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Multiple cardiac metastases from a nonfunctioning pancreatic endocrine tumor
( Yong Hyeok Choi ),( Hye Suk Han ),( Sung Nam Lim ),( Sang Yeub Lee ),( Ji Hae Koo ),( Ok Jun Lee ),( Ki Hyeong Lee ),( Seung Taik Kim ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1
Introduction: Pancreatic endocrine tumors (PETs) are uncommon neoplasm and the most common metastatic site is liver. However, intrathoracic metastasis of PET is very rare. The authors report a case of nonfunctioning PET with multiple cardiac metastases. Case report: A 56-year-old man presented with progressively worsening palpable abdominal mass. Computed tomography (CT) scan of abdomen revealed relatively well marginated inhomogeneous low attenuation masses in the head and tail of pancreas. CT scan of chest and transthoracic echocardiography showed multiple, enhancing masses in left pericardium. A needle biopsy was performed on the masses in the tail of pancreas and left ventricular apical pericardium; histologic examination revealed PET by morphology on H&E and by immunohistochemical staining which was positive for synaptophysin, chromogranin, and CD 56. Conclusion: This is the first report of PET with multiple cardiac metastases of previously undescribed metastatic sites. Although it is very rare, PET has the potential to metastasize to heart or pericardium, and for patients with PETs who present with new cardiac symptoms or signs, the clinician should be alert for the possibility of cardiac metastases.
Seasonal distribution of airborne pollen in Ulsan, Korea in 2009-2010
Choi, Seung-Hyeok,Jung, In-Yong,Kim, Dong-Yeop,Kim, Yang-Ho,Lee, Ji-Ho,Oh, In-Bo,Choi, Kee-Ryong The Ecological Society of Korea 2011 Journal of Ecology and Environment Vol.34 No.4
To determine the peak dispersal times of allergenic pollen grains in Ulsan, Korea, we performed continuous airborne pollen counts at three stations (Sts. A, B, and C) in Ulsan from August 2009 to November 2010. Pollen grains were sampled using a Durham sampler. Two peak pollen dispersal seasons were observed per year. The peak seasons generally coincided with the flowering period of anemophilous trees: Taxodiaceae (February), Alnus (March), Cupressaceae (April), Quercus, and Pinus (May), and with the flowering phase of herbs from August to November, e.g., Humulus, Artemisia, Gramineae, and Ambrosia from August through September. The highest concentration of airborne pollen was from Pinus (68%), followed by Quercus (15%), Alnus (6%), and Humulus (2%); whereas very low pollen concentrations were from Taxodiaceae, Cupressaceae, Artemisia, Gramineae, and Ambrosia (${\leq}$ 1% of the annual total airborne pollen concentration). Our findings indicate that Alnus and Humulus pollen are major allergens whereas those of Pinus and Quercus are minor allergens. The concentration of Alnus pollen grains at St. C was over five times that at Sts. A and B. This finding implies that individuals living at or near St. C are exposed to high concentrations of Alnus pollen before and after March, which is the flowering period of the alder tree. From August to September, individuals living at or near St. B are exposed to high concentrations of Humulus pollen. Our study suggests that Alnus pollen may be the major aeroallergen causing pollinosis in the spring at St. C and Humulus pollen may be the major aeroallergen in autumn at St. B.
HBV : There is Good Correlation between HBsAg and HBV DNA Irrespective of Lamivudine Resistance
( Yong Hoon Choi ),( Jeong Han Kim* ),( Hong Seok Choi ),( Yong Hwang ),( Young Baek Kim ),( Jun Jae Kim ),( Hee Won Moon ),( Soon Young Ko ),( Won Hyeok Choe ),( So Young Kwon ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background: It is well known that HBsAg level shows good correlation with HBV DNA level in chronic hepatitis B (CHB) patients. However, there is limited data about correlation between HBsAg level and HBV DNA level in lamivudine (LMV) resistant CHB patients. Methods: Treatment naive CHB patients and LMV resistant CHB patients were included for analysis. Pearson`s correlation coeffi cient between pretreatment HBsAg level and HBV DNA level was calculated. In LMV resistant group, baseline HBsAg level and HBV DNA level before rescue therapy were used. Results: Total forty-eight patients in treatment naive group (Group A) and fifty patients in LMV resistant group (Group B) were enrolled. Male patients were 43 (77.1%) in Group A and 28 (56.0%) in Group B. HBeAg positive patients were 23 (47.9%) in Group A and 29 (58.0%) in Group B. Mean HBsAg was 3.3 log10 IU/mL in Group A and 3.7 log10 IU/mL in Group B. Mean HBV DNA was 5.4 log10 IU/mL in Group A and 6.9 log10 IU/mL in Group B. HBsAg level and HBV DNA level showed good correlation in Group A (r=0.0471, P=0.002), and also in Group B (r=0.531, P<0.001). In HBeAg positive patients, these correlations were also good in both Group A (r=0.530, P=0.019) and Group B (r=0.454, P-0.013). In HBeAg negative patients, correlation was good only in Group B (r=0.498, P=0.022) but not in Group A (r=0.393, P=0.087). Conclusions: Correlation between HBsAg level and HBV DNA level is good in both treatment naive CHB patients and LMV resistant CHB patients. We can assume that LMV resistance does not affect HBsAg secretion. Further investigation about correlation of HBsAg and HBV DNA during treatment is warranted.
위장관 ( 胃腸管 ) : 소화기암과 연관되어 발생한 다발적 원발성 악성종양
윤용범(Yong Bum Yoon),송인성(In Sung Song),김정룡(Chung Yong Kim),이효석(Hyo Suk Lee),최상운(Sang Woon Choi),최규완(Kyu Wan Choi),김용태(Yong Tae Kim),한철주(Cheol Joo Han),이준혁(Joon Hyeok Lee),류지곤(Ji Kon Ryu),정현채(Hyun Chae C 대한소화기학회 1991 대한소화기학회지 Vol.23 No.3
N/A Owing to the development of diagnostic techniques and treatment modalities, more and more cases of multiple primary cancers are being discovered and active researches concerning maltiple primary cancers are being done. The mortrality due to cancers of gastrointestinal tract occupies more than two thirds (68.4%) of total number of deathes due to cancers in Korea, but researches on multiple primary cancers concerning gastrointestinal tract are lacking. We reviwed 70 cases of multiple primary cancers concerning gastrointestinal tract, we experienced in the past decade. The ratio of male to female was 3.7:1, the mean age was 52.8 years. From 70 patients with multiple primary cancers, sixty patients had synchronous multiple primary cancers and ten patients had metachronous ones. The frequent sites involved were stomach (51.9%) and liver (21.2%). The most frequent combination of primary and secondary cancer was stomach cancer and primary liver cancer (27%). These results may be contributed to the actual incidence of each cancer, and routine staging work-up of liver for stomach cancer and routine gastroopy for primary liver cancer. In synchronous cancers, majority of the second cancers were found incidentally during routine staging work-up (58.3%) or during operation (8.4%), whereas only 33.3% of second cancers were found due to concomittent symtoms. Thus the incidence of each multiple primary cancer in our study may reflect the relative frequency of each cancer in Korea. In order to determine the true risk of occurrence of multiple primary cancers in Korea, prospective studies based on the large population of community should be conducted.
S-345 Castleman``s disease in intrapulmonary lymph node presenting as solitary pulmonary nodule
( Seung Hyeok Choi ),( Seung Yong Park ),( Yeong Hun Choe ),( So Ri Kim ),( Yong Chul Lee ),( Heung Bum Lee ),( Seoung Ju Park ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Castleman's disease is an uncommon lymphoproliferative disorder which can occur wherever lymph nodes are presens. Castleman's disease in the chest develops usually in mediastinal or hilar lymph node. A 53-year-old woman was admitted to our hospital for further evaluation of a pulmonary nodule detected incidentally in health check up.Computer tomography demonstrated that this nodule was 27×25mm, well-defined in the right upper lobe. On MRI of chest MRI, which was performed to further diagnosis, the nodule was located on perihilar area of the right upper lobe and showed high signal intensity in T2 weight imaging and rapid and strong enhancement in dynamic contrast image, suspected to be a sclerosing hemangioma. We performed right upper lobectomy with lymph node dissection and the pathologic examination revealed that the pulmonary nodule was Castleman's disease arising from an intrapulmonary lymph node. We here report a rare case of Castleman's diseas in intrapulmonary lymph node presenting as solitary pulmonary nodule, suggesting that Castleman's disease should be considered in patinet with a nodule in perihiarl area.
팽대부 선근종의 임상적, 병리학적, 면역조직화학염색의 특징
최용혁 ( Yong Hyeok Choi ),김미진 ( Mi Jin Kim ),한정호 ( Joung Ho Han ),윤순만 ( Soon Man Yoon ),채희복 ( Hee Bok Chae ),윤세진 ( Sei Jin Youn ),강민호 ( Min Ho Kang ),성노현 ( Rohyun Sung ),최재운 ( Jae Woon Choi ),박선미 ( Seon 대한소화기학회 2013 대한소화기학회지 Vol.62 No.6
Background/Aims: Ampullary adenomyoma is a benign lesion whose malignant potential has yet to be confirmed. Despite its benign nature, adenomyoma is frequently misdiagnosed as a carcinoma or adenoma and is overtreated by extensive surgery. This study was performed to analyze the clinical, pathological, and immunohistochemical features of adenomyomas in the ampulla of Vater. Methods: Nine cases of adenomyoma in the ampulla of Vater, diagnosed in Chungbuk National University Hospital between 2008 and 2011, were enrolled in this study. We reviewed the clinical data on the symptoms, laboratory data, and radiologic findings of the abdominal computed tomography and endoscopic retrograde cholangiopancreatography. For pathological analysis, all the slides were reviewed by one pathologist, and immunohistochemical stainings with antibodies against cytokeratin 7 (CK7), cytokeratin 20 (CK20), α-smooth muscle actin (α-SMA), and Ki-67 antigen were performed. Results: All the cases were CK7 positive and CK20 negative. A strong cytoplasmic expression of α-SMA was confirmed in all cases. The Ki-67 index was less than 1% in eight cases and 5% in one case. Four cases underwent endoscopic papillectomy, and one case received surgical ampullectomy during colorectal cancer surgery. Five cases that underwent endoscopic or surgical treatment remained symptom-free for three years. Four cases that were closely observed with repeated endoscopic examinations exhibited no interval changes in the papillary lesions. Conclusions: Endoscopic biopsy and immunohistochemistry can aid in the diagnosis of ampullary adenomyomas. Endoscopic papillectomy or surgical ampullectomy is adequate for the treatment of symptomatic ampullary adenomyomas. (Korean J Gastroenterol 2013;62:352-358)
외부 후긴장 공법 적용에 따른 무도상 판형교의 동적거동 분석
박용걸(Yong-Gul Park),최동호(Dong-Ho Choi),최정열(Jung-Youl Choi),최준혁(Jun-Hyeok Choi) 한국철도학회 2006 한국철도학회논문집 Vol.9 No.2
The major objective of this study is to investigate the effects and application of external post-tensioning method for steel plate girder bridge. It analyzed the mechanical behaviors of steel plate girder bridge with applying external post-tensioning on the finite element analysis, field test and laboratory test for the lateral dynamic characteristics. As a result, the reinforcement of steel plate girder bridge the external post-tensioning method are obviously effective for the lateral dynamic response which is non-reinforced. The analytical and experimental study are carried out to investigate the post-tension force decrease lateral acceleration and deflection on steel plate girder bridge for serviceability. And the external post-tensioning method reduce dynamic maximum displacement(about 10∼24%), the increase of dynamic safety is predicted by adopting external post-tensioning method. From the dynamic test results of the servicing steel plate girder bridge, it is investigated that the change degree of natural frequency is very low with applying the external post-tensioning method The servicing steel plate girder bridge with external post-tensioning has need of the reasonable reinforcement measures which could be reducing the effect of lateral dynamic behavior that degradation phenomenon of structure by an unusual response characteristic and a drop durability.