전신성 홍반성 루푸스에서 F-18 FDG PET상 기저핵 포도당대사 증가 소견을 보이는 무도병 1예 : Evidence for Bilateral Putaminal Hypermetabolism on F-18 FDG PET

서욱장,정선미,고수진,이창근,김재승,임주혁,유빈,문희범 대한핵의학회 2003 핵의학 분자영상 Vol.37 No.5

Purpose: We describe a 54-year-old woman with systemic lupus erythematosus (SLE) who suddenly presented with chorea and had positive antiphospholipid antibodies. F-18 FDG PET showed abnormally increased glucose metabolism in bilateral putamen and primary motor cotex. Tc-99m ECD SPECt also showed abnormally increased regional cerebral blood flow in bilateral putamen. She was treated with corticosteroid and aspirin after which the symptoms improved. Four months later, follow up F-18 FDG PET showed improvement with resolution of hypermetabolism in bilateral putamen. This case suggests that striatal hypermetabolism is associated with chorea in SLE.

구강 편평세포암종에서 E-cadherin 및 β-catenin 발현의 변화 : Correlation with Histologic Features and p53 Expression

서진건,권창석,박진배,윤혜경,김우형,이희철 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.4

Objective : Altered expression of cell adheion molecules is associated with biologic behavior of tumor. The aim of this study is to evaluate the expression pattern of E-cadherin, β-catenin and p53 protein according to histologic grade and invasion pattern of squamous cell carcinoma of the oral cavity and the relationship between E-cadherin, β-catenin and p53 protein expression. Methods and Material : The materials were fifty seven cses of squamous cell carcinoma, and clinicl parameers such as age, sex, tumor location, stage and recurrence were recorded. Histologic review was done based on histologic grade and invasion pattern(nodular vs infiltrative). Immunohistochemical stains for E-cadherin and β-ca tenin were interpreted based on staining pattern as los of membranous expression and cytoplasmic expression and p53 protein expression was defined as positive if more than 10% of nuclei were reactive. Statistical analysis between E-cadherin, β-catenin and p53 protein expressions and histologic grade and invasion pattern and the relationship between E-cdherin, β-catenin and p53 protein expressions were perfomed. Results : There wa positive correlation between higher histologic grade and infiltrative pattern. Loss of membranous expression and cytoplasmic expression of E-cadherin were noted in 33.3% and 57.9%, respectively, and loss of membranous expression of E-cadherin showed increaing tendency in poorly differentiated carcinomas, however, there was no significant difference of cytoplasmic expression rate of E-cadherin according to histoogic grade. Altered expression of E-cadherin was more frequent in poorly differentiated carcinomas. Loss of membranous expression and cytoplasmic expression of E-cadherin were more frequent in carinomas with infiltrative pattern than in carcinomas with nodular pattern, but their diferences were not significant, Loss of membranous expression and cytoplasmic expression of β-catenin were observed in 19.3% and 80.7%, respectively. Loss of membranous expression of β-catenin howed no positive correlation according to histologic grade and invasion pattern, but cytoplasmic expression rate of β-catenin was higher in poorly differentiated carcinomas and in carcinomas with infiltrative pettern. p53 protein expression rate was 45.6%, and showed invreasing tendency in poorly differentiated carcinomas, but no significant relationship with invasion pattern. There was an inverse relationship of loss of membranous expression and cytoplasmic expression of E-cadherin and β-catenin. Altered expression of E-cadherin was related to cytoplasmic expression of β-catenin, however, there were no significant relationship between altered expressions of E-cadherin and β-catenin and p53 protein expression. Conclusion : In squamous cell carcinomas of the oral cavity, altered expression of E-cadherin and β-catenin was more frequent in poorly differentiated carcinomas and in carcinomas with infiltrative pattern and there was positive correlation betwween altered expression of E-cadherin and β-catenin. These findings suggest that altered expressions of E-cadherin and β-catenin may have a role in the development of squamous cell carcinomas with aggressive biologic behavior. but altered explosions of E-cadherin and β-catenin. These findings suggest that altered expressions of E-cdherin and β-catenin my have a role in the development of squmaous cell carcinomas with aggressive biologic behavior. But altered expression of E-cadherin and β-catenin might not be related to p53 protein expression. Further study on genetic mutation related to altered expression of E-cadherin and β-catenin will be needed

진공증착 장비를 이용한 유기발광 소자 제작

서유석,박훈,홍진수,채희백 순천향대학교 기초과학연구소 2004 순천향자연과학연구 논문집 Vol.10 No.2

We fabricated OLEDs(organic light emitting diodes) by vacuum evaporation. In our experiments, well-known materials are used; indium-tin-oxide(ITO) coated glass for anode, Al for cathode. N,N'-diphenyl-N,N'-bis(3-methylpheny)1,1'-bipheny-4,4'-diamine (TPD) for hole-transport layer, and tris(8-hydrxyquinoline) aluminum (Alq3) for an emissive and electron-measured J-V,L-V and J-Current efficiency I-V-L by using Keithley 236 source-measure unit and Minolta Luminance meter LS-100.

Cd/Te 몰분율에 따라 MOVPE 법으로 성장된 HgCdTe 박막의 특성

서대원,Lanh, Ngoc-Tu,김창경,서상희,김병국,김진상 경북대학교 센서기술연구소 2002 센서技術學術大會論文集 Vol.13 No.1

생활체육참가자 스포츠가치관에 미치는 영향

서희진 서울대학교 체육연구소 2001 서울大學校 體育硏究所論集 Vol.22 No.1

The purpose of this study was to explore the influence of participation in sport activity as essential element of life on the view of values in sport. More specifically, this study was to analyze the difference of the view of values in sport between participants and non-participants and the influence on degree of participation in sport activity(frequency, endurance, intensity) by investigating the influences on the subordinate variables of the values in sport: economic value, social value, recreational value, aesthetic value, character value and physical value. The subiects of this study who were sampled were 945 male and female adults who lived in Seoul using stratified cluster sampling and PPS(probability proportionate to size) sampling method. The data collected by questionnaire that was designed for this study consisted of responses to items constructed to represent each variable. The questionnaire for this study used Moon(1999)'s questionnaire that transformed from value division model of Evarett(1962) was verified through reliability and validity and designed to answer the questions with self-administrated method. Statistics employed in this study were t-test, multiple correlation analysis and multiple regression analysis. Based on the procedures and results, the following conclusions were warranted: First, there is a difference in the view of value in sport between the participants and non-participants, More specifically, The participants reveal higher social, recreational, and aesthetic value in sport than non-participants. Second, the degree of sport participation has infuenre on the view of values More specifically, the frequency, endurance, and intensity of sport participation has influence on recreational value in sport. And also, only the frequency participation variable has influence on aesthetic value, character value and physical value.

"응급구조"란 용어의 개념에 관한 응급구조과 학생들의 의미수용변화

서경희,김학수,김진회 한국응급구조학회 2000 한국응급구조학회지 Vol.4 No.1

This is a study to evaluate the effects of the change of EMT students' acceptance on meaning "Korean style translation of EMT". The major instruments of this study were Korean Self-Analysis Acceptance Opinionnaire. This Questionnaire contains 3 items which measure students' opinions or attitudes. The data were analyzed by the path analysis - with SPSS and AMOS package program. The result are as follows: 1) Y(before admission) = 0.11X1(teaching)+0.12 X2(elder)+0.57X2(peer)+E. 2) Y(student) = 0.87X1(teaching)+0.49 X2(elder)+0.59X2(peer)+E. 3) Y(before graduation) = 0.57 X1(teaching)+0.63X2(elder)+0.73X2(peer)+E.

내진을 고려한 수평형 원심펌프의 구조해석에 관한 연구

서영수,정희택,권진회 경상대학교 생산기술연구소 2003 工學硏究院論文集 Vol.19 No.-

The rotating machinery such as the centrifugal pump related to the safety in nuclear power plants have to evaluate their structural integrity and operability through the experimental test, computational analysis or the combination of the test and the analysis. The paper presented is currently aimed at the computational analysis of the designed nuclear pump in the sense of the structural integrity and operability for the centrifugal machinery pump. The commercial finite element analysis program(MSC/NASTRAN)was available to perform the static analysis on the horizontal centrifugal pump installed on the gas stripper system. The numerical results are analysed with respect to the natural frequency, nozzle loads as well as seismic loads, and also the shaft critical analysis along with evaluation of deflection are verified to ensure that the design results meet the seismic requirements.

반복적인 실신 및 실신전환자의 기립경사 검사시 뇌혈류 변화

조수진,김준수,이광호,정진상,송희정,이상철,서정돈,이원로 대한신경과학회 1999 대한신경과학회지 Vol.17 No.3

3개 대학병원의 주 진단 코딩사례 평가

서순원,김광환,부유경,서진숙,서정돈,윤석준,이영성,이무식,정희웅 한국의료QA학회 2002 한국의료질향상학회지 Vol.9 No.1

Background : Coding of principal diagnosis is essential component for producing reliable health statistics. We performed this study to evaluate the current practice of principal diagnoses determination and coding, and to give some basic data to improve coding of principal diagnosis. Method : Nineteen medical record administrators(MRAs) of 3 university hospitals participated in coding principal Dx. From August 1, 2001 to August 31, 2001. From each hospital, 10 medical records of patients with high frequency disease were selected randomly. Each 10 medical records were grouped into three(A,B,C). Then, these 30 medical records were given to each MRAs for coding. At the same time questionnaire was given to each of them. Questions were to prove how they decide and code the principal diagnosis among many current diagnoses ; how they decide and code the principal diagnosis when day see irrelevant diagnosis recorded as the principal diagnosis in medical record, when only tentative diagnoses were recorded without final diagnosis, and when different diagnoses were recorded in different sheets of same record. Agreement of coding among 3 hospitals were compared and survey results were analysed with SAS 6.12. Results : Agreement of coding was found in medical records 5-6 of each 10 medical records. Causes of disagreement were as follows. Difference of clinician’s opinion from each hospital; mixed use of guideline from KCD-3 and guideline from DRG; difference in 4th digit classification according to the absence of pathology report in the medical record; difference of abbreviations among hospitals. 57.9% of decided principal diagnosis after consulting to KCD-3 guideline. When there were difficulties in determining the principal diagnosis, 42.1% of MRAs decided principal diagnosis after discussion with the physician, 26.3% after discussion with fellow MRAs. Conclusion : There were differences in coding among hospitals. To minimize the difference, we suggest the development of disease-specific guidelines for coding in addition to the current general guideline such as KCD-3. To do this, Coding Clinic which can produce guidelines is needed.

DTC를 이용한 새로운 파라메터 추출법

서용진,신희갑,이철인,장의구 중앙대학교 기술과학연구소 1994 기술과학연구소 논문집 Vol.24 No.-

In the manufacturing of VLSI circuits, variations of device characteristics due to the slight differences in process parameters drastically aggravate the performances of fabricated devices. Therefore, it is very important to establish optimal process conditions in order to minimize device sensitivities. In this paper, we used one-dimensional process simulator, SUPREM-Ⅱ, and two-dimensional device simulator, MINIMOS 4.0 in order to extract optimal process parameter which can minimize changes of the device characteristics caused by process parameter variation in the case of short channel nMOSFET and pMOSFET device. From this simulation, we have derived the dependence relationship between process parameters and device characteristics. Here, we have presented a method to extract process parameters from design trend curve(DTC)obtained by process and device simulations.