Slide Session : OS-IFD-07 ; Infectious Disease : In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus

( Myung Jin Lee ),( Kye Hyung Kim ),( Jong Youn Yi ),( Su Jin Choi ),( Chung Jong Kim ),( Nak Hyun Kim ),( Kyoung Ho Song ),( Pyoeng Gyun Choi ),( Ji Hwan Bang ),( Wan Beom Park ),( Eu Suk Kim ),( San 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus Myung Jin LEE1, Kye-Hyung KIM1, Jongyoun YI2, SuJin CHOI1, Chung-Jong KIM1, Nak- Hyun KIM1, Kyoung-Ho SONG1, Pyoeng Gyun CHOI1, Ji-Hwan BANG1, Wan Beom PARK1, Eu Suk KIM1, Sang-Won PARK1, Hong Bin KIM1, Nam Joong KIM1, Myoung- Don OH1 Seoul National University College of Medicine, Korea1, Pusan National University School of Medicine, Korea2 Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel Bunyavirus, severe fever with thrombocytopenia syndrome virus (SFTSV). No effective antiviral therapy is proven yet, but clinical use of ribavirin (RBV) has been tried. We investigated the antiviral effect of RBV against SFTSV in vitro. Methods: To test for cytotoxicity of RBV, Vero cells were treated with different concentrations of RBV (3.90 to 500 μg/mL, two-fold dilution) and analyzed by cell viability MTS assay 48h post-infection. To determine antiviral activity of RBV against SFTSV, Vero cells were infected with SFTSV strain Gangwon/Korea/2012 at 100 TCID50 (50% tissue culture infective dose) per well in a 96-well plate, and RBV was added at the concentrations showing no or minimal cytotoxicity. Viral RNAs were extracted from the culture supernatants and quantifi ed using one-step real-time reverse transcription- PCR to amplify the partial large segment of SFTSV. Statistical analysis was done by one-way ANOVA with Tukey`s post hoc test. Results: Cytotoxicity due to RBV was not observed at RBV concentration =31.3 μg/ mL. Viral RNAs at 24h post-RBV treatment were reduced with increasing RBV concentrations (1-32 μg/mL), compared with those of mock-treated cells (P <0.01, Figure). Half maximal inhibitory concentration (IC50) of RBV was 3.69 μg/mL at 24h post-RBV treatment. Conclusions: Our study shows that RBV has antiviral effect against SFTSV in a dose-dependent manner. Further studies are required to evaluate the effi cacy of RBV in SFTS.

Not Voice but Case Match Matters in VP Ellipsis and Pseudogapping of English

Myung-Kwan Park,Sunjoo Choi 한국언어학회 2015 언어 Vol.40 No.2

Park, Myung-Kwan & Choi, Sunjoo. 2015. Not Voice but Case Match Matters in VP Ellipsis and Pseudogapping of English. Korean Journal of Linguistics, 40-2, 000-000. This paper develops a Case/case-theoretic account for what Merchant (2008) calls voice mismatch in ellipsis constructions of English. Merchant (ibid.) reports that VP ellipsis as an elision of smaller size VP allows voice mismatch, but Pseudogapping and Sluicing as an elision of bigger size vP/TP do not. However, Tanaka (2011) argues against Merchant's dichotomy in voice mismatch between VP ellipsis and Pseudogapping, reporting that voice mismatch in both types of ellipsis is permissible or not while interacting with what Kehler (2000) calls discourse coherence relations between ellipsis and antecedent clauses. Departing from Kehler's (2000) insight, we suggest that vP undergoes ellipsis in a resemblance discourse relation, but VP does so in a cause/effect discourse relation. Given the asymmetry in the size of ellipsis in tandem with discours relations, we argue that since Accusative as well as Nominative Case is checked outside VP, the VP to be elided can meet the identity condition on ellipsis with its antecedent VP as the object element in the former and the subject one in the latter or vice versus have not been Case-checked yet, thus being identical in terms of Case-feature at the point of derivation building a VP. (Dongguk University)

Reliability Considerations of Hybrid Power Systems for Critical Facilities

Choi, Se Jin · Ham, Young Hwan · Kim, Myung Chin 충북대학교 컴퓨터정보통신연구소 2008 컴퓨터정보통신연구 Vol.27 No.2

본문참고

On English Verbal Anaphor: VP Replacement and VP Ellipsis

Myung-Kwan Park,Sunjoo Choi 현대문법학회 2017 현대문법연구 Vol.96 No.-

Myung-Kwan Park and Sunjoo Choi. 2017. On English Verbal Anaphor: VP Replacement and VP Ellipsis. Studies in Modern Grammar 96, 89-107. It has been noted that VP replacement do so is not allowed with verbal passives, though it is with unaccusatives (Hallman 2013). This paper develops an identity-based account for this contrast. Bruening (2016) recently reports that VP replacement is permitted even with passives in some restricted environments. Reformulating Miller's (2011) three options for VP anaphor (i.e., VP replacement and VP ellipsis), Bruening (2016) suggests two factors governing the choice of VP anaphor. Departing from Bruening (2016), however, this paper provides an identity-based account for the issue concerned, by demonstrating that VP replacement and VP ellipsis are derived in a similar way but they require different operational domains in tandem with the identity domain for VP replacement or ellipsis. Grounded on some key representative examples, we suggest that passives as well as unaccusatives require syntactic identity, but that they are distinguished in terms of the category where VP replacement or ellipsis applies. Furthermore, the difference between VP replacement and VP ellipsis concerning the size of operational domain can be extended to account for causative-inchoative alternations. In doing so, we argue that meeting the identity condition is crucial for VP replacement as well as VP ellipsis.

담도 및 췌장 악성종양에서의 CAl9-9의 진단적 가치에 대한 평가

명승재,최승목,김은옥,최호순,이성구,김명환,민영일,류진숙 大韓消化器病學會 1995 大韓消化器病學會誌 Vol.27 No.3

연구논문 : 중학교 과학교사들의 수업 실행 전문성 개발을 위한 교사교육 요구

최영 ( Young Choi ),이무상 ( Mu Sang Lee ),송명섭 ( Myung Seub Song ) 경북대학교 과학교육연구소 2010 科學敎育硏究誌 Vol.34 No.2

본 연구는 중학교 과학교사의 수업 실행 전문성의 개발을 위한 교사교육에 대한 요구를 조사하는데 그 목적이 있다. 최영 등의 틀(2010)을 보완하여 중학교 과학교사의 수업실행 전문성의 개발에 대한 교사교육의 요구를 조사하는 설문지를 제작하였다. 과학수업 전문성 6요소, 36관점에 대한 발달과 학습 수준, 교사교육의 필요도와 우선 요구도를 조사하였다. 대구지역 중학교 과학교사 203명의 수업 실행 전문성의 발달 수준과 학습 수준은 2.45와 3.12이었다. 발달 수준과 학습 수준 향상을 위한 교사교육의 필요도는 3.45, 3.16이었고, 교사교육의 우선 요구도가 가장 높은 요소는 `수업 계획`이었고 관점은 각각 `개인차를 고려한 계획`과 `학습 활동 계획`이었다. 교사교육의 필요도와 우선 요구도는 교사의 유형에 따라 유의미한 차이를 보였으며, 특히 경력이 적은 교사들과 지구과학 전공 교사들의 필요도와 우선 요구도가 높았다. 이상과 같은 교사교육에 대한 과학교사들의 요구는 수업 실행 전문성의 요소와 관점별로 발달 수준과 학습 수준을 향상시키는데 적합한 교사교육 프로그램 개발에 도움을 줄 것이라고 기대한다. The purpose of this study is to survey the need of in-service education for the professional development of middle school science teachers` teaching practice. The questionnaire was modified by Young Choi`s framework(2010) to survey the level of the progression in the professional development and learning, the degree of in-service education necessity, and the degree of priority of need. The questionnaire was administered to 203 middle school science teachers in Daegu. The mean level of the progression in the professional development and learning were 2.45 and 3.15. The degrees of in-service education necessity to improve level of the progression in the professional development and learning was 3.45, and 3.16. The element and aspect highest degree of priority of need were `element 1. planning coherent sequences of lessons` and `aspect 1-4. planning difference among individuals`, `aspect 1-2. planning learning activity`. The degree of in-service education necessity and the degree of priority of need was a significant difference according to almost all of the teachers` characteristics.

평야지재배 조생종 벼의 이화학적 및 식미특성 분석

정진일,김기영,최윤희,최원영,고종철,오명규,홍하철,이승엽,이명철 한국국제농업개발학회 2004 韓國國際農業開發學會誌 Vol.16 No.4

평야지재배 적응 조생종 벼 품종의 선발 및 품종 육성의 기초 자료로 활용코자 극조생종(1품종)과 조생종(10품종) 및 준조생(3품종)등 총 14품종을 산간지(운봉)와 평야지(익산)에 지역별 표준재배법으로 공시한 결과, 1. 극조생종 및 조생종들은 감온성이 커 산간지에서 출수가 빠르나, 준조생종에 속하는 상미벼, 영덕34호, 히또메보레 등은 감광성이 감온성보다 커, 평야지재배에서 4일정도 빨리 출수하였다. 2. 수량성은 대부분의 품종들이 산간지재배에 비해 평야지 재배에서 높았고 대체로 출수가 빠른 품종일수록 지역간의 수량차가 크게 나타났으며, 출수가 다소 늦은 준조생종들은 산간지와 평야지의 재배에서 수량차가 크지 않아 산간지 뿐만 아니라 평야지에서도 적응성이 높았다. 3. 단백질함량은 숙기가 다소 늦은 품종일수록 낮은 경향을 보였고 산간지보다는 평야지에서 낮았으며, 품종간에는 오대벼, 운봉30호, 영덕34호, 신석조생, 상미벼 등이 함유량이 낮았다. 4. 식미치는 산간지재배가 평야지에 비해 보다 높게 나타났고, 출수가 늦을수록 높았으며, 지역간 차가 크게 나타난 품종은 극조생종인 키라라397이었고, 출수가 늦은 상미벼와 히또메보레는 차가 적었다. 5. 산온도와 수량과의 상관은 산간지에서만 영향이 있을 뿐 평야에서는 영향이 적고 일사량과 일조시수가 수량에 보다 상관성이 높았으며, 식미치는 적산온도와는 부의상관, 생육 일수와는 정상관을 보였다. This experiment was carried out to clarify the difference of rice yield and the quality of rice in southern plan area and in alpine area. Yield and quality of fourteen early varieties were investigated under the different transplanting dates and planting densities in southern plan area(Iksan) and in alpine area(Unbong). In the alpine area, extremely early variety and early varieties headed early compared to the plain area, but medium early varieties headed about 4 days late unlike the alpine area. The yield difference of most early varieties including Kilara 397 of extremely early flowering variety were greater in plain area than in alpine. The different of yield between plain and alpine area was less in varieties with Sinseogjosaeng, Odaebyeo, Akidagomachi, and Yeungdeuk34. The rate of protein was lower in plain area than alpine and more lately flowering than early, but palatability of milled rice was higher at the alpine area and more lately flowering varieties. Correlation coefficients between yield and meterological data during maturity, yield shower the significant correlation with integrated solar radiation and sunshine hours at cultured in southern plan area, but it showed only cumulative temperature in alpine area. Palatability of miller rice was positive correlation at growth duration but negative correlation at cumulative temperature.

Metro optical Ethernet 소프트웨어의 연구

방만원,박종현,이명은,최명선,김명조 木浦大學校 應用科學硏究院 2001 應用科學硏究誌 Vol.1 No.-

본 논문에서는 메트로 옵티컬 이더넷의 소프트웨어 구조에 관한 연구를 위하여 10기가 비트 이더넷 스위치에 적용될 QoS 지원 소프트웨어의 적용성을 자원할당 방식 시그널링 프로토콜인 RSVP와 트래픽 특성에 따라 CoS를 구분하는 DiffServ가 10 기가비트이더넷 스위치에 활용 가능한지를 네트웍크 프로세스 처리 능력과 확장성 측면에서 분석하였다. 결론적으로 RSVP, Diffserv와 802.1p는 구현 및 상혼 연동이 가능하다. 그러나 이것은 기업 내부망으로 한정된다는 단점을 가지고 있다. 일반적으로 중소규모의 특정 기업의 내부망에 위의 기술들을 구현하는 것은 어려움이 없다. 그러나 공중망에서의 적용은 아직까지는 어려움이 많이 존재하며 서비스 제공자간의 연동은 거의 불가능하다. 따라서 이러한 기술들은 End-to-End QoS를 보장하는 것에 목적을 두고 있다.

Cellulase 活性에 대한 몇 가지 金屬 이온의 影響

崔明子 연세대학교 교육대학원 1976 연세교육과학 Vol.10 No.-

도시주민의 B형 간염에 대한 예방적 건강행위 이행에 관한 연구

崔翔旭,李明淑,廉容泰 고려대학교 의과대학 1990 고려대 의대 잡지 Vol.27 No.3

Hepatitis B infection is one of the most prevalent epidemic diseases in Korea. As a control measure, improving the preventive health behavior and concerns of appropriate people cannot be overemphasized. In light of the above reasons, an interview survey was performed to clarify the relationships between the variables related to health behavior and those related to health beliefs on hepatitis B infection. A total of 509 housewives who were invited to a hepatitis B screening campaign was selected for the study. These women were separated into two groups :those who participated in the campaign(258 persons) and those who did not participate(251 persons). The results were as follows : 1. Variables of socio-demographic characteristics, cue to action, and health belief were significantly associated with variables of preventive health behavior on serological test for hepatitis B. 2. The participating group had higher degree of general knowledge, susceptibility, severity, benefit and health concerns of hepatitis B infection. 3. Results of multiple regression study with variables of health beliefs, cue to action, and socio-demographic characteristics showed that the total of those variables could explain 65.4% of preventive health behavior for hepatitis B. 4. Stepwise discriminant analysis study between the participating and nonparticipating group with all the detailed variables of health belief, cue to action, and socio-demographic characteristics resulted in a hit ratio of 89.5%.