그람양성구균에 대한 Teicoplanin과 Vancomycin의 시험관내 항균력

최태열,김경숙,전용관,서일혜,김정욱,이웅수,안정열,김홍석,정재용,최효선,김덕언,유진우 대한감염학회 1994 감염 Vol.26 No.1

An increasing frequency of methicillin resistant S. aureus(MRSA), methicillin resistant coagulase negative staphylococci(MRCNS) and Enterococcal infection have been observed in recent years. Teicoplanin is a new glycopeptide antibiotic obstained from the Actinoplanes teicomycetius. The molecular structure and spectrum of antimicrobial activity of teicoplanin is simillar to those of vancomycin, and has been reported to have an excellent in vitro and in vivo effect against various gram-positive infections. Therefore, we evaluated the in vitor susceptibility of gram positive cocci, such as, S. aureus, coagulase negative Staphylococci(CNS), and Enterococci to teicoplanin and vancomycin. The total 253 strains consisted of MSSA(40), MRSA(53), MSCNS(47), MRCNS(48), and Enterococci(65). They were assayed by disc diffusion and agar dilution. During the study, 57% of S. aureus and 49% of CNS showed resistance to methicillin. The inhibitory diameter of teicoplanin was 15-20mm in MSSA, 12-19mm in MRSA, 13-24mm in MSCNS, 11-23mm in MRCNS, and 15-22mm in Enterococci respectively, and showed sensitivity in all but 8 strains(3.2%). The range of the minimum inhibitory concentration (MIC) of teicoplanin to MSSA, MRSA, MSCNS, MRCNS and Enterococci were 9.12-2.0㎍/ml, 0.25-2.0㎍/ml, & 0.25-32㎍/ml, 0.12-1.0㎍/ml respectively. One case of S. haemolyticus was resistant to teicoplanin (32㎍/ml) by the agar dilution method. Eight minor (3.2%) and one major(0.4%) error was observed when the MIC and disk diffusion data were correlated with teicoplanin. As for vancomycin the inhibitory diameter was 17-21mm in MSSA, 15-21mm in MRSA, 18-26mm in MSCNS, 18-25mm in MRCNS, and 16-22mm in Enterococci respectively. The range of the MIC of vancomycin to MSSA, MRSA, MSCNS, MRCNS, and Enterococci were 0.25-1.0㎍/ml, 0.25-4.0㎍/ml, 0.5-2.0㎍/ml and 0.5-2.0㎍/ml respectively. One minor error (0.4%) was seen with the vancomycin disk. The MIC90 of MSSA and MRSA exhibited the same results in teicoplanin (1.0㎍/ml, 1.0㎍/ml), and vancomycin(2.0㎍/ml, 2.0㎍/ml). MSCNS and MRCNS exhibited greater MIC90 with teicoplanin(4.0㎍/ml, 8.0㎍/ml) than vancomycin(2.0㎍/ml, 2.0㎍/ml). Incontrase Enterococci were more susceptible to teicoplanin(0.5㎍/ml) than to vancomucin (2.0㎍/ml). Results from this analysis indicated that both teicoplanin and vancomycin were very excellent for gram positive infections, especially those resistant to methicillin.

진단 초음파를 이용한 정상 성인의 정중신경 측정

이정아,임길병,이홍재,정웅태,황현오 최신의학사 2003 最新醫學 Vol.46 No.11-12

호르몬 불응성 전립선암 환자에서 mitoxantrone과 prednisone의 병합화학요법 후 통증완화 및 삶의 질 측정

이홍우,이지열,김세웅,이충범,강성학,조용현,황태곤,박용현,윤문수 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.3

목적 : 호르몬 불응성 전립선암 환자의 생명을 연장시키는 치료법은 현재로는 없으며, 현 시점에서의 치료목표는 증상의 경감 및 소실에 따른 삶의 질 향상에 두고 있다. 호르몬 불응성 전립선암의 고식적인 치료에 일차적인 치료법으로 간주되는 mitoxantrone과 prednisone의 화학요법이 호르몬 불응성 전립선암 환자의 통증완화 및 삶의 질에 어떠한 영향을 미치는지 알아보았다. 방법 : 1998년 7월부터 1999년 12월까지 증상이 있는 18명의 호르몬 불응성 전립선암 환자를 대상으로 하였으며, 일차적인 치료의 목표는 환자 본인이 기록하는 McGill-Melzack 6단계 통증척도에서 진통제의 증량 없이 2점이 감소(또는 첫 점수가 1점일 경우 통증의 완전소실)하는 것으로 하였다. 이러한 기준은 최소 3주 간격으로 시행한 자가 기록조사에서 연속적으로 2번 이상 유지될 때 유효한 것으로 간주하였다. 건강과 관련된 삶의 질 측정은 전신적 치료의 임상적 응용을 위한 실제적인 측정방법으로 개발되어 환자가 직접 작성하는 전립선암 특이성 삶의 질 측정기구(Prostate Cancer-Specific Quality-of-Life Instrument : PROSQOLI)의 비례연속형의 자가측정 척도(linear analogue self-assessment scale : LASA)를 이용하였으며, ECOG performance status를 사용하여 전신상태의 변화도 측정하였다. 결과 : 통증의 경감으로 나타나는 고식적인 치료의 반응은 66.7%(12/18)에서 나타났으며, 반응의 지속기간은 2개월에서 10개월까지로 평균 4.2±3.6개월이었다. PROSQOLI로 측정한 삶의 질은 통증에 대한 고식적인 치료반응을 보인 12명(66.7%) 모두가 삶의 질이 개선되었으며 특히 통증, 변비, 소변보기, 전반적인 복지상태에서의 유의한(p<0.05) 증가를 보였다. 치료 후 혈장 PSA 수치는 고식적인 반응의 유무에 관계없이 별 다른 변화를 보이지 않았으며, 골주사 또는 전산화 단층촬영으로 측정한 방사선학적 병변은 고식적인 반응을 보인 2명을 제외하고 치료 전과 비교하여 차이를 보이지 않았다. 병합 화학요법과 관련된 특별한 부작용은 관찰되지 않았다. 결론 : 통증을 동반한 호르몬 불응성 전립선암에서 mitoxantrone과 prednisone의 병합화학요법은 66.7%의 환자에서 통증의 감소 및 삶의 질이 향상되었다. 현재는 혈장 PSA 수치, 병소의 크기나 개수등이 치료의 지침이나 치료결과의 판정을 위한 객관적인 기준으로 사용되는 경향이 있지만, 앞으로는 환자를 중심으로 통증을 포함한 삶의 질 측정이 고식적 치료 후 치료결과 판정에 있어 객관적이고 적절한 방법이 될 것이다. Background : There is no evidence that therapeutic modalities prolong the survival of patients with hormone-refractory prostate cancer nowadays. The main goal of treatment is therefore improvement in quality-of-life including palliation of symptoms. We performed this study to investigate the benefit of mitoxantrone and prednisone chemotherapy in patients with symptomatic hormone-refractory prostate cancer using relevant end points of palliation regarding to pain and quality-of-life. Methods : From July 1998 to December 1999, we assessed the 18 patients with symptomatic hormone-refractory prostate cancer receiving mitoxantrone and low dose prednisone. The treatment end point was a palliative response defined as a 2-point decrease in pain assessed by a 6-point pain scale complemented by patients (or complete loss of pain if initially 1+) without an increase in analgesic medication and maintained for two consecutive evaluations at least 3 weeks apart. Health-related quality-of-life was evaluated with a series of linear analogue self-assessment(LASA) scale of the Prostate Cancer-Specific Quality-of-Life Instrument (PROSQOLI) and performance status was also measured. Results : Palliative responses were observed in 12(66.7%) of 18 patients. The duration of palliative responses were 4.2±3.6 months(range: 2 to 10 months). Treatment was well tolerated without specific side effects. There were no differences in prostate-specific antigen (PSA) level following treatment and no significant changes of radiologic findings evaluated by bone scan and/or CT were noted except 2 cases after chemotherapy. All the responding patients had an improvement in quality-of-life scales and performance status, however serum PSA levels were not changed. Conclusions : Chemotherapy with mitoxantrone and prednisone provides palliation and an improvement in quality-of-life for more than half (66.7%) of the patients with symptomatic hormone-refractory prostate cancer.

진행 위암환자에서 Lymphokine-Activated Killer (LAK) 활성의 저하

홍원선,김영환,송재관,강윤구,이진오,강태웅,김정룡 대한내과학회 1990 대한내과학회지 Vol.38 No.3

Natural killer(NK) and lymphokine-activated killer(LAK) activities were determined in 31 patients with unresectable stomach cancer before and immediately after chemotherapy with 5-fluorouracil, adriamycin and mitomycin C(FAM) and 31 healthy volunteers. The major purposes of the study were focused on whether peripheral blood lymphocytes(PBL) in stomach cancer patients had a similar ability in the generation of LAK activity to those in healthy volunteers and what the effect was of chemotherapy with FAM on the generation of LAK activity. LAK cells were generated in vitro by culturing human PBL with 100 U/㎖ of recombinant human interleukin-2(rH-IL-2) for 72 hours. K562(human myelogenous leukemia cell line) and MKN-45(human stomach adenocarcinoma cell line) were used as target cells for NK and LAK activities. NK activity against K562, a sensitive line, was significantly depressed in patients with stomach cancer compared with that in healthy volunteers(p<0.01). However, LAK activity against K562 was similar to that of the controls. Age, sex and performance status(ECOG 0-2 and 3-4) did not have an influence on both NK and LAK activities. LAK activity was significantly higher than NK activity, either against K562 or MKN-45, in both healthy volunteers and patients with stomach cancer(p<0.001). NK and LAK activities against MKN-45, a NK-resistant line, in patients with stomach cancer showed significantly lower levels than those in healthy volunteers. We also analyzed the effect of chemotherapy with FAM on NK and LAK activities, with no suppression of NK and LAK activities being observed. In this study, we have demonstrated that PBL of stomach cancer have a reduced ability to generate LAK activity in response to rH-IL-2. However, LAK activity generated from PBL receiving chemotherapy with FAM was similar to that of PBL without chemotherapy.

A Feasibility Study on the Han River Area as the Construction Site for the Kyung Bu Canal

Chung, Tae-Woong,Son, Bu-Soon,Kim, Ki-Hyun,Kim, Jong-Oh Korean Society for Environmental Sanitary Engineer 2000 대한환경위생공학회지 Vol.15 No.3

To facilitate the carriage of goods and products, an improvement of the transportation system is greatly needed in Korea. The construction of the Kyung Bu canal that can traverse over the wide area of southern Korea os proposed to be one of the most favorable choices to resolve this need. To fulfill this plan, we investigated the possibility of connecting the Han River (in the midwest) with the Nak-tong River (in the southeast) via the Cho-ryeong tunnel (20.5 km long and 125 m high). According to topographic and geological mapping analysis, we are capable of selecting the optimal locations for the tunnels and locking systems. The water requirement for high locking systems can be satisfied by constructing additional dams above the Choong-ju area or by introducing water saving lock system. The results of our investigation support the idea such a canal system, if constructed, could lead to a revolution of the Korea's transportation system.

Attenuation of High - Frequency Lg Waves around the Yangsan Fault area , the Southeast Korea

(Tae Woong Chung),(Kie Hwa Lee) 대한지구물리학회 2002 지구물리 Vol.5 No.1

N/A N/A

Depth-dependent seismicity and crustal heterogeneity in South Korea

Chung, Tae Woong,Iqbal, Muhammad Zafar,Lee, Youngmin,Yoshimoto, Kazuo,Jeong, Jina Elsevier 2018 Tectonophysics Vol.749 No.-

<P><B>Abstract</B></P> <P>Depth-dependent seismicity has been suggested in the seismogenic layer, which is divided into upper and lower layers by its seismicity boundary. Since large earthquakes tend to occur in the lower layer, the structure of the seismogenic layer, which includes the seismicity boundary, provides important information for seismic hazard assessment. Using 107 land-based earthquakes, the structure of the seismogenic layer in South Korea was studied with focal depth determination by identifying the minimum residuals between the observations and several models. The same procedure was done for the depth relocation of 138 events associated with the Gyeongju earthquake (M<SUB> <I>L</I> </SUB> 5.8), the largest event in South Korea in the last two centuries. The geothermal temperature at the focal depth was also estimated for all earthquakes, including the Gyeongju earthquake cluster and the Pohang earthquake (M<SUB> <I>L</I> </SUB> 5.4), which caused more damage than did the Gyeongju earthquake. As observed in a large-scale averaging of mainland China, a 12-km seismicity boundary was suggested due to the frequent seismicity in the upper layer. At 12-km depth at the Gyeongju earthquake site, the geothermal temperature reached 300 °C, and the occurrence of aftershocks was limited below that depth. Based on the rigorously estimated depth, we separated the scattering attenuation, <I>Q</I> <SUB> <I>s</I> </SUB> <SUP>−1</SUP>, by a multiple lapse time window analysis using individual earthquakes and found higher and lower values for events in the upper and lower layers, respectively. This depth-dependent observation suggests differences in heterogeneity between the upper and lower seismogenic layers and supports the hypothesis that the seismicity of a depth-dependent seismogenic layer is related to cracks, which diminish with depth. Our results suggest that the upper limit of the focal depth can be predicted from the depth of the seismicity boundary for normal large earthquakes.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The seismicity boundary of seismogenic layer in South Korea was identified. </LI> <LI> Crustal seismic-wave scattering strength exhibits depth-dependent heterogeneity between the two layers. </LI> <LI> The upper limit of the focal depth of large earthquakes can be predicted from the depth of the seismicity boundary. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Focal depths versus number of earthquakes for South Korea, and the Gyeongju earthquake cluster. The seismogenic layer (<I>S.L.</I>) consists of upper and lower layers divided at 12-km depth. The histograms with orange fill denote focal depth temperatures higher than 300 °C. Red and blue stars denote the ML 5.8 and 5.1 events, respectively. In the right graph, the scattering Q<SUP>−1</SUP> values with frequencies are shown as connected lines of events exclusively included in the upper and lower layers, respectively.</P> <P>[DISPLAY OMISSION]</P>

Seismicity boundary depth of Mainland China

Tae-Woong Chung,Muhammad Zafar Iqbal,Hui Zhou 대한지질학회 2018 대한지질학회 학술대회 Vol.2018 No.10

CNS Involvement in Hemophagocytic Lymphohistiocytosis: CT and MR Findings

Tae Woong Chung 대한영상의학회 2007 Korean Journal of Radiology Vol.8 No.1

Hemophagocytic lymphohistiocytosis (HLH) is a rare disorder that is characterized by proliferation of benign histiocytes, and this commonly involves the liver, spleen, lymph nodes, bone marrow and central nervous system (CNS). We report here on the CT and MR imaging findings in a case of CNS HLH that showed multiple ring enhancing masses mimicking abscess or another mass on the CT and MR imaging.

경주 지진 여진의 진원 깊이 연구

정태웅 ( Tae Woong Chung ),모하메드자파르 ( Muhammad Zafar Iqbal ) 한국지구물리·물리탐사학회 2017 지구물리와 물리탐사 Vol.20 No.1

2016년 9월 12일 경주지진(규모 5.8)의 103개 여진의 진원 깊이를 HYPO71과 HYPOINVERSE를 이용한 진원 재결정을 통하여 역산하였다. 한반도에서 지역에 따라 변화하는 속도를 나타내는 7개 모델을 비교한 분석에서 전구간 선형가중치를 둔 HYPO71이 HYPOINVERSE에 비해 진앙 부근 모델이 잔차가 더 적은, 바람직한 결과를 얻었다. 규모가 큰 지진과 S파 진앙거리가 짧은 지진자료는 진원깊이 불확실성이 비교적 작게 관찰되었다. Hypocentral depths of 103 aftershocks of the 12 September 2016 Gyeongju earthquake (ML 5.8) were inverted by epicentral relocation, using HYPO71 and HYPOINVERSE. From the comparison of seven models that reflect regional velocity structure in the southern Korean Peninsula, HYPO71 with linear weighting over the whole range showed less residuals than HYPOINVERSE for the model near the epicenter. Less uncertainties of focal depths were observed for the events with large magnitude and short range of the closest S-phase distance.