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Choi, J.-S.,Jeon, M.-H.,Moon, W.-S.,Moon, J.-N.,Cheon, E.J.,Kim, J.-W.,Jung, S.K.,Ji, Y.-H.,Son, S.W.,Kim, M.-R. PHARMACEUTICAL SOCIETY OF JAPAN 2014 Biological & pharmaceutical bulletin Vol.37 No.1
The potential hair growth-promoting activity of rice bran supercritical CO2 extract (RB-SCE) and major components of RB-SCE, linoleic acid, policosanol, gamma-oryzanol, and gamma-tocotrienol, were evaluated with the histological morphology and mRNA expression levels of cell growth factors using real-time reverse transcriptase-polymerase chain reaction (PCR) in C57BL/6 mice. RB-SCE showed hair growth-promoting potential to a similar extent as 3% minoxidil, showing that the hair follicles were induced to be in the anagen stage. The numbers of the hair follicles were significantly increased. In addition, mRNA expression levels of vascular endothelial growth factor (VEGF), insulin-like growth factor-1 (IGF-1), and keratinocyte growth factor (KGF) were also significantly increased and that of transforming growth factor-beta (TGF-beta) decreased in RB-SCE-treated groups. Among the major components of R13-SCE, linoleic acid and gamma-oryzanol induced the formation of hair follicles according to examination of histological morphology and mRNA expression levels of cell growth factors. In conclusion, our results demonstrate that RB-SCE, particularly linoleic acid and gamma-oryzanol, promotes hair growth and suggests RB-SCE can be applied as hair loss treatment.
β-cyclodextrin 을 이용한 난황의 콜레스테롤 제거
박우문,유익종,지중룡,전기홍,김천제,임상빈 한국축산학회 1997 한국축산학회지 Vol.39 No.5
This study was carried out to remove cholesterol from liquid egg yolk by using β-cyclodextrin(β-CD) which formed insoluble complex by binding with cholesterol existed in oil-water interface of egg yolk. The conditions of treatment varied with the centrifugal force, mixing temperature, mixing time, distilled ratio and β-CD : cholesterol molar ratio, and the removal efficiency of cholesterol of each treatment was measured. The optimal conditions of centrifugal force, mixing temperature and mixing time to remove β-CD. cholesterol complex were 2,000 g, 35℃ and 15 min, respectively. The ratio of egg yolk to distilled water was 1 : 3 with the most cholesterol removal and with the highest solid content remained. When the molar ratios of β-CD to the egg yolk cholesterol were 3: 1, 5: 1 and 6: 1, the efficiencies of cholesterol removal were 75.0, 88.9 and 95.9%, respectively, and the contents of remnant solid were 68.2, 64.6 and 56.9%, respectively. As the amount of added β-CD increased, cholesterol removal efficiency was increased but valuable nutrients of egg yolk also decreased. Therefore, it was concluded that the molar ratio of 3 : 1 -5 : 1 for β-CD : cholesterol was most effective in removing cholesterol from egg yolk, considering the amount of valuable components remained.
Keyboard Frame의 평면경사각과 측면경사각 및 Keypad 평면회전각의 변화가 Typing 수행도에 미치는 영향에 관한 연구
이면우,전영호,장성록,이도준,최재호,김대철,지철규,박현구 한국경영과학회 1990 한국경영과학회 학술대회논문집 Vol.- No.1
Occupational disease among typists such as Carpal Tunnel Syndrome (CTS) and tendonitis has increased along with the rapid expansion of office automation. During typing, the posture can be defined as forearm pronation, ulnar abduction, wrist extension and finger flexion. The CTS results from awkward posture between forearm-wrist-hand and the keyboard arrangement. Therefore, ergonomic principles should be emphasized in keyboard design. The objective of the study is to improve keyboard design by analyzing anatomical posture of forearm and hand during typing. An experimental study was performed to investigate relationships between a keyboard and typing performance. Results showed that typing performance is dependent to angles and slopes of a keyboard. Statistcal analysis indicated that the suggested ergonomic keyboard improved typing speed significantly(17%).
Ji, M.K.,Kabra, A.N.,Choi, J.,Hwang, J.H.,Kim, J.R.,Abou-Shanab, R.A.I.,Oh, Y.K.,Jeon, B.H. Elsevier Science 2014 Ecological engineering Vol.73 No.-
The endocrine-disrupting chemical, bisphenol A (BPA) has attracted much attention due to its estrogenic activity and widespread environmental distribution. The toxicity and cellular stresses of BPA to Chlamydomonas mexicana and Chlorella vulgaris and its biodegradation/bioaccumulation by both microalgae were investigated. The 120-h EC<SUB>50</SUB> of BPA for C. mexicana and C. vulgaris were 44.8 and 39.8mgL<SUP>-1</SUP>, respectively. The dry cell weight and chlorophyll a content of both microalgae decreased with increasing BPA concentration higher than 10mgL<SUP>-1</SUP>. Growth of C. vulgaris was significantly inhibited at 50mgL<SUP>-1</SUP> BPA compared to C. mexicana. Total nitrogen (TN) and total phosphorous (TP) removal was higher in C. mexicana than in C. vulgaris. Microalgae performed the bioaccumulation and biodegradation of BPA to varying extents at different initial BPA concentrations. The highest rates of BPA biodegradation, 24 and 23% by C. mexicana and C. vulgaris, respectively, were achieved at 1mgL<SUP>-1</SUP> BPA. Both the total fatty acid and carbohydrate contents increased with increasing BPA concentration. This study demonstrated that C. mexicana was more tolerant to BPA and could be used for treatment of BPA contaminated aqueous systems.
TRIP형 Duplex Stainless 강의 상온 인장 특성에 미치는 N 함량의 영향
지정훈(J. H. Ji),김세라(S. R. Kim),황시우(S. W. Hwang),최점용(J. Y. Choi),박경태(K. T. Park) 한국소성가공학회 2010 한국소성가공학회 학술대회 논문집 Vol.2010 No.10
(1) 저 Ni 계 이상(duplex) STS 강을 개발하기 위해 Fe- 20Cr- 5Mn- 0.2Ni- xN (x=0.1, 0.2, 0.3, 중량%)강 냉연소둔재의 인장특성과 인장변형 중 미세조직 변화에 미치는 N 첨가의 영향을 조사하였다. (2) Fe- 20Cr- 5Mn- 0.2Ni- xN (x < 0.3) STS 강의 경우 N 함량 증가에 따라 강도 및 연신율은 증가하였다. 이는 N 함량 증가에 따른 austenite 분율 증가에 의한 austenite 소성변형 중 일어나는 TRIP의 기여도가 증가하기 때문이다. In the present study, room temperature tensile behaviors of duplex stainless steels with the low Ni content were investigated to examine the effect of nitrogen addition. For this purpose, nitrogen of 0.1~0.3 wt.% was added to the steels. The steels were cold rolled (~70 % reduction) and then annealed at 1100 C for 5 min. Both strength and ductility increased with increasing the N content. Especially, in the case of the steel containing 0.3 wt.% N, tensile strength exhibited ~1000 ㎫, and the elongation became ~50 %. Deformation of austenite in the present duplex stainless steel was dominated by transformation induced plasticity, and greatly affected the overall deformation.
DED 공정에서의 비정상 분말 공급이 적층 품질에 미치는 영향
양정호(J. H. Yang),어두림(D. R. Eo),지성훈(S. H. Ji),한지수(J. S. Han),양승원(S. W. Yang),남기욱(K. W. Nam),윤종천(J. C. Yoon),이협(H. Lee),박상후(S. H. Park) Korean Society for Precision Engineering 2021 한국정밀공학회 학술발표대회 논문집 Vol.2021 No.11월
레이저 기반의 DED (Directed Energy Deposition) 적층 기술은 이동하는 레이저 빔의 초점 영역에 금속 분말을 공급하여 제품을 한층씩 적층하여 제작을 하는 공정으로 항공우주, 자동차, 조선, 의료와 같은 다양한 산업분야에서 사용되고 있다. 하지만 공정 중에 발생되는 열누적으로 인한 열변형, 분말 부족으로 인한 증착 높이 부족 등의 적층 불량이 발생되고 있으며 특히, 분말을 공급하는 노즐의 막힘 현상은 공정 중에 비정상적인 분말 공급으로 적층 품질 저하 및 적층 실패를 초래하는 대표적인 공정 불량 현상 중 하나이다. 본 연구에서는 레이저 기반 DED 공정 중 노즐 막힘에 따른 적층 불량 현상을 파악하기 위해 Computational Fluid Dynamics (CFD)와 적층 제조 공정을 활용하였다. 열유동해석 프로그램을 이용하여 노즐이 막혔을 때를 비대칭 분사 형태로 공정 모델링을 하였으며, 해석 결과를 통해 분말분포가 뷴일, 불균일할 때의 열 분포를 분석하였다. 실험에도 해석과 같은 공정으로 시편을 적층하여 분석하였다. 불균형한 분말 분사는 적층 비드 및 멜트풀의 불균일성을 초래하였으며 적층이 지속될수록 불균형성의 누적으로 제품 불량을 초래하게 되었다. 이 연구 결과를 통해 DED 공정 중에 노즐 불량으로 발생되는 현상을 예측할 수 있는 기반 데이터로 활용할 예정이며 공정 불량의 모니터링을 위한 기본 자료로 적용될 수 있을 것으로 사료된다.