정신과 폐쇄 병동 환경 평가에 영향을 미치는 임상변인 : 치료의 질적 향성을 위한 예비적 연구 The Preliminary Study for Promoting the Quality of Psychiatric Inpatient Treatment

서정석,류은정,이상미,한미희,최귀순,손인기,남범우 건국대학교 의과학연구소 2003 건국의과학학술지 Vol.13 No.-

Purpose: IS prelminary study was designed to assess the clinical variables influencing on the ward atmosphere in psychiatric closed ward and to promote the quality of psychiatric inpatient treatment. Method: 41 psychiatric inpatients were selected in Chung-ju hospital, Konkuk university. Ward Atmosphere Scale(W AS) was used to evaluate patients' perception of ward milieu. WAS score were compared among subgroups with respect to the clinical variables such as duration of admission, frequency of admission, and diagnosis. Results: Significantly, patients who have hospitalized for 1 month to 2 months reported lower score of WAS and patients who have hospitalized for longer than 2 months reported higher score of WAS. The relationship between educated levels and WAS score was not significant. First admitted patients reported significantly lower score of WAS. Bipolar patients reported significantly higher score of WAS and alcohol related patients reported significantly lower score of WAS. Conclusion: The 1st admitted patients, patients with alcohol problem and educated patients were had less satisfied with psychiatric closed ward. Thus, by considering these factors, more specified therapeutic approach and plan should be conducted.

退行性關節炎 韓方治療에 對한 最近 硏究 動向 : 臨床硏究 方法論을 中心으로 Herbal Medicines in the Treatment of Osteoarthritis in Pubmed and Chinese Medical Journals

서병관,류성룡,이송실,허정은,백용현,이재동,최도영,조윤제,김남재,박동석 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-

Objective : The aim of this study was to review systemically clinical trials on the effectiveness and safety of herbal medicines in the treatment of osteoarthritis. Methods : Computerized literature searches were carried out on seven electronic databases, and hand-searching on some chinese medical journals in library of Kyung Hee Medical Center. Trial data were extracted in a standardized, predefined manner and assessed independently. Results : 1. Thirty reports of clinical trials and two reports of meta-analyses concerning herbal medicine were collected and reviewed Among these reports three medical herbs were applied as topical medicine and others as internal medicine. 2. The western studies established NSAIDs or placebo as their control group. Five chinese reports established formulated herb pill(Ruanshnagshenjin pill) as their control group and Six did not establish a control group at all. 3. ACR was the most highly used diagnostic criteria in the western studies while the Chinese used their official criteria established by their government or the criteria of their text books. 4. 20 reports chose the Lequesne functional index, SHAQ, WOMAC OA index, AIMS, and their own unique scoring system as the criteria of analysing the effect. Others chose clinical symptoms, articular functions, and lab finding as their criteria. 5. 7 single herbs and 19 formulated herbs were studied. Among the formulated herbs, Achyranthes japonica was studied in 10 of the studies and Angelica gigantis Radix in 8, making them the most often studied herbs among the studies.

최대/최소 경계 스키마 추출 기법을 이용한 XML 문서의 DTD 추출

박경현,최은선,이종연,박정석,류근호 충북대학교 컴퓨터정보통신 연구소 2000 컴퓨터정보통신연구 Vol.8 No.2

XML이 인터넷상의 데이터 교환의 표준으로 대두되면서 데이터 모델이나 플랫폼에 관계없이 데이터의 전송이 가능하게 되었다. 특히 데이터 중심의 XML 문서의 경우 전송시의 부하를 줄이기 위해 DTD없이 전송되는 경우가 일반적이다. 그러한 이유로 전송받은 XML 데이터의 저장 효율을 높이고 질의를 최적화하며 사용자에게 편의성을 제공해주기 위해서는 XML 데이터로부터 DTD 추출이 필수적으로 요구된다. 이 논문에서는 이러한 DTD를 추출하기 위해 반구조적 데이터의 스키마 추출 기법을 적용한다. 특히, 반구조적 데이터의 최소 경계 스키마를 추출하는데 데이터로그를 이용하는 기존의 방법보다 효율적인 방법인 시뮬레이션을 적용함으로써 보다 향상된 DTD 추출 기법을 제시한다. XML makes it possible for data to be exchanged regardless of the data model in which it is represented or the platform on which it is stored, serving as a standard for data exchange format on the internet. Especially, It is natural to send XML data without DTD on the internet when XML is data-centric XML. Therefore it is needed to extract DTD to store XML data efficiently, to optimize queries, and to help users browse XML data. In this paper, Techniques for upper/lower bound schema extraction are applied to extract DTD from XML data. Especially we propose an efficient technique for extracting DTD by using simulation which is better than datalog as a lower bound schema extraction method.

월경전증후군의 진단분류학적 개념 및 원인과 치료 : Nosology, Etiology, and Treatment

문석우,서정석,류은정,남범우 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-

Since the emergence of the term premenstrual syndrome (PMS) in the 1950s, PMS has become an increasingly discussed topic in popular media sources. Thus self management techniques are easily accessed by women through the media or through their peers. Premenstrual dysphoric disorder (PMDD) comprises extremely distressing emotional and behavioral symptoms. Women with PMDD report premenstrual symptoms, primarily mood symptoms, that are severe enough to seriously interfere with their life style and relationships and usually do not respond to conservative and conventional interventions. Although women with PMS are most often seen in primary care or by their obstetricians/gynecologists, the result of recent study suggested a high rate of missed diagnoses. The premenstrual syndromes include the more common PMS, the less prevalent PMDD, and menstrual psychosis. The etiology of PMS and PMDD is still largely unknown. That PMS and PMDD are primarily biological phenomena is underscored by recent, convincing evidence. Therapeutic interventions for PMS and PMDD range from the conservative to treatment with psychotropic medication and, for the more extreme cases, hormonal therapy or surgical procedures.

뇌하수체 종양 제거술 시행 후 뒤늦게 발생한 횡문근 융해증과 동반된 중추성 열

장제혁,최규남,김일환,노은지,김윤정,유충헌,고정해,박봉수,김태균,권민정,이순희,박정현 인제대학교 2008 仁濟醫學 Vol.29 No.-

Body temperature is controlled by thermoregulatory center of the hypothalamus. We report a case of 24 years old man with central fever. He was subjected to a partial excision of pituitary tumor compressing optic chiasm four years ago. He has received hormonal therapy for panhypothyroidism after removal of pituitary tumor. And He received gamma knife operation for partially contrast-enhancing masses in suprasellar and both hypothalamic areas that is probably postoperatively remnant or recurrent tumor of pituitary adenoma. One year after gamma knife operation, he presented with a febrile syndrome of unknown origin including rhabdomyolysis. All usual investigations proved negative. We diagnosed him as central fever with rhabdomyolysis. He received medical ICU care with cooling bed, ice pack. And his symptom improved. Postoperative hyperthermia may result following resection of the pituitary tumor. When central fever is suspected taking note of past history, a quick recognition of course of fever can help reduce the using of unnecessary antibiotics and hospital stay.

한국인 알코올의존환자에서의 제1형 부신피질자극 호르몬 분비 촉진 호르몬수용체의 유전자 다형성에 관한 연구

김철민,김성곤,김지훈,김현경,김미경,유정현,민은정 대한생물치료정신의학회 2011 생물치료정신의학 Vol.17 No.2

스트레스 반응에 중요한 역할을 하고 있는 CRHR1 유전자 SNP와 알코올 의존과의 연관성에 관한 선행 연구들이 있다. 이에 본 연구는 백인을 대상으로 조사했던 기존연구와는 달리 한국인 남녀를 대상으로 하여 알코올 의존군과 정상 대조군의 CRHR1 유전자형 빈도 및 대립유전자형 빈도를 비교하였다. 본 연구의 연구대상자들은 알코올 의존군 268명(남자 218명, 여자 50명)과 정상 대조군 137명(남자 78명, 여자 59명)이었다. CRHR1 유전자 SNP를 SNP database와 선행연구를 근거로 선정한 후, 연구 대상자들의 이러한 SNP 유전자형을 PCRRFLP방법으로 조사하였다. 그 결과, 한국인의 CRHR1 유전자 SNPs로 7개(rs242938, rs404623, rs28364027, rs16940686, rs937, rs878886, rs878887)가 분석되었다. 이중 rs28364027의 A 대립 유전자의 빈도는 남녀 각각에서 알코올 의존군이 대조군보다 유의하게 높았다. 그리고 rs28364027의 AA 유전자형 및 A 대립 유전자와 rs878886의 CC유전자형 및 C 대립유전자의 빈도는 알코올 의존군내에서 여성이 남성보다 유의하게 높았다. 이러한 결과를 종합해 보면 CRHR1 유전자 SNP가 알코올 의존의 유전적 원인의 중요한 요인일 가능성을 제시하고 있다. 또 이러한 CRHR1 유전자 SNP가 알코올 의존의 유전적 원인에서 남녀간 차이를 설명할 수 있을 가능성도 시사하고 있다. Objectives:There were several preceding studies investigating the association between alcohol dependence and corticotropine releasing hormone receptor1(CRHR1) gene SNPs that play an important role in response to stress. The frequencies of CRHR1 genotypes and alleles were compared between alcohol-dependent patients and normal control subjects. Methods:The subjects were 268 alcohol-dependent patients(218 males, 50 females) and 137 normal controls(78 male, 59 female). CRHR1 gene SNPs were investigated according to the SNP database and the results from previous studies, and their genotypes were analyzed by polymerase chain reaction(PCR) and restriction fragment length polymorphism(RFLP). Results:Seven CRHR1 gene SNPs(rs242938, rs404623, rs28364027, rs16940686, rs937, rs878886, rs878887) were found in Korean subjects. The frequency of rs28364027 A allele was significantly higher in alcohol-dependent patients than normal controls in both genders. In alcohol-dependent patients, the frequencies of AA genotype and A allele of rs28364027, and of CC genotype and C allele of rs878886 were higher in female than male. Conclusion:These results suggest that CRHR1 gene SNP is one of the important genetic factors in the etiology of alcohol dependence. And also it is supposed that the different frequency of SNP genotype could explain stress-related gender difference in the genetic etiology of alcohol dependence.

The analysis of plaque composition on underexpansion site in patients with acute myocardial infarction treated with drug eluting stents (초)

Eun Jeong Cho,Wang Soo Lee,Sang Wook Kim,Jee Eun Kwon,Min Seok Oh,Jung Eun Kim,Eun Young Kim,Ki Woo Seo,Kwang Je Lee,Tae Ho Kim,Chee Jeong Kim,Wang Seong Ryu 대한내과학회 2009 대한내과학회지 Vol.77 No.4S

Original Article : Regional prevalence of non-alcoholic fatty liver disease in Seoul and Gyeonggi-do, Korea

( Eun Haeng Jeong ),( Dae Won Jun ),( Yong Kyun Cho ),( Young Gil Choe ),( Seung Ho Ryu ),( Seung Min Lee ),( Eun Chul Jang ) 대한간학회 2013 Clinical and Molecular Hepatology(대한간학회지) Vol.19 No.3

Background/Aims: The prevalence of nonalcoholic fatty liver disease (NAFLD) in Korea has increased recently. The aim of the present study was to determine the regional differences in the prevalence and characteristics of NAFLD. Methods: From January 2009 to December 2010, 161,891 Seoul and Gyeonggi-do residents receiving a health examination at our institution were enrolled in this cross-sectional study. After applying exclusion criteria, the data of 141,610 subjects (80,943 males, 60,667 females) were analyzed. The presence of NAFLD was established by ultrasound examination. Results: The overall prevalence of NAFLD was 27.3% (38.3% in men, 12.6% in women). When standardized according to age, area, and sex, the prevalence of NAFLD was 25.2%. The age and area standardized prevalence of NAFLD was higher for men (34.4%) than for women (12.2%; P<O.OOl). The overall prevalence of NAFLD was higher in Gyeonggi￢do (27.7%) than in Seoul (26.9%; P<O.OOl). Among the men, the prevalence of NAFLD was higher in Gyeonggi-do (39.2%) than in Seoul (37.4%; P<O.OOl), while for the women it was higher in Seoul (13.2%) than in Gyeonggi-do (12.0%; P<O.OOl). Conclusions: The regional prevalence of NAFLD differed between Seoul and Gyeonggi-do. Further studies are needed to establish the etiology of this difference. (Clin Mol HepatoI2013;19:266-272)

HCV, Alcoholic : PE-095 ; The regional prevalence of non-alcoholic fatty liver disease among Korean workers living in Seoul and Gyeonggi-do

( Eun Haeng Jeong ),( Yong Kyun Cho ),( Seung Ho Ryu ),( Dae Won Jun ),( Seung Min Lee ),( Eun Chul Jang ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-

Background: The prevalence of Non-alcoholic fatty liver disease (NAFLD) is increasing in Korea recently. Regional differences in NAFLD prevalence and characteristics need to be investigated. Methods: From January 2009 to December 2010, the Seoul and Gyeonggi-do residents who had checked up health exam at our institution 161,941 participants were enrolled in this cross-sectional study. After exclusion criteria, 141,660 subjects (men 80,977, women 60,683) were analyzed. NAFLD was presented by ultrasonographic findings. Results: 1. Both the prevalence of obesity (BMI≥25, kg/m2) and NAFLD were higher in Gyeonggi-do (29.2, 26.8%) than in Seoul (28.7, 25.1%) respectively (p=0.045, p<0.001). 2. The prevalence of Obesity was higher in Kangbuk than Kangnam area (29.6 vs 27.7 % p<0.001), regardless of gender (men in Kangbuk 39.9 vs. men in Kangnam 38.8%, p<0.033; women in Kangbuk 16.3 vs. women in Kangnam 13.0%, p<0.001). There were no difference in prevalence of NAFLD between Kangbuk and Kangnam area, but among women, Kangbuk was higher than Kangnam (13.8 vs 12.5% p=0.001). 3. There were no difference in prevalence of NAFLD between Kangbuk and 3 distincts in Kangnam (Kangnam-gu, Seocho-gu, Songpa-gu), but among men, 3 distincts in Kangnam was higher than Kangbuk (35.5 vs. 33.8%, p=0.006), and among women, Kangbuk was higher than 3 distincts in Kangnam (13.8 vs. 10.9%, p<0.001). Conclusions: There was difference of regional prevalence of the NAFLD in Seoul and Gyeonggi-do in Korea. The further study will be needed about the cause of the difference of regional prevalence.

Mitochondrial oxidative phosphorylation reserve is required for hormone- and PPARγ agonist-induced adipogenesis

Ryu, Min Jeong,Kim, Soung Jung,Choi, Min Jeong,Kim, Yong Kyung,Lee, Min Hee,Lee, Seong Eun,Chung, Hyo Kyun,Jung, Saet Byel,Kim, Hyun-Jin,Kim, Koon Soon,Jo, Young Suk,Kweon, Gi Ryang,Lee, Chul-Ho,Shong Springer-Verlag 2013 Molecules and cells Vol.35 No.2