筋小胞體의 ATPase Kinetics에 關한 硏究

朴映淳,李承兩,朴泰水,庾基洙,李 弘,金允坤 圓光大學校 1982 論文集 Vol.16 No.2

본 연구에서는 토끼 골격근 소포체에서 분리한 근소포체의 ATPase활성에 대한 일반적 특성과 수종의 2가 양이온(??)의 영향에 관한 연구를 하였다. ATPase활성과 Ca uptake에 미치는 2가 양이온의 저해 효과와 저해기작은 Dixon plot, Lineweaver-Burk plot, Hanes-Woolf plot, Woolf-Augustinsson-Hofstee plot, Eadie-Scatchard plot, Arrhenius plot등을 이용하여 분석하였으며 그 결과는 다음과 같다. 1. 근소포체의 ATPase는 ??과 ??의 존재하에서 활성화 되어지며 ??의 농도가 4mM일 때 ??의 최적 농도는 0.1mM이었다. 2. 근소포체의 ATPase는 ??-ATPase와 (??)-ATPase로 구성되어 있고 (??) - ATPase의 활성은 ??-ATPase의 활성보다 높았다. 3. ATPase의 활성화 에너지는 약 19Kcal/mol이었다. 4. ATPase 활성에 미치는 2가 양이온은 12.5㎛과 400㎛의 범위 내에서 이온 농도가 증가됨에 따라서 활성도는 점점 감소되었다. 5. ATPase활성율 50% 저해시키는데 2가 양이온의 농도는 Ki값과 같아서 ??, ??, ?? Pd ??에 대한 각각의 농도는 10㎛, 30㎛, 130㎛ 및 350㎛이었다. 특히 ??은 저 농도에서 (12.5-100㎛)는 활성제로, 고농도에서 (200-400㎛)는 저해제로 작용하는 것 같다. 6. 2가 양이온은 ATPase의 Km에는 변화를 주지 않으나 Vmax의 저하를 일으키는 것으로 보아 비경쟁 저해제임이 판정되었다. 7. 2가 양이온은 가역적 저해제임이 판명되었다. 8. Ca 吸收能에 대한 CuCl₂의 阻害는 50~500㎛의 CuCl₂농도에서 현저히 나타났으며 이 현상은 Ca 吸收能과 ATPase 活性과 밀접한 관계를 보여주는 것이다. General properties of the ATPase and the effects of the divalent cations (??) on the total ATPase activity of the fragmented sarcoplasmic reticulum (FSR) isolated from rabbit skeletal muscle were investigated in the present resent research. The inhibitory effect of divalent cations on the FSR ATPase activity and its mechanism were analyzed by various plots such as Dixon plot, Lineweaver-Burk plot, Hanes-woolf plot, Eadie-Scatchard plot and Arrhenius plot. The results obtained were as follows: 1. The FSR ATPase is activated by ?? and ??; the optimum concentration of is 0.1 mM in the presence of 4 mM MgCl₂. 2. The FSR ATPase could be distinguished as ??-ATPase and (??)-ATPase. The activity of (??)-ATPase predomiant over that of ??-ATPase. 3. The apparent energies of activation for total ATPase was approximately 19Kcal/mole. 4. The inhibitory effects of the divalent cations on the enzyme activity increased as the concentrations of the divalent cations increased in the concentrations between 12.5 and 400㎛. 5. Concentration of 50% inhibition for each divalent cation was almost identical with the inhibition constant (ki). The Ki's were 10,30,130, and 350㎛ for ??, ??, ??, and ??, respectively. ?? seemed to be anactivator at lower concentrations and an inhibior at higher concentratios. 6. The divalent cations did not change the Km but decreased the Vmax of the FRS ATPase, suggesting that they are noncompetitive inhibitors on the FSR ATPase. 7. The divalent cations were also found to be revesible inhibitors on the FSR ATPase. 8. The inhibitory effect of CuCl₂on a uptake increased as the concentration CuCl₂increased in the range between 50㎛.

관동맥질환에서 저밀도 지단백 입자 크기의 분포

임효영,김인숙,승기배,강동헌,전두수,장기육,박준철,이수영,홍순조,최규보 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.8

정신보건법의 주요 쟁점 조항에 대한 선진국과의 사례 비교

홍진표,황순찬,박수빈,서동우,정은기,김진학,박종익,안주연,김수정,장홍석 大韓神經精神醫學會 2009 신경정신의학 Vol.48 No.2

Objectives The Mental Health Act is an initiative aimed at changing and shaping mental health services and protecting human rights of persons with mental disorders. Since the Mental Health Act was legislated in 1995, four amendments have been made according to the issues that arose from public concerns. However, there are still many debates about the human rights protection of the mentally iII. This study aimed to provide information regarding major aspects of the Mental Health Act by comparing them among several developed countries. Methods Current Mental Health Acts of the state of Michigan in the United States, Scotland in England, the state of Victoria in Australia, and Japan were reviewed. Issues regarding the Korean Mental Health Act were collected from seminar materials, news media contents, and mental health professionals Results The definition of subjects in Korean Mental Health Act was more inclusive than other countries and was derived from a medical classification of mental illness. Family members or guardians were granted important responsibilities for deciding the involuntary admission of mentally ill patients in Korea and Japan. In Western countries, Mental Health Review Tribunals or courts have the primary responsibility for important decisions about mentally ill patients. The regulation of immediate dis- charge after request by voluntarily admitted patients was not enacted in all countries except Korea. The mandatory procedure for involuntary admission in Western countries includes an individual case review with personal interview by a Mental Health Review Tribunal or court. Conclusion The Korean Mental Health Act appears to meet the basic standards of Guidelines from international organizations. Our traditional culture and inherent health systems seem to influence the legal regulation of mental health service and might be related to the problems of human rights protection of mentally ill patients in Korea.

MPLmS 기반의 VPN 기술 구현

홍록기,백순흠 공주영상정보대학 2002 논문집 Vol.9 No.-

본 논문에서는 MPLmS 기반의 VPN 기술 구현을 위한 구성 요소 및 설계 기술 위주로 연구하였다. MPLmS 기반의 VPN 망을 구성할 경우 기존의 IP 망에서의 홉 바이 홉 전달 방식과는 차별화되는 패킷을 전달할 수 있으며, 이러한 방식은 시그널링 기술에 있어서 기존의 라우팅 프로토콜을 참조한 FIB에 의해 LSP를 설정하기 위한 LIB가 구성되어 레이블이 맵핑되고 O-LSR간의 경로 설정이 이루어지고 패킷 전달을 고속화되게 함으로써 기존의 회선 용량의 증가로 인한 여러 가지 문제점을 개선할 수 있도록 하였다. 또한 Lambda를 이용한 코어 망에서는 물리적인 토폴로지를 각각의 노드간에 직접 파장 경로를 설정하여 고속의 패킷 포워딩을 가능하게 하고 있다. 하지만 광 신호를 OXC만으로 스태틱하게 전달하지 않고 OXC에 입력된 광 신호를 다이나믹한 경로를 설정할 수 있도록 MPLmS에서 제어할 수 있는 연구가 고려되어야 하고 또한 VRF 테이블 구성에서 더욱 더 효과적인 구성을 할 수 있도록 지속적인 연구가 필요하다.

실용적인 전자투표 프로토콜 제안

홍영기,이재신,김순석,김성권 중앙대학교 정보통신연구소 1999 정보통신연구소논문집 Vol.1 No.1

정보화 시대에 세계적으로 컴퓨터의 보급 및 네트워크의 발달로 컴퓨터 응용분야에서 많은 발전이 이루어지고 있다. 그 중에서도 암호학을 이용한 전자투표는 전자화 되어 가는 민주 사회에서 필요한 요소로 부각되고 있다. 그러나 지금까지의 전자 투표는 중요성에도 불구하고 많은 문제점이 지적되었다. 본 논문에서는 추적할 수 없는 통신망[1]과 신뢰할 수 있는 선거관리센터를 가정함으로써 전자 투표의 요구사항인 안전성, 공정성, 투표자의 비밀성, 선거 집계의 정확성 등을 만족하는 대규모적이고 실용적인 전자투표 프로토콜을 제안한다. 블라인딩기법(Blinding Technique)을 이용하여 투표자의 투표내용을 노출시키지 않고 투표권을 획득하며, 부정할 수 없는 도전 및 응답프로토콜(Challenge and Responsible Protocol)을 사용하여 투표자와 집계자 사이의 부정을 확인할 수 있으며, 투표자나 집계자의 부정으로 인한 전자 투표의 무결성과 투표자의 프라이버시를 보호하기 위해 투표자의 익명을 기반으로 안전한 전자투표를 방식을 제안한다. We have seen a lot of developments on computer application areas with the wide spread use of computers and the rapid growth of communication network. It is necessary to use a cryptographic technique for electronic voting, but, at present, despite of its importance electronic voting protocols so far have many shortcomings. In this paper, with the assumption of untraceable communication channels and trustable voting centers we propose a large-scale and practical electronic voting protocol satisfying protocol requirements, such as secureness, fairness, privacy of voter and correctness. Voters are able to get a vote without revealing their voted information by using the blinding technique. We can find the injustice between a voter and the tallier by using undeniable challenge and responsible protocol. Also, we proposes a secure protocol that compensates a integrity of electronic voting and protects a privacy of voter from outer attacks as using a anonymity of voter.

광학센서를 이용한 알약계수기의 계수알고리즘 향상에 관한 연구

홍인기,이순걸,김문상 경희대학교 산학협력기술연구원 2002 산학협력기술연구논문집 Vol.8 No.-

It is fundamental to count and pack the pills in the medicine manufacture field but those tasks are time and labor consuming. Thus, the need for automation of those tasks is necessarily getting increased in order to get effective mass production. It is significant to perceive pills quickly and precisely. There were many trials for this processing but the performance of the existing counting machines varies about size, shape and dispersion tendency of pills. In this paper, the authors try to improve the counting performance of a pill counting machine that has optical sensors with the neural network. The passing signal of pill is acquired with optical sensor and the passage signal of the pill is extracted as input patterns. The gradient and integration of signal during passing time and the time keeping the pill interrupt the light from the LED are used as characteristic feature. The back propagation and perception algorithm are used for training. Experimental results with several pills show that the designed algorithm is a little bit effective to reduce the noise effect which is generated from interference among the machine components and unreliable environment.

파노라마촬영장치의 선형단층상에 의한 하악골의 협설단면 평가

홍순기,김재덕 대한구강악안면방사선학회 2001 Imaging Science in Dentistry Vol.31 No.2

Purpose : To evaluate the precision of measurements of distances and angle in the cross-sectional views of linear tomogram of panorama and to assess the technique for visualizing the mandibular canal. Methods : Ten dry mandibles were radiographically examined with 3 continuous cross-sectional views of linear tomogram of panorama and 4 continuous computed tomograms. The distance between the superior border of canal and alveolar crest and the bucco-lingual width of alveolar bone at the level of the superior border of canal and the angle between the two lines above were measured. Measurements were performed by radiologist and implantologist group and compared with measurements on computed radiograms of the same areas. Results : The measurements differences for the distance of alveolar bone height between in panorama and in CT showed 0.9 mm±0.6 mm by radiologists and 1.3 mm±0.8 mm by implantologists. There was no statistically significant difference between two groups' measurements. The differences in measurements for the distance of alveolar bone width between in panorama and in CT showed 0.5 mm±0.8 mm by radiologists and 2.5 mm±1.4 mm by implantologists. There was significant difference (P〈 0.05) between two groups' measurements. The average bucco-lingual inclination of alveolar bone above mandibular canal was average 95.8° in CT. The difference of measurements between two groups was average 1 ±0.9°. Three cross-sectional views of panorama could show that the mandibular canal crosses antero-lingually and slopes inferiorly from the posterior segment of the mandible. Conclusions : The measurements in the linear tomogram of panorama by radiologists gave the accurate values of the distances and the angle compared with the values in computed tomograms. (Korean J Oral Maxillofac Radiol 2001;31:101-7)

尋常性좌창(Acne Vulgaris)에 對한 Vibramycin의 臨床的效果

洪起煥,安順姬,朴定圭,李水月 中央醫學社 1973 中央醫學 Vol.25 No.4

尋常性?瘡이 顔面에 甚한 女高生 40名을 double-blind試驗에 依하여 Vibramycin(Vibramyin 100mg을 1日 1回 經口的으로 投與)을 投與하여 다음의 結果를 얻었다. 1) Vibramycin 4週間 投與하였을 때 治癒率 은 80.0%이고 placebo를 投與時는 29.3%를 나타내었다. 그리고 治療效果는 投藥 3週에 顯著이 나타나기 始作하였다. 2) 投藥中止後 3週에는 治癒率이 Vibramycin 投藥群에서 減少를 보였으며 2名은 再發되었다. 3) 投藥 4週동안 治療效果가 不充分한 患者에게 3週間 더 延長하였을 때는 더욱 顯著한 效果를 볼 수 있었다. Forty high school girls with acne vulgaris were included in a double-blind trial to assess the tLapeu tic effect of Vibramycin (100 mg Vibramycin capsule, orally, once daily). The results, assessed clinically are as follows; 1. When Vibramycin was administered for 4 weeks, the cure rate showed 80. 0% and in the case of placebo, 29.3%, and the effectiveness was significantly appeared at 3 weeks of treatment. 2. In follow-up study, at 3 weeks after cessation of Vibramycin treatment, the cure rate decreased in Vibramycin group, and especially, in two girls, rashes like as inflammatory papules and pustules was reappeared. 3. When Vibramycin was administered another 3 weeks in addition, to those whom the effectiveness was insufficient in spite of 4 week-treatment, it had showed significantly beneficial effect.

폐결핵 환자의 우울 상태

홍정표,최선희,조만종,이성주,박종,김기순,김양옥 朝鮮大學校 附設 醫學硏究所 1997 The Medical Journal of Chosun University Vol.22 No.1

The main purpose of this study is to identify and evaluate the depressive states for the patients with chronic pulmonary tuberculosis. A questionnaire(Self-rating Depression Scale, SDS) survey was performed toward 57 pulmonary tuberculosis patients with initial treatment who started chemotherapy and 53 pulmonary tuberculosis patients with retreatment, admitted to one tuberculosis-centered hospital and two general hospital. Fifty three healthy persons as control group were investigated with the same questionnaire for comparison. The survey was performed from July to August 1996. The results are as follws : 1. The patients had significantly high scores in the depression than control and the patient with retreatment showed significantly high scores in the depression than the patient with initia1treatment(P<0.01). 2. The depressive levels of the patients were associated with duration of admission and the expectancy of recovery (P<0.05). 3. The percentage of the subjects with 40 or more scores tentatively classifiable as psychologically depressed was 67.1% of the total subjects, 48.4% of the control groups, 75.0% of the patient with initial treatment and 84.1% of the patient with retreatment. Because patient with pulmonary tuberculosis with initial treatment showed higher depression scores than normal persons, and patients with retreatment due to failure of initial treatment showed higher depression scores than initial treatment, it is necessary to give attention to depression of the patients during treatment of pulmonary tuberculosis.

廢有機鹽素化合物의 燒却處理

鄭淳亨,李泰鎬,鄭洪基 대구보건대학 1992 대구보건대학 論文集 Vol.13 No.-

The objective of this study was to oxidize chloromethanes waste with pyrolytic incineration unit. This experiment was carried out in actual plant. We have studied incineration temperature VS. removal rate of waste Liquid, removal of Hcl and Cl₂ in the flue gas. The results obtained were as followa : 1) In combustion condition for the temperature of 950℃ and the residence time of 1, 2 seconds, waste chloromethanes and cyan compounds were nearly decomposed. 2) The removal of Hcl and Cl₂ for the use of NaOH in the flue gas was very excellent. 3) The scrubbing of the dust was effected with NaOH solution.