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N/A To evaluate the significance of intestinal metaplasia as a guide for precancerous lesions in gastric cancer, we studied the frequency and subtypes of intestinal metaplasia in 189 patients including 64 cases of chronic gastritis, 45 with gastric ulcers and 80 with gastric cancer who underwent gastroscopic biopsies in the department of internal medicine of Chonnam Univerity Hospital. The results were the following: 1) The overall positivity of intestinal metaplasia in 189 patients with various gastric lesions was 57 percents with 47 percents in chronic gastritis, 62 percents in gastric ulcer and 61 percents in gastric cancer. 2) The positivity of intestinal metaplasia in gastric cancer in well differentiated types (69%) was not so higher than in undifferentiated types (48%). But the positivity of intestinal metaplasia in gastric cancer of intestinal type (84%) was higher than in gastric type (21%) with statistical significance (p<0.005). 3) The frequency of intestinal metaplasia showed increasing tendency with aging. 4) According to the Hematoxylin-Eosin, PAS and Alcian-Blue stain, intestinal metaplasia is divided into 3 subtypes. Type II enterocolic metaplasia is not detected in chronic gastritis but in only one case of gastric ulcer. The presence of enterocolic metaplasia is 20 out of 49 patients with gastric cancer, with 44 percents in intestinal type and 0 percent in gastric type. The result of this study suggests that type II. Benterocolic type of intestinal rnetaplasia plays a significant role as a precancerous lesion in intestinal type of gastric cancer.
N/A For the differential diagnosis of asymptomatic HBsAg carrier with normal liver function by the liver scan, authors applied the maximum likelihood method as follows: 1) Ninety-six cases who underwent both peritoneoscopic liver biopsy and liver scan were divided randomly into two groups. In one group scoring table was made and in the other group diagnostic accuracy of the data was evaluated. The diagnostic accuracy in general was 53.2% and those in normal, liver cirrhosis, nonspecific reactive hepatitis, and chronic active hepatitis were 85.7%, 75%, 62.5%, and 12.5%, respectively. 2) Twenty-eight liver scans of aymptomatic HBsAg carrier with normal liver function were revealed to be normal in 23 cases (82.2%) and liver cirrhosis in 5 cases (17.8%). In conclusion the maximum likelihood method was considered to be useful in the differential diagnosis of liver scans. And we recommend a careful evaluation of asymptomatic HBsAg carrier with normal liver function in view of the fact that 17.8% of them was diagnosed as liver cirrhosis in this study.
N/A Glycyrrhizin, one of the active component of licorice root, has been known to have various therapeutic effects in chronic hepatitis. For the assessment of therapeutic effect of glycyrrhizin preparation, we administered 40 ml of glycyrrhizin preparation intravenously in 566 ml of dextrose solution for 8 to 12 weeks, who had no symptomatic and biochemical improvement (more than 5 fold increase compared to normal value) during recent 3months in 17 patients with chronic active hepatitis. Also, laboratory follow-up of serum transaminase, HBsAg, and serum electrolyte were repeated at intervals of 7 days. The results were as follows. 1) In 16 out of 17 patients with chronic active hepatitis, serum transaminase level decreased to half value after glycyrrhizin preparation for 8 to 12 weeks duration. 2) In 14 out of 17 patients (82%), serum transaminase dropped to 2 fold level compared to normal value after 2 to 10 weeks treatment (mean SGOT: 4.5 weeks. SGPT: 5 weeks). 3) Serum transaminase were normalized in 7 out of 17 patients(42%) after 3 to 12 weeks treatment (mean SGOT: 6. 5 weeks, SGPT: 8 weeks). 4) There was no seroconversion of HBsAg during treatment. 5) There were no signs of pseudoaldosteronism including changes of serum sodium and potassium, presence of edema or hypertension during treatment.
N/A The balance of mucosal defensive factors and aggressive factors is important for ulcerogenesis. Gastrointestinal mucus is a complex glycoprotein which is secreted from variable types of cells in the gastrointestinal tract. Glycoprotein plays an important role as a mucosal defensive factor.We have treated 30 cases of endoscopically diagnosed gastric ulcers with teprenone (Selbex) for the evaluation of the therapeutic efficacy. Every patient was treated with teprenone 50 mg t.i.d. for 8 weeks and underwent endoscopic, clinical and laboratory assessments before and after 8 weeks of the treatment. Aiajor symptoms of gastric ulcer have been improved in 2 out :30 cases (83.4%) after 8 weeks of the medication with teprenone. While, the improvement of gastric ulcer evaluated by endoscopy was observed in 21 out of 30 cases (70.0%). No significant side effects were observed except a mild elevation of SGOT in one patient.
N/A The biological characteristics and the genesis of gastric carcinoma, the most common malignancy in Korean adult male, have not been established so far. Estrogen receptors (ER) have been idnetified in many hormone-dependent cancer such as breast cancer, prostate cancer and ovarian cancer and utilized clinically to provide hormonal therapeutic manipulation. In order to find any hormonal relation in gastric cancer, the presence of ER was examined in 38 patients with primary gastric carcinoma, six with benign stomach lesions and 17 normal gastric tissues, using monoclonal antibody by enzyme immunoassay in cystosol. The results obtained were as follows; 1) ER concetration (Mean+SD) in cytosol from noraml gastric tissue, benign gastric lesion and gastric cancer tissue were 5.6+4.6, 14.617.7 and 20.1+41.7 fmol/mg protein, respectively. Positivities of ER in normal gastric tissue, benign gastric lesion and gastric cancer tissue were 0, 16.7 and 21.1%, respectively. Concentration and positivity of ER were higher in gastric cancer tissue, especially in female gastric cancer tissue, than noraml gastric tissue and benign gastric lesion. 2) Highest value of ER concentration and ER posiitvity according to the macroscopic classification of the gastric carcinoma was observed in Borrmann type II. There was an increasing tendency in ER positivity as the size of the cancer increase. 3) ER concentration and positivity according to the histologic pattern were higher in poorly and well differentiated tubular adenocarcinoma than mucinous adenocarcinomas, signet ring cell carcinoma and moderately differentiated tubular adenocarcinomas. 4) Concentration and postitivity of ER from cancerous tissue of the postmenopausal patients were more higher than that of the premenopausal patients. These results suggested that there was close reation between the presence of ER and the evolution of gastric carcinoma, but not with the degree of histologic malignancy.