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- 저자 : Gang Seong-Jin (검색결과 249 건)
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Risperidone이 백서의 억제된 자발적 교대행동에 미치는 영향
이기철,이정호,김진규,정홍경,천강훈,류정환,최영민,전성일 대한생물치료정신의학회 1998 생물치료정신의학 Vol.4 No.2
Objectives : Recently, some case reports have shown that risperidone is effective to refractory obsessive-compulsive disorder. Possible explanations for efficacy of risperidone in refractory obsessive-compulsive disorder maybe due to that it is both serolonin and dopamine receptor antagonist. On the basis of serotonin-dopamine interaction hypothesis, a biological etiology of obsessive-compulsive disorder, the effect of risperidone was evaluated to the suppressed spontaneous alternation behaviour of animal model of obsessive-compulsive disorder in rats. Methods : The apparatus for spontaneous alternation behaviour was a black plexiglas T-maze with distinctive black and white goal boxes. Black gullotine doors separated the start box and the goal boxes from the main body of the T-maze Small cups were placed in the corners of both goal boxes(all arms measured 50×10cm) 24 hours prior to experiment, rats(Spraque-Dawley) were food-deprived. The food-deprived rats were put into T-maze, in which both goal boxes were baited with small amounts of chocolate milk. Each rat was given 2 set of 7 trials during which it was placed in the start box and allowed to choose the one of the goal boxes for checked. After baseline of the number of choices of spontaneous alternation behaviour was stabilized, the pontaneous alternation disrupted by nonselective 5-HT agonist, 5-MeODMT (1.25mg/kg/IP). The experimental animals were stratified into 5 groups, fluoxetine(10mg/kg/IP), risperidone(0.1mg/Kg/IP), haloperidol(0.1㎎/Kg/IP), fluoxetine(10mg/Kg) with haloperidol(0.1 mg/Kg), and saline(0.5cc/IP) control group. Each drugs were injected for 21 days as a chronic treatment. The protective effects were evaluated on the nest day of discontinuation of the each drugs among 5 groups. Results : 1) After 21 days of the drug treatment, the risperidone group and the fluoxetine group showed significant difference from the haloperidol group and the saline control group on the protection of the 5-MeODMT induced suppression of spontaneous alternation behaviour. 2) The fluoxetine group and fluoxetine with haloperidol group showed significant difference between before and after treatment in the protection of 5-MeODMT induced suppression of spontaneous alternation behaviour. The risperidone group also showed significant difference between before and after treatment in the protection of 5-MeODMT induced suppression of spontaneous alternation behaviour, but the protective effect of risperidone was superior to fluoxetine. Conclusion : These findings suggest that both risperidone and fluoxetine have a favorable effect in the protection of 5-MeODMT induced suppression of spontaneous alternation behaviour. We think that risperidone can be possible alternatives to SSRIs in the treatment of refractory obsessive-compulsive disorder in clinical situation.
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젊은 성인에서 신체 만족도에 따른 문제해결양식, 대인관계문제와 우울증상과 자살사고와의 관련성
차승민,김태성,강문희,권명진,김정란,왕성근,지익성 대한생물치료정신의학회 2011 생물치료정신의학 Vol.17 No.2
Objectives:The aim of this study was to evaluate that problem solving styles, interpersonal problems, depression and suicidal ideation according to body image satisfaction. Methods:One hundred and nineteen young healthy normal subjects filled out administered the Body Dysmorphic Disorder Examination-Self Report (Korean version of BDDE-SR K-BDDE-SR), Problem Solving Style Scale(Korean version PSS), Korean Inventory of Interpersonal Problem(KIIP), Korean version of the Depression Anxiety Stress Scale(KDASS-21), Korean version of Beck Scale for Suicidal Ideation(Korean version SSI) and Korean version of Reynolds Suicidal Ideation Questionnaire(Korean version SIQ) for a month. Results:Out of the 119 subjects, 39%(N=46) was male and 61%(N=73) was female. In high K-BDDE-SR group (higher than 67), helplessness was significantly higher than low K-BDDE-SR group(lower than 67), and problem-solving confidence, creative style, approach style were significantly lower than low K-BDDE-SR group. Also, Higher level of all KIIP factors in High K-BDDE-SR group was significantly differ than low K-BDDE-SR group. In High K-BDDE-SR group, K-DASS-21, SSI, and SIQ were significantly higher than low K-BDDE-SR group. Using multiple regression analysis contributing variance toward the total factor score of K-BDDE-SR of participants were K-DASS-21 and SIQ. Conclusion:Our results indicates that high tendency of dissatisfied body images have differences in helplessness, problem-solving confidence, approach style, interpersonal problems, depression and suicidal ideation compared to low tendency of dissatisfied body images. It is necessary to study body dysmorphic disorder patients group in the future.
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최영호,서홍주,임영혁,김정중,박성강,이석기,임진수,김은규 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2
Pulmonary blastoma is a very rare primary neoplasm of the lung. We experienced a case of pulmonary blastoma in a 40 years old man. The mediobasal segmentectomy of the right lower lobe was performed. The patient was discharge on the postoperative days 6. There is no evidence of recurrence or metastasis on followup study during 7 months period after operation.
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반월상 사구체신염 (Crescentic Glomerulonephritis)의 병리적 분석
정성진 ( Jeong Seong Jin ),유선진 ( Yu Seon Jin ),윤여욱 ( Yun Yeo Ug ),이창화 ( Lee Chang Hwa ),강경원 ( Gang Gyeong Won ),강종명 ( Kang Jong Myeong ),박찬현 ( Park Chan Hyeon ),박문향 ( Park Mun Hyang ) 대한신장학회 2003 Kidney Research and Clinical Practice Vol.22 No.3
배 경 : 반월체는 보우만 강을 전체적으로 혹은 부분적으로 채우는 두 층 이상의 세포로 정의 되며, 이러한 반월체가 보이면서 심한 염증성 사구체 손상이 주로 나타나며 급속히 진행되는 신장 질환을 반월상 사구체신염이라고 한다. 이 질환은 병리학적 분류에 따라 치료 및 임상적 진행이 다르다. 한 임상 기관에서의 반월상 사구체신염의 병리 경험을 모아서 분석하였다. 방 법 : 저자들은 1987년 1월부터 2002년 2월까지 한양대학교병원 병리과에서 신생검으로 진단된 반월상 사구체신염 25예를 항사구체기저막 질환 (Ⅰ군), 면역복합체 사구체신염 (Ⅱ군), ANCA와 연관된 사구체신염 (Ⅲ군) 그리고 특발성 반월상 사구체신염 (Ⅳ군) 4개의 군으로 나누고, 질환에 따라 다시 세부 분류하여 진단시 임상 및 생검 소견의 조직학적 차이점을 조사하였다. 결 과 : 총 25예 중 항사구체기저막 질환으로 분류되는 예는 없었고 면역복합체 사구체신염군으로 분류된 8예 증 감염 후 사구체신염이 3예, IgA nephropathy가 3예, Henoch-Scho¨nlein purpura가 2예가 있었으며, 그리고 ANCA와 연관된 사구체신염으로 분류된 12예 중 현미경적 다발성 혈관염이 7예, Wegener 육아종증이 4예, ANCA 관련 사구체신염 1예가 있었으며, 특발성 반월상 사구체신염이 5예가 있었다. 총 25예 중 남녀의 비율은 비슷하였고 평균 연령은 Ⅱ군이 32.0세, Ⅲ군이 59.3세, Ⅳ군은 39.0세였으며 생검 당시의 혈청 크레아티닌의 평균값은 각각 9.1, 5.2, 8.8 ㎎/dL이었다. 광학 현미경 소견상 각 질환군에서 사구체 반월체의 평균 빈도 (%)는 Ⅱ군 64.4%, Ⅲ군 43.7%, Ⅳ군 51.2%였으며 신세뇨관의 염증 세포 평균 침윤 정도 (score)는 Ⅱ군 0.8점, Ⅲ군 0.4점, Ⅳ는 0.6점이었고 신간질의 평균 섬유화 정도 (score)는 Ⅱ군 1.0점, Ⅲ군 0.8점, Ⅳ군 1.2점이었으며 동맥 및 세동맥의 평균 경화증 정도 (score)는 Ⅱ군 1.4점, Ⅲ군 0.9점, Ⅳ군 1.6점이었다. 면역형광 현미경 소견상 주로 Ⅱ군에서 A 및 C3에 대한 침착을 관찰할 수 있었다. 이상의 결과에서 광학 현미경 소견상 Ⅱ군에서는 반월체 빈도가 높게 관찰되었고 Ⅲ군에서는 섬유화 정도가 적게 관찰되었으며 동맥 경화증의 경우 Ⅲ군 에서 적은 빈도로 관찰되었다. 결 론 : 반월상 사구체신염의 임상 및 병리학적 소견을 재검토함으로써 유사한 증례의 조기 진단에 도움이 되리라 사료되며 앞으로 좀 더 많은 증례를 대상으로 분석하면 각 질환군의 병리적 특징과 예후 인자를 밝히는데 도움이 될 것으로 생각한다. Background: Crescentic glomerulonephritis is expressed pathologically by cresecent formation in Bowman`s capsule and clinically by rapidly progressive loss of renal function. The pathologic experience of crescentic glomerulonephritis in one institution was analyzed here. Methods: We classified 25 cases of crescentic glomerulonephritis patients into 4 categories and reviewed the cases pathologically and clinically. Results: We found no case with group 1 (anti-GBM disease), 8 cases in group Ⅱ (immune complex glomerulonephritis) including 3 patients with IgA nephropathy, 2 patients with Henoch-Scho¨nlein purpose and 3 patients with APSGN, 12 cases in group Ⅲ (ANCA-associated glomerulonephritis) including 7 patients with microscopic polyangitis, 4 patients with Wegener`s granulmatosis and 1 patient with ANCAGN, and 5 cases in group Ⅳ (idiopathic crescentic glomerulonephritis). The mean ages of patients with proup Ⅱ, Ⅲ, and Ⅳ were 32.0 59.3 years old respectively, and mean serum creatinine levels at the time of biopsy were measured as 9.1, 5.2, 8.8mg/dL in each group. On light microscopic findings, the frequency of crescents in glomeruli was 64.4% in group Ⅱ, 43.7% in group Ⅲ, and 51.2% in group Ⅳ. The score of infiltration into tubules of inflammatory cells was 0.8 in group Ⅱ, 0.4 in group Ⅲ, and 0.6 in group Ⅳ and the score of fibrosis in interstitium was 1.0 in group Ⅱ, 0.8 in group Ⅲ and 1.2 in group Ⅳ. The score of aherosclerosis in arteries was 1.4, 0.9 and 1.6 in each group. Conclusion: We conclude that the precise diagnosis and classification of crescentic glornerulone phritis by an early renal biopsy and clinical assessments are important in the management of rapidly progressive(crescentic) glomerulonephritis. Since the number of the cases was not so enough, we could not analyze the statistical significance between morphologic differences of each group of crescentic glomerulonephritis, but if more case were collected, acknowledgements of differences and prognostic factors in pathologic findings could be possible.
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Calculation of GHGs Emission from LULUCF-Cropland Sector in South Korea
Seong-Jin Park,Chang-Hoon Lee,Myung-Sook Kim,Sun-Gang Yun,Yoo-Hak Kim,Byong-Gu Ko 한국토양비료학회 2016 한국토양비료학회지 Vol.49 No.6
The land use, land-use change, and forestry (LULUCF) is one of the greenhouse gas inventory sectors that cover emission and removals of greenhouse gases resulting from land use such as agricultural activities and land use change. Particularly, LULUCF-Cropland sector consists of carbon stock changes in soil, N₂O emissions from disturbance associated with land use conversion to cropland, and CO₂ emission from agricultural lime application. In this paper, we conducted the study to calculate the greenhouse gases emission of LULUCFCropland sector in South Korea from 1990 to 2014. The emission by carbon stock changes, conversion to cropland and lime application in 2014 was 4424, 32, and 125 Gg CO₂-eq, respectively. Total emission from the LULUCF- Cropland sector in 2014 was 4,582 Gg CO₂-eq, increased by 508% since 1990 and decreased by 0.7% compared to the previous year. Total emission from this sector showed that the largest sink was the soil carbon and its increase trend in total emission in recent years was largely due to loss of cropland area.
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Shin, Seong-Ah,Lee, Hae-Nim,Choo, Gang-Sik,Kim, Hyeong-Jin,Che, Jeong-Hwan,Jung, Ji-Youn MDPI 2017 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.18 No.2
<P><I>Ixeris dentata</I> (Thunb. Ex Thunb.) Nakai (ID) exhibits various physiological activities, and its related plant derived-products are expected to represent promising cancer therapeutic agents. However, the anticancer effects of ID extract on breast cancer cells classified as estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) are still unknown. In this study, we investigated the anti-cancer effects and analyzed the molecular mechanism of ID extract in T47D, MCF-7 (ER-, PR-positive, HER2-negative), SK-BR-3(ER-, PR-negative, HER2-positive), and MDA-MB-231 (Triple-negative) through in vitro studies. Additionally, we examined its anti-tumor effects through in vivo studies. Our findings indicated that ID extract-induced apoptosis was mediated via various survival pathways on four breast cancer cells by identifying the factors including Bcl-2 family, phospho-Akt and phospho-nuclear factor-κB (NF-κB). Based on in vitro findings that induced apoptosis via Akt-NF-κB signaling, we investigated the effects of ID extract on mice bearing MDA-MB-231 cells. The results showed that ID extract significantly decreased MDA-MB-231 tumor volume and weight via inducing apoptosis by suppressing phospho-Akt. Overall, these results indicate that ID extract induces apoptosis through the Akt-NF-κB signaling pathway in MDA-MB-231 breast cancer cells and tumors, and it may serve as a therapeutic agent for triple-negative human breast cancer.</P>
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