단크론항체를 이용한 소 로타바이러스 감염증 치료시험

최해연 ( Hae Yean Choi ),박재명 ( Jae Myong Park ),이은정 ( Un Jeong Lee ),조우영 ( Woo Young Cho ),이종인 ( Jong In Lee ),조부제 ( Bu Jae Cho ),정운선 ( Un Sun Chung ) 한국가축위생학회 1999 韓國家畜衛生學會誌 Vol.21 No.2

To study the efficacy monoclonal antibody(MAb) against bovine rotavirus(BCV) in treatment of calf diarrhea, the MAb was fed to 166 calves with diarrhea from Chung-buk area. The results were summarized as follows. 1. Among the 1,049 calves investigated, 166(16%) calves were infected with BCV. 2. The monthly rate of BCV infection were higher in October to December compared with other months of the year. 3. Among the 166 calves with diarrhea, 137(83%) calves were recovered. 4. Young calves within 7-day-old were more effective in treatment than other ages and the rate of treatment was 86%. 5. Most effective period for treatment of rotavirus was at the first stage of infection.

수종 생약의 Hepatoma cell line에 미치는 형태적 변화의 동정

이은주,정용자 慶星大學校 1998 論文集 Vol.19 No.2

The cells included in medium were invastigated to be aggregated and destroyed slowly by treatment with Lactuca dentata Makino. var. flaviflora Makino. On the other hand, the cells treated with Equisetum arvense L were aggregated to be coat-like. The case of Capsicum annuum L. var. angulosum Mill, the cells became vague after 2 days and then destroyed. This procedure was faster than other. The chromasome was more condensated after 37hr treated with Capsicum annuum L. var. angulosum Mill.

특정기업지원적 산업정책의 전개 : 성과와 문제점

이승훈,정운찬 서울대학교 사회과학연구소 1996 社會科學과政策硏究 Vol.18 No.2

Hepatoma cell에 증식억제작용을 나타내는 식물들

이은주,정용자 慶星大學校 1998 論文集 Vol.19 No.1

We have studied that the effect on the inhibition of the cancer cell growth by the 3-[4,5-Dime wthylthiazol-2 yl]-2,5-diphenyl-tetrazolium bromide(MTT) assay, to investigate the anticancer effect with plants, observed around us, by culturing the human hepatoma cell-line. And we knew it was the best condition that the cell number was 4×10³ cells/well and the time of culture is 48 hours. We found that Equisetum arvense L. and Lactuca dentata Makino. var. Flaviflora Makino. exhibited a good anticancer effect and especially Capsicum annum L. angulosum Mill exhibited the best effect of them.

상악 전치부 후방 견인 시 이동 양상과 응력 분포에 관한 삼차원 유한요소법적 연구

정애진,김운수,이수행,강성수,최희인,조진형,김상철 대한치과교정학회 2007 대한치과교정학회지 Vol.37 No.2

상악 전치부 후방 견인 시의 이동 양상 및 응력 분포를 건조 두개골을 전산화 단층 촬영에 의해 3차원 영상화한 유한 요소 모델 상에서 알아보고자 하였다. 피질골 절단술의 시행 여부와 고정원, 힘의 작용점을 각기 달리 설정하여 8개의 실험군을 구성하여 비교하였다. 통상적인 T-loop을 이용하여 공간폐쇄를 하는 경우 전치부는 후하방으로 경사이동 하였으며, 구치부에서도 약간 전방 이동하였다. 피질골 절단술을 동반하여 전치부를 견인한 경우, 전치부 골편에서의 응력 분포가 전반적으로 넓게 분포되었으며, 전치부 경사의 정도가 적은 반면에 변위량은 훨씬 더 많았다. 협측에서의 견인 시 상악 협측에 식립된 미니 임플랜트와 견치 power arm간에 견인력을 가한 경우가 미니 임플랜트로 고정원이 강화된 제2소구치와 견치 브라켓 간에 견인력을 가한 경우보다 전치부의 후하방 경사 정도가 적었다. 구개측에서 power arm에 대한 견인 시 정중구개봉합 부위에 식립한 미니 임플랜트로부터 견인력을 가한 경우가 상악 제1, 2대구치 간 구개면에 식립된 미니 임플랜트로부터 견인력을 가한 경우보다 전치부의 후하방 경사 정도가 컸다. 이러한 결과로써 치아이동 시 피질골 절단술의 효과와 저항중심에 대한 교정력 벡터 조정의 의미를 확인할 수 있었다. Objective: The purpose of this study was to evaluate the displacement pattern and the stress distribution shown on a finite element model 3-D visualization of a dry human skull using CT during the retraction of upper anterior teeth. Methods: Experimental groups were differentiated into 8 groups according to corticotomy, anchorage (buccal: mini implant between the maxillary second premolar and first molar and second premolar reinforced with a mini implant, palatal: mini implant between the maxillary first molar and second molar and mini implant on the midpalatal suture) and force application point (use of a power arm or not). Results: In cases where anterior teeth were retracted by a conventional T-loop arch wire, the anterior teeth tipped more postero-inferiorly and the posterior teeth moved slightly in a mesial direction. In cases where anterior teeth were retracted with corticotomy, the stress at the anterior bone segment was distributed widely and showed a smaller degree of tipping movement of the anterior teeth, but with a greater amount of displacement. In cases where anterior teeth were retracted from the buccal side with force applied to the mini implant placed between the maxillary second premolar and the first molar to the canine power arm, it showed that a smaller degree of tipping movement was generated than when force was applied to the second premolar reinforced with a mini implant from the canine bracket. In cases where anterior teeth were retracted from the palatal side with force applied to the mini implant on the midpalatal suture, it resulted in a greater degree of tipping movement than when force was applied to the mini implant between the maxillary first and second molars. Conclusion: The results of this study verifies the effects of corticotomies and the effects of controlling orthodontic force vectors during tooth movement.

大學 男女 球技選手들의 最大無機的 Power

김태운,유재충,안덕균,선우섭,이한,손두욱,박충서 慶熙大學校 社會體育硏究所 1994 體育科學論叢 Vol.- No.7

The purpose of the present research is to compare characteristics of maximal anaerobic power observed in different types of sports and player's sex differences. We have reached the following conclusions from the results we obtained by measuring maximal anaerobic power and blood lactate concentration of 60 elite university male and female players during the exercise of bicycle ergometer: 1. As to absolute and relative values of maximal anaerobic power, male players are higher in the order of rugby and handball, whereas female players are higher in the order of hockey and soccer, but no significant differences are observed between types of sports. 2. Male players are noticably higher in absolute values of maximal anaerobic power(p<0.001), but relative value is very simi1ar to that of female players. 3. It is estimated that the fact, that female players show obvious higher mean anaerobic power(p<0.001) during the 3,4KP excercise is due to sex differences in ocdurrence work load of maximal anaerobic power. 4. Comparison of blood lactate concentration at each work load in different types of sports and player's sex differences show an increase in proportion to mean anaerobic power. The results given above clearly show the differences between the type of sports such as rugby and hockey requiring power and speed, and the type of sports such as handball and soccer requiring edurance.

주요우울증 입원환자에서의 Cortisol 억압지수에 관한 연구

정도언,이정균 大韓神經精神醫學會 1985 신경정신의학 Vol.24 No.2

19명의 주요 우울증 환자와 20명의 정상대조군에서 dexamethasone 억제 검사를 시행한 소견을 토대로 8:00시, 16:00시 및 23:30시 각각에서 cortisol 억압지수를 산출하여 그 유용성에 대해 살펴 보았다. 1. 8:00시 및 16:00시의 cortisol 억압지수 소견상 우울증 환자군과 정상 대조군 사이에 유의한 차이가 없었으며 이는 dexamethasone 억제검사시 소견과 일치했다. 2. 8:00시, 16:00시 및 23:30시의 cortisol 억압지수에 대해 각각 감도, 특이도 및 예측율을 산출해 이를 dexamethasone 억제검사소견에서 계산한 결과와 비교한 바 10:00시 cortisol 억압지수에서 47%, 90%, 82%로 16:00시 억압지수가 진단적으로 가장 우수함을 알 수 있었다. 39 adults (19 major depressive inpatients and 20 normal controls) underwent the dexamethasone suppression test (DST) and serum cortisol concentrations at 8:00, 16:00 and 23:30 hour were determined in duplicate by radioimmunoassay technique. Utilizing the above previously published data, CSI (the ratio of predexamethasone cortisol concentration divided by the posdexamethasone cortisol concentration determined at the same time of the day) 8:00, 16:00 and 23:30 hour were calculated and comparisons were made between the CSI results and the already available DST results. The results and the conclusions are as follows; 1. Statistically significant difference of the CSI results was noted at 8:00 and 16:00 hour between the major depressives and the normal controls (Student's t-test, two-tailed, p<0.05). 2. The CSI at 16:00 hour proved to be superior to the DST result in sensitivity, specificity, and predictive value (47%, 90% & 82% vs 42%, 80% & 67%). The cortisol suppression index at 16:00 hour may serve as a valid and convenient tool for diagnosing patients with major depression.

精神科 行旅病者에 對한 臨床的 硏究

金正彦,徐光潤,李丙允 고려대학교 의과대학 1982 고려대 의대 잡지 Vol.19 No.3

This epidemiological investigation of the mental disorders was based on study of 461 cases of psychiatric charity patients, who had been hospitalized between Oct. 1981 and Feb. 1982 at the Seoul Municipal Hospital and Chungryang Ri Hospital. The purpose of this study was to gain basic data and information of these charity patients, which would be helpful to clinical practice and public health administration in general. The following results were obtained; 1. Two hundred thirty four cases of the subject were male and 227 cases were female. Male to Female ratio of all cases was 1.1:1. 2. In diagnostic classification, 60.5% of the subject were schizophrenic disorder and 10.2% were affective disorder. Other clinical entities were epilepsy(6.1%), organic mental disorder(5.6%), alcoholic psychosis(5.4%), paranoid disorder(4.1%), mental retardation and so forth. 3. In the age distribution, those group with age ranged from 21 to 30 years old, were predominated. 4. Many of the subject had relatively poor academic achievement, and were unemployed. 5. 53.4% of all cases were in unmarried, and 13.2% were in divorced. Unmarried cases were seen predominantly in epilepsy(67.9%), personality disorder(61.5%), schizophrenia (58.8%) and affective disorder(53.2%). 6. 75.5% of all cases were chronic illed (over 1 year duration), and 72.3% had history of readmission. 7. 74.8% of the subject were referred by police, because of nonmedical causes rather than medical ones. Direct events for referral were wandering on road(44.5%), visiting governor's office(21.5%), and social welfare and discipline(19.5%) in order of frequency. 8. In the hospital days, 33.2% of all cases were between 7-14 days and 30.8% were between 15-30 days.

Streptomyces 속 균주 HA-40이 생산하는 내열성 α-Amylase의 효소학적 성질

신운섭,이동희,이현우,권태종,정호권 建國大學校 附設 産業技術硏究所 1988 논문집 Vol.13 No.-

토양으로부터 분리한 Streptomyces 속 균주 HA-40이 생산하는 내열성 α-amylase의 효소학적 성질을 조사한 결과는 다음과 같다. 효소의 작용 최적 온도는 65℃였으며 activation energy 는 16.9Kcal/mole이었고 60℃에서는 안정하였으나 70℃에서는 30분 처리로 약 50%, 1시간 처리로 약 75%가 실활하였다. 그러나 ??를 0.1mM농도로 첨가한 경우엔 70℃ 에서 1시간 처리하여도 잔존활성도가 55%이상으로 열변성에 대한 ??의 보호효과가 있었다. 본 효소는 pH7에서 활성이 가장 강하였으며 안정성도 가장 높았다. 그리고 금속이온 중에서 ??의 첨가로 효소활성이 증대되었으며 ??, ??, ??등에 의해서 활성이 저해되었다. 각종 효소저해제는 대부분 영향을 미치지 못하였으나 EDTA가 반응액 중에 공존하면 효소활성이 강하게 저해되었다 본 효소는 maltotriose이하의 당류에 대해서는 분해력이 없었으며 amylose에 대한 환원당 생성력을 100으로 하였을때 soluble starch 108, amylopectin 94, glycogen 87, dextrin 48, potato starch 25, corn starch 18로 생전분에 대한 분해력은 soluble starch에 비해서 1/4∼1/5 정도밖에 되지 않았다. 그리고 soluble starch에 대한 Km 치는 1.9㎎/㎖였다. The properties of a thermostale α-amylase produced from Streptomyces sp. strain HA-40, isolated from soil, were investigated. The optimal temperature of the enzyme was 65℃ and the enzyme was stable below 60℃. However, at 70℃ about 75% of the activity was lost after 1hr treatment, but by the addition of ?? in the concentration of 0.1mM only 45% of the activity was lost. The enzyme was most active and stable at around pH 7. The activity of the enzyme was increased by the addition of ??, but depressed by ??, ??, and EDTA. The enzyme could be hydrolyze soluble starch, amylose, amylopectin and glycogen well, and could also digest dextrin and raw starch. The Km value for soluble starch was 1.9㎎/㎖.

MCF-7에 미치는 인근식물들의 항암효과 Screening Test

곽수영,이은주,정용자 慶星大學校 1998 論文集 Vol.19 No.1

We have studied that the effect on the inhibition of the cancer cell growth by the 3-[4,5-Dimewthylthiazol-2 yl]-2,5-diphenyl-tetrazolium bromide(MTT) assay, to investigate the anticancer effect with plants, observed around us, by culturing the human MCF-7 mammary gland adenocarcinoma cell-line. And we knew it was the best condition that the cell number was 4×10³ cells/well and the time of culture is 48hours. We observed the effect on the inhibition of the cuncer cell growth with plants, observed us and we can find that Capsicum annum L. angulosum Mill exhibited a good anticancer effect.