중등도 및 중증고혈압에서 Nifedipine 설하투여의 강압효과에 관한 연구

김영훈,서순규,최인석,김열홍,안희권,심완주,노영무 대한내과학회 1986 대한내과학회지 Vol.31 No.5

In order to assess the efficacy of sublingual nifedipine in the acute treatment of moderate to severe hypertension, a single blind test was done in 30 patients, 10 males and 20 females, aged 40 to 76 years, with moderate to severe hypertension. The patients with mean sitting blood pressure(BP) of more than J40 mmHg received sublingual placebo, and BP and pulse rate(PR) were measured in sitting position 10,20 and 30 minutes after the sublingual placebo was given. The patients with post-placebo 30 minutes sitting mean BP of less than 13pmmHg were excluded from the study. The placebo treatment period was followed by the administration of 10mg of sublingual nifedipine, and BP and PR were measured 10,20,30 and 45 minutes after nifedipine was given. BP decreased with placebo treatment(p$lt;0. 01 by paired t-test, preplacebo vs. post-placebo 30 minutes). With sublingual nifedipine BP started to fall in 10 minutes and reached the lowest levels in 30 or 45 minu1es. The systolic BP decreased from 198.0±21.4mmHg to 159±20.4mmHg, diastolic BP from 122.5±13.0 mmHg to 103.2±14.4 mmHg and mean from 147.7±13.4 mmHg to 121.7±14.8 mmHg 45minutes after nifedipine(p$lt;0.01 by paired t-test). The average fall in systolic BP/diastolic BP/mean BP 45 minutes after nifedipine was 39/19/26 mmHg(p$lt;0. 001, by paired t-test). The maximal fall in systolic BP correlated better with pretreatment value(r=0.42) than the maximal fall in diastolic pressure(r=0.21), PR increased from 79±12 to 87±11/minute with nifedipine(p$lt;0.001, by paired t-test). Side effects were mild facial flushing(16.7%) and palpitation (3.3%). The findings suggest that a dose of 10mg of sublingual nifedipine is a simple, effective and safe method for the acute treatment of moderate to severe hypertension and can be used as a non-injecting alternative agent for the treatment of hypertensive emergency.

CsI(Li) 단결정의 섬광특성

강희동,도시홍,이우교,김완,노태익,문병수 한국센서학회 1999 센서학회지 Vol.8 No.5

CsI(Li) single crystals doped with 0.02, 0.1, 0.2 and 0.3 mole% lithium as an activator were grown by Czochralski method. The lattice structure of grown CsI(Li) single crystal was bcc, its lattice constant was 4.568 Å. The absorption edge of CsI(Li) single crystal was 245 nm, and the spectral range of luminescence was 300 ∼ 600 nm, its maximum luminescence intensity appeared at 425 nm. The energy resolutions of CsI(Li) single crystal doped with 0.2 mole% lithium were 14.5 % for ^(137)Cs(662 keV), 11.4 % for ^(54)Mn(835 keV) and 17.7 o and 7.9 o for ^(22)Na(511 keV and 1275 keV), respectively. The relation formula of y -ray energy versus energy resolution was In ( FWHM% ) = -0.893 lnE + 8.456 and energy calibration formula was logE_r=1.455los(ch.)-1.277. The phosphorescence decay time of CsI(Li) crystal doped with 0.2 mole% lithium was 0.51 s at room temperature, and its time resolution measured by CFT(constant-fraction timing method) was 9.0 ns.

Sparganosis 2 예

이연복,노병인,김정원 대한피부과학회 1972 大韓皮膚科學會誌 Vol.10 No.3

Two cases of sparganosis is reported. 45 year old male officer had a bean sized, migrating soft nodular lesion in the subcutaneous tissue of the left thigh and generalized itching sensation for 6 years duration. From the lesion one sparganum (22 cm in length) was obtained. 35 year oId sister had a bean sized subcutaneous nodular mass on left lower leg for 10 years duration and removed one sparganum (5 cm in legth) by surgical excision. The worms pale milky white and ribbon like in shape.

방사성 동위원소옥소(131I)에 의한 갑상선질환의 임상적 연구

이정상,이문호,고창순,노흥규,구인서,서환조,이경자,이홍규 대한핵의학회 1970 핵의학 분자영상 Vol.4 No.2

서울대학교 의과대학 내과학교실 및 방사성 동위원소 진료실에서 1960년 5월부터 1969년 10월까지 진료한 2,658명의 각종 갑상선 질환 환자에 대하여 131I에 의한 각종 갑상선 기능 검사 및 기능 항진증 환자에 대한 131I의 치료 성적을 종합 검토하여 아래와 같은 결론을 얻었다. 1) 2,658명의 갑상선 질환 환자중 독성 미만성 선종이 929명(34.9%)으로 가장 많고 비중독성 미만성 선종 및 비중독성 결절성 선종이 각각 762명(28.7%), 699명(26.3%)이며 기능저하가 210명(7.9%), 독성 결절성 선종이 58명(2.2%)였다. 2) 갑상선 질환의 성별 발생 빈도는 남자 300명(11.4%), 여자 2,358명(88.6%)로서 그 비는 1:8였다. 3) 연령별 발생 빈도는 20∼49세에서 전체의 79.1%인 2,102명이며 기능 항진증의 경우는 79.0%에 달하였다. 4) 각종 갑상선 기능 검사중 131I 섭취율, 131I 혈청내 방사능 BMR치등에 대한 고찰을 하는 한편 기능항진 및 저하증때 나타내는 각종 자학증세를 관찰하였다. 5) 갑상선 기능 항진증 환자 867명에 대하여 131I 치료를 하고 그 중 579명에서 47.8%의 초회 치료율을 확인하였다. 6) 131I 투여 후의 합병증인 기능 저하증의 발생 빈도는 초회 투여에서 6.75%였다. 7) 갑상선의 $quot; A summary of the clinical data of the (131)^I-thyroid function tests and the therapeutic results of 1(31I)^ among the 2,658 patients of various thyroid diseases treated over the past 10 years from May 1960 to Oct. 1969 at the Radioisotope Clinci and Laboratory, SNUH were presented and discussed. 1) The patients examined consisted of 929 cases (34.9%) of diffuse toxic goiter, 762 cases (28.7%) of diffuse nontoxic goiter, 699 cases (26.3%) of nodular nontoxic goiter, 58 cases (2.2%) of nodular toxic goiter and 210 cases (7.9%) of hypothyroidism. 2) There were 300 (11.4%) male and 2358 (88.6%) female, showing a ratio of 1:8. 3) The majority of patients (79.1%) were in the 3rd-5th decade of their lives. 4) The normal ranges, diagnostic values of (131)^I uptake test, 48 hrs serum activity, BMR and main subjective symptoms of various thyroid diseases were discussed. 5) In the 579 patients among 867 cases with hyperthyroidism treated with (131)^I, 47.8% were confirmed to be cured completely after single therapeutic doses. 6) The complications of 131I therapy were discussed and myxedema had developed in 6.75% of our patients. 7) The results of (131)^I thyroid function tests were analysed among the 160 cases of thyroid diseases which were confirmed the diagnosis with histopathological measures.

Nucleolar snoRNA and Ribosome Production

Ro-Choi, Tae Suk Korean Society of Molecular Biology 1997 Molecules and cells Vol.7 No.4

논문 : 금속성 응집제와 모노클로라민의 상호작용이 Polyamide계 RO막 성능에 미치는 영향

김경화 ( Kyung Hwa Kim ),홍승관 ( Seung Kwan Hong ),박찬혁 ( Chan Hyuk Park ),윤성로 ( Seong Ro Yoon ),홍성표 ( Seong Pyuo Hong ),이종화 ( Jong Hwa Lee ) 대한상하수도학회 2006 상하수도학회지 Vol.20 No.4

The bench-scale chlorine exposure study was performed to investigate the effect of pretreatment by free chlorine and monochloramine (NH2Cl) on the performance of RO membranes made of polyamide (PA). Feed monochloramination at 2㎎/L did not cause significant productivity loss compared to free chlorine. However, metal coagulants reacted with monochloramine, the PA membrane suffered from a gradual loss of membrane integrity by chlorine oxidation, which was characterized as a decrease in salt rejection. Especially, RO membranes exposed to alum coagulants with monochloramine revealed the salt rejection lower than those exposed to iron coagulants. XPS membrane surface analysis demonstrated that the chlorine uptake on the membrane surface increased and carbon peaks were shifted significantly when exposed to alum coagulants with monochloramine.

Pro-Apoptotic and Immunostimulatory Tetrahydroxanthone Dimers from the Endophytic Fungus Phomopsis longicolla

Rö,nsberg, David,Debbab, Abdessamad,Má,ndi, Attila,Vasylyeva, Vera,Bö,hler, Philip,Stork, Bjö,rn,Engelke, Laura,Hamacher, Alexandra,Sawadogo, Richard,Diederich, Marc,Wray, Vict American Chemical Society 2013 Journal of organic chemistry Vol.78 No.24

<P>Four tetrahydroxanthone dimers (<B>1</B>–<B>4</B>) and four biogenetically related monomers (<B>5</B>–<B>8</B>), including the new derivatives <B>4</B>–<B>6</B>, were isolated from the endophyte Phomopsis longicolla. The absolute configurations of <B>2</B>–<B>4</B> were established for the first time by TDDFT electronic circular dichroism calculations, and that of phomoxanthone A (<B>1</B>) was revised by X-ray crystallography. Phomoxanthone A (<B>1</B>) showed the strongest pro-apoptotic activity when tested against a panel of human cancer cell lines, including cisplatin-resistant cells, whereas it was up to 100-fold less active against healthy blood cells. It was also the most potent activator of murine T lymphocytes, NK cells, and macrophages, suggesting an activation of the immune system in parallel to its pro-apoptotic activity. This dual effect in combating cancer cells could help in fighting resistance during chemotherapy. Preliminary structure–activity studies of isolated compounds and derivatives obtained by semisynthesis (<B>9a</B>–<B>11</B>) hinted at the location of the biaryl axis and the presence of acetyl groups as important structural elements for the biological activity of the studied tetrahydroxanthones.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/joceah/2013/joceah.2013.78.issue-24/jo402066b/production/images/medium/jo-2013-02066b_0011.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jo402066b'>ACS Electronic Supporting Info</A></P>

A Study on Brand Identity through Emotional Marketing : Focusing on Taste Marketing

Ro,Sun Young (사)한국디지털디자인협의회 2006 (사)한국디지털디자인협의회 conference Vol.2006 No.2

The European Stability Pact and Feedback Policy Effects

Creel, Je'ro^me 세종대학교 국제경제연구소 2002 Journal of Economic Integration Vol.17 No.3

With a two-country dynamic model in a monetary union with wealth private behaviors, we study the implications of public debt on monetary and fiscal policies. The model used has Keynesian features in the short run and Wicksellian ones in the long run. We analyse the effects of asymmetric fiscal policies in Euroland and show that such a situation creates two feedback effects which reduce the efficiency of economic policues. First, because of the inability of one government to implement an expansionary fiscal policy, the other government has to substitute for it to reach economic targets. Second, the ECB's involvement in macroeconomic stabilisation will be exacerbated. the more substantial these effects, the more coordination is needed between European governments and the ECB.

Yuha's Early Bilingual Reading:A Case Study

Lee, Ok Ro이옥노 崇實大學校 大學院 1983 崇實大學校 大學院 論文集 Vol.1 No.-