정신분열증의 음성증상 및 양성증상의 연관성

유재학,박광식 국립서울정신병원 1993 臨床硏究論文集 Vol.1993 No.-

기술교과 교육 제도 및 연구의 국제적 동향 : ICTES '95 발표 논문을 중심으로 through Analyzing of Papers Presented at the ICTES '95

이재원,김진순,류창렬,노태천,최완식,최유현,송일민 충남대학교 공업교육연구소 1995 論文集 Vol.18 No.1

The purposes of this study were: (a) to analyze the papers presented at the ICTES according to the papers' representing countries and their main subjects, (b) to analyze the educational systems of the countries in technology education, and (c) to review the international trends of technology education through the papers presented at the conference. The papers(64 total) presented at the ICTES could be classified into eight countries of papers representing Japan(37), Taiwan(8), Korea(6), U. S. A.(3), India(3), Philippines(3), China(2), Singapore(2). The main subjects the papers dealt with could also be classified into educational system/history(9). curriculum/objectives and contents(9), international activities(9), methods/teaching-learning process and teaching materials and new media(40). Followings were the major and new issues presented at the ICTES: (a) Introduction of each country's technology education system. (b) Proposition of a new framework for technology education and a world core curriculum in technology education. (c) Creativity and problem-solving for the instructional method of technology education. (d) Methods and utilization of high technology media in technology education. (e) Necessity of engineering concept in technology education in technology oriented society. (f) Proposition of philosophical direction of technology education based on famous Asian philosophers.

진균성 부비동염 환자의 상악동내 농성 분비물에 대한 세균 배양 및 항생제 감수성 결과

이윤식,김용재,김재호,정유삼,이봉재 대한이비인후과학회 2000 대한이비인후과학회지 두경부외과학 Vol.43 No.10

초음파 시험법에 의한 실존 콘크리트 구조체의 압축강도 추정식에 관한 연구

권영웅,유재은,신정식 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2

This study concerns the new strength equation of concrete by ultrasonic pulse velocity test. There are not only few estimate strength equations of concrete by nondestructive test, but also many problems to apply them because of time, cost, easiness, structural damage, reliability and so on. For this study, there performed a series of test and proposed a equation as follows ; Linear : fck = 70.57Vp - 222.9, r²=91.3% Quadratic : fck = 19.868Vp² - 76.6Vp + 48.1, r²=91.7% here, fc estimated compressive strength of concrete by MPa Vp : Ultrasonic Pulse Velocity of concrete by km/sec.

소아과 입원 환자에 대한 통계적 고찰

정용현,서우식,유재홍,변상현 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.2

For the purpose of assessing the disease patterns by the body organ system in patients of the pediatric age, we performed a statistical analysis of diseases of patients admitted to the department of pediatrics at Chungnam National University Hospital from January 1990 to December 1994. The results obtained were as follows : 1. Total numbers of in-patients were 8,007, of which 4,923 were male and 3,084 were female. The ratio male to female was 1.60 : 1. 2. Prevalence of the diseases classified by body organ system was in the following order : neonatal diseases (34.6%), respiratory diseases (17.4%), infectious diseases (11.5%), congenital anomalies (5.5%), digestive diseases (5.1%), genitourinary diseases (4.9%), neoplasm (4.7%), blood diseases (3.3%), nervous system diseases (2.8%), metabolic and endocrine diseases (2.4%), circulatory system diseases (2.3%), skin and subcutaneous diseases (1.3%), musculoskeletal and connective tissue diseases (1.2%), mental and behavior disorders (0.4%). 3. Major diseases in each body organ system were as follows : 1) infectious diseases : unspecified acute gastroenteritis (35.9%), viral meningitis (10.4%), Rotaviral enteritis (6.8%), sepsis (6.7%), measles (5.8%). 2) neoplasm ; ALL (34.1%), AML (15.8%), Wilms tumor (12.8%), NHL (8.2%), neuroblastoma (5.6%) 3) blood diseases : allergic purpura (24.2%), aplastic anemia (17.1%), ITP (16.4%), iron deficiency anemia (15.8%). 4) metabolic and endocrine diseases : short stature (22.0%), hypocalcemia (13.8%), metabolic acidosis (9.6%), IDDM (6.4%). 5) mental and behavior diseases : neurosis (47.7%), mental retardation (18.2%). 6) Nervous and sensory system diseases : epilepsy (43.2%), cerebral palsy (12.1%), otitis media (9.3%), encephalopathy (6.2%). 7) circulatory system diseases: congestive heart failure (29.2%), dilated cardiomyopathy (8.0%), rheumatic fever (8.0%), mitral insufficiency (6.8%), hypertension (6.4%). 8) respiratory diseases : pneumonia (40.1%), URI (9.6%), acute tonsillitis (9.4%), asthma (8.5%), acute bronchiolitis (8.3%), croup (7.1%), acute bronchitis (4.1%). 9) digestive system diseases : unspecified hepatitis (22.8%), acute gastritis (13.8%). CAH (12.6%), intussusception (7.8%), constipation (7.1%). 10) skin and subcutaneous diseases : cellulitis (23.1%), lymphadenitis (19.7%), urticaria (15.6%), atopic dermatitis (8.8%), furuncle (8.2%). 11) musculoskeletal and connective tissue diseases : Kawasaki disease (76.8%), JRA (8.5%), SLE (7.0%). 12) genitourinary system diseases : UTI (29.0%), minimal change nephrotic syndrome (27.3%), APSGN (7.6%), APN (4.9%). 13) congenital or chromosomal abnormalities : VSD (38.7%), ASD (10.5%), TOF (8.4%), PDA (5.2%), CHPS (4.5%), Down syndrome (4.1%). 14) neonatal diseases : jaundice (32.0%), prematurity (12.7%), RDS (5.7%), sepsis (4.5%), birth asphyxia (3.0%), SGA (3.0%). 15) Others : febrile convulsion (45.6%), failure to thrive (9.2%), FUO (8.9%), drug intoxication (8.2%). 4. Common diseases for admission in pediatrics were in the following order : jaundice, pneumonia, unspecified acute gastroenteritis, VSD, RDS, URI, acute tonsillitis, acute lymphadenitis, ALL, sepsis, asthma, acute bronchiolitis, UTI.

데스크탑 마이크로 성형시스템의 가진성형에 따른 동특성 연구

홍동표,고유곤,홍용,김현식,이재완 한국공작기계학회 2009 한국공작기계학회 춘계학술대회논문집 Vol.2009 No.-

In this study, a desktop forming system which enables hydro dynamic bearing forming was developed. It consists of power train system, frequency forming system, manufactured Die-set, and controller of desktop forming system. The desktop micro forming system is focused on a higher load capacity and a shorter forming time than conventional system. Therefore it was designed for power train capability and load condition of Ball Screw. Moreover, a Piezo actuator was installed to make accurate machining possible, however, the Piezo actuator generate noise and vibration. Thus we performed the analysis of dynamic characteristics through the experiment about developed system in order to reduce such problems and discuss the alternative methods.

New phenalenone derivatives from the Hawaiian volcanic soil-associated fungus Penicillium herquei FT729 and their inhibitory effects on indoleamine 2,3-dioxygenase 1 (IDO1)

Jae Sik Yu,Se Yun Jeong,Chunshun Li,Taehoon Oh,Mincheol Kwon,Jong Seog Ahn,Sung-Kyun Ko,Yoon-Joo Ko,Shugeng Cao,Ki Hyun Kim 대한약학회 2022 Archives of Pharmacal Research Vol.45 No.2

Phenalenone derivatives sourced from fungi arepolyketides that have attracted signifi cant interest becauseof their diverse chemical structures and potential bioactivities. As part of our ongoing quest to discover novel naturalproducts with biological properties from diverse naturalresources, three unreported phenalenone derivatives ( 1–3 ),named ent -12-methoxyisoherqueinone ( 1 ), (−)-scleroamide( 2 ), and (+)-scleroamide ( 3 ), together with four known phenalenonederivatives, ent -atrovenetinone ( 4 ), isoherqueinone( 5 ), herqueinone ( 6 ), and ent -peniciherquinone ( 7 ) wereisolated from the Hawaiian soil fungus Penicillium herqueiFT729, collected on the Big Island, Hawaii. Compounds 2 and 3 were enantiomers, which were separated using achiral-phase HPLC column, which provided optically purecompounds 2 and 3 . The structures of the novel compoundswere established by extensive spectroscopic analyses,including 1D and 2D NMR and high-resolution ESIMS. Their absolute confi gurations were determined using quantumchemical electronic circular dichroism (ECD) calculations. The inhibitory activity of the isolated compounds( 1–7 ) against indoleamine 2,3-dioxygenase 1 (IDO1) wasassessed. Compounds 1, 5–7 inhibited IDO1, with IC 50values of 32.59, 36.86, 19.05, and 24.18 μM, respectively. These fi ndings demonstrated that the phenalenone derivatives1 and 5–7, as IDO1 inhibitors, are promising anticancerimmunotherapeutic agents.

Src/Syk-Targeted Anti-Inflammatory Actions of Triterpenoidal Saponins from Gac ( <i>Momordica cochinchinensis</i> ) Seeds

Yu, Jae Sik,Kim, Jun Ho,Lee, Seulah,Jung, Kiwon,Kim, Ki Hyun,Cho, Jae Youl World Scientific Publishing Company 2017 The American journal of Chinese medicine Vol.45 No.3

<P><I>Momordica cochinchinensis</I> Spreng (family Cucurbitaceae), also known as gac, or red melon, is an edible Southeast Asian fruit valued for its nutritional and medicinal properties. Specifically, Momordicae Semen, the seeds of the gac fruit, is used in traditional Chinese medicine to treat boils, rheumatic pain, muscle spasm, hemorrhoids, and hemangiomas. In this study, a chemical investigation into a gac seed ethanol (EtOH) extract resulted in the identification of three triterpenoidal saponins (<B>1</B>-<B>3</B>), which were investigated for their anti-inflammatory effects. Among the saponins, momordica saponin I (compound <B>3</B>) reduced the production of nitric oxide (NO) in LPS-activated RAW264.7 cells without inducing cytotoxicity. The mRNA levels of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 were decreased by momordica saponin I. Additionally, the translocation of p65 and p50 (subunits of the transcription factor NF-<TEX>$ \kappa $</TEX>B) into the nucleus was remarkably inhibited. Furthermore, the phosphorylation levels of inflammatory signaling proteins (I<TEX>$ \kappa $</TEX>B<TEX>$ \alpha $</TEX>, Src, and Syk) known to be upstream regulatory molecules of p65 were decreased under momordica saponin I-treated conditions. The molecular targets of momordica saponin I were confirmed in overexpression experiments and through immunoblot analyses with Src and Syk. This study provides evidence that momordica saponin I could be beneficial in treating inflammatory diseases, and should be considered a bioactive immunomodulatory agent with anti-inflammatory properties.</P>

LC : Effects of Oral Branched Chain Amino Acid on Serum Albumin Concentration in Patients with Liver Cirrhosis

( Jae Hyuk Choi ),( Woo Jin Chung ),( Yu Jin Lee ),( Yu Jin Kang ),( Jung Min Lee ),( Eun Sung Choi ),( Sang Min Lee ),( Byoung Kuk Jang ),( Jae Seok Hwang ),( Eun Soo Kim ),( Kyung Sik Park ),( Kwang 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1

Background/Aim: The use of oral branched chain amino acid (BCAA) for enriched supplement in liver cirrhotic patients is increasing now. This study aimed to examine the effects of BCAA as well as factors associated with the effectiveness to in crease serum albumin concentration. Methods: We reviewed retrospectively medical records of cirrhotic patients who received oral BCAA from January 2004 to December 2012 at Keimyung University Dongsan Hospital . We analyzed the changes of serum albumin concentration after use of oral BCAA and several factors which affected to the effectiveness of oral BCAA. Results: Total 89 patients were included (64 men; mean age, 63.0 ± 8.7 years). Hepatitis B (57.3%), alcohol (15.7%), hepatitis C (14.6%), and others (12.4%) were the causes of liver cirrhosis. Patients with Child-Pugh class A, B, and C were 28.1, 42.7, and 29.2%. Patients were treated with daily oral BCAA (mean dose ± standard deviation, 8.76 ± 2.25 mg/day; median follow-up period, 95 days). 1. Increased albumin group after use of oral BCAA were 27 and non-increased groups were 62 patients. 2. Antiviral therapy was used in patients with hepatitis B (33.3%) during oral BCAA treatment. Antiviral therapy in patients with hepatitis B (80.0% vs. 55.6%; P=0.123) was not significant difference with albumin level after oral BCAA treatment. 3. According to univariate and multivariate analysis, Patients with CP class A or B (OR, 3.611 ; 95 % CI, 1.168-11.169; P=0.026), initial eunatremia (OR, 6.298 ; 95 % CI, 2.064-19.214 ; P=0.001) were increased albumin concentration after oral BCAA treatment. Conclusion: Oral BCAA in patients with liver cirrhosis is effective both as compensated and uncompensated. Oral BCAA effectively increased serum albumin in cirrhotic patients with CP A or B than C. So, early administration of oral BCAA in cirrhotic patients seemed to be needed for better life quality.

Bioactivity-guided isolation of ginsenosides from Korean Red Ginseng with cytotoxic activity against human lung adenocarcinoma cells

Jae Sik Yu,노현수,Kwan-Hyuck Baek,Seul Lee,Sil Kim,Hae Min So,Eunjung Moon,Changhyun Pang,Tae-Su Jang,Ki Hyun Kim 고려인삼학회 2018 Journal of Ginseng Research Vol.42 No.4

Background: Lung cancer is the leading cause of cancer-related death worldwide. In this study, we used a bioactivity-guided isolation technique to identify constituents of Korean Red Ginseng (KRG) with antiproliferative activity against human lung adenocarcinoma cells. Methods: Bioactivity-guided fractionation and preparative/semipreparative HPLC purification were used with LC/MS analysis to separate the bioactive constituents. Cell viability and apoptosis in human lung cancer cell lines (A549, H1264, H1299, and Calu-6) after treatment with KRG extract fractions and constituents thereof were assessed using the water-soluble tetrazolium salt (WST-1) assay and terminal deoxyribonucleotidyl transferaseemediated dUTP nick end labeling (TUNEL) staining, respectively. Caspase activation was assessed by detecting its surrogate marker, cleaved poly adenosine diphosphate (ADP-ribose) polymerase, using an immunoblot assay. The expression and subcellular localization of apoptosis-inducing factor were assessed using immunoblotting and immunofluorescence, respectively. Results and conclusion: Bioactivity-guided fractionation of the KRG extract revealed that its ethyl acetatee soluble fraction exerts significant cytotoxic activity against all human lung cancer cell lines tested by inducing apoptosis. Chemical investigation of the ethyl acetatesoluble fraction led to the isolation of six ginsenosides, including ginsenoside Rb1 (1), ginsenoside Rb2 (2), ginsenoside Rc (3), ginsenoside Rd (4), ginsenoside Rg1 (5), and ginsenoside Rg3 (6). Among the isolated ginsenosides, ginsenoside Rg3 exhibited the most cytotoxic activityagainst all human lung cancer cell lines examined,withIC50 values ranging from161.1 mMto 264.6 mM. The cytotoxicity of ginsenoside Rg3 was found to be mediated by induction of apoptosis in a caspaseindependent manner. These findings provide experimental evidence for a novel biological activity of ginsenoside Rg3 against human lung cancer cells. 2018 The Korean Society of Ginseng, Pu