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측모 두부 방사선 계측 사진에서 안면골의 예상 성장량과 실제 성장량의 비교
서진건,이희철 인제대학교 1999 仁濟醫學 Vol.20 No.1
이 연구는 측모 추부 방사선 계측 사진을 이용하여 성장 중인 아동의 두개 안면 부위에서의 성장과 발육에 대하여 양과 방향을 예측할 수 있는 Ricketts의 방법에 따라서 예상한 값과 실측치를 비교하고 분석하여, 그 예측의 정확성을 확인하고자 시행하였다. 특이한 질환이 없는 정상 아동과 안면 부위의 골격적인 부조화나 치열의 부정교합이 있더라도 치료를 받은 적이 없는 6세에서 16세(평균 12.3세) 사이의 아동 54명(남자 25명, 여자 29명)을 대상으로 각각 측모 두부 방사선 계측사진을 촬영하였고, 계측하여 초기 계측치로 이용하였다. 9개월에서 48개월(평균 19.8개월) 후의 악안면 부위의 예상치를 Ricketts의 방법에 따라서 구했다. 각 대상에서 동일 기간이 경과한 후에 촬영한 두 번째 측모 두부 방사선 사진을 계측하였다. 이 실측치를 예상치와 비교하였다. 각 항목들을 전체적으로 비교하고, 성, 골격적인 특성, 연령, 예상 및 관찰 기간에 따른 군별로 각각 비교하여 다음과 같은 결과를 얻었다. 1. 연구 대상 전체에서 비교한 19개의 예측 항목 중에서 9개의 항목이 통계학적으로 유의한 차이를 보이지 않고 일치하는 것으로 나타났고, 10개의 항목이 통계학적으로 유의한 차이를 보였다. 일치하지 않은 10개 항목 중 5개 항목이 치아 및 치열에 관한 예측 항목이었다. 전반적으로 치아 및 치열에 관한 예측은 통계학적으로 유의한 차이를 보였다. 2. 남자 군에서 13개의 항목, 여자 군에서 10개의 항목이 통계학적으로 유의한 차이를 보이지 않고 일치하는 것으로 나타났다. 남자 군에서 6개의 예측 항목, 여자군에서 9개의 항목이 통계학적으로 유의한 차이를 보였다. 3. 제1급 또는 제3급 부정 교합 군보다 상악이 상대적으로 과성장한다고 보여지는 제2급 부정 교합 군에서 통계학적으로 유의한 차이를 보이지 않고 일치하는 항목이 많았다. 전반적으로 하악의 성장 양상을 나타낸다고 보여지는 항목에 비하여 상악의 성장 양상을 나타낸다고 보여지는 항목에서 통계학적으로 유의한 차이를 보이지 않고 일치하는 항목이 많았다. 4. 13세 이전의 연령 군보다 14세 이후의 연령 군에서 통계학적으로 유의한 차이를 보이지 않고 일치하는 항목이 많았다. 5. 13개월에서 24개월까지의 예측 기간 군보다 12개월 이하의 예측 기간 군과 25개월 이상의 예측 기간 군에서 통계학적으로 유의한 차이를 보이지 않고 일치하는 항목이 많았다. This study was intended to compare and analyze the predicted growth by Ricketts' method, which forecasts amount and directions of craniofacial development on the lateral cephalometrics, comparing with real growth in growing children. A group of 54 children (25 males and 29 feamles) with no orthodontic treatment or under normal growing, age from 6 to 16(mean 12.3) were randomly selected for this study. The first lateral cephalometrics were taken and analyzed. After the analysis of the first cephalometrics, using these resultant values, growth prediction of craniomaxillofacial region uras performed by Ricketts' method within 9 to 48 months(average 19 months) interval. After same interval, second lateral cephalometrics were taken and analyzed. The prediction values were compared with the results of second film analysis. The results were compared entirely and divided into sex. skeletal characteristics, age and prediction term groups. This study, the results were as follows : 1.All 19 measurements were compared, 9 measurements showed no statistical significant difference, but 10 measurements sowed statistical significant difference. The latter included 5 measurements concerning tooth and denture pattern. There was statistical significance to forecast tooth or denture pattern generally. 2.13 measurements in male group and 10 measurements in female group showed no statistical significant difference, but 6 measurements in male group and 9 measurements in female group showed statistical significant difference. 3.There was statistical significant difference in the class I and III malocclusion groups more than in the class II malocclusion group with tendency to overgrowth of maxilla. The gorwth pattern of mandible was statistical significant difference more than the growth pattern of maxilla. 4.There was statistical significant difference in aged under 13 group more than in aged over 14 group. 5.There was statistically significant difference in observation period between 13 and 24 months more than observation period under 12 months and over 25 months.
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구강 편평세포암종에서 E-cadherin 및 β-catenin 발현의 변화 : Correlation with Histologic Features and p53 Expression
서진건,권창석,박진배,윤혜경,김우형,이희철 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.4
Objective : Altered expression of cell adheion molecules is associated with biologic behavior of tumor. The aim of this study is to evaluate the expression pattern of E-cadherin, β-catenin and p53 protein according to histologic grade and invasion pattern of squamous cell carcinoma of the oral cavity and the relationship between E-cadherin, β-catenin and p53 protein expression. Methods and Material : The materials were fifty seven cses of squamous cell carcinoma, and clinicl parameers such as age, sex, tumor location, stage and recurrence were recorded. Histologic review was done based on histologic grade and invasion pattern(nodular vs infiltrative). Immunohistochemical stains for E-cadherin and β-ca tenin were interpreted based on staining pattern as los of membranous expression and cytoplasmic expression and p53 protein expression was defined as positive if more than 10% of nuclei were reactive. Statistical analysis between E-cadherin, β-catenin and p53 protein expressions and histologic grade and invasion pattern and the relationship between E-cdherin, β-catenin and p53 protein expressions were perfomed. Results : There wa positive correlation between higher histologic grade and infiltrative pattern. Loss of membranous expression and cytoplasmic expression of E-cadherin were noted in 33.3% and 57.9%, respectively, and loss of membranous expression of E-cadherin showed increaing tendency in poorly differentiated carcinomas, however, there was no significant difference of cytoplasmic expression rate of E-cadherin according to histoogic grade. Altered expression of E-cadherin was more frequent in poorly differentiated carcinomas. Loss of membranous expression and cytoplasmic expression of E-cadherin were more frequent in carinomas with infiltrative pattern than in carcinomas with nodular pattern, but their diferences were not significant, Loss of membranous expression and cytoplasmic expression of β-catenin were observed in 19.3% and 80.7%, respectively. Loss of membranous expression of β-catenin howed no positive correlation according to histologic grade and invasion pattern, but cytoplasmic expression rate of β-catenin was higher in poorly differentiated carcinomas and in carcinomas with infiltrative pettern. p53 protein expression rate was 45.6%, and showed invreasing tendency in poorly differentiated carcinomas, but no significant relationship with invasion pattern. There was an inverse relationship of loss of membranous expression and cytoplasmic expression of E-cadherin and β-catenin. Altered expression of E-cadherin was related to cytoplasmic expression of β-catenin, however, there were no significant relationship between altered expressions of E-cadherin and β-catenin and p53 protein expression. Conclusion : In squamous cell carcinomas of the oral cavity, altered expression of E-cadherin and β-catenin was more frequent in poorly differentiated carcinomas and in carcinomas with infiltrative pattern and there was positive correlation betwween altered expression of E-cadherin and β-catenin. These findings suggest that altered expressions of E-cadherin and β-catenin may have a role in the development of squamous cell carcinomas with aggressive biologic behavior. but altered explosions of E-cadherin and β-catenin. These findings suggest that altered expressions of E-cdherin and β-catenin my have a role in the development of squmaous cell carcinomas with aggressive biologic behavior. But altered expression of E-cadherin and β-catenin might not be related to p53 protein expression. Further study on genetic mutation related to altered expression of E-cadherin and β-catenin will be needed
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