고 콜레스테롤 식이 및Cholic Acid 로 유발된 생쥐의 담석 형성 및 담낭의 전자현미경적 형태 연구

최상욱,정규원,이영석,선희식,한남익,이창돈 대한간학회 2000 Clinical and Molecular Hepatology(대한간학회지) Vol.6 No.3

'목적: 콜레스테롤과 콜산 식이를 장기간 투여하여 유발되는 담석 형성 과정 및 담낭 상피세포의 미세구조 변화를 전자 현미경을 이용하여 관찰함으로써 담석 형성 과정을 간접적으로 이해하기 위해 연구하였다. 대상과 방법: 생쥐 40마리를 고 콜레스테롤 콜산 식이를 먹인 후 2주 간격으로 10마리씩 희생 시켜 담낭 및 담즙 내용물의 변화를 주사 및 투과 전자 현미경을 이용하여 8주 동안 관찰한 후 대조군과 비교했다. 결과: 담석 형성 과정은 처음에는 작은 결정, 미석이 모여 크게 응집되어, 담석괴(concretion)를 형성하고, 일부는 용해 되면서 커다란 담석이 형성됨을 관찰하였다. 주사 전자 현미경상 고 콜레스테롤- 콜산 식이를 장기간 투여시 담낭 세포 표면에 점액 충전물 혹은 잔설이 점막 표면에 덮이고, 여기에 콜레스테롤 결정이 핵화되어 담석이 형성되는 양상을 보였다. 첨단부 돌출이 있는 부위에서는 점액과 미융모가 뭉쳐져 양배추 꽃 또는 부정형의 백색 구형 물질을 형성해 담낭 상피 세포 위에 붙어 있었다. 투과 전자 현미경상 담낭 상피 세포에서 세포질 내 지방 소적이 증가되었다. 또한 세포 내 지상 돌기가 뚜렷했으며, 첨단부 분비 과립의 증가가 현저하였다. 담낭 상피 세포에서는 어두운 세포와 밝은 세포가 관찰되었으며, 밝은 세포에서는 수성 변성과 세포 괴사가 관찰되었다. 결론: 고 콜레스테롤-콜산 식이를 장기간 투여하면 담석의 핵화 또는 성장에 영향을 미쳐 담석 형성이 유발 될 수 있을 것으로 사려되며, 또한 담낭 상피 세포에서의 점액 분비 증가가 담석 형성의 유발 인자 중의 하나로 생각되며, 분비된 점액과 담석과의 관계는 향후 계속 연구되어야 할 것으로 생각된다.$quot; Background/Aims: The experimental production of cholesterol gallstone suggests that alteration of the nature of gallbladder mucus may be a factor in the induction of gallbladder stones. This study was designed to clarify the changes of the gallbladder epithelia and the role of a high cholesterol-cholic acid diet (CCD) in the formation of the gallstones. Method: Forty mice were fed on a diet of natural 1% high-cholesterol egg yolk and 2.5% cholic acid for 8 weeks. The mice were sacrificed biweekly and followed up for 8 weeks. The gallbladder tissues and bile were prepared for electron microscopic examination. We observed the ultrastructural changes of the epithelia and the sediments of the gallbladder bile with scanning and transmission electron microscopic observation. Results: 1) Process of Gallstone formation in bile: At the 2nd week in mice fed with CCD, the crystals grew up by appositional layering into monoliths and then by aggregation into mulberry-shaped stones. At the 8th week many stones and numerous concrements were observed. 2) Scanning electron microscopic findings: In mice fed with CCD, the scattered whitish patches of epithelial cell surfaces exhibited the cauliflower-like apical protrusion secreting mucin. These protrusions appeared to be swellings of the apical plasmalemma and they were mixed with the mucus and microvilli. 3) Transmission electron microscope findings: At the 2nd week, numerous electron lucent secretory granules were observed in the apical zone of the epithelial cells. Increased numbers of fat vacuoles were also observed in the basal area of epithelium. Two types of cells were observed in the lining epithelium: dark and light cells. Conclusion: This study suggests that long-term administration of CCD, and the resultant increased secretion of glycoprotein from gallbladder epithelial cells, could be a factor in the induction of the gallstones.

하이데거 철학에 있어 신의 의미

최상욱 한국하이데거학회 1997 존재론 연구 Vol.2 No.-

Small Angle Neutron Scattering of Arborescent Polystyrene Solutions and Blends

최상욱,Robert M. Briber 한국고분자학회 2001 한국고분자학회 학술대회 연구논문 초록집 Vol.2001 No.4

豫備罪에 관한 各國의 立法例

崔相旭 연세법학회 1999 연세법학 Vol.6 No.2

豫備罪의 共犯

催相旭 江原大學校 比較法學硏究所 2001 江原法學 Vol.13 No.-

SHS법에 의한 $TiB_2-Al_2O_3$계 복합물의 합성 및 상압소결에 관한 연구

최상욱,조동수,김세용,남건태 한국세라믹학회 1994 한국세라믹학회지 Vol.31 No.5

A composite of TiB2-Al2O3 system was successfully prepared from a mixture of TiO2, B2O3, and Al by self-propagating high temperature synthesis (SHS) with a novel characteristic, utilizing the internal oxidation heat of aluminium metal of the mixture, instead of by a conventional technique, externally heating a mixture of Ti, B and Al2O3. From a mixture with B/Ti molar ratio of =2.0, pure two phases of TiB2 and $\alpha$-Al2O3 with good crystallinity and small, uniform sizes were formed. However, when the B/Ti molar ratio of the mixture goes to a value less than 2.0, in addition to the above main minerals, a small smounts of metastable phases such as TiB and Ti3B4 were formed. It was found that about 60%, the optimum green density of compacts gave their highest reaction rate and temperature during SHS process. TiB2-Al2O3 system composite with B/Ti molar ratio of =2.0 could be pressurelessly sintered even at 190$0^{\circ}C$ under Ar gas flows without any addition of sintering aids, showing their good properties such as 91.2% in relative density, 2750 kgf/$\textrm{mm}^2$ in Vickers hardness and 2620 kgf/$\textrm{cm}^2$ in flexural strength.

성매매처벌법의 허와 실

崔相旭 江原大學校 比較法學硏究所 2004 江原法學 Vol.19 No.-

도시주민의 B형 간염에 대한 예방적 건강행위 이행에 관한 연구

崔翔旭,李明淑,廉容泰 고려대학교 의과대학 1990 고려대 의대 잡지 Vol.27 No.3

Hepatitis B infection is one of the most prevalent epidemic diseases in Korea. As a control measure, improving the preventive health behavior and concerns of appropriate people cannot be overemphasized. In light of the above reasons, an interview survey was performed to clarify the relationships between the variables related to health behavior and those related to health beliefs on hepatitis B infection. A total of 509 housewives who were invited to a hepatitis B screening campaign was selected for the study. These women were separated into two groups :those who participated in the campaign(258 persons) and those who did not participate(251 persons). The results were as follows : 1. Variables of socio-demographic characteristics, cue to action, and health belief were significantly associated with variables of preventive health behavior on serological test for hepatitis B. 2. The participating group had higher degree of general knowledge, susceptibility, severity, benefit and health concerns of hepatitis B infection. 3. Results of multiple regression study with variables of health beliefs, cue to action, and socio-demographic characteristics showed that the total of those variables could explain 65.4% of preventive health behavior for hepatitis B. 4. Stepwise discriminant analysis study between the participating and nonparticipating group with all the detailed variables of health belief, cue to action, and socio-demographic characteristics resulted in a hit ratio of 89.5%.

수술후 발생한 양측성 후복막강 농양 1예

양진모,노희정,윤영연,오용석,변재영,정해억,김창섭,홍관수,안석주,최상욱 대한감염학회 1994 감염 Vol.26 No.2

저자들은 50세의 남자에서 수술후 발생한 양측성 후복막강 농양에 대해 경피적 배농술로 성공적으로 치료한 1예를 문헌 고찰과 함께 보고하는 바이다. Retroperitoneal abscesses are complicated serious surgical infections marked by an insidious, occult process leading to considerable mortality and morbidity. Knowledge of the anatomy of the retroperitoneal spaces as well as an increased awareness of the symptoms, physical findings, and causes of these abscesses are the keys to prompt and efficient therapy. Recently percutaneous guided catheter drainage has changed the traditional surgical therapeutic approach to this disease in the majority of cases. We report a case of postoperative complicated bilateral retroperitoneal abscess successfully treated with percutaneous guided catheter drainage combined with medical control.

Pontine Infarction 에 의한 Locked-in Syndrome 1 예

최상욱,정인식,이민상,김부성,조세현,이창돈,윤승규,김범생 대한내과학회 1987 대한내과학회지 Vol.33 No.3

The locked-in syndrome, meaning complete immobility except for vertical eye movement and blinking, is a rare disease. We experienced a case of 1ocked-in syndrome due to pontine infarction. A 73-year old woman was admitted to the hospital because of vomiting and semicomatose mentality. The patient was quadriplegic and she present a bilateral horizontal gage palsy, but vertical eye movement and eye blinking were preserved. Brain CT revealed poorly defined hypodense area involving pons. EEG showed diffuse slow wave with a-wave from post. occipital lobe. In BAEP, peak latencies for wave III k V were slightly delayed.