MONTE CARLO SIMULATION을 이용한 이상값 탐색방법의 효율성 비교

유종영 용인대학교 산업경영연구소 2003 산업경영논총 Vol.10 No.-

We considered the problem for confirmation of multiple outliers and leverage points. Identification of multiple outliers and leverage points is difficult because of the masking effect and swamping effect. Jong-Young YOO and Kisoo-Ahn(2002) identified multiple outliers and leverage points by using the adjacent effects which are high-breakdown robust estimators. In this thesis, We proved the efficiency of Jong-Young YOO and Kisoo-Ahn's method by comparing with five procedure(Sequential testing of maximum internally studentized residual, Sequential testing of maximum externally studentized residual, Marasinghe's multistage procedure and two procedure based on recursive residuals).

고령자의 스포츠참가와 생활만족도에 관한 연구

정종훈,김종표,김유수,안종학 東亞大學校附設스포츠科學硏究所 1999 스포츠科學硏究論文集 Vol.17 No.-

The issues for the aged have been appearing on the stage as the deep social problems since the end of 1970's when our communities began to enter into high level industry, which were concerned by people in modern times. The starting time to study on the aged in Korea was from the 1960's. Moreover, it was lively proceeded during the end of the 1970's and the 1980's. At first, it mainly dealt medical issues for them, then, spread up to their social concerns later. This study was to research about the participating type of the aged' leisure, sports activities, as well as its changable relationships with life satisfaction on the premise regarding the necessity of positive practice toward leisure and its participation as the positive solution scheme from the aged' issues, which was based on the social concerns related with the aged. According to the questionary method, to select the main group who were over 60-years-old, men and women in Pusan, it was studied and analyzed regarding the realities of the aged's leisure activities, the participating attitude in sports, the relationships between the degree of satisfaction life when participating in sports activities and the life satisfaction. The results were as follows ; 1. Among the low ranking scopes of the participating attitude in sports, in case of participating in sports for the self-training of character-building themselves, it significantly had and effect on the satisfaction of life. 2. In case of building their own character through sports activities, it had the highest effect on the satisfaction of life. 3. The satisfaction of sporting activities in their childhood had and effect on the life satisfaction.

Correction: Bioinspired M-13 bacteriophage-based photonic nose for differential cell recognition

Moon, Jong-Sik,Kim, Won-Geun,Shin, Dong-Myeong,Lee, So-Young,Kim, Chuntae,Lee, Yujin,Han, Jiye,Kim, Kyujung,Yoo, So Young,Oh, Jin-Woo Royal Society of Chemistry 2017 Chemical Science Vol.8 No.2

<P>Correction for ‘Bioinspired M-13 bacteriophage-based photonic nose for differential cell recognition’ by Jong-Sik Moon <I>et al.</I>, <I>Chem. Sci.</I>, 2017, DOI: 10.1039/c6sc02021f.</P>

비선형효과와 파형경사를 고려한 소파블럭 중량산정

유동훈(Yoo Dong Hoon),윤종주(Yoon Jong Joo),장문엽(Jang Moon Yup) 대한토목학회 2010 대한토목학회 학술대회 Vol.2010 No.10

파활동경사를 고려한 소파블록 중량산정

유동훈(Yoo Dong Hoon),윤종주(Yoon Jong Joo),정평교(Jung Pyung Kyo),장문엽(Jang Moon Yup) 대한토목학회 2009 대한토목학회 학술대회 Vol.2009 No.10

프랜차이즈 스포츠센터의 서비스 품질이 고객만족 및 재구매 의도에 미치는 영향

이종길,이종호,유종렬 충남대학교 체육과학연구소 2006 體育科學硏究誌 Vol.23 No.1

The franchise sports center has been most popularized among sports service industry and has worked as a pivot of life sports. These franchise sports center should have an efforts to get the competitiveness by maintaining and managing of existing customers with differentiated marketing activities. Therefore, the study of deep analysis about the relationship of service quality, customer satisfaction, re-purchasing intention and word of mouth effect would become foundation to increase service quality, maximize customer satisfaction, and maintain existing customers and eventually it would become a major factor in establishing future marketing strategies. To achieve the purpose of this study, the questionnaires was conducted on male and female adults who use franchise sports centers in Oct. 2005. For the purpose of this study, the purposive random sampling method was used and four franchise sports centers of the most biggest sports center "R" was selected. The questionnaire was distributed to 400 members of franchise sports centers and finally, 372 data have selected except for unreliable 28 data. The finally selected data was analyzed with SPSS program V.10.0. In order to examine the characteristics of sample, the frequency analysis was performed and to examine the reliability of survey tool, reliability analysis was performed. Also, to analyze basic statistic quality and verify the hypotheses of the study, t-test, one-way ANOVA and regression analysis were conducted. Through the methods mentioned above, the results drawn from the analysis are as follows; First, as a result of examining the different customers' perceptions on service quality, customer satisfaction, re-purchasing intention and effects of word of mouth by demographic factors, except for the gender, age, re-purchasing intention and effects of word of mouth, statistically significant differences were indicated on the social status and customer satisfaction. Second, as a result of examining different customers' perceptions on service quality, customer satisfaction, re-purchasing intention and effects of word of mouth by using behavior of sports center, except for customer satisfaction, re-purchasing intention and effects of word of mouth, statistically significant differences were indicated on reliability of service quality. Third, to analyze the effects of perceived service quality on customer satisfaction ,the multiple regression analysis was conducted. Among five factors in service quality, 3 factors, tangibility, empathy and responsiveness gave statistically significant effects on customer satisfaction. Forth, to analyze the effects of perceived service quality on re-purchasing intention, the multiple regression analysis was conducted. Among five factors in service quality, 2 factors, tangibility and confidentiality gave statistically significant effects on re-purchasing intention. Fifth, to analyze the effects of perceived service quality on effects of word of mouth, the multiple regression analysis was conducted. Among five factors in service quality, 3 factors, tangibility, responsiveness and confidentiality gave statistically significant effects on re-purchasing intention. Sixth, to analyze the effects of customer satisfaction on re-purchasing intention, simple regression was conducted. The customer satisfaction imposed statistically significant influence on customers' re-purchasing intention. Seventh, to analyze the effects of customer satisfaction on effects of word of mouth, simple regression was conducted. The customer satisfaction imposed statistically significant influence on effects of word of mouth. Finally, to analyze the causal relation in service quality, customer satisfaction, re-purchasing intention and word of mouth, path analysis was conducted. Service quality affected customer satisfaction, re-purchasing intention and word of mouth. Customer satisfaction as a mediator variable between service quality and post purchase behavior also affected re-purchasing intention and wold of mouth. Also, correlations between re-purchasing intention and word of mouth imposed statistically significant influence.

조혈모세포이식 환자에서 침습성 진균 감염에 대한 Micafungin의 예방 효과 및 안전성

김시현,이동건,최수미,권재철,박선희,최정현,유진홍,이성은,조병식,김유진,이석,김희제,민창기,조석구,김동욱,이종욱,민우성,박종원 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Background: Micafungin, a potent inhibitor of 1,3-β-D-glucan synthase, is a novel antifungal agent of the echinocandin class. In vitro study showed that micafungin was effective against Aspergillus species as well as Candida species, but clinical data on the prophylactic efficacy against invasive fungal infections (IFIs) other than candidiasis are still lacking. Materials and Methods: We identified 60 consecutive adult hematopoietic stem cell transplantation (HSCT) recipients who received at least 3 doses of micafungin during neutropenic period. Micafungin was started as an alternative in patients who were intolerant or had adverse events (AEs) to primary prophylactic antifungal agents. We retrospectively reviewed the medical records and analyzed the efficacy and safety of micafungin for prophylaxis against IFIs. Results: The patients either had autologous (n=9) or allogeneic (n=51: 1 syngeneic, 24 sibling, 26 unrelated donor) HSCT. Itraconazole oral solution (n=58) was the most frequently used first line antifungal agent for prophylaxis and was administered for median 11 days. The most frequent cause of switch to micafungin was vomiting (n=42). The duration of neutropenia and micafungin administration was median 13 and 12 days, respectively. A successful outcome was achieved in 45 (75%) patients. Empirical antifungal therapy was initiated in 13 (22%) patients. There were 2 cases (3.3%) of breakthrough fungal infections which comprised a probable invasive pulmonary aspergillosis and a possible invasive fungal sinusitis. There was no case of invasive candidiasis. A total of 53 (88%) patients experienced at least one AE regardless of causality during micafungin administration. The most frequent AEs were hypokalemia, vomiting, diarrhea, and elevated serum aspartate aminotransferase or alanine aminotransferase. Among the aforementioned AEs, only 1 case of diarrhea could be classified as a probable relation with micafungin when causality was assessed. There was no AEs that caused discontinuation of micafungin. Conclusions: Micafungin seems to be a safe and effective agent for prophylaxis of IFIs including aspergillosis as well as candidiasis in HSCT recipients. However, further large, prospective, and randomized comparative studies are warranted for aspergillosis.

現代組織과 個人의 相互作用에 관한 考察

劉鍾海 연세대학교 행정대학원 1982 延世行政論叢 Vol.9 No.-

行政改革의 理論的 考察

劉鐘海 연세대학교 행정대학원 1974 延世行政論叢 Vol.2 No.-

유전성 대사질환에서의 동종조혈모세포이식 : 단일 기관에서의 경험 A single center experience

유건희,김흥렬,이지은,이호영,천정미,성기웅,구홍회,이문향,진동규,김종원,김대원,김형록 대한조혈모세포이식학회 2001 대한조혈모세포이식학회지 Vol.6 No.2

배경: 유전성 대사질환의 치료로서 효소 요법 및 유전자 치료가 제한적인 현실에서 동종 조혈모세포이식이 현재로선 가장 중요한 치료가 될 수 있다. 본 연구에서는 단일 기관에서 유전성 대사질환에 대해 동종 조혈모세포이식을 시행한 경험을 보고하고자 하였다. 방법: 삼성서울병원 유전성 대사질환 조혈모세포이식팀에서는 1999년 12월부터 2001년 3월까지 총 6례의 유전성 대사질환을 대상으로 동종 조혈모세포이식을 시행하였다. 대상 질환은 Hunter 증후군 3례, galactosialidosis 1례, 이염성 백질이영양증 1례, 부신백질이영양증 1례였으며 성별 분포는 남아가 5명, 여아가 1명이었으며 연령 분포는 2년 9개월에서 15년 9개월이었다. 5례는 HLA 일치 혈연간 골수이식이었으며 1례는 HLA 불일치 T 림프구 제거 말초혈액 조혈모세포이식이었다. 전처치는 모두 BuCy를 사용하였으며 이식편대숙주반응의 예방에는 cyclosporine을 사용하였다. 이식된 세포는 유핵세포가 4.81×10^(8)(2.40~7.01×10^(8))/kg이었으며 CD34+ 세포는 3.65×10^(6)(0.88~10.72×10^(6))/kg이었다. 결과: 이식 후 조혈기능의 회복은 모두 조기에 달성되었으며(ANC>500: 정중 9.5일, 범위 9~14일; PLT>50K: 정중 32일, 범위 23~34일) 이식과 관련된 합병증은 Gr I의 aGVHD 3례, 국한성의 cGVHD 1례, 경증의 간정맥 폐쇄성 질환이 1례이었다. 모든 환자에서 직간접적으로 이식 후 효소의 생산이 증가함이 확인되었으며 임상적인 호전을 보인 경우가 4례, 질병 진행이 중단된 경우가 1례, 질병이 진행된 경우가 1례이었다. 질병 진행이 중단되었던 1례는 면역억제제 투여 중 수두 감염에 의한 폐출혈로 사망하였다. 결론: 유전성 대사질환에서 동종 조혈모세포이식이 가장 중요한 치료법으로 사용될 수 있고 중추신경계 증상이 나타나기 전, 가능한 조기에 조혈모세포이식을 시행하는 것이 바람직할 것이며 적극적인 지지 요법이 필요하다. 향후 더 많은 임상 경험이 필요하리라 사료된다. Background: Allogeneic hematopoietic stem cell transplantation (HSCT) may be the most important treatment modality to cure a number of genetic metabolic disorders because of the limitation of enzyme replacement or gene therapy. In this study, we report our single center experience about HSCT in several genetic metabolic disorders. Methods: We performed 6 cases of HSCT for genetic metabolic disorders from December 1999 to March 2001. Patients' diagnoses were Hunter syndrome (3), galactosialidosis (1), metachromatic leukodystrophy (1), and adrenoleukodystrophy (1). Stem cell sources were bone marrow from HLA matched sibling donors in 5 patients and mother's peripheral blood stem cells in one patient who did not have HLA matched donors. Busulfan and cyclophosphamide for conditioning, and cyclosporine for the prevention of graft versus host disease were used in all patients. Transplanted total nucleated cell counts were median 4.81×10^(8)(2.40~7.01×10^(8))/kg , and CD34+ cells 3.65×10^(6)(0.88~10.72×10^(6))/kg. Results: All patients achieved early hematologic recovery (median 9.5 days, range 9~14 days for ANC>500/μL; median 32 days, range 23~34 days for PLT>50,000/μL). Transplant-related complications were 3 cases of grade 1 acute GVHD, a case of limited chronic GVHD, and a case of mild hepatic veno-occlusive disease. Enzyme levels were normalized in 4 patients evaluated and there were indirect evidences of enzyme production in the other 2 patients after HSCT. Four of the 6 patients showed symptomatic improvement, 1 patient (galactosialidosis) experienced disease stabilization without progression before he eventually died due to pulmonary hemorrhage, and the other 1 patient deteriorated progressively even after HSCT. Conclusions: Allogeneic HSCT can be done as the only curative treatment in a number of genetic metabolic disorders. It seems desirable to perform HSCT as early as possible before the onset of central nervous system symptoms. More experience and long term follow up is needed to evaluate the efficacy and to monitor the long term transplant-related complications.