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평면응력 문제의 동적해석을 위한 적응적 요소망 형성 전략
尹鍾烈,洪承杓 弘益大學校 科學技術硏究所 2005 科學技術硏究論文集 Vol.16 No.-
Finite Element Method(FEM) is the representative approximate analysis method which is the most widely used in various fields of engineering. In order to use the FEM for structural analysis, element type and mesh should be chosen. The effective mesh is essential to get more accurate results in short time using FEM, and the expert knowledge and experience are necessary. Adaptive mesh generation is a technique that improves the accuracy of FEM results through a refinement of mesh using the results of the previous analysis step. In this study, the concept of representative strain value is introduced to analyze structures subjected to dynamic loadings using the adaptive mesh generation. Representative strain value based on the standard deviation of strain can be used as a sign of error in an element. The study presents a criteria for regeneration of mesh that applies for both r-method and h-method. This study examines the validity of the suggested strategy to obtain effective mesh through a culvert examples under fixed varying load. The proposed strategy reduces the calculation and a good accuracy is obtained.
Flurbiprofen 함유 키토산 제제가 치은 섬유아세포에 미치는 영향
정종평,박윤정,이승진,유인철,최상묵 梨花女子大學校 藥學硏究所 1997 藥學硏究論文集 Vol.- No.6
The main goal of periodontal regeneration is to be achieved by epithelial exclusion, periodontal ligament cell activation or alveolar bone regeneration. The purpose of this study was to investigate on the physico-chemical and biological characteristics of biodegradable chitosan beads. Chitosan beads were fabricated by ionic gelation with sodium tripolyphosphate and they had the size in 300㎛ diameter. As therapeutic agent, flurbiprofen was incorporated into the beads by 10, 20% loading contents. The release of drugs from the chitosan beads was measured in vitro. Also, biological activity tests of flurbiprofen loaded chitosan beads including cytotoxicity test, ihhibition of IL-1β production, suppression to PGE_2 production, collagenase inhibition test, the ability of total protein synthesis, and tissue response were evaluated. The amount of flurbiprofen released from chitosan was 33-50% during 7 days. Minimal cytotoxicity was observed in chitosan beads. Flurbiprofen released from chitosan beads significantly suppressed the IL-1β production of monocyte, PGE_2 production and markedly inhibited collagenase activity. Meanwhile, flurbiprofen released from this system showed increased ability for protein synthesis. Throughout 4-week implantation period, no significant inflammatory cell infiltrated around chitosan bead and also fibroblast like cell types at the beads-tissue interface were revealed with gradual degradation of implanted chitosan beads. From these results, it was suggested that flurbiprofen loaded chitosan beads can be effectively useful for biocompatible local delivery system in periodontal regeneration.
METRx™ 기구를 이용한 후방 경추부 추궁추간공 제거술의 예비 결과
박형천,윤승환,박종운,하윤,현동근,김은영,박현선,임대철 대한척추신경외과학회 2004 Neurospine Vol.1 No.1
Objectives: Posterior cervical microscopic laminoforaminotomy has been a preferred procedure for a posterolateral cervical disc or foraminal stenosis. However, neckpain from wide skin incision and muscle injury are some of disadvantages. The authors performed cervical microscopic laminoforaminotomy with METRx™ tubular dilator system and were compared the results with classical cervical microscopic foraminotomy. Methods: Six patients underwent posterior cervical microscopic laminoforaminotomy using the METRx™ during 6 months. We have selected 10 patients from our institution as a comparison group. Preoperative and postoperative pain score composed of the radicular and neck component was examined and disability score also recorded. Diameters and lengths of laminoforaminotomy on the postoperative CT also were compared with two methods Results: Postoperative pain scores to the radiculopathies were not different but postoperative pain scores to the neckpain on the follow up periods were significantly different. The average vertical and transverse diameters of the laminoforaminotomy defect on the postoperative CT scans were not different between two groups. Average hospital stay of the classical methods was 8.8±7.5 days comparison with 4.5±0.54days of new procedure. Conclusions: Posterior cervical microscopic laminoforaminotomy with METRx™ systems seems to provide similar decompression and clinical results as classical methods compared to classical methods and shows superior results for postoperative neckpain and hospital stays.
만성활동성 (慢性活動性) 간질환자에서 (肝疾患者) Glycyrrhizin preparation ( Stronger Neo - minophagen C ) 의 투여효과
윤종만(Chong Mann Yoon),박종춘(Jong Chun Park),박광숙(Kwang Sook Park),범희승(Hee Seung Bom),유종선(chong Sung Rheu),박세원(Seh Won Park),국돈표(don Pio Kook),김성열(Seong Rhyull Kim) 대한소화기학회 1984 대한소화기학회지 Vol.16 No.2
N/A Glycyrrhizin, one of the active component of licorice root, has been known to have various therapeutic effects in chronic hepatitis. For the assessment of therapeutic effect of glycyrrhizin preparation, we administered 40 ml of glycyrrhizin preparation intravenously in 566 ml of dextrose solution for 8 to 12 weeks, who had no symptomatic and biochemical improvement (more than 5 fold increase compared to normal value) during recent 3months in 17 patients with chronic active hepatitis. Also, laboratory follow-up of serum transaminase, HBsAg, and serum electrolyte were repeated at intervals of 7 days. The results were as follows. 1) In 16 out of 17 patients with chronic active hepatitis, serum transaminase level decreased to half value after glycyrrhizin preparation for 8 to 12 weeks duration. 2) In 14 out of 17 patients (82%), serum transaminase dropped to 2 fold level compared to normal value after 2 to 10 weeks treatment (mean SGOT: 4.5 weeks. SGPT: 5 weeks). 3) Serum transaminase were normalized in 7 out of 17 patients(42%) after 3 to 12 weeks treatment (mean SGOT: 6. 5 weeks, SGPT: 8 weeks). 4) There was no seroconversion of HBsAg during treatment. 5) There were no signs of pseudoaldosteronism including changes of serum sodium and potassium, presence of edema or hypertension during treatment.
위궤양에 대한 Teprenone ( Selbex ) 의 효과
윤종만(Chong Mann Yoon),범희승(Hee Seung Bom),최성규(Sung Kyu Choi),박일종(Il Chong Park),박해옥(Hae Ok Park),류종선(Jong Sun Rew),양대현(Dae Hyun Rang),조정곤(Jong Kon Cho) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.2
The balance of mucosal defensive factors and aggressive factors is important for ulcerogenesis. Gastrointestinal mucus is a complex glycoprotein which is secreted from variable types of cells in the gastrointestinal tract. Glycoprotein plays an important role as a mucosal defensive factor.We have treated 30 cases of endoscopically diagnosed gastric ulcers with teprenone (Selbex) for the evaluation of the therapeutic efficacy. Every patient was treated with teprenone 50 mg t.i.d. for 8 weeks and underwent endoscopic, clinical and laboratory assessments before and after 8 weeks of the treatment. Aiajor symptoms of gastric ulcer have been improved in 2 out :30 cases (83.4%) after 8 weeks of the medication with teprenone. While, the improvement of gastric ulcer evaluated by endoscopy was observed in 21 out of 30 cases (70.0%). No significant side effects were observed except a mild elevation of SGOT in one patient.
위내시경으로 (胃內視鏡) 진단된 각종 위질환 (胃疾患) 에서의 장상피화생의 (腸上皮化生) 유형에 관한 연구
윤종만(Chong Mann Yoon),박광숙(Kwang Sook Park),범희승(Hee Seung Bom),박일종(Il Chong Park),류종선(Jong Sun Rew),양대현(Dae Hyun Yang),조정곤(Jung Kon Cho) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.1
N/A To evaluate the significance of intestinal metaplasia as a guide for precancerous lesions in gastric cancer, we studied the frequency and subtypes of intestinal metaplasia in 189 patients including 64 cases of chronic gastritis, 45 with gastric ulcers and 80 with gastric cancer who underwent gastroscopic biopsies in the department of internal medicine of Chonnam Univerity Hospital. The results were the following: 1) The overall positivity of intestinal metaplasia in 189 patients with various gastric lesions was 57 percents with 47 percents in chronic gastritis, 62 percents in gastric ulcer and 61 percents in gastric cancer. 2) The positivity of intestinal metaplasia in gastric cancer in well differentiated types (69%) was not so higher than in undifferentiated types (48%). But the positivity of intestinal metaplasia in gastric cancer of intestinal type (84%) was higher than in gastric type (21%) with statistical significance (p<0.005). 3) The frequency of intestinal metaplasia showed increasing tendency with aging. 4) According to the Hematoxylin-Eosin, PAS and Alcian-Blue stain, intestinal metaplasia is divided into 3 subtypes. Type II enterocolic metaplasia is not detected in chronic gastritis but in only one case of gastric ulcer. The presence of enterocolic metaplasia is 20 out of 49 patients with gastric cancer, with 44 percents in intestinal type and 0 percent in gastric type. The result of this study suggests that type II. Benterocolic type of intestinal rnetaplasia plays a significant role as a precancerous lesion in intestinal type of gastric cancer.