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Sarcomatoid Carcinoma Arising from Mature Cystic Teratoma
Ho-Chang Lee1, Seung-Myoung Son, Yong-Moon Lee, Ji Hae Koo, Song-Yi Choi, Ok-Jun Lee, Eun-Hwan Jeong 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.2
Malignant transformation of mature cystic teratoma (MCT) is rare. Sarcomatoid carcinoma is a neoplasm comprising malignant mesenchymal cells and a conventional carcinomatous area. Here, we report on a case of sarcomatoid carcinoma arising from an MCT in the left ovary of a 45-year-old female. A unilocular cyst consistent with MCT was observed; however, a nodule within the cyst was confirmed from the resected ovary. Microscopically, the nodule showed both squamous cell carcinoma and pleomorphic sarcomatous components admixing with each other. Lining epithelial cells at the periphery of the main tumor showed squamous metaplasia. When a sarcomatous component is observed in the ovary tumor, it is important to find a squamous cell component, either benign or malignant.
이윤형(Yun-Hyung Lee),안종갑(Jong-Kap Ahn),소명옥(Myung-Ok So),이준탁(Jun-Tack Lee) 한국마린엔지니어링학회 2007 한국마린엔지니어링학회 학술대회 논문집 Vol.2007 No.-
A simple tuning methods of PI, PD and PID controller are proposed for an integrating process with time delay. This is based on matching the coefficients of corresponding powers of s in the numerator and that in the denominator of the closed-loop transfer function. For set-point tracking problem, the derived controller is found to be a PD controller which is shown by Lee's tuning rule based on minimizing the performance indexes (lSE, IAE, ITAE) using a real-coded genetic algorithm. A method can be also proposed PI, PID controllers according to tuning parameter lambda (A) similar to IMC method. Simulation example is given to illustrate the set-point tracking performance of the proposed method.
Lee, Jae-Chan,Jeon, Che-Ok,Lim, Jee-Min,Lee, Sang-Mi,Lee, Jung-Min,Song, Sung-Min,Park, Dong-Jin,Li, Wen-Jun,Kim, Chang-Jin Plant molecular biology and biotechnology research 2005 Plant molecular biology and biotechnology research Vol.2005 No.
A moderately halophilic, Gram-negative bacterium, strain BH539^(T), which was isolated from a solar saltern at Taean in Korea, was considered to be a member of the genus Halomonas. Strain BH539^(T) grew at salinities of 1-25% (w/v) and at temperatures of 10-45 ℃. Cells were short rods that were motile by means of several flagella. Their major fatty acids were C_(18:1)ω7c, C_(16:0) and C_(19:0) cyclo ω8c. The genomic DNA G+C content was about 65 mol% and the predominant ubiquinone was Q-9. Phylogenetic analyses based on 16S rRNA gene sequences indicated that the isolate formed a branch of the species Cobetia marina. However, 23S and 16S rRNA gene sequence similarities revealed that strain BH539^(T) was related more closely to the type strains of the genus Halomonas. Phylogenetic analyses based on 23S rRNA gene sequences also indicated that the strain formed a phyletic line within the genus Halomonas. Therefore, it was concluded that strain BH539^(T) should be classified within the genus Halomonas, rather than Cobetia. On the basis of physiological and molecular properties, strain BH539^(T) represents a novel species of the genus Halomonas, for which the name Halomonas taeanensis sp. nov. is proposed. The type strain is BH539^(T) (=KCTC 12284^(T)=DSM 16463^(T)).
Lee, Ha-Na,Jin, Hyeon-Ok,Park, Jin-Ah,Kim, Jin-Hee,Kim, Ji-Young,Kim, BoRa,Kim, Wonki,Hong, Sung-Eun,Lee, Yun-Han,Chang, Yoon Hwan,Hong, Seok-Il,Hong, Young Jun,Park, In-Chul,Surh, Young-Joon,Lee, Jin Korean Society for Molecular and Cellular Biology 2015 Molecules and cells Vol.38 No.4
Piperlongumine, a natural alkaloid isolated from the long pepper, selectively increases reactive oxygen species production and apoptotic cell death in cancer cells but not in normal cells. However, the molecular mechanism underlying piperlongumine-induced selective killing of cancer cells remains unclear. In the present study, we observed that human breast cancer MCF-7 cells are sensitive to piperlongumine-induced apoptosis relative to human MCF-10A breast epithelial cells. Interestingly, this opposing effect of piperlongumine appears to be mediated by heme oxygenase-1 (HO-1). Piperlongumine upregulated HO-1 expression through the activation of nuclear factor-erythroid-2-related factor-2 (Nrf2) signaling in both MCF-7 and MCF-10A cells. However, knockdown of HO-1 expression and pharmacological inhibition of its activity abolished the ability of piperlongumine to induce apoptosis in MCF-7 cells, whereas those promoted apoptosis in MCF-10A cells, indicating that HO-1 has anti-tumor functions in cancer cells but cytoprotective functions in normal cells. Moreover, it was found that piperlongumine-induced Nrf2 activation, HO-1 expression and cancer cell apoptosis are not dependent on the generation of reactive oxygen species. Instead, piperlongumine, which bears electrophilic ${\alpha},{\beta}$-unsaturated carbonyl groups, appears to inactivate Kelch-like ECH-associated protein-1 (Keap1) through thiol modification, thereby activating the Nrf2/HO-1 pathway and subsequently upregulating HO-1 expression, which accounts for piperlongumine-induced apoptosis in cancer cells. Taken together, these findings suggest that direct interaction of piperlongumine with Keap1 leads to the upregulation of Nrf2-mediated HO-1 expression, and HO-1 determines the differential response of breast normal cells and cancer cells to piperlongumine.
Near-Infrared Photoresponsivity of ZnON Thin-Film Transistor with Energy Band-Tunable Semiconductor
Lee, Hyun-Mo,Jeong, Hyun-Jun,Ok, Kyung-Chul,Rim, You Seung,Park, Jin-Seong American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.36
<P>Amorphous oxide semiconductors have attracted attention in electronic device applications because of their high electrical uniformity over large areas, high mobility, and low-temperature process. However, photonic applications of oxide semiconductors are highly limited because of their larger band gap (over 3.0 eV). Here, we propose low band gap zinc oxynitride semiconductors not only because of their high electrical performance but also their high photoresponsivity in the vis-NIR regions. The optical band gap of zinc oxynitride films, which is in the range of 0.95-1.24 eV, could be controlled easily by changing oxygen and nitrogen ratios during reactive sputtering. Band gap tuned zinc oxynitride-based phototransistors showed significantly different photoresponse following both threshold voltage and drain current changes due to variation in nitrogen-related defect sites.</P> [FIG OMISSION]</BR>
Lee, Sang-Min,Kim, Soon-Hee,Kim, Ji-Sung,Wang, Joong-San,Kim, Sung-Won,Kim, Nyeon-Jun,Lee, Sook-Hee,Min, Kyoung-Ok International Academy of Physical Therapy Research 2011 Journal of International Academy of Physical Ther Vol.2 No.2
The purpose of this study is to examine the changes in bone mineral density in long-stay patients of a geriatric hospital in relation to physical therapy, thereby providing basic data for preventing the onset or deterioration of osteoporosis in inpatients of geriatric hospitals or relevant facilities. The subjects of this study were 133 elderly patients who had been in H geriatric hospital in Yongin-si for more than four years. Their bone mineral density T-scores at admission and those after four years were measured to compare and analyze the changes in bone mineral density in relation to physical therapy. According to the results, the decrease in T-score for the group without physical therapy was greater by .40 than that for the group with physical therapy, indicating a statistically significant difference between the two groups(p<.01). Accordingly, physical therapy proved to be effective in preventing bone mineral density loss and maintaining the current density.