Hepatic Cirrhosis Occurring in a Young Woodchuck(Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus(WHV)

Kyu-shik Jeong,정원일,Jae-yong Chung,Mi-young An,Chae-yong Jung,Gyoung-jae Lee,Jong-soo Kang,Byeong-cheol Kang,Young-heun Jee,Bruce H Williams,Young-oh Kwon,Da-hee Jeong 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2

Cirrhosis Occurring in a Young Woodchuck (Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus (WHV)Da-hee Jeong, Won-il Jeong, Jae-yong Chung, Mi-young An, Chae-yong Jung, Gyoung-jae Lee1, Jong-soo Kang1, Byeong-cheol Kang2, Young-heun Jee3, Bruce H Williams4, Young-oh Kwon5 and Kyu-shik Jeong*College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea1Shinwon Scientific Co., LTD, Research Institute, Suwon, Korea2Clinical Research Institute, Seoul National University, Seoul 110-744, Korea3College of Veterinary Medicine, Jeju National University, Jeju 690-756, Korea

降水物 tritium濃度의 年中變化

蔡貞淑,尹柱庸,田載植 충남대학교 자연과학연구소 1983 忠南科學硏究誌 Vol.10 No.1

A series of measurements of tritium concentration in precipitation has been carried out at the College of Sciences, Chungnam National University for a period of one year from March 1982 to February 1983. Samples were taken from every precipitation and processed through electrolytic enrichment for liquid scintillation counting of tritium activity. Results are summarized in a table and figure which shows a rough periodicity in the annual variation of tritium concentration with a maximum monthly mean of 1318±197 TR in April 1982 and a minimum of 220±37 TR in July of the same year.

농촌주민의 혈중 납과 카드뮴 농도에 관한 조사연구

정현숙,조영채,이동배 忠南大學校 環境問題硏究所 1991 環境硏究 Vol.9 No.-

The purpose of this study was to find out blood lead and cadmium concentration levels of rural residents. The blood samples were collected from 140 rural residents in 5 nonpolluted regions in Kunbuk-Myun, Kumsan-Gun, Chungnam province from August 31 to September 30, 1990 and analyzed by atomic absorption spectrophotometry. The results were summerized as follow : The mean concentration level(range) of blood lead was 0.240±0.060㎍/ml(0.130-0.390㎍/ml) for males and 0.237±0.056㎍ /ml(0.120-0.370㎍/m) for females. There was no statistically significant difference among age groups and sexes. The distributions were similar to normal distribution in both sexes. The mean concentration level(range) of blood cadmium was 0.066±0.099㎍/ml(0.012-0.582㎍/ ml) for males and 0.060±0.062㎍/ml(0.015-0.392㎍/ml) for females. There was no statistically significant difference among age groups and sexes. The distributions were skewed to the low level ranges in both sexes. The lead concentration level in whole blood did not show statistically sinificant difference among kinds of farming product. But the cadmium level of the rice-ginseng-tobacco farmers was statistically significantly high (p<0.005). The cadmium concentration level in whole blood was 0.040±0.027㎍/ml for the rice-ginseng farmers, 0.076±0.100㎍/ml ofr the rice-tobacco famers, and 0.158±0.171㎍/ ml for the rice-ginseng-to-bacco farmers. There were no statistically significant difference in blood lead and cadmuim concentration levels among groups classified by drinking habit, smoking habit and exposed years to pesticides. The correlation coefficent between the blood lead and cadmium concentration levels was statistically significant(R=0.2054, P<0.05).

급성심근경색증의 조기진단에 있어서 Myoglobin의 진단적 의의

이정헌,김종근,정병천,서강석,박정배,조용근,류재근,전재은,채성철,박의현 大韓應急醫學會 1999 대한응급의학회지 Vol.10 No.2

Background: Exact and early diagnosis of acute myocardial infarction (AMI) is essential for the subsequent routine management of this frequent cardiovascular disease. Currently, AMI has been diagnosed using the combination of the history, electrocardiogram(ECG), and biochemical markers of myocardial necrosis. At present, many biochemical markers are used to diagnose AMI. In this study, the predictive values of serum myoglobin and creatine kinase-MB(CK-MB) were compared in the emergency department. Methods: Fifty-four consecutive patients who presented within 12 hours from onset of chest pain of presumed cardiac origin were enrolled into the study. Patients with trauma or renal failure were excluded. The serial serum myoglobin and CK-MB levels were obtained prospectively at admission and 2, 4, 6, 12, 24 and 48 hours after admission. We compare the levels of serum myoglobin and CK-MB within 2, 4, 6, 8, 10, 12, 24, and 48 hours after symptom onset respectively. And we compare the sensitivity, specificity, positive predictive value, and negative predictive value of myoglobin and CK-MB. Results: using World Health Organization criteria, 28 AMI patients were identified. Mean time from symptom onset to presentation was 4.1±1.3 hours. The predictive values of serum myoglobin were better than those of CK-MB within 6 hours after symptom onset. But, 6 hours after symptom onset, the predictive values of CK-MB were better than those of serum myoglobin. The false positive cases of serum myoglobin were 3-one was lung cancer with pleural effusion and the others were unstable angina. The false positive cases of CK-MB were 6-one case was viral myocarditis and the ohters were unstable angina. Conclusion: To compare the serum myoglobin and CK-MB in the diagnosis of AMI, serum myoglobin had better predictive values than CK-MB within 6 hours after symptom onset and useful in the early diagnosis of AMI. But, 6 hours after symptom onset, CK-MB had better predictive values than serum myoglobin and useful in following up.

정신분열병 및 정신분열형 장애에 대한 올란자핀의 효과와 안전성

안용민,강대엽,권준수,김창윤,김철응,반건호,신영민,이기철,이동우,이중서,조현상,채정호,김용식 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.4

연구목적 : 본 다기관 공동임상연구는 국내 환자를 대상으로 새로운 항정신병약물인 올라자핀의 치료 효과와 안전성을 확인하고자 시행되었다. 방 법 : 1999년 7월부터 2000년 3월까지 국내 10개 병원에 방문한 정신분열병 및 정신분열형 장애 105명을 대상으로 비대조 개방 임상연구를 시행하였다. 중등도 이상의 정신병 증상을 지니거나, 부작용으로 약물교체가 필요한 경우 또는 기분장애 증상의 치료가 필요한 환자를 대상으로 하였다. 2∼7일간의 약물 배설기간 후에 1일 10mg의 올란자핀을 투여하였고, 이후로 3∼7일 간격으로 용량을 조절하여 총 8주간 투여하였다. 치료 효과는 PANSS(Positive and Negative Syndrome Scale), BPRS(Brief Psychiatric Rating Scale), CGI(Clinical Global Impression-Severity), MADRS(Montgomery-Asberg Depression Rating Scale), HAM-A(Hamilton Rating Scale for Anxiety)로 판정하였다. 안전성 평가는 자발적인 이상반응 보고, 활력징후와 혈액 검사 및 SAS(Simpson-Angus Scale), BARS(Barnes Akathisia Rating Scale), AIMS(Abnormal Involuntary Movement Scale)척도를 이용하였다. 결 과 : 105명중에서 85.7%인 90명이 8주간의 치료를 완료하였다. 평균 최빈 용량은 일일 16.1(±4.7)mg이었고, 종료시점에서의 BPRS전체 점수가 기저 상태에 비해 40%이상 감소된 반응군은 69.5%이었다. PANSS의 양성 증후군과 일반정신병리 뿐만 아니라 음성 증후군 소척도에서도 유의한 감소를 보였으며, 이 감소들은 치료 초기부터 나타나서 8주간 지속되었다. 43.8%의 피험자가 중등도 이상의 우울증상을 같이 지니고 있었으며, 올란자핀에 의해 MADRS와 HAM-A가 유의하게 감소하였다. 치료 기간 동안에 활력징후에는 뚜렷한 변화가 없었으나 체중은 8주간 지속적으로 증가하였다. SAS와 AIMS는 감소하였으며, 정좌불능증을 제외한 나머지 추체외로 증상의 발생비율도 낮았다. 임상적인 증상이나 징후를 동반하지 않는 ALT/SGPT의 상승을 보였지만 프로락틴을 포함하는 대부분의 혈액 검사상 뚜렷한 이상 변화는 없었다. 결 론 ; 비록 본 임상연구가 비대조 개방 임상연구로서 많은 제한점을 가지고 있지만, 올란자핀이 기존 약물에 내약성을 보이거나 기분증상을 동반하는 정신병에 치료 효과가 있었다. 그리고 기존 항정신병약물 치료시에 문제가 되었던 추체외로 증상과 고프르로락틴 혈증을 포함하는 대부분의 부작용면에서 안전성을 보여 주었다. Objective : This multicenter clinical trial was carried out to investigate the efficacy and the safety of olanzpine for the treatment of Korean patients. Mothod : 105 patients with schizophrenia and schizophreniform disorder, visited at 10 mental or university hospitals, had received an open and non-comparative treatment with olanzapine for 8 weeks. Patients had psychotic or depressive symptoms with the severity above moderate degree or intolerable side effects to previous antipsychotics. After a wash-out period of 2-7 days, 10mg olanzapine was prescribed initially to all the patients, and then the dosage could be adjusted within the range of 5-20mg/day of olanzapine by 3-7 days. Results : 90(85.7%) of 105 patients completed the 8-weeks trial and the mean modal dose of olanzapine was 16.1(±4.7%)mg/day. At the end of the trial, 73 patients(69.5%) were classified as responder, which was defined as 40% or more improvement in BPRS(Brief Psychiatric Rating Scale) score comparing to baseline. There was a significant reduction in the scores of PANSS(Positive and Negative Syndrome Scale)and subscales including negative symptom scores and CGI. Also weekly analysis showed that the reductions in scores were kept on for the whole period of the trial. 43.8% of all the patients had depressive symptoms at the baseline and total scores of MADRS(Montgomery-Asberg Depression Rating Scale) and HAM-A(Hamilton Rating Scale for Anxiety) were also reduced after the trials. Vital signs revealed no clinically significant changes but continuous weight gain was observed during the treatment with olanzapine. The scores of SAS(Simpson-Angus Scale) and AIMS(Abnormal Involuntary Movement Scale) for assessing the EPS(extrapyramidal symptoms)and tardive dyskinesia respectively were significantly decreased and only a few patients reported EPS as adverse events. Although mild and clinically non-significant of ALT/SGPT was observed, most laboratory parameters including plasma prolactin level showed to significant changes during the trial. Conclusions : Although this trial had many limitations because it was a non-comparative and open study, olanzapine showed high efficacy on the positive, negative and depressive symptoms in schizophrenia and schizophreniform disorder.In addition to that, olanzapine showed a substantially favorable safety profile, such as low incidence of EPS and hyperprolactinemia.

일부 도시지역 주민들의 혈중 미량금속 농도 분포

박종현,정용준,조영채 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.2

To have a fundamental knowledge of blood trace metal concentration in an urban population exposed to an artificially polluted environment, 232 healthy adults (122 male and 110 female) with no known possibilities of being exposed to trace metals or compounds, were sampled during the period of Sep. 2001 through Feb. 2002. Blood concentrations of trace metals were measured by Atomic Absorption Spectrophotometer and the following results were obtained. The mean blood concentration of Cu was higher in women[1.71 ㎍/㎖(0.53-5.60 ㎍/㎖)] than in men [1.34 ㎍/㎖ (0.08-4.32 ㎍/㎖)] with a significant statistical difference(P=0.013), The mean blood concentration of Fe was higher in men [503.7 ㎍/㎖(104.7-803.5㎍/㎖)] than in women [394.5㎍/㎖(64.0-855.0 ㎍/㎖)] with a significant statistical difference (P=0.000). The mean blood concentration of Mg was higher in men [48.37 ㎍/㎖(15.30-82.50 ㎍/㎖)] than in women [33.47 ㎍/㎖(20.32-71.16㎍/㎖)] with a significant statistical difference (P=0.000). The mean blood concentration of Zn was higher in women[11.27 ㎍/㎖(5.60-20.65 ㎍/㎖)] than in men[10.51 ㎍/㎖(4.33-19.80㎍/㎖)] with no statistical significance. Each blood trace metal concentration showed a log-normal distribution pattern. and Cu. Fe. Mg and Zn. all of which are known as essential trace metal. had a broad concentration width.

운동형태의 차이가 Alloxan유발 당뇨쥐의 혈당 및 인슐린 농도에 미치는 영향

윤진환,정일규,김종오,이희혁,지용석,오봉석,채정룡 대한스포츠의학회 2003 대한스포츠의학회지 Vol.21 No.1

The Purpose of this study was to investigate the effect of exercise intensity on blood glucose and insulin levels in diabetic rats with alloxan. Twenty sprague-dawley male rats were assigned to power training groups(n=10) and endurance training groups(n=10). Diabetes was induced by single injection of alloxan(50 mg/kg B.W) Blood glucose and insulin were determined every week for 4-weeks. The conclusion of this study follows as below: 1) There was significantly different on blood glucose levels in two groups. 2) There was significantly different on insulin levels in two groups These results suggest that proper exercise intensity in diabetic rats can significantly decrease blood glucose and insulin level and make good glycemic control. In conclusion, it has been found that regular prolonged endurance training with diabetic rats, improves insulin and blood glucose.

노인에서 정서 인식의 저하

이경욱,채정호,최인철,이해국,권용실,이정태 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.2

Objectives : The purpose of this study was to investigate whether elderly and young adults differ in their recognition of facial expressions of emotion. Methods : A total of 120 (elderly group 53, young group 67) subjects participated in this study. Korean facial expressions of emotion including happiness, sadness, fear, anger, disgust, surprise and neutral were used as stimuli for facial affect recognition test. Computerized facial affect recognition test that consists of facial affect discrimination test and facial affect intensity test was performed. Results : For facial affect discrimination test, there was a significant difference between two groups (F==3.986, P<.01) after controlling the effect of education. Elderly participants showed significantly less correct recognition rate with sadness, anger and disgust (p<.05). For facial affect intensity test, there was no significant difference between the groups in recognition of emotional intensity. Chi-square test or t-test was done according to the clinical variables. Multivariate analysis of covahance was done to test group differences of correct recognition rate and emotional intensity. Conclusion : This is the first report of differential decrease of facial affect recognition in elderly using Korean facial expressions. This study suggests that the decrement of facial affect recognition maye be a part of normal aging process.

한약재의 탕제시간에 따른 잔류농약성분의 경시적 변화

김종대,정용준,조영채 忠南大學校 環境問題硏究所 2002 環境硏究 Vol.20 No.-

To investigate the sequential changes of the residual pesticides such as diazinon, chlorpyrifos, dichlofluanid and procymidone in crude drugs by boiling time, the crude drugs were soaked in pesticide-water at 2.0ppm that general standard detection concentration and 20.0ppm detected commonly in crops separately and dried. These were boiled for several times such as 10, 30, 60, 120, 240, 360, 480 minutes and residual pesticide concentration of the drugs was analyzed by gas chromatograph. The obtained results were summerized as follows. The concentration of diazinon and chlorpyrifos added 2ppm and 20ppm in crude drugs after 10 min boiling was decreased rapidly and the concentration was decreased significantly on statistics according to the time lapse and was not detected after 240 minutes boiling. The concentration of dichlofluanid added 2ppm in crude drugs was decreased rapidly after 10 min boiling and the pesticide in high concentration as 20ppm was almost resolved after 30 minutes boiling. Also it was decreased significantly on statistics according to the time lapse. The concentration of procymidone decomposed slowly at 2ppm and 20ppm and remained 0.002ppm at 2ppm, 0.150ppm at 20ppm after 480 min boiling. The concentration of the organophosphorous pesticide dropped rapidly at 2ppm and 20ppm after 10 min boiling. The concentration decreased significantly by boiling time and not detected after 240 min boiling. The concentration of the organochloro pesticide decomposed slowly at 2ppm and 20ppm and remained 0.001ppm at 2ppm, 0.074ppm at 20ppm after 480 minutes decocting. Considering above the results, the diazinon, chlorpyrifos and dichlofluanid was decomposed rapidly by boiling time but procymidone in the crude drugs was remained for a long time especially. Therefore, it will be considered to set up permissible standard about the residual pesticides and to manage the concentration in crude drugs.

일부 산업장 남성근로자들의 흡연·음주실태에 따른 혈압 및 혈액검사치의 특성

유창균,정용준,조영채 韓國保健敎育.健康增進學會 2003 보건교육건강증진학회지 Vol.20 No.1

This study was conducted to estimate the incidence and the degree of cigarette smoking and drinking among working men, and then to investigate the effects on blood pressure, various hematological indices and blood chemistry. The sample consisted of 2,287 male workers who had undertaken a general health check-up during the two-year period from January, 2000 to December, 2001. Such factors as blood pressure, blood glucose, lipid profiles, and liver function tests were determined and then analyzed with respect to the subjects smoking and/or drinking status. The major findings from this study are: 1. The drinking and smoking status have shown that 52.7% of participants were in the habit of both drinking and smoking while 11.6% were not associated with either. On the other hand 25.4% were involved only in drinking and 10.2% only in smoking. In the group smoking over 21 cigarettes per day over 30, the age group occupied the largest proportion at 20.1%. 2. Regarding the relationship between smoking and/or drinking status, and blood pressure, hematology and blood chemistry, the smoking and/or drinking group had significantly higher levels of blood pressure, both systolic and diastolic, Hb &ct, TG, LDL-C, SGOT, and γ-GTP, than the non-smoking and/or non-drinking group. But HDL-C was significantly lower in the smoking group and significantly higher in the drinking group than the non-smoking/non-drinking group. 3. Regarding amount smoked, a larger number of cigarettes per day was significantly associated with the higher levels of blood pressure, systolic and diastolic, TG, TC, LDL-C, Hb, Hct, and γ-GTP. As for the amount drunk, an increasing amount of alcohol intake was associated with rising levels of blood pressure, systolic and diatolic, TG, TC, LDL-C, HDL-C, Hb, SGOT, and γ-GTP. 4. Regarding the correlation among all the variables stated above, the smoking and drinking amount was shown to be in the positive correlation with blood pressure, both systolic and diastolic, TG, TC, Hb, and γ-GTP. On the contrary, LDL-C and HDL-C was in a positive correlation only with the amount drunk amount, and Hct only with the amount smoked. 5. As with systolic and diastolic blood pressure, the odds ratio of the smoking group was 2.35 and 2.58 compared to the non-smoking/drinking group, whereas it was 1.47 and 1.75 in the smoking/drinking group. Concerning serum lipids, the smoking/drinking group had 1.97 times the levels of TG in the non-smoking/non-drinking group, though the smoking group had 1.55 times the levels of HDL-C in the non-smoking/non-drinking group. As with liver function test results, the drinking group had 2.50 times and the smoking/drinking group had 4.41 times the levels of γ-GTP in the non-smoking/drinking group, respectively. The above results revealed that smoking and alcohol intake were effected the results of blood pressure and laboratory tests. Specifically, not only the smoking/drinking group but also those only smoking or only drinking were not as desirable as the non-smoking and non-drinking group to the results of blood pressure and laboratory tests.