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구강점막 부착용 케토프로펜 고분자 필름의 제조 및 평가
박진석,이상은,강봉석,이경록,이은주,박정숙 충남대학교 약학대학 의약품개발연구소 2014 藥學論文集 Vol.29 No.-
Abstract – The objective of this study was to prepare ketoprofen-loaded buccal adhesive patch. The adhesive patch was formulated by casting method using aqueous soluble polymer povidone K17 (PVP 17PF) as film-forming agent and hydroxypropylmethylcellulose (HPMC) as adhesive agent. To compare the effect of HPMC type, different molecular weight of K4M and K15M HPMC was used. The physicochemical properties of patches such as appearance, thickness, in vitro release, and adhesiveness were investigated. The concentration of ketoprofen was determined spectrophotometrically at a wavelength of 233 nm. The appearance of prepared patches was semi-transparent, light-yellow or almost colorless, and odorless. Thickness of each patches (n=6) was 0.895 ± 0.033 mm for K4M patch and 0.727 ± 0.036 mm for K15M patch. In vitro release test, both K4M and K15M patches showed over 20% release within 30 min. At 120 min, K4M and K15M patches demonstrated 95% and 67.5% release of ketoprofen, respectively, and up to 240 min, both patches released drug completely. Maximum adhesive force of K4M and K15M patches was 6.571 ± 2.703 gf and 2.735 ± 1.151 gf, respectively. Moreover, it took 28.29 ± 0.38 sec and 28.30 ± 0.34 sec for K4M and K15M patch to peel off them after adhesion, showing no significant difference. In conclusion, thickness, in vitro release, and maximum adhesive force could be modulated by alteration of polymer types.
정봉식,이규한,김진길 東亞大學校 附設 情報通信硏究所 1999 情報通信硏究所論文誌 Vol.7 No.1
In this paper the band-stop filter that rejects the undesired 3th and 5th harmonics generated from high frequench generator is analyzed and optimized. The length of the band-stop filter is setup initially a quarter of a wavelength fo the harmonic, but initial filter structure is unable to cutoff the harmonics because of the fringing effect at the input of the choke. To reduce the mismatch between the cutoff frequency and the harmonics, the length of the choke is optimized by using iterative Levenberg-Marquardt Algorithm.
박용진,한주윤,정봉주 한국경영과학회 2000 經營 科學 Vol.17 No.3
This paper proposes an evaluation model for internet shopping mall business by defining its characteristics and evaluation criteria. We analyzed the characteristics of internet shopping mall business environments and classified the business into four major categories. We derived the evaluation criteria which can evaluate all categories comprehensively. The proposed criteria are cost, netizen, technology, transaction, and marketing, each of which gives a significant Impact on the business profitability. Based on these criteria, a quantitative evaluation method was developed. We also proposed a penta-classification scheme which can be used to identify the overall characteristic shape of each internet shopping mall business site. An actual application of our evaluation model was illustrated in order to show that our proposed model may be used in the real business sites.
이진태,정연숙,안봉전 대한본초학회 2002 大韓本草學會誌 Vol.17 No.2
Objectives : Salicorna herbacea is not well known in research except hat it contains plenty of minerals. This is the first report that showed bioactive functions of the extract from Salicornia herbacea, and examined the possibility to develop as a new cosmetic materials. Methods : Hot Water Extract(W.E), Ethanol Extract(E.E) and Crude Extract(C.E) were used as samples. Using Sephadex LH-20, Hot Water extract fractions and Ethanol extract fractions were gained that used for the experiments. Results : In searching for antibacterial activity, the halos for Propionibacterium acnes which are causal bacteria for pimples was identified in 5,000 ppm and 10,000 ppm. In fraction 1 of E.E, it showed 68% Electron Donating Ability(EDA), 61% of tyrosinase inhibiton effect and 50% of Angiotensin Converting Enzyme Ⅰ (AEC) inhibition effect in 10,000 ppm, respectively. In the measurement of astringent effect, W.E of Salicornia herbacea revealed 50% of astringent effect in 10,000 ppm. In the experiment of growth inhibiting ability for human melanoma SK-MEL-5, 5,000 ppm W.E showed over 60% of growth inhibiting ability. Conclusion : It was identified EDA, tyrosinase, astringent could be used for cosmetic materials, and melanoma growth inhibiting ability for the skin and ACE hindrance effect for medical materials.
공간능력, 시지각 회상 능력, 학습양식에 따른 지구와 달의 운동 개념
김봉섭,정진우,양일호,정지숙 한국교원대학교 과학교육연구소 1998 청람과학교육연구논총 Vol.8 No.1
The purpose of this study was to investigate the relationship among spatial ability, learning styles, visual-perception-recall ability, and the conceptual construction of the earth and moon's motion. Four paper-and-pencil tests were used to measure students' cognitive variables. Spatial ability was measured by Spatial Visualization Test, visual-perception-recall ability was measured by Rey's Figure which also have used to test visual-perception-recall ability of right-temporal lobes, and VVT were used to investigate students' learning styles. Further, the test of concept construction was consisted of 15 items about the earth and moon's motion developed by researcher. One hundred and twenty-seven 6th-, one hundred and sixteen 7th-, eighty-seven 9th-grade, ninety-three college students were participated in the investigation of the effects of age and learning style on conceptual construction. In the analysis of students' performances, spatial ability, visual-perception-recall ability, and conceptual achievement showed an increasing pattern with grading. In addition, visual learner's conceptual achievement showed a significantly higher score on conceptual test than verbal learner's(p<0.05). The results of the present study supported the hypothesis that learning styles would differently influence to learning atmospheric concepts by students' learning styles. This study also indicated to be considered the students' spatial ability in learning atmospheric concepts.
황인진,정봉식 東亞大學校附設情報技術硏究所 2005 情報技術硏究所論文誌 Vol.12 No.2
In this paper the compactness of aperture-coupled array antenna with CP(circularly polarized) radiation for 2.4GHz wireless communication hand-set is designed. the compact operation of microstrip antenna is obtained by inserting suitable slits in the radiating patch, and CP radiation by perturbing the diagonal corners in the radiating patch, which generates the resonant mode of interest into two nearly degerate modes. Feed network of array antenna is made by using a two-layer and aperture-coupled structure. By numerical and experimental results, the patch size of compact CP micro strip antenna is reduced about 37% than conventional one without compact technique.