusion, TBLB is a diagnostic procedure with good yield and safety, but percutaneous needle aspiration, transbronchial needle aspiration, and bronchial washing fluid cytology may be a complementary procedure to overcome the limitation of TBLB and get higher diagnostic yield for SPN.

비유기중의 소유방염에 대한 항균펩타이드(Buforin Ⅱb)의 효능실험

김인송,권성균,임형준,이완규 한국수의공중보건학회 2002 예방수의학회지 Vol.26 No.3

Recently, a novel antimicrobial peptide including Buforin II has been emphasized to kill multi-drug resistant bacteria and avoid promoting multi-drug resistance. This study evaluated the efficacy of an antimicrobial peptide (Buforin IIb) on bovine mastitis. Based on the Minimum inhibitory concentration(MIC, 4 g/ml) of Buforin IIb, syringes were made five concentration(MIC×10, ×50, ×100, ×300, and ×500). Thirty three cows(38 quarters) with bovine mastitis were selected using California mastitis test and grouped in dependant on drug concentration and treatment duration. Each group treated by intramammary infusion twice a day for 3 5 days. The milk samples of 5 groups were aseptically collected from quarters at 0, 3, 7 and 14 days, and 2 groups were collected at 0, 5, 9 and 14 days after first treatment. Collected samples were used for bacterial culture and somatic cell count. Bacterial number(log_(10) mean CFU/ml) was decreased in dependant on drug concentration and extending treatment duration. In group D(MIC×300), bacterial number was decreased from 4.59±0.10(day 0) to 2.89±1.37(day 3), 4.04±0.33(day 7), and 4.19 ± 0.10(day 14), respectively(p 0.05). Bacterial number of B2(MIC×50, 5 days treated) is decreased, approximately 10%, than group B1(MIC×50, 3 days treated). Somatic cell count of group D was slightly decreased from 11,100(×10³)(day 0), to 7,386(×10³)(3 day), 6,886(×10³)(day 7), and 9,661(×10³)(day 14). Staphylococcus spp., was the most common isolate, was bacteriologically cured 100% by Buforin IIb treatment. Overall results indicate that Buforin IIb could have possibility to cure bovine mastitis, if higher concentration over experimental concentration were treated with extending treatment duration.