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만성활동성 (慢性活動性) 간질환자에서 (肝疾患者) Glycyrrhizin preparation ( Stronger Neo - minophagen C ) 의 투여효과
윤종만(Chong Mann Yoon),박종춘(Jong Chun Park),박광숙(Kwang Sook Park),범희승(Hee Seung Bom),유종선(chong Sung Rheu),박세원(Seh Won Park),국돈표(don Pio Kook),김성열(Seong Rhyull Kim) 대한소화기학회 1984 대한소화기학회지 Vol.16 No.2
N/A Glycyrrhizin, one of the active component of licorice root, has been known to have various therapeutic effects in chronic hepatitis. For the assessment of therapeutic effect of glycyrrhizin preparation, we administered 40 ml of glycyrrhizin preparation intravenously in 566 ml of dextrose solution for 8 to 12 weeks, who had no symptomatic and biochemical improvement (more than 5 fold increase compared to normal value) during recent 3months in 17 patients with chronic active hepatitis. Also, laboratory follow-up of serum transaminase, HBsAg, and serum electrolyte were repeated at intervals of 7 days. The results were as follows. 1) In 16 out of 17 patients with chronic active hepatitis, serum transaminase level decreased to half value after glycyrrhizin preparation for 8 to 12 weeks duration. 2) In 14 out of 17 patients (82%), serum transaminase dropped to 2 fold level compared to normal value after 2 to 10 weeks treatment (mean SGOT: 4.5 weeks. SGPT: 5 weeks). 3) Serum transaminase were normalized in 7 out of 17 patients(42%) after 3 to 12 weeks treatment (mean SGOT: 6. 5 weeks, SGPT: 8 weeks). 4) There was no seroconversion of HBsAg during treatment. 5) There were no signs of pseudoaldosteronism including changes of serum sodium and potassium, presence of edema or hypertension during treatment.
위암종에서 Epidermal Growth Factor Receptor 의 발현에 관한 연구 - 면역조직화학적 염색 및 in situ Hybridization -
조정곤(Jung Kon Cho),류도현(Do Hyun Rheu),최성규(Sung Kyu Choi),유종선(Jong Sun Rew),윤종만(Chong Mann Yoon),박창수(Chang Soo Park) 대한내과학회 1996 대한내과학회지 Vol.51 No.1
N/A Objectives: Gastric carcinoma is the leading cause of death among cancer patients in Korea. The etiologic factors of gastric carcinoma were suggested to chronic gastritis, genetic defect, food and environmental factor. Recently, the studies for oncogene and tumor marker have been actively performed to investigate the causes of gastric carcinoma. Epidermal growth factor receptor(EGFR) has homology in amino acids with c-erb B2 oncogene product. EGFR was identified in the placenta, chorionic villi and gastrointestinal mucosa. But it was more expressed in tumor cells, and it may be usedas a tumor marker. Methods: To investigate the correlation between EGFR and malignant potentiality in gastric carcinoma, we performed in situ hybridization of EGFR mRNA and immunohistochemistry of c-erb B2 and EGFR in 127 cases of formalin fixed paraffin embedded tissue sections of gastric carcinoma. Results: The positive reaction for c-erb B2, EGFR protein and EGFR mRNA was identified in the cytoplasm of tumor cells. The positive ratio was 44.196 in c-erb B2, 63.8% in EGFR, and EGFR mRNA was expressed in 72.4% of cases. The expression of c-erb B2 was not related with differentiation of cells, tumor size, invasiveness and metastasis. However the expression of EGFR and EGFR mRNA was related to the invasion of primary tumor and lymph node metastasis (p<.0.05). And expression of EGFR mRNA was increased in the advances of clinical stage. Conclusion: These above results suggest that the expression of EGFR mRNA is related with malignant potentiality of gastric carcinoma. EGFR mRNA might be used as tumor marker and prognostic factor of gastric carcinoma.
양성 위궤양으로 진단된후 내시경검사로 경과 관찰중 확인된 위암에 대한 검토
최성규,김기태,김세종,유종선,윤종만,구철,류도현,문범 대한소화기내시경학회 1996 Clinical Endoscopy Vol.16 No.2
To examine the relationship between gastric ulcer and gastric cancer, we investigated petients with gastric ulcer diagnosed from 1986 to l993. We reviewed the endoscopic reports and films of patients with gastric ulcer retrospective1y. We excluded the patients who was diagnosed as gastric cancer in two years follow-up. The results were as follaws; 1) During follow-up of the original cohort, there were 5 patients(0.5~%) in whom gastric cancer developed at the same site initially diagnosed as gastric ulcer. The gross type of the lesion was early gastric cancer in two and advanced gastric cancer in three patients. 2) The time interval between the initia1 diagnosis of gastric ulcer and cancer development was from 31 months to 70 months (average 51 months). 3) At the initial examination of 5 gastric cancer patients, the diagnosis was active gastric ulcer in four, multiple gastric ulcer in one, and linear gastrie ulcer in one patient. Characteristic endoscopic findjngs were gastric ulcer with clubbing mucosal folds in three and gastric ulcer with bleeding in one patient. 4) During the follow-up period, endoscopicailly and histologically healing of gastric uleer was observed in one patient and histologic finding showed chronic superficial gastritits with intestinal metaplasia. These results suggest that gastric ulcers rarely progress to gastric cancer. However if the endoscopic findings are suspicious for malignancy, then follow-up endoscopy until complete healing should be done.
양대현,한상우,주영은,김신묵,김세종,윤종만,김태두,류도현,지미선,유종선 대한소화기내시경학회 1994 Clinical Endoscopy Vol.14 No.1
Leiomyosarcoma of the duodenum is an uncommon tumor and have not specific symptoms and signs, almost all cases of tumor were diagnosed in operating room. This tumor is generally firm, relatively well encapsulated, lobulated and often soft if they undergo hemorrhagic necrosis. Most authors emphasized the relative number of mitosis as the most reliable findings of leiomyosarcoma. Recently, we experienced a case of leiomyosarcoma of duodenum which was confirmed by operative and pathological diagnosis.