노래부르기 과업이 브로카 실어증자의 읽기와 조음 능력에 미치는 영향

윤혜연,권도하 대구대학교 특수교육재활과학연구소 2012 再活科學硏究 Vol.30 No.1

이 연구는 가사보며 노래부르기 과업으로 브로카 실어증자의 읽기와 조음능력을 향상 시키고자 하였다. 3명의 브로카 실어증 대상자로 하였으며 연구 방법은 사전-사후 검사를 사용하였다. 이 연구에서 사용된 노래부르기 과업은 3단계로 구성되어있다. 노래는 대상자에게 있어 익숙한 노래 5곡을 선정하였다. 1단계는 제공된 MP3파일로 노래를 들으며 따라부르기를 한다. 2단계는 문자단서로 제공된 노래가사를 한 음절씩 짚으며 따라 부르기를 하고, 3단계에서는 음을 점진적으로 제거하며 가사 읽기를 시도한다. 이에 치료실외에서도 하루에 3회씩 연습할 수 있도록 지도하였다. 그 결과 노래부르기 과업은 읽기, 조음능력 뿐만 아니라 따라말하기, 이름대기 등 전반적인 언어능력에 있어 향상을 보였다. The purpose of this research was to explore the effect of singing while reading the lyrics had on the reading and articulation skills of people with Broca’s aphasia. The study consisted of three subjects with Broca’s aphasia and the results were analysed by pre-to-post analysis. Thirdly, through the implementation of the task of singing, linguistic abilities, such as reading, intonation, word-repeating and naming skills were all improved. The five songs that were chosen were songs that the participants were familiar with. The first stag involved participants singing along to the songs that were given to them as an MP3 file. The second stage involved participants looking at the hard copy of the lyrics and then breaking up each syllable while singing out loud and the third stage involved gradually omitting the tone from the songs and getting participants to only read the lyrics out loud. Participants were advised to repeat these three steps three times a day outside of the treatment room. The results of this study are as follows: Firstly, there was an improvement in the reading skills following singing tasks. Secondly, through implementing the task of singing there was an articulation in the clarity of intonation. Thirdly, through the implementation of the task of singing, improvements in reading, the ability to intonate, repeating words and naming skills were evident; as well as an overall improvement to the linguistic ability of the people.

자기교시 언어치료전략을 사용한 문장지도 프로그램이 정신지체아동의 언어능력에 미치는 효과

윤선연,권도하 대구대학교 특수교육재활과학연구소 2004 再活科學硏究 Vol.22 No.1

본 연구의 목적은 자기 교시 언어치료 전략을 사용한 문장 지도 프로그램이 정신지체 아동의 언어 능력에 미치는 효과를 증명하는 것이다. 본 실험은 3명의 피험자에게 40분 한 세션으로 일주일에 4회 지도하였다. 실험은 사전, 치료, 유지의 세 단계로 구성되었으며 AB 실험설계를 이용하였다. 의문사 이해력과 구어 표현력 사전, 사후, 유지 단계에서 평가되었다. 그 결과는 다음과 같다. 첫째, 의문사를 이해하는 능력은 모든 피험자들이 향상 되었다. 그리고 계속적으로 의문사 이해능력이 유지되었다. 둘째, 본 실험에서 모든 피험자들의 구어 표현력의 향상되었다. 구어 표현력 또한 지속적으로 유지되었다. 결론적으로 자기 교시 언어치료 전략을 사용한 문장 지도 프로그램이 정신지체 아동의 언어 능력을 향상시키는데 효과적이었다. 본 연구는 자기 교시 언어치료 전략을 사용한 문장 지도 프로그램이 정신지체 아동의 언어 능력에 미치는 효과를 증명하기 위하여, 12~13세 중도(중도)교육가능급 정신지체아동 3명을 대상으로 지도하였다. 실험은 사전평가, 치료, 유지의 세 단계로 구성되었으며 AB설계를 사용하였다. 의문사 이해력과 구어 표현력이 사전, 사후, 유지 단계에서 평가되었다. 실험 결과, 첫째, 의문사를 이해하는 능력이 모든 피험자들이 향상되었고, 계속적으로 의문사 이해능력이 유지되었다. 둘째, 모든 피험자들의 구어 표현력의 향상되었다. 구어 표현력 또한 지속적으로 유지되었다. 결론적으로 자기 교시 언어치료 전략을 사용한 문장 지도 프로그램이 정신지체 아동의 언어 능력을 향상시키는데 효과적이었다. First, the ability to understand interrogative was improved after treatment in all subjects. The subjects maintained the ability to understand an interrogative continuously. Second, this research showed the improvement of children's ability to express the spoken language in all subjects. The subjects maintained the ability to express the spoken language continuously. In conclusion, the sentence instruction program by using self-instruction language treatment strategy was effective on improving the language ability of mentally retarded children.

Ziprasidone의 자연적 임상경험에 대한 후향적 조사 연구 : 3개 대학병원의 경험

이승재,강도형,홍경수,주연호,김남식,권준수 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.3

Objectives : This naturalistic retrospective study investigated the effectiveness of ziprasidone measured by mean improve-ments of the Cltnical Global Impression (CGI-I). Secondary objectives included prescribing patterns, tolerability and safety. Methods : From May to July 2006, 98 psychiatric patients who have been taking ziprasidone for at least 2 weeks were selected. Their current clinical statuses were assessed by the interview and laboratory tests including electrocardiogram (ECG). Data on DSM-IV diagnoses, dosing, concomitant psychotropic medications, clinical changes, adverse effects, and laboratory findings were collected retrospectively. Results : Ziprasidone was mostly prescribed for a switch from another antipsychotics for the treatment of schizophrenia. Two main reasons for a switch were unsatisfactory efficacy and poor tolerance, especially weight gain, of the preceding anti-psychotic medication, Participants as a whole showed mean 2.7±1.0 of the CGI-Improvement. Significant weight reduction after switching to ziprasidone occurred, which was related to the clinical improvement. No significant increase of the QTc interval except one case was observed. Conclusion : The present study confirmed previous tolerability and safety data of ziprasidone as well as the results of its effectiveness.

장애아 부모의 스트레스와 대처

김동연,권도하,전겸구,조인수,윤치연 大邱大學校 障碍人綜合硏究所 1998 再活科學硏究 Vol.14 No.1

본 연구에서는 장애아 부모들이 경험하는 스트레스와 대처를 보다 명확하게 규명하기 위하여 장애아 부모(62명)와 정상아 부모(135명)를 비교하였다. 그 결과, 정서적 스트레스와 관련해서는 장애아 부모가 정상아 부모에 비하여 상태 분노, 특성 분노, 분노 표출, 및 우울에서 유의하게 높게 나타났다. 또한 대처 방식과 관련해서는 장애아 부모가 정상아 부모에 비하여 소극적 철수, 고집, 체념 및 자기 비판에서 유의하게 높게 나타났다. 끝으로, 신체증상과 관련해서는 장애아 무모가 정신아 부모에 비하여 불면증과 심장 질환 증상에서 유의하게 높게 나타났다. An attempt was made to compare the parents of children with disabilities and those of normal children in terms of their emotional stress and coping styles. The scales utilized in the present study were Korean adaptation of STAXI, the multidimensional coping scale, and Korean adaptation of CES-D. The major findings revealed that (1) the parents of children with disabilities compared to those of normal children showed higher levels of state anger, trait anger, and depression. (2) The parents of children with disabilities compared to those of normal children employed more frequently 'passive withdrawal,' 'perseverance,' 'fatalism,' and 'self-criticism', suggesting that they are more frequently employing ineffective coping styles. (3) The parents of children with disabilities compared to those of normal children were suffering from insomnia and cardiac symptoms. Finally, the present findings were discussed and implications for future studies are suggested.

정신분열병의 임상적 고위험군의 특징 : '서울청년클리닉'의 자연 추적 관찰 예비연구

유소영,이경진,강도형,이승재,하태현,위휘,이애라,송지연,김성년,권준수 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.1

Objectives : The aims of this study were to identify the intake and following process for subjects at high risk of transition to schizophrenia and to examine the neurocognitive, social, and emotional functions of the subjects compared with healthy controls. Methods : Symptomatic individuals judged at high risk for schizophrenia ('clinical high risk') within Youth Clinic were assessed and followed up. They performed a neurocognitive function test, a social function test and an affective function test. Twenty healthy controls were recruited in this study. Results : Among eighty-two subjects contacted through the Youth clinic, sixteen subjects were judged as the clinical high risk group. Fourteen subjects among the clinical high risk group showed deficits in several domains of neurocognitive functions, such as visual recall memory, verbal short term memory and executive function. Social and affective functions are also impaired in the Cli-nical high risk group compared with healthy controls. Two of 15 subjects (13%) developed a psychotic disorder within 6 months. Conclusion : This study illustrates the state of follow-up study for a clinical high risk group. Despite low numbers and short durations, some impairment of several functions in the clinical high risk group suggests possible predictors of psychosis.

Synthesis and Biological Evaluation of Manassantin Analogues for Hypoxia-Inducible Factor 1α Inhibition

Kwon, Do-Yeon,Lee, Hye Eun,Weitzel, Douglas H.,Park, Kyunghye,Lee, Sun Hee,Lee, Chen-Ting,Stephenson, Tesia N.,Park, Hyeri,Fitzgerald, Michael C.,Chi, Jen-Tsan,Mook Jr., Robert A.,Dewhirst, Mark W.,Le American Chemical Society 2015 Journal of medicinal chemistry Vol.58 No.19

<P/><P>To cope with hypoxia, tumor cells have developed a number of adaptive mechanisms mediated by hypoxia-inducible factor 1 (HIF-1) to promote angiogenesis and cell survival. Due to significant roles of HIF-1 in the initiation, progression, metastasis, and resistance to treatment of most solid tumors, a considerable amount of effort has been made to identify HIF-1 inhibitors for treatment of cancer. Isolated from <I>Saururus cernuus</I>, manassantins A (<B>1</B>) and B (<B>2</B>) are potent inhibitors of HIF-1 activity. To define the structural requirements of manassantins for HIF-1 inhibition, we prepared and evaluated a series of manassantin analogues. Our SAR studies examined key regions of manassantin’s structure in order to understand the impact of these regions on biological activity and to define modifications that can lead to improved performance and drug-like properties. Our efforts identified several manassantin analogues with reduced structural complexity as potential lead compounds for further development. Analogues <B>MA04</B>, <B>MA07</B>, and <B>MA11</B> down-regulated hypoxia-induced expression of the HIF-1α protein and reduced the levels of HIF-1 target genes, including cyclin-dependent kinase 6 (Cdk6) and vascular endothelial growth factor (VEGF). These findings provide an important framework to design potent and selective HIF-1α inhibitors, which is necessary to aid translation of manassantin-derived natural products to the clinic as novel therapeutics for cancers.</P>

Enhanced On-Demand Multicast Routing Protocol For Multimedia

Do-Yeon Kim,Jin-Woong Cho,Jang-Yeon Lee,Sung-Kwon Park 대한전자공학회 2009 JUCT : Journal of Ubiquitous Convergence Technolog Vol.3 No.1

It is currently required wireless and transmission of the large scale multimedia contents in the network environment, and this requirement is increased more and more. A mobile ad-hoc network routing protocols for transmission of multimedia contents need to have low delay time and to maintain the established route because of their characteristics. In this paper, the proposed protocol, termed HODMRP (History-based On-Demand Multicast Routing Protocol), is advanced On-Demand Multicast Routing Protocol (ODMRP) by adding the criterion which is the session history for establishing route. HODMRP have better Packet Delivery Ratio (PDR) value and lower delay time than ODMRP by the simulation results.

Effect of Plant Growth Regulators on Callus Induction of Rhododendron brachycarpum

Do Yeon Kwon(권도연),Chan Hoon An(안찬훈),Jeong Ho Song(송정호) 한국약용작물학회 2018 한국약용작물학회 학술대회논문집 Vol.2018 No.2

Acute pulmonary toxicity and inflammation induced by combined exposure to didecyldimethylammonium chloride and ethylene glycol in rats

Kwon, Do Young,Kim, Hyun-Mi,Kim, Eunji,Lim, Yeon-Mi,Kim, Pilje,Choi, Kyunghee,Kwon, Jung-Taek JAPANESE SOCIETY OF TOXICOOGICAL SCIENCES 2016 JOURNAL OF TOXICOLOGICAL SCIENCES Vol.41 No.1

<P>Didecyldimethylammonium chloride (DDAC), an antimicrobial agent, has been reported to induce pulmonary toxicity in animal studies. DDAC is frequently used in spray-form household products in combination with ethylene glycol (EG). The purpose of this study was to evaluate the toxic interaction between DDAC and EG in the lung. DDAC at a sub-toxic dose (100 mu g/kg body weight) was mixed with a non-toxic dose of EG (100 or 200 mu g/kg body weight), and was administrated to rats via intratracheal instillation. Lactate dehydrogenase activity and total protein content in the bronchoalveolar lavage fluid (BALF) were not changed by singly treated DDAC or EG, but significantly enhanced at 1 d after treatment with the mixture, with the effect dependent on the dose of EG. Total cell count in BALF was largely increased and polymorphonuclear leukocytes were predominantly recruited to the lung in rats administrated with the mixture. Inflammatory cytokines, tumor necrosis factor-alpha and interleukin-6 also appeared to be increased by the mixture of DDAC and EG (200 mu g/kg body weight) at 1 d post-exposure, which might be associated with the increase in inflammatory cells in lung. BALF protein content and inflammatory cell recruitment in the lung still remained elevated at 7 d after the administration of DDAC with the higher dose of EG. These results suggest that the combination of DDAC and EG can synergistically induce pulmonary cytotoxicity and inflammation, and EG appears to amplify the harmful effects of DDAC on the lung. Therefore pulmonary exposure to these two chemicals commonly found in commercial products can be a potential hazard to human health.</P>

Neonatal isoerythrolysis in Thoroughbred foals

Kwon, Do Yeon,Choi, Seong Kyoon,Cho, Young Jae,Cho, Gil Jae The Korean Society of Veterinary Science 2011 大韓獸醫學會誌 Vol.51 No.1

Two 4-day-old Thoroughbred foals with acute clinical signs of depression, elevated pulse and respiratory rates, anemia, and jaundice were referred to the equine hospital of Korea Racing Authority. The foals were seemingly normal at birth, but showed clinical signs such as abnormal behavior, jaundice and anemia suddenly after ingestion of the mare's colostrum, followed by death at 4 days after birth. According to the results of the hematology, serum chemistry analysis, jaundice foal agglutination test, and blood groups test, the foals were diagnosed as neonatal isoerythrolysis (NI) caused by the mare's antibodies. These results suggested that the pregnant mares have a potential for NI.